Metal-organic-framework-based sitagliptin-release platform for multieffective radiation-induced intestinal injury targeting therapy and intestinal flora protective capabilities [0.03%]
基于金属有机骨架的西他列汀递送平台在多效放射引起的小肠损伤修复治疗及保护肠道菌群中的应用研究
Dan He,ZhiHui Li,Min Wang et al.
Dan He et al.
In patients with abdominal or pelvic tumors, radiotherapy can result in radiation-induced intestinal injury (RIII), a potentially severe complication for which there are few effective therapeutic options. Sitagliptin (SI) is an oral hypogly...
Neutrophil N1 polarization induced by cardiomyocyte-derived extracellular vesicle miR-9-5p aggravates myocardial ischemia/reperfusion injury [0.03%]
心肌细胞来源的外泌体miR-9-5p诱导中性粒细胞N1极化加重心肌缺血再灌注损伤
Yeshen Zhang,Xinzhong Li,Yining Dai et al.
Yeshen Zhang et al.
Neutrophil polarization contributes to inflammation and its resolution, but the role of neutrophil polarization in myocardial ischemia/reperfusion (I/R) injury remains unknown. Cardiomyocytes (CMs) participate in cardiac inflammation by sec...
Photothermal Fe3O4 nanoparticles induced immunogenic ferroptosis for synergistic colorectal cancer therapy [0.03%]
光热Fe3O4纳米粒子诱导免疫原性铁死亡用于协同结直肠癌治疗
Yue Li,Jia Chen,Qi Xia et al.
Yue Li et al.
Photothermal therapy (PTT) is a promising non-invasive treatment that has shown great potential in eliminating tumors. It not only induces apoptosis of cancer cells but also triggers immunogenic cell death (ICD) which could activate the imm...
Recombinant Lactococcus lactis secreting FliC protein nanobodies for resistance against Salmonella enteritidis invasion in the intestinal tract [0.03%]
分泌FliC蛋白纳米抗体的乳酸菌株用于抵抗肠炎沙门氏菌入侵肠道
Ming Yang,Kui Gu,Qiang Xu et al.
Ming Yang et al.
Salmonella Enteritidis is a major foodborne pathogen throughout the world and the increase in antibiotic resistance of Salmonella poses a significant threat to public safety. Natural nanobodies exhibit high affinity, thermal stability, ease...
Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2 polarization by activating the PI3K-AKT-mTOR signaling pathway [0.03%]
缺氧胶质瘤源性外泌体miR-25-3p通过激活PI3K-AKT-mTOR信号通路促进巨噬细胞M2极化
Zhiwei Xue,Junzhi Liu,Wenchen Xing et al.
Zhiwei Xue et al.
Background: Exosomes (EXO) play crucial roles in intercellular communication and glioma microenvironment modulation. Tumor-associated macrophages are more likely to become M2-like type macrophages in the immunosuppressive...
Dual-responsive renal injury cells targeting nanoparticles for vitamin E delivery to treat ischemia reperfusion-induced acute kidney injury [0.03%]
一种用于治疗缺血/再灌注急性肾损伤的维生素E输送纳米颗粒及其靶向受损肾小管上皮细胞的双重响应性研究
Jiahao Zhang,Xi Ren,Zhaoyang Nie et al.
Jiahao Zhang et al.
Ischemia/reperfusion (I/R) is an important inducer of acute kidney injury (AKI), and triggers the generation of reactive oxygen species (ROS) and the expression of matrix metalloproteinase 2 (MMP2), exacerbating kidney damage. Given the imm...
Colostrum-derived extracellular vesicles: potential multifunctional nanomedicine for alleviating mastitis [0.03%]
初乳源外泌体：缓解乳腺炎多功能纳米药物的潜力
Yindi Xiong,Taiyu Shen,Peng Lou et al.
Yindi Xiong et al.
Bovine mastitis is an infectious disease that causes substantial economic losses to the dairy industry worldwide. Current antibiotic therapy faces issues of antibiotic misuse and antimicrobial resistance, which has aroused concerns for both...
NIR-II light based combinatorial management of hypertrophic scar by inducing autophagy in fibroblasts [0.03%]
基于近红外二区光的组合管理通过诱导成纤维细胞自噬来治疗肥厚性疤痕
Yunxian Dong,Haibin Wang,Youliang Zhang et al.
Yunxian Dong et al.
The hypertrophic scar (HS) is a prevalent cutaneous fibrotic disorder that impacts both the aesthetic and functional aspects of the skin, there is an urgent need for a highly safe and effective approach to address the challenge of HS with t...
Correction: GSH-responsive polymeric micelles-based augmented photoimmunotherapy synergized with PD-1 blockade for eliciting robust antitumor immunity against colon tumor [0.03%]
纠正：基于GSH响应的聚合物胶束增强型光免疫治疗与PD-1阻断协同作用，激发针对结肠肿瘤的强大抗肿瘤免疫力
Chenlu Huang,Xinyu Yang,Huidong Li et al.
Chenlu Huang et al.
Published Erratum
Journal of nanobiotechnology. 2024 Oct 15;22(1):624. DOI:10.1186/s12951-024-02899-2 2024
Histidine phosphatase-ferroptosis crosstalk modulation for efficient hepatocellular carcinoma treatment [0.03%]
组氨酸磷酸酶-铁死亡互作调控高效治疗肝癌
Yang Qin,Xiaoli Ling,Yunxian Li et al.
Yang Qin et al.
Altering the mechanisms of tumor cell death and overcoming the limitations of traditional chemotherapy is pivotal to contemporary tumor treatment. Inducing ferroptosis, while circumventing safety concerns associated with ferrous vectors, th...