Auxin, a plant hormone, is crucial for organ initiation and differential growth stages. Yet the underlying molecular pathways integrating the auxin signalling into these two continuous stages of organ formation remain unclear. In a new stud...
ATGL-mediated lipid droplet lipolysis promotes collective migration in Drosophila [0.03%]
Drosophila中ATGL介导的脂滴脂解促进集体迁移
Israel J Wipf,Emma J Lowden,Michelle S Giedt et al.
Israel J Wipf et al.
While lipid droplets (LDs), organelles central to lipid and energy homeostasis, are implicated in cancer cell migration, their roles during collective cell migration remain unknown. We use Drosophila border cell (BC) migration as an in vivo...
The absence of Trim28 in nephron progenitors results in impaired kidney development and function [0.03%]
肾原基中缺少Trim28会导致肾脏发育和功能异常
Balazs Palhazi,Alireza Paikari,Greta Clarén et al.
Balazs Palhazi et al.
The TRIM28 gene encodes a transcriptional regulator involved in a variety of molecular processes. Inactivation of TRIM28 has been linked to the epithelial subtype of Wilms tumor, the most common pediatric renal malignancy. Therefore, TRIM28...
TIE2-ANG1 signalling acts as a master regulator of heart development, playing crucial roles during embryonic cardiac trabeculation. In a new study, Xianghu Qu and colleagues show that endocardial TIE2 signalling in the mammalian embryonic h...
Ce Shan,Ziwei Zhang,Li Du et al.
Ce Shan et al.
Teeth serve as a powerful model to dissect epithelial-mesenchymal interaction-mediated organogenesis. While most non-mammalian vertebrates exhibit lifelong tooth renewal (polyphyodonty), mammals have largely lost this capacity and become pr...
Maternal patterning in early Drosophila embryos: how much information can single maternal gradients supply? [0.03%]
果蝇早期胚胎中的母体模式形成：单一浓度梯度能提供多少信息？
Eric Wieschaus
Eric Wieschaus
Anterior-posterior patterning in Drosophila relies on positional information supplied by the graded distributions of three maternally supplied transcription factors originally identified in large-scale mutagenesis screens. Here, I examine t...
The people behind the papers - Vighnesh Ghatpande, Can Cenik and Steve Vokes [0.03%]
论文背后的人 - 瓦根什·噶塔潘德、坎·岑尼克和史蒂夫·沃克斯
The vertebrate limb buds, the embryonic precursors to arms and legs, emerge as cellular outgrowths from the somatic layer of the lateral plate mesoderm. In their work, Vighnesh Ghatpande, Can Cenik and Steve Vokes provide a comprehensive re...
Classical mutagenesis studies in Drosophila identified three graded maternally supplied factors that serve as the initial 'input signal' for anterior-posterior patterning programmes. However, the relative contributions of these factors and ...
The Drosophila ovary produces two waves of adult follicles and a novel pupal wave that turns over [0.03%]
果蝇卵巢产生两波成年卵泡和一波新型蛹期卵泡替代波
Wayne Yunpeng Fu,Allan C Spradling
Wayne Yunpeng Fu
Ovarian follicles in most species are assumed to develop using a single pathway. However, in Drosophila pupae, lineage tracing 2,937 single-cell clones identified three follicle "waves" that follow distinct programs arrayed anterior to post...