The people behind the papers - Allan Spradling and Wayne (Yunpeng) Fu [0.03%]
论文背后的科研人——Allan Spradling & 冯允朋博士
In most species, ovarian follicles are thought to develop using a single pathway. However, in their study, Allan Spradling and Wayne (Yunpeng) Fu show that female Drosophila primordial germ cells (PGCs) give rise to three distinct follicula...
A primitive endoderm-centric view of mammalian development [0.03%]
从哺乳动物早期胚胎原始内胚层细胞 fate 的角度重新审视发育体系架构
Rebecca P Kim-Yip,Denis F Faerberg,Eszter Posfai
Rebecca P Kim-Yip
The primitive endoderm (PE), or hypoblast in humans, is a conserved extra-embryonic lineage essential for mammalian development that fulfills key roles in embryo patterning, such as contributing to the gut endoderm, providing nutrient and g...
EpiCure (Epithelial Curation): a versatile and handy tool for curation of epithelial segmentation [0.03%]
上皮图像注释工具EpiCure（Epithelial Curation）: 一款功能强大且易于使用的上皮细胞分割结果的注释工具
Gaëlle Letort,Léo Valon,Arthur Michaut et al.
Gaëlle Letort et al.
Despite advances in deep-learning and bioimage analysis, manual curation of segmented and tracking data is still required to extract accurate quantitative single cell temporal information from large tissue/embryo movies. However, very few t...
HDAC1/2-mediated repression of Wnt receptor expression orients asymmetric division polarity in C. elegans [0.03%]
组蛋白脱乙酰酶HDAC1/2介导的Wnt受体表达抑制使大肠杆菌的不对称分裂极性定向化
Mar Ferrando-Marco,Shuxiao Lin,Beatriz Garcia Del Valle et al.
Mar Ferrando-Marco et al.
Asymmetric cell division generates distinct daughter cells essential for tissue development, yet the mechanisms orienting division polarity within tissues remain incompletely understood. Here, we uncover a role for chromatin-mediated transc...
Correction: Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc [0.03%]
纠正：lobe通过介导Notch信号转导控制果蝇眼 imaginal 碟中特定区域的生长
Joshua J Chern,Kwang-Wook Choi
Joshua J Chern
Published Erratum
Development (Cambridge, England). 2026 Aug 1;153(15):dev205728. DOI:10.1242/dev.205728 2026
Helen Willsey is an Associate Professor at the Weill Institute for Neuroscience at the University of California, San Francisco (UCSF), USA. Helen's group uses frog models to dissect how risk genes contribute to psychiatric disorders. We spo...
Ingression of cardiac outflow tract wall that forms the inferior midline intercalated valve swelling was disrupted in mice with altered β-catenin, Shh, and FGF8 signaling [0.03%]
在小鼠中，当β-catenin、Shh和FGF8信号改变时，心脏流出道壁向下方中线间隔瓣突 ingress 异常
Haiyue Feng,Yuke Ji,Zixuan Li et al.
Haiyue Feng et al.
Previous studies from us and others suggest that the second heart field (SHF)-derived outflow tract (OFT) wall can undergo a cell fate transition to mesenchymal cells within the intercalated valve swelling (ICVS). However, the trajectory of...
Auxin, a plant hormone, is crucial for organ initiation and differential growth stages. Yet the underlying molecular pathways integrating the auxin signalling into these two continuous stages of organ formation remain unclear. In a new stud...
ATGL-mediated lipid droplet lipolysis promotes collective migration in Drosophila [0.03%]
Drosophila中ATGL介导的脂滴脂解促进集体迁移
Israel J Wipf,Emma J Lowden,Michelle S Giedt et al.
Israel J Wipf et al.
While lipid droplets (LDs), organelles central to lipid and energy homeostasis, are implicated in cancer cell migration, their roles during collective cell migration remain unknown. We use Drosophila border cell (BC) migration as an in vivo...