Ingression of cardiac outflow tract wall that forms the inferior midline intercalated valve swelling was disrupted in mice with altered β-catenin, Shh, and FGF8 signaling
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Previous studies from us and others suggest that the second heart field (SHF)-derived outflow tract (OFT) wall can undergo a cell fate transition to mesenchymal cells within the intercalated valve swelling (ICVS). However, the trajectory of this transition and... ...
