LCN2 promotes focal adhesion formation and invasion by stimulating Src activation [0.03%]
LCN2通过促进Src激活来促进焦粘附形成和侵袭
Bhagya Shree Choudhary,Nazia Chaudhary,Bushra K Khan et al.
Bhagya Shree Choudhary et al.
Previous work has demonstrated that Lipocalin2 (LCN2) expression promotes invasion and migration in multiple tumor types. The mechanisms by which LCN2 promotes invasion and migration remain unclear. Previous work from our laboratory demonst...
Megan Balzarini,John Kim,Hilla Weidberg
Megan Balzarini
Mitochondria are metabolic hubs that are essential for cellular homeostasis. Most mitochondrial proteins are translated in the cytosol and imported into the organelle. However, import machineries can become overwhelmed or disrupted by physi...
AID-2×RBD27, an auxin-inducible degron-based Rab27 trapper that reversibly inhibits the function of Rab27A in melanocytes [0.03%]
一种新型的基于细胞因子诱导的降解基序的Rab27诱捕器可使黑色素细胞中的Rab27A功能可逆失活
Akira Sugawara,Yuto Maruta,Mitsunori Fukuda
Akira Sugawara
Small GTPase Rabs are evolutionarily conserved regulators of intracellular membrane traffic and regulate multiple steps in membrane trafficking. Although various approaches have been used to identify the function(s) of individual Rabs, no s...
Coilin and SUMOylation influence PARP1 dynamics and the DNA damage response [0.03%]
Coilin和SUMO化影响PARP1动态以及DNA损伤反应
Sara K Tucker,Blaise C Seale,David T Brown et al.
Sara K Tucker et al.
Coilin is a nucleoplasmic protein that is enriched in some cell types in the Cajal Body (CB). CBs take part in the biogenesis of many different types of ribonucleoproteins (RNPs) such as small nuclear RNPs. Coilin is known as the CB marker ...
A minimal mathematical model for polarity establishment and centralspindlin-independent cytokinesis [0.03%]
极化建立及中央纺锤体独立有丝分裂胞质分裂的数学模型
Ondrej Maxian,Katrina M Longhini,Michael Glotzer
Ondrej Maxian
Cell polarization and cytokinesis are fundamental processes in organismal development. In the Caenorhabditis elegans model system, both processes are partially driven by local inhibition of contractility at the cell poles. This inhibition c...
Eleonora Zilio,Tim Schlegel,Marta Zaninello et al.
Eleonora Zilio et al.
Mitochondria are dynamic and heterogeneous organelles that rewire their network and metabolic functions in response to changing cellular needs. To this end, mitochondria integrate a plethora of incoming signals to influence cell fate and su...
Quantitative comparison of fluorescent proteins using protein nanocages in live cells [0.03%]
利用蛋白质纳米笼在活细胞中定量比较荧光蛋白
Giulia Viola,Yasmeen Ibrahim,Kyle A Jacobs et al.
Giulia Viola et al.
To standardize comparison of fluorescent protein performance on a molecule-by-molecule basis in a physiological intracellular environment, we constructed fluorescent protein tagged I3-01 peptides that self-assemble into stable sixty subunit...
Laurie P Lee-Glover,Martin Picard,Timothy E Shutt
Laurie P Lee-Glover
As we have learned more about mitochondria over the past decades, including about their essential cellular roles and how altered mitochondrial biology results in disease, it has become apparent that they are not just powerplants pumping out...
Focus on numbers: characterizing protein accumulation at DNA double strand breaks [0.03%]
聚焦数字：DNA双链断裂处蛋白质聚集的特征分析
Graziana Modica,Joannie Roy,Antoine G Godin et al.
Graziana Modica et al.
Unrepaired DNA double strand breaks can lead to cell death or genomic rearrangements. The DNA damage response (DDR) is a complex signaling cascade in which a plethora of factors act to finely tune repair pathway choice. Several DDR proteins...
The phosphorylation of Pak1 by Erk1/2 for cell migration requires Arl4D acting as a scaffolding protein [0.03%]
Arl4d作为支架蛋白通过erk1/2介导pak1磷酸化以促进细胞迁移
Ting-Wei Chang,Ming-Chieh Lin,Chia-Jung Yu et al.
Ting-Wei Chang et al.
Activation of extracellular signal-regulated kinases 1 and 2 (Erk1/2) at the plasma membrane usually leads to their translocation to various intracellular sites, where scaffolding proteins mediate substrate targeting. However, in platelet-d...