Clathrin-mediated endocytosis as an axis for the etiopathogenesis of Parkinson's disease [0.03%]
网格蛋白介导的内吞作用作为帕金森病发生发展的核心轴
Amal Kaci,Susanne Herbst,Claudia Manzoni et al.
Amal Kaci et al.
Clathrin-mediated endocytosis (CME) is a core process in eukaryotic cells, providing a mechanism to selectively take up cargo from the extracellular space into the cytoplasm. Emerging data from both Mendelian and idiopathic forms of Parkins...
Advancing lung cancer therapy - leveraging cell biology to improve immunotherapy and anti-angiogenic strategies [0.03%]
肺癌治疗的进步—利用细胞生物学改善免疫疗法和抗血管生成策略
Jozafina Haj-Shomaly,Alejandro Castillo-Kauil,Carla Bloom et al.
Jozafina Haj-Shomaly et al.
The standard of care for lung cancer typically involves a multidisciplinary approach including surgery, chemotherapy, radiotherapy, targeted therapy and immunotherapy, with treatment strategies tailored to the cancer subtype, disease stage ...
The EH Binding protein EHBP1 operates in a ciliary functional module affected by INPP5E dysfunction [0.03%]
EH结合蛋白EHBP1在受INPP5E功能障碍影响的纤毛功能模块中起作用
Kae R Whiting,Mariam Aslanyan,Imke Peters et al.
Kae R Whiting et al.
Inositol polyphosphate-5-phosphatase E (INPP5E) encodes the ciliary protein INPP5E, which plays an important role in regulating the phospholipid membrane makeup of the primary cilium. Here we utilize proximity labelled proteomics of INPP5E ...
Ajay B Murakonda,Naava Naslavsky,Steve Caplan
Ajay B Murakonda
Endosome fission is essential for the generation of carrier vesicles and recycling of receptors to the plasma membrane. Early events in endosome fission depend on the generation of Arp2/3-mediated branched actin, which segregates cargo and ...
Silvia Tassan-Lugrezin,Silje A C A Debets,Laura van Niftrik et al.
Silvia Tassan-Lugrezin et al.
Cristae, convolutions of the inner mitochondrial membrane, provide an extended surface area for respiratory chain complexes and ATP synthases. Crista structure has been extensively researched in opisthokont model organisms, such as yeast an...
Francesca Esposito,Sofia Francia
Francesca Esposito
DNA double-strand breaks (DSBs) are among the most cytotoxic and most frequent lesions that arise in the mammalian genome; they occur as a result of both external insults and internal metabolic activities. Failures in damage signalling and ...
PA200 differentially regulates the proteasome and inhibits migration of NSCLC cells [0.03%]
PA200差异化地调节蛋白酶体并抑制非小细胞肺癌细胞迁移
Ayse S Yazgili,Georgia A Giotopoulou,Sabine J Behrend et al.
Ayse S Yazgili et al.
Proteasome activator 200 (PA200; also known as PSME4) is upregulated in non-small cell lung cancer (NSCLC) and linked to poor prognosis. We have previously demonstrated that the overexpression of PA200 in NSCLC is associated with immune eva...
Sayantanee Paul,Khandan Ilkhani,Nathan Strozewski et al.
Sayantanee Paul et al.
The receptor tyrosine kinase (RTK)/extracellular signal-regulated kinase (ERK) signaling pathway controls cell proliferation, differentiation, and survival. The transcriptional repressor Capicua (Cic) has emerged as a key target for ERK-med...
Cancer metabolism in radiation sensitization: complementary roles of O-GlcNAc Transferase (OGT) and PARP1 [0.03%]
放疗增敏中的糖基化和聚ADP核糖转移酶的作用机制研究
Elena Efimova,Yue Liu,Sera Averbek et al.
Elena Efimova et al.
For double-strand breaks (DSBs) formed by radiation, onset of 5' to 3' end resection is a deciding factor in repair pathway choice, favoring homologous recombination (HR) over non-homologous end-joining (NHEJ). Studying HR-proficient MCF7 b...
Alternatively-spliced STIM2.3 is an evolutionary late Store-operated Calcium Entry regulator expressed in brain [0.03%]
交替剪接产生的STIM2.3是进化中晚期的_store-operated钙离子入口_调节因子，在脑部表达
Vanessa Poth,Hoang Thu Trang Do,Lukas Jarzembowski et al.
Vanessa Poth et al.
Ca2+ homeostasis is essential for cellular functions, with regulation by Store-Operated Ca2+ Entry (SOCE) omnipresent. Due to a reduced ER-luminal Ca2+ affinity, STIM2 regulates basal cytosolic Ca2+ but also increases interaction and activa...