Gayatri Puri,Roméo S Blanc
Gayatri Puri
Stem cell behavior is tightly regulated by signals from the surrounding immune environment. Immune cells play an indispensable role in the maintenance, activation and differentiation of tissue-resident stem cells (TSCs). These interactions ...
Broad H3K4me3 domains support oocyte genome silencing and maturation but are dispensable for repression in early embryos [0.03%]
广义H3K4me3区域支持卵细胞基因组的沉默和成熟但在早期胚胎中抑制时则无足轻重
Trine Skuland,Madeleine Fosslie,Sherif Khodeer et al.
Trine Skuland et al.
Epigenetic reprogramming and embryonic genome activation (EGA) are crucial events during early development. Establishment of distinctive broad histone H3 lysine 4 trimethylation (H3K4me3) domains in the oocyte is necessary for genome silenc...
Non-autonomy of age-related morphological changes in the C. elegans germline stem cell niche [0.03%]
秀丽隐杆线虫生殖干细胞生态位的形态学变化独立于年龄而发生
Nilay Gupta,Mia Sinks,E Jane Albert Hubbard
Nilay Gupta
Declines in tissue renewal and repair due to alterations in tissue stem cells is a hallmark of aging. Many stem cell pools are maintained by morphologically complex niches. Using the C. elegans hermaphrodite germline stem cell system, we an...
Mouse scalp development requires Rac1 and SRF for the maintenance of mechanoresponsive mesenchyme [0.03%]
Rac1和SRF对于维持机械响应间充质从而进行毛囊发育的必要性
Bharath H Rathnakar,Alex Rackley,Hae Ryong Kwon et al.
Bharath H Rathnakar et al.
Rac1 is a small GTPase that regulates cell proliferation, migration, and differentiation processes crucial for development. Mutations in specific guanine nucleotide exchange factors and GTPases that regulate Rac1 are associated with Adams-O...
Activity of the SWI/SNF complex is indispensable for syncytiotrophoblast formation [0.03%]
SWI/SNF复合体在合胞体滋养层形成中的不可或缺作用
Henrieta Papuchova,Andreas Lackner,Terezia Vcelkova et al.
Henrieta Papuchova et al.
Developmental transitions are characterized by coordinated changes in lineage-specific gene expression programs and chromatin states. Yet, how these shifts in cell fate occur during placental development remains largely unknown. Here, we us...
Non-autonomy of age-related morphological changes in the C. elegans germline stem cell niche [0.03%]
秀丽隐杆线虫生殖干细胞生态位中形态学变化与衰老无关
Nilay Gupta,Mia Sinks,E Jane Albert Hubbard
Nilay Gupta
Declines in tissue renewal and repair due to alterations in tissue stem cells is a hallmark of aging. Many stem cell pools are maintained morphologically complex niches. Using the C. elegans hermaphrodite germline stem cell system, we analy...
Fer3 is uniquely expressed in NotchOFF hemilineages where it promotes interneuron identity [0.03%]
Fer3在NotchOFF半神经节中独特表达并促进中间神经元的分化
Kasey C Drake,Sen-Lin Lai,Chris Q Doe
Kasey C Drake
In the Drosophila nervous system, neuroblasts (NBs) divide to produce a clone of neurons that establish distinct fates via precise timing and patterning of transcription factors (TFs). The final step in neurogenesis is a Notch/Numb asymmetr...
VPS45 and SYP4 Qa-SNARE proteins jointly regulate auxin distribution and plant development in Arabidopsis [0.03%]
拟南芥中的VPS45和SYP4 Qa-SNARE蛋白共同调控生长素分布及植物发育
Kosuke Ogita,Narumi Fukasawa,Wang Ruian et al.
Kosuke Ogita et al.
The plant hormone auxin is directionally transported in plant tissues by the actions of the auxin transport proteins. PIN-FORMED (PIN) family proteins asymmetrically localize at the plasma membrane (PM), and facilitate auxin efflux, thereby...
Mohannad Dardiry,Aissam Ikmi
Mohannad Dardiry
Many animals retain the capacity to transform their form and function throughout life, yet developmental biology has predominantly focused on early stages. Non-bilaterian animals, in particular, offer opportunities to investigate the princi...
Functional dissection of H3K4 Methyltransferases reveals distinct catalytic and non-catalytic roles in C. elegans development [0.03%]
功能性剖析H3K4甲基转移酶揭示了其在秀丽隐杆线虫发育中具有不同的催化和非催化作用
Benedetta Attianese,Hua Wang,Katrine Madsen et al.
Benedetta Attianese et al.
The KMT2 class of histone methyltransferases regulates methylation of Histone 3 Lysine 4 (H3K4), a conserved post-translational modification associated with active transcription. However, studies highlighted catalytic-independent functions ...