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Mutual repression between Pax2 and Snail factors regulates the epithelial/mesenchymal state during intermediate mesoderm differentiation

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The pronephros is the first renal structure in the embryo, arising by mesenchymal to epithelial transition (MET) of the intermediate mesoderm (IM), where Pax2 induces epithelialization and differentiation of this mesenchyme. Here we show that Snail1 is suffici... ...