The people behind the papers - Charisios Tsiairis, Jaroslav Ferenc and Marylène Bonvin [0.03%]
论文背后的人们——Charisios Tsiairis，Jaroslav Ferenc和Marylène Bonvin
Hydra, a freshwater polyp, comprises a simple oral-aboral body plan, wherein multipotent epithelial cells differentiate into tentacle cells at the oral/mouth end and into basal disc cells at the aboral/foot end. In their study, Charisios Ts...
Ectodysplasin overexpression reveals spatiotemporally dynamic tooth formation competency in stickleback and zebrafish [0.03%]
ectodysplasin 过表达揭示三刺鱼和斑马鱼牙齿形成潜能的时空动态变化
Zoe Z Chen,Sujanya N Narayanan,Lena M Stagliano et al.
Zoe Z Chen et al.
Organ initiation is often driven by extracellular signaling molecules that activate precursor cells competent to receive and respond to a given signal, yet little is known about the dynamics of competency in space and time during developmen...
Frozen potential: embryo research at the crossroads of ethics, regulation and scientific opportunity [0.03%]
伦理、监管和科学机遇间的平衡：胚胎研究面临挑战
Mina Popovic,Catello Scarica,Susana M Chuva de Sousa Lopes et al.
Mina Popovic et al.
In an era of expanding reproductive possibilities, the human embryo has come to represent both immense potential and profound constraint. Advances in medically assisted reproduction (MAR) have led to the cryopreservation of hundreds of thou...
The people behind the papers - Maria Avdeeva, Madeline Chalifoux and Eszter Posfai [0.03%]
论文背后的人们——玛丽亚·阿夫德叶娃、麦迪森·夏利福和埃丝特尔·波斯法
During pre-implantation development of the mouse embryo, cells must undergo their first fate decision. While key regulators of this process are known, the variability in lineage trajectories within and between embryos during this stage of d...
Chd4 remodels chromatin to control retinal cell type specification and lineage termination [0.03%]
CHD4重塑染色质以控制视网膜细胞类型决定和谱系终止
Sujay Shah,Suma Medisetti,José Alex Lourenço Fernandes et al.
Sujay Shah et al.
During development, neural progenitor cells modify their output over time to produce different types of neurons and glia in chronological sequences. Epigenetic processes have been shown to regulate neural progenitor potential, but the under...
The non-canonical thioreductase Tmx2b is essential for neuronal survival during zebrafish embryonic brain development [0.03%]
非 canonical 硫还原酶Tmx2b对发育中斑马鱼胚胎脑的神经元存活必不可少
Jordy Dekker,Wendy Lam,Herma C van der Linde et al.
Jordy Dekker et al.
Biallelic variants in thioredoxin-related transmembrane 2 protein (TMX2) can cause a malformation of brain cortical development characterized by microcephaly, polymicrogyria and pachygyria by an unknown mechanism. To investigate and visuali...
The skate spiracular organ develops from a unique neurogenic placode, distinct from lateral line placodes [0.03%]
滑板气门器由独特的神经生成胎皮发育而来，与侧线胎皮不同
J Andrew Gillis,Katharine E Criswell,Michael A Palmer et al.
J Andrew Gillis et al.
The spiracular organ is an epithelial pouch or tube lined with mechanosensory hair cells, found embedded in the wall of the spiracle in many non-teleost jawed fishes. It is innervated via a branch of the anterior lateral line nerve and usua...
Mushroom bodies tiny regulates Sidekick localization to tricellular adherens junctions [0.03%]
蘑菇体tiny调控Sidekick定位到三细胞粘附连接点
Dhaval Gandhi,Brian P Griffin,Maria E Bustillo et al.
Dhaval Gandhi et al.
The Drosophila cell adhesion molecule Sidekick is a key component of tricellular adherens junctions in epithelia, and localizes to specific synaptic layers in the optic lobes. Using mutagenesis of endogenous Sidekick, we showed that its enr...
Manifold roles of CCR7 chemokine GPCR in differentiation of human trophoblast into extravillous and syncytiotrophoblast lineages [0.03%]
趋化因子受体CCR7在人类滋养细胞向 extravillous和syncytiotrophoblast分化中的多种作用
Eun-Ja Yoon,Mariana Beltcheva,Syed S Ali et al.
Eun-Ja Yoon et al.
CCR7 chemokine G protein-coupled receptor is expressed in extraembryonic tissues of the early human embryo, including trophectoderm and its derivatives cytotrophoblast (CTB), extravillous trophoblast (EVT), and syncytiotrophoblast (STB). Ho...
Acid sphingomyelinase is a gatekeeper of placental labyrinthine architecture and function [0.03%]
酸鞘磷脂酶是胎盘迷路结构和功能的守门人
Isidora Rovic,Katherine Szelag,Han Li et al.
Isidora Rovic et al.
Sphingolipids are a class of bioactive signaling lipids that regulate an array of fundamental cellular processes, including cell survival, proliferation, and differentiation. Deficiency of acid sphingomyelinase-an enzyme of the sphingolipid...