Conserved biochemical activity and function of phosphatidylinositol 5 phosphate 4 kinase regulates growth & development [0.03%]
泛素化磷脂底物PI(5)P的磷脂酶J内酯酶活性及其在生长和发育中的作用
Harini Krishnan,Suhail Muzaffar,Sanjeev Sharma et al.
Harini Krishnan et al.
Co-ordination of function between multiple cells, mediated by hormones or growth factors, is a critical requirement for multi-cellularity. Phosphoinositides, generated by lipid kinase activity, are second messengers that mediate such signal...
Max L B Grönloh,Werner J van der Meer,Merel E Tebbens et al.
Max L B Grönloh et al.
Leukocytes traverse the vasculature to reach sites of infection by sequentially crossing two distinct barriers - the endothelial barrier, during transendothelial migration (TEM), and the pericyte barrier, during trans-pericyte migration (TP...
Differential roles of cyclin-CDK1 complexes in cell migration and invasion [0.03%]
细胞周期蛋白-CDK1复合体在细胞迁移和侵袭中的不同作用机制
Joseph H R Hetmanski,Michael J Jones,Matthew Hartshorn et al.
Joseph H R Hetmanski et al.
We have previously described a central role for CDK1 at the nexus of adhesion signalling and cell cycle progression, demonstrating that CDK1 has a non-canonical role in regulating integrin adhesion complexes and in the migration of cancer c...
CLASP1 regulates Dynein for PLK1-mediated spindle organization and cytokinesis in oocyte meiosis [0.03%]
CLASP1通过PLK1介导的纺锤体组织和有丝分裂来调节动力蛋白
Meng-Meng Shan,Ping-Shuang Lu,Yuan-Jing Zou et al.
Meng-Meng Shan et al.
The meiotic spindle organization and cytokinesis are important for mammalian oocyte maturation. CLIP-associating protein (CLASP) 1 is a member of microtubule plus-end binding proteins, which is reported to regulate cytokinesis in mitosis; h...
MatriCom: a scRNA-Seq data mining tool to infer ECM-ECM and cell-ECM communication systems [0.03%]
MatriCom：一种用于推断基质-基质和细胞-基质通信系统的scRNA-Seq数据挖掘工具
Rijuta Lamba,Asia M Paguntalan,Petar B Petrov et al.
Rijuta Lamba et al.
The ECM is a complex meshwork of proteins forming the framework of all multicellular organisms. Protein interactions are critical to building and remodeling the ECM meshwork, while interactions between ECM proteins and receptors are essenti...
Hypothesis that ancestral eukaryotes sexually proliferated without kinetochores or mitosis [0.03%]
关于祖先真核生物在没有动粒或有丝分裂的情况下通过性繁殖增殖的假说
Bungo Akiyoshi
Bungo Akiyoshi
Eukaryotes possess two different mechanisms to transmit genetic material - mitosis and meiosis. Because mitosis is universal in all present-day eukaryotes, it has been widely assumed, despite the absence of definitive evidence, that meiosis...
A single-chain antibody-based AID2 system for conditional degradation of GFP-tagged and untagged proteins [0.03%]
一种基于单链抗体的AID2系统 用于GFP标记及非标记蛋白质的条件性降解
Moutushi Islam,Takefumi Negishi,Naomi Kitamoto et al.
Moutushi Islam et al.
Protein knockdown using an improved auxin-inducible degron (AID2) technology has proven to be a powerful tool for studying protein function. The current approach requires the fusion of target proteins with a degron tag, a process typically ...
Adherens junctions limit septate junction length in Drosophila midgut enterocytes but are not required for polarity [0.03%]
斑马鱼肠上皮细胞的黏着带限制了分隔连接的长度但不是极性形成的必需条件
Cátia A Carvalho,Mihoko A Tame,Daniel St Johnston
Cátia A Carvalho
Adherens junctions formed by E-cadherin adhesion complexes play central roles in the organisation and apical-basal polarisation of both mammalian and insect epithelia. Here we investigate the function of the components of the E-cadherin adh...
In vitro reconstitution of a minimal human centrosome scaffold capable of forming and clustering microtubule asters [0.03%]
体外重构能够形成和聚集微管放射状阵列的最小人类中心体支架模型
Manolo U Rios,Weronika E Stachera,Nicole E Familiari et al.
Manolo U Rios et al.
CDK5RAP2/CEP215 is a key pericentriolar material (PCM) protein that recruits microtubule-nucleating factors at human centrosomes. Using an in vitro reconstitution system, we show that CDK5RAP2 is sufficient to form micron-scale scaffolds us...
SLC-25A46 regulates mitochondrial fusion through FZO-1/Mitofusin and is [0.03%]
SLC-25A46通过FZO-1/Mitofusin调控线粒体融合并且与帕金森病相关
Hiroyuki Obinata,Taisei Watanabe,Hironori Takahashi et al.
Hiroyuki Obinata et al.
Mitochondria are dynamic organelles shaped by sequential fission and fusion events. The mitochondrial protein SLC25A46 has been identified as a causative gene for mitochondrial neuropathies. However, the function of SLC25A46 in mitochondria...