Voltage-gated calcium channels generate blastema Ca2+ fluxes restraining zebrafish fin regenerative outgrowth [0.03%]
电压门控钙通道产生限制斑马鱼鳍再生过度生长的芽体钙通量
Heather K Le Bleu,Rea G Kioussi,Astra L Henner et al.
Heather K Le Bleu et al.
Adult zebrafish fins regenerate to their original size regardless of damage extent, providing a tractable organ size control model. Gain-of-function of voltage-gated K+ channels in fibroblast-lineage blastema cells or inhibition of the Ca2+...
Integrin is required for basement membrane crossing and branching of an invading intracellular tube [0.03%]
整合素对入侵性细胞管穿越基底膜和分支分化是必需的
Lauren N Meyer,Michael Hertel,Jeremy Nance
Lauren N Meyer
The narrowest biological tubes are comprised of cells that hollow to form an intracellular lumen. Here, we examine early lumenogenesis of the C. elegans excretory cell, which branches to form an H-shaped intracellular tube spanning the leng...
Evolution of complete metamorphosis through temporal shifts in Chronologically inappropriate morphogenesis (Chinmo) and Broad [0.03%]
通过时间上不适当的形态发生(Chinmo)和Broad的时空变化产生完全变态的发展历史
Hana Nagata,Yuichiro Suzuki
Hana Nagata
The origin of complete metamorphosis in insects is one of the major unresolved mysteries of insect evolution. The proposed juvenile stage regulator, chronologically inappropriate morphogenesis (chinmo), may provide some insights into the ev...
Ingrid Tsang
Ingrid Tsang
For post-docs pursuing an academic career, the transition to a group leader position can be a notoriously difficult one, not least because the availability of necessary support and training for this varies so greatly between labs and instit...
Glial adherens junction proteins act with SAX-7/L1CAM to promote dendrite extension in C. elegans [0.03%]
粘附连接蛋白通过与SAX-7 / L1CAM协同促进秀丽隐杆线虫的树突延伸
Elizabeth R Cebul,Arthur Marivin,Leland R Wexler et al.
Elizabeth R Cebul et al.
Adherens junctions (AJs) stabilize cell contacts by coupling adhesion molecules to the cytoskeleton. AJ proteins have been studied extensively in epithelia, but less is known about their roles in other cell types. Here, we describe a role f...
Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers [0.03%]
神经嵴诱导需要SALL4介导的BAF募集到谱系特异性增强子中
Martina Demurtas,Samantha M Barnada,Emma van Domselaar et al.
Martina Demurtas et al.
Neural crest induction begins early during neural plate formation, requiring precise transcriptional control to activate lineage-specific enhancers. Here, we demonstrate that SALL4, a transcription factor associated with syndromes featuring...
Nikola Sekulovski,Amber E Carleton,Chien-Wei Lin et al.
Nikola Sekulovski et al.
Formation of the amnion in humans is crucial for fetal development and a healthy pregnancy. In addition to providing a protective layer to the developing fetus as a component of the amniochorionic fetal membranes, the amnion serves as a sig...
The people behind the papers - Fuyun Bian, Kimiasadat Golestaneh, Emily Davis and Abdullah Khan [0.03%]
论文背后的人- bian fuyun，kimiasadat golestaneh，emily davis和abdullah khan
During mammalian eye development, Sox2 is involved in the gene regulatory network that helps retinal progenitor cells (RPCs) gain neural competence, but how it mechanistically contributes to this process is unclear. In a new study, Issam Al...
Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity [0.03%]
唇皮素与CD36家族吞噬受体在顶端细胞外基质依赖的窄管完整性保护中的相反作用
Alexandra C Belfi,Sage G Aviles,Rachel Forman-Rubinsky et al.
Alexandra C Belfi et al.
All exposed epithelial surfaces, including the walls of internal tubes, are lined by a lipid and glycoprotein-rich apical extracellular matrix (aECM) that helps shape and protect the apical domain. Secreted lipocalins are lipid transporters...
Compensatory action of different types of cis-regulatory elements buffers the striped expression of Drosophila pair-rule-genes [0.03%]
不同类型的顺式调控元件的补偿作用可稳定果蝇成对规则基因的条带表达模式
Matthew D Fischer,Kristen Au,Minh Lê et al.
Matthew D Fischer et al.
The striped expression of pair-rule-genes in Drosophila embryos is a paradigm for understanding transcriptional control of development. Pair-rule-striped expression is regulated by two types of cis-regulatory elements: stripe-specific eleme...