The LRRK2 G2019S variant rewires Rab GTPase phosphorylation after lysosomal damage and promotes cell death in human macrophages [0.03%]
LRRK2基因G2019S突变通过Rab GTP酶磷酸化将溶酶体损伤与巨噬细胞死亡联系起来
Rebecca Morrison,Simeon R Mihaylov,Chak Hon Luk et al.
Rebecca Morrison et al.
Variants in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, yet how these variants alter immune cell function remains unclear. Because LRRK2 is activated by lysosomal damage in macrophages, we ...
Meeting report - CellExIt#1, the first international symposium on cell extrusion [0.03%]
细胞排出会议报告-CellExIt#1首次国际细胞排出研讨会
Naoka Shiratsuchi,Yasuyuki Fujita,Simon de Beco et al.
Naoka Shiratsuchi et al.
In April 2026, the first international symposium on cell extrusion (CellExIt#1) was held in St Jean-Cap-Ferrat in the south of France. The meeting gathered investigators who, through different perspectives and disciplines, are dissecting th...
Vimentin intermediate filaments support autophagosome biogenesis at ER-endosome contact sites in response to starvation [0.03%]
星形蛋白中间纤维支持ER-晚期内体接触位点处的自噬体形成以响应饥饿反应
Quentin Frenger,Dobrawa Amiri Czajkowski,Carla Alemany et al.
Quentin Frenger et al.
Macroautophagy (autophagy) is a fundamental catabolic process requiring the biogenesis of the autophagosome to support cell survival during stress. Although the roles of F-actin and microtubule cytoskeleton in autophagy are well established...
Sibylle Schleich,Aurelio A Teleman
Sibylle Schleich
NIFK is a nucleolar protein involved in ribosome biogenesis which interacts with Ki-67 and is recruited to the perichromosomal layer during mitosis. NIFK expression is elevated in multiple cancers and its expression correlates with poor pro...
A Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65 [0.03%]
涉及TMED9和GRASP65的前proTGFα高尔基体旁路分泌机制
Susanne S Steigleder,Isabel Döring,Marina Tauber et al.
Susanne S Steigleder et al.
We recently demonstrated that the endoplasmic reticulum export of proTGFα is tightly gated and that proteostasis factors, including the intramembrane protease RHBDL4, can promote its release by an unknown mechanism. While investigating a p...
A Tca17TRAPPC2L/TRAPPC11/12/13 subcomplex directs TRAPPIII to autophagy [0.03%]
Tca17TRAPPC2L/TRAPPC11/12/13亚复合物可将TRAPPIII导向自噬
Mario Pinar,Vivian de Los Ríos,Silvia Rodríguez-Pires et al.
Mario Pinar et al.
TRAPP complexes are master regulators of membrane trafficking. TRAPPs are targeted to different locales by pathway-specific subunits decorating a core hetero-heptamer to build TRAPPII (Golgi exit) and TRAPPIII (autophagosomes and ER-Golgi t...
Lizanne Oliveira,Jomon Joseph
Lizanne Oliveira
Annulate lamellae (AL) are endoplasmic reticulum (ER) subdomains harbouring a subset of nucleoporins (Nups), the proteins that assemble into the nuclear pore complexes (NPCs) on the nuclear envelope (NE). AL have been observed in a variety ...
SNED1 fibrillar assembly in the extracellular matrix requires fibronectin and collagen I [0.03%]
纤连蛋白和胶原I对细胞外基质中SNEDD1纤维聚集体形成是必需的
Leanna Leverton,Dharma Pally,Asantewaa Jones et al.
Leanna Leverton et al.
The extracellular matrix (ECM) is a meshwork of proteins that orchestrates a broad range of cellular phenotypes, including proliferation, adhesion, migration, and differentiation. SNED1 is a newly characterized ECM glycoprotein that promote...
The yeast DENN domain protein Avl9 contributes to recycling and sorting of endosomal cargos [0.03%]
酵母DENN结构域蛋白Avl9参与内体货物的循环和分拣
Daniel J Rioux,Samreen Manj,Derek C Prosser
Daniel J Rioux
In yeast and humans, the conserved DENN-domain (Differentially Expressed in Normal and Neoplastic tissue) protein Avl9 is thought to play roles in membrane traffic and secretion, but its precise function remains poorly defined. Since DENN-c...
OpticalFlow3D - a tool for measuring amorphous motion in three-dimensional fluorescence microscopy images [0.03%]
光学流3D——一种测量三维荧光显微图像中无定形运动的工具
Rachel M Lee,Leanna R Eisenman,Chad M Hobson et al.
Rachel M Lee et al.
Motion is an essential component of any living system. It is rich with information, but it is often challenging to quantitatively extract biologically informative results from the motion apparent in microscopy images. This challenge is exac...