Counterregulatory roles of GLI2 and GLI3 in osteogenic differentiation via Gli1 expression
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The GLI1/GLI2/GLI3 transcription factors mediate Hedgehog (Hh) signaling, which is crucial for bone development. During intramembranous ossification, mesenchymal stem cells (MSCs) are directly differentiated into osteoblasts. Under basal and Hh pathway-stimula... ...
