In vitro reconstitution of a minimal human centrosome scaffold capable of forming and clustering microtubule asters
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CDK5RAP2/CEP215 is a key pericentriolar material (PCM) protein that recruits microtubule-nucleating factors at human centrosomes. Using an in vitro reconstitution system, we show that CDK5RAP2 is sufficient to form micron-scale scaffolds using nanometer-scale ... ...
