MnO2 and roflumilast-loaded probiotic membrane vesicles mitigate experimental colitis by synergistically augmenting cAMP in macrophage [0.03%]
载有MnO2和罗氟司特的益生菌膜囊泡通过协同增强巨噬细胞内环磷酸腺苷水平缓解实验性结肠炎
Chengjun Song,Jiamin Wu,Jinhui Wu et al.
Chengjun Song et al.
Background: Ulcerative colitis (UC) is one chronic and relapsing inflammatory bowel disease. Macrophage has been reputed as one trigger for UC. Recently, phosphodiesterase 4 (PDE4) inhibitors, for instance roflumilast, ha...
Anti-ferroptosis exosomes engineered for targeting M2 microglia to improve neurological function in ischemic stroke [0.03%]
靶向M2小胶质细胞的抗铁死亡外泌体改善缺血性卒中后神经功能损伤
Yong Wang,Zhuohang Liu,Luyu Li et al.
Yong Wang et al.
Background: Stroke is a devastating disease affecting populations worldwide and is the primary cause of long-term disability. The inflammatory storm plays a crucial role in the progression of stroke. In the acute phase of...
A SU6668 pure nanoparticle-based eyedrops: toward its high drug Accumulation and Long-time treatment for corneal neovascularization [0.03%]
一种SU6668纯纳米颗粒眼药滴剂：实现高药物积累和长期治疗角膜新生血管化的方法
Han Wu,Jinfa Ye,Minjie Zhang et al.
Han Wu et al.
Corneal neovascularization (CNV) is one of the common blinding factors worldwide, leading to reduced vision or even blindness. However, current treatments such as surgical intervention and anti-VEGF agent therapy still have some shortcoming...
Effective delivery of miR-150-5p with nucleus pulposus cell-specific nanoparticles attenuates intervertebral disc degeneration [0.03%]
人核盘细胞特异性纳米颗粒有效递送miR-150-5p缓解椎间盘退变
Hua Jiang,Hongyu Qin,Qinghua Yang et al.
Hua Jiang et al.
Background: The use of gene therapy to deliver microRNAs (miRNAs) has gradually translated to preclinical application for the treatment of intervertebral disc degeneration (IDD). However, the effects of miRNAs are hindere...
Dynamic monitoring soft tissue healing via visualized Gd-crosslinked double network MRI microspheres [0.03%]
可视化Gd交联双网络MRI微球用于动态监测软组织修复进展情况
Tongtong Chen,Zhengwei Cai,Xinxin Zhao et al.
Tongtong Chen et al.
By integrating magnetic resonance-visible components with scaffold materials, hydrogel microspheres (HMs) become visible under magnetic resonance imaging(MRI), allowing for non-invasive, continuous, and dynamic monitoring of the distributio...
Multifunctional elastin-like polypeptide nanocarriers for efficient miRNA delivery in cancer therapy [0.03%]
用于癌症治疗的多功能弹性蛋白多肽纳米载体实现高效的微小核糖核酸输送
Jisan Hong,Dahye Sim,Byung-Heon Lee et al.
Jisan Hong et al.
Background: The exogenous delivery of miRNA to mimic and restore miRNA-34a activity in various cancer models holds significant promise in cancer treatment. Nevertheless, its effectiveness is often impeded by challenges, i...
Dynamic hydrogel-metal-organic framework system promotes bone regeneration in periodontitis through controlled drug delivery [0.03%]
基于动态水凝胶-金属有机骨架的药物控制递送系统促进牙周炎骨再生
Qipei Luo,Yuxin Yang,Chingchun Ho et al.
Qipei Luo et al.
Periodontitis is a prevalent chronic inflammatory disease, which leads to gradual degradation of alveolar bone. The challenges persist in achieving effective alveolar bone repair due to the unique bacterial microenvironment's impact on immu...
Publisher Correction: Impact of doxorubicin-loaded ferritin nanocages (FerOX) vs. free doxorubicin on T lymphocytes: a translational clinical study on breast cancer patients undergoing neoadjuvant chemotherapy [0.03%]
出版更正：与自由多柔比星相比，载有多柔比星的铁蛋白纳米笼（FerOX）对T淋巴细胞的影响：新辅助化疗乳腺癌患者的转化临床研究
Marta Sevieri,Francesco Andreata,Francesco Mainini et al.
Marta Sevieri et al.
Published Erratum
Journal of nanobiotechnology. 2024 May 27;22(1):288. DOI:10.1186/s12951-024-02532-2 2024
Single-atom nanozymes shines diagnostics of gastrointestinal diseases [0.03%]
单原子纳米酶在胃肠道疾病诊断中的应用闪烁光辉
Sijia Hua,Xiulin Dong,Qiuxia Peng et al.
Sijia Hua et al.
Various clinical symptoms of digestive system, such as infectious, inflammatory, and malignant disorders, have a profound impact on the quality of life and overall health of patients. Therefore, the chase for more potent medicines is both h...
Exosome-sheathed porous silica nanoparticle-mediated co-delivery of 3,3'-diindolylmethane and doxorubicin attenuates cancer stem cell-driven EMT in triple negative breast cancer [0.03%]
包裹外泌体的多孔二氧化硅纳米颗粒介导的3,3'-二吲哚甲烷和阿霉素共递送可减轻三阴性乳腺癌中的癌症干细胞驱动的上皮间质转化
Rupali Sarkar,Souradeep Biswas,Rituparna Ghosh et al.
Rupali Sarkar et al.
Background: Therapeutic management of locally advanced and metastatic triple negative breast cancer (TNBC) is often limited due to resistance to conventional chemotherapy. Metastasis is responsible for more than 90% of br...