KATANIN is required for the formation of complete preprophase bands and subsequent division positioning in two asymmetric divisions of the maize stomatal complex [0.03%]
KATANIN在调控玉米气孔复合体的两次不对称分裂中的作用
Stephanie E Martinez,Carolyn G Rasmussen
Stephanie E Martinez
Microtubule dynamics underpin cell division, movement, and growth in eukaryotic organisms. KATANIN p60 is a microtubule-severing protein that promotes proper cell elongation and division. In plants, division positioning is initiated in late...
FGD1 restrains actomyosin contractility to promote suprabasal junction maturation in stratified keratinocytes [0.03%]
FGD1通过限制肌动蛋白肌球蛋白收缩性促进角化鳞状细胞中表皮基底上层连接的成熟
Diana I Hotea,Alexandra Jetté,Amy Beaudin et al.
Diana I Hotea et al.
The epidermis is a stratified epithelium in which keratinocytes differentiate as they move from basal to suprabasal layers, a process during which tissue integrity relies on the coordinated remodeling of intercellular junctions and the cyto...
Identification of feeding apparatus components in a heterotrophic marine flagellate [0.03%]
异养海洋鞭毛类摄食装置鉴定
Gillian Clifford,Samuel J P Taylor,Midori Ishii et al.
Gillian Clifford et al.
Diplonemids are highly abundant heterotrophic single-celled flagellates that are widespread in the world's ocean. They have a highly complex microtubule-based feeding apparatus (cytostome-cytopharynx complex) located adjacent to the deep fl...
Cooperative definition of ER exit sites by Tango1, Sec16 and Sec12 [0.03%]
Tango1、Sec16和Sec12共同定义ER退出位点
Zhi Feng,Mercedes Martín,Marta Rojas et al.
Zhi Feng et al.
Endoplasmic reticulum (ER) exit sites (ERES) are dynamic ER subdomains where secretory cargos are concentrated and exported towards the Golgi apparatus. The conserved proteins Sec16 and Sec12 have long been implicated in ERES organization, ...
Phosphorylation of the AP2 µ2 subunit by p70S6 kinase facilitates clathrin-mediated endocytosis [0.03%]
蛋白激酶p70S6通过磷酸化AP2的μ2亚基促进皮层内吞作用
Aleksandra Tempes,Agnieszka Brzozowska,Tomasz Węgierski et al.
Aleksandra Tempes et al.
Clathrin-mediated endocytosis (CME) internalizes cell-surface receptors via clathrin-coated invaginations of the plasma membrane. Both clathrin and endocytic cargo are recruited to these sites by the adaptor protein complex AP2. AP2 cycles ...
Msh2 depletion impairs cell differentiation, proliferation and metabolism in esophageal organoids [0.03%]
Msh2缺失会影响食道类器官的细胞分化、增殖和代谢
Marjorie Rolland,Dominique Jean,Maude Hamilton et al.
Marjorie Rolland et al.
Due to a rapid cell turnover, the esophageal stratified squamous epithelium must maintain homeostasis. This process is ensured by a long-lived subpopulation of basal stem cells that express Keratin 15 (Krt15). However, the mechanisms that s...
The LRRK2 G2019S variant rewires Rab GTPase phosphorylation after lysosomal damage and promotes cell death in human macrophages [0.03%]
LRRK2基因G2019S突变通过Rab GTP酶磷酸化将溶酶体损伤与巨噬细胞死亡联系起来
Rebecca Morrison,Simeon R Mihaylov,Chak Hon Luk et al.
Rebecca Morrison et al.
Variants in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, yet how these variants alter immune cell function remains unclear. Because LRRK2 is activated by lysosomal damage in macrophages, we ...
Meeting report - CellExIt#1, the first international symposium on cell extrusion [0.03%]
细胞排出会议报告-CellExIt#1首次国际细胞排出研讨会
Naoka Shiratsuchi,Yasuyuki Fujita,Simon de Beco et al.
Naoka Shiratsuchi et al.
In April 2026, the first international symposium on cell extrusion (CellExIt#1) was held in St Jean-Cap-Ferrat in the south of France. The meeting gathered investigators who, through different perspectives and disciplines, are dissecting th...
Vimentin intermediate filaments support autophagosome biogenesis at ER-endosome contact sites in response to starvation [0.03%]
星形蛋白中间纤维支持ER-晚期内体接触位点处的自噬体形成以响应饥饿反应
Quentin Frenger,Dobrawa Amiri Czajkowski,Carla Alemany et al.
Quentin Frenger et al.
Macroautophagy (autophagy) is a fundamental catabolic process requiring the biogenesis of the autophagosome to support cell survival during stress. Although the roles of F-actin and microtubule cytoskeleton in autophagy are well established...
Sibylle Schleich,Aurelio A Teleman
Sibylle Schleich
NIFK is a nucleolar protein involved in ribosome biogenesis which interacts with Ki-67 and is recruited to the perichromosomal layer during mitosis. NIFK expression is elevated in multiple cancers and its expression correlates with poor pro...