Cited4a limits cardiomyocyte dedifferentiation and proliferation during zebrafish heart regeneration [0.03%]
Cited4a限制斑马鱼心脏再生过程中心肌细胞的去分化和增殖
Rachel Forman-Rubinsky,Angela Paul,Wei Feng et al.
Rachel Forman-Rubinsky et al.
Cardiac regeneration involves the interplay of complex interactions between many different cell types, including cardiomyocytes. In regeneration, cardiomyocytes undergo dedifferentiation and proliferation to replace lost cells at the injury...
The cell adhesion molecule Echinoid promotes tissue survival and separately restricts tissue overgrowth [0.03%]
黏附分子Echinoid促进组织存活并限制组织过度生长
Danielle C Spitzer,William Y Sun,Anthony Rodríguez-Vargas et al.
Danielle C Spitzer et al.
The growth and survival of cells depends both on their intrinsic properties and interactions with their neighbors. In a screen of genes encoding cell surface proteins for knockdowns that affect clone size or shape in mosaic Drosophila imagi...
Gabriel E Valdebenito,Margarete Diaz-Cuadros
Gabriel E Valdebenito
The secreted Nimrod NimB1 negatively regulates early steps of apoptotic cell phagocytosis in Drosophila [0.03%]
果蝇唾液腺NimB1胞外基团通过抑制细胞凋亡的早期过程来负调控凋亡细胞吞噬作用
Asya Dolgikh,Samuel Rommelaere,Aseel Ghanem et al.
Asya Dolgikh et al.
Efferocytosis, the efficient clearance of apoptotic cells (ACs) by phagocytes, is vital for maintaining tissue homeostasis. Here, we reveal the role of the secreted protein NimB1 in reducing apoptotic cell recognition and binding in the ear...
Compensation for X-linked Pdha1 silencing by Pdha2 is essential for meiotic double-strand break repair in spermatogenesis [0.03%]
在精子发生过程中，同源重组中交联双链断裂的修复需要PDHA2对X连锁PDHA1沉默进行补偿作用
Chen Pan,Keisuke Shimada,Hsin-Yi Chang et al.
Chen Pan et al.
It is known that various testis-specific mitochondrial proteins are associated with energy metabolism and male meiosis. PDHA2 is a testis-specific mitochondrial protein, and its encoding gene is speculated to be an autosomal retrogene of th...
Mutual repression between Pax2 and Snail factors regulates the epithelial/mesenchymal state during intermediate mesoderm differentiation [0.03%]
Pax2和Snail因子之间的相互抑制作用调节中间中胚层分化过程中的上皮间质状态
Juan M Fons,Oscar H Ocaña,M Angela Nieto
Juan M Fons
The pronephros is the first renal structure in the embryo, arising by mesenchymal to epithelial transition (MET) of the intermediate mesoderm (IM), where Pax2 induces epithelialization and differentiation of this mesenchyme. Here we show th...
The people behind the papers - Justina Stark, Ivo Sbalzarini and Michael Brand [0.03%]
论文背后的科研人——朱莉塔·斯塔克、伊沃·斯巴尔扎里尼和迈克尔·布兰德
Morphogens are secreted from a local source and form long-range gradients. Existing computational models to study morphogen gradients typically simplify the tissue geometry. In a new study, Justina Stark and colleagues investigate the contr...
FBXO24 targets SLC25A26 for K6-linked polyubiquitination to maintain mitochondrial function during spermiogenesis [0.03%]
FBXO24通过K6连接的多泛素化作用靶向SLC25A26以在精子发生过程中维持线粒体功能
Yunlong Zheng,Bingbing Wu,Fucheng Dong et al.
Yunlong Zheng et al.
Asthenozoospermia is one of the major causes for male infertility, typically resulting from malformed flagella and dysfunctional mitochondria. However, the pathogenic mechanisms underlying asthenozoospermia remain unclear. Here, we show an ...
From bench to business: translating academic advances into industry innovations [0.03%]
从理论到实践：将学术成就转化为产业创新
Oscar J Abilez,Alok Javali,Jacob Jones et al.
Oscar J Abilez et al.
Many developmental and stem cell biologists will be familiar with writing grant applications that discuss how their fundamental research findings might translate into discoveries that improve health and society, but what is really involved ...
The transcription factor Wilms' tumor protein 1 (WT1) has been previously implicated in mesothelial and vascular smooth muscle cell (SMC) fate specification during mouse embryonic development. In their study, Bettina Wilm and colleagues sho...