Circulating extracellular vesicle-derived miR-1299 disrupts hepatic glucose homeostasis by targeting the STAT3/FAM3A axis in gestational diabetes mellitus [0.03%]
妊娠糖尿病患者外泌体衍生的循环miR-1299通过靶向STAT3 / FAM3A轴破坏肝脏葡萄糖稳态
Xuyang Chen,Xinyi Tao,Min Wang et al.
Xuyang Chen et al.
Background: Extracellular vesicles (EVs) are membrane-enclosed structures containing lipids, proteins, and RNAs that play a crucial role in cell-to-cell communication. However, the precise mechanism through which circulat...
Youthful small extracellular vesicles restore the function and reparative capacity of inflammatory-impaired periodontal ligament stem cells via delivering protein biglycan for bone regeneration [0.03%]
青春小细胞外囊泡通过递送蛋白biglycan修复受损的牙周韧带干细胞功能及骨组织再生潜能
Jiaqi Yang,Junxiang Su,Zhuo Sun et al.
Jiaqi Yang et al.
Regenerating inflamed bone defects represents a severe clinical challenge due to the undesirable inflammatory microenvironment. The inflammatory stimulus poses a weighty threat to the regenerative capacity of endogenously derived mesenchyma...
Preparation and characterization of BSA-loaded liraglutide and platelet fragment nanoparticle delivery system for the treatment of diabetic atherosclerosis [0.03%]
用于治疗糖尿病动脉粥样硬化的载BSA的利拉鲁肽和血小板片段纳米递送系统制备及表征
Mingping He,Ming Fang,Limin Fan et al.
Mingping He et al.
Background: Diabetic atherosclerosis is one of the main causes of morbidity and mortality worldwide, but its therapeutic options are limited. Liraglutide (LIR), a synthetic analog of GLP-1 approved as an anti-obesity drug...
Multi-omics analyses reveal the responses of wheat (Triticum aestivum L.) and rhizosphere bacterial community to nano(micro)plastics stress [0.03%]
多组学分析揭示纳米（微）塑料胁迫对小麦和根系细菌群落的影响
Ming Zhuang,Chengkui Qiao,Lijun Han et al.
Ming Zhuang et al.
The pervasive existence of nanoplastics (NPs) and microplastics (MPs) in soil has become a worldwide environmental concern. N/MPs exist in the environment in a variety of forms, sizes, and concentrations, while multi-omics studies on the co...
Nanoparticle-mediated cell pyroptosis: a new therapeutic strategy for inflammatory diseases and cancer [0.03%]
纳米颗粒介导的细胞炎性坏死：炎症和癌症治疗的新策略
Lin Zhao,Haipeng Cheng,Zhongyi Tong et al.
Lin Zhao et al.
Pyroptosis, a lytic form of cell death mediated by the gasdermin family, is characterized by cell swelling and membrane rupture. Inducing pyroptosis in cancer cells can enhance antitumor immune responses and is a promising strategy for canc...
Correction: A nanozyme-functionalized bilayer hydrogel scaffold for modulating the inflammatory microenvironment to promote osteochondral regeneration [0.03%]
题图：负载纳米酶的双层水凝胶支架调节炎性微环境促进软骨-骨再生研究进展
Chuan Hu,Ruipeng Huang,Jiechao Xia et al.
Chuan Hu et al.
Published Erratum
Journal of nanobiotechnology. 2024 Aug 23;22(1):505. DOI:10.1186/s12951-024-02768-y 2024
Intranasal delivery of small extracellular vesicles reduces the progress of amyotrophic lateral sclerosis and the overactivation of complement-coagulation cascade and NF-ĸB signaling in SOD1G93A mice [0.03%]
经鼻递送小细胞外囊泡可减缓SOD1G93A小鼠渐冻症的进程并抑制补体凝血级联反应和NF-κB信号通路的过度激活
Jinrui Zhou,Fuxiang Li,Bin Jia et al.
Jinrui Zhou et al.
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive motoneuron degeneration, and effective clinical treatments are lacking. In this study, we evaluated whether intranasal delivery of mesenchymal stem cell-der...
Beyond hype: unveiling the Real challenges in clinical translation of 3D printed bone scaffolds and the fresh prospects of bioprinted organoids [0.03%]
超越炒作：揭开3D打印骨支架临床转化的真实挑战及生物打印类器官的新兴前景
Xiangyu Zhao,Na Li,Ziqi Zhang et al.
Xiangyu Zhao et al.
Bone defects pose significant challenges in healthcare, with over 2 million bone repair surgeries performed globally each year. As a burgeoning force in the field of bone tissue engineering, 3D printing offers novel solutions to traditional...
A novel HER2 targeting nanoagent self-assembled from affibody-epothilone B conjugate for cancer therapy [0.03%]
一种用于癌症治疗的新型HER2靶向纳药：Affibody-埃坡霉素B缀合物自组装纳米药物
Xuelin Xia,Xiaoyuan Yang,Wenhui Gao et al.
Xuelin Xia et al.
Epothilone B (Epo B), a promising antitumor compound effective against various types of cancer cells in vitro. However, its poor selectivity for tumor cells and inadequate therapeutic windows significantly limit its potential clinical appli...
Optimal development of apoptotic cells-mimicking liposomes targeting macrophages [0.03%]
一种模拟凋亡细胞的脂质体靶向巨噬细胞的研究
Li Zhang,Yujiao Li,Xing Liu et al.
Li Zhang et al.
Macrophages are multifunctional innate immune cells that play indispensable roles in homeostasis, tissue repair, and immune regulation. However, dysregulated activation of macrophages is implicated in the pathogenesis of various human disor...