Identification of locally activated spindle-associated proteins in oocytes uncovers a phosphatase-driven mechanism [0.03%]
鉴定出局部激活的纺锤体相关蛋白质揭示了一种磷酸酶驱动机制
Xiang Wan,Gera Pavlova,C Fiona Cullen et al.
Xiang Wan et al.
The meiotic spindle forms only around the chromosomes in oocytes, despite the exceptionally large volume of the cytoplasm. This spatial restriction is likely to be governed by local activation of key microtubule regulators around the chromo...
Distinct impacts of human co-chaperone UNC45 paralogues on Drosophila muscle development and function [0.03%]
UNC45辅分子对果蝇肌肉发育和功能的不同的影响
Daniel A Smith,Morgan I Mullens,Raul Ramos et al.
Daniel A Smith et al.
Uncoordinated-45 (UNC45) is a conserved protein required for myosin accumulation during muscle development. Invertebrates have one unc-45 gene whereas vertebrates have two paralogues, UNC45A and UNC45B, which exhibit differential expression...
Edward Jenkins,Clare Latta,Hoang Anh Le
Edward Jenkins
Immune cells play a fundamental role in coordinating physiological processes, from early stage development through to trained host immunity. Hence, an enhanced insight into the dynamic interactions across all immune cell subsets is imperati...
Importin α regulates ciliogenesis and cilia length with implications for Xenopus nephrogenesis [0.03%]
进口蛋白α调节纤毛发生和纤毛长度，对非洲爪蟾肾生成具有重要意义
Natalie Mosqueda,Patrick James Sutton,Christopher W Brownlee
Natalie Mosqueda
Cilia are microtubule-based organelles essential for a wide range of biological processes ranging from facilitating fluid flow to transducing developmental and growth signals. Defects in cilia structure or function can lead to ciliopathies....
Cellular elasticity drives the mechano-adaptation against fluid shear stress [0.03%]
细胞弹性驱动的流体剪切应力力学适应性
Ditipriya Mallick,Indranil Ghosh,Tanmoy Mondal et al.
Ditipriya Mallick et al.
Cancer cells adapt to external biophysical cues but how the cytoskeletal remodeling facilitate this mechano-adaptation is largely unexplored. Here, we demonstrate that the intrinsic non-muscle myosinII (NMII) activity and self-organization ...
Charcot-Marie-Tooth type 2A variants of mitofusin 2 sensitize cells to apoptotic cell death [0.03%]
线粒体融合蛋白2的Charcot-Marie-Tooth型2A变异体使细胞易于发生凋亡性细胞死亡
Mariana Joaquim,Maria-Bianca Bulimaga,Marie A Mohn et al.
Mariana Joaquim et al.
The neuropathy Charcot-Marie-Tooth (CMT) is an incurable disease with a lack of genotype-phenotype correlation. Variants of the mitochondrial protein mitofusin 2 (MFN2), a large GTPase that mediates mitochondrial fusion, are responsible for...
Reinhard Fässler,Arnoud Sonnenberg
Reinhard Fässler
Integrins are widely expressed cell adhesion receptors that link extracellular matrix proteins to the cytoskeleton. Most integrins connect to the actin cytoskeleton through different types of adhesion plaques, including nascent adhesions an...
Claire Overly Cottom,Evan Billings,Michelle Bush et al.
Claire Overly Cottom et al.
The major feature that distinguishes Gram-negative bacteria from Gram-positive bacteria is the presence of both an inner and outer membrane. Both membranes contain lipoproteins, peripheral membrane proteins, α-helical membrane proteins and...
EKLF/KLF1 coordinates specialized transcriptional networks required to maintain the integrity of terminal erythropoiesis [0.03%]
EKLF/KLF1协调特异性的转录网络以维持晚期红细胞成熟的完整性
M N Gnanapragasam,P Jiang,A R Dhara et al.
M N Gnanapragasam et al.
Erythroid Krüppel Like Factor (EKLF/ KLF1) is a C2H2 zinc finger transcription factor that plays a critical role in all aspects of erythropoiesis. Mutations in KLF1 lead to diverse phenotypes ranging from mild to severe anemias. Patients w...