Hollow spiky MnOx nanocarriers amplify radiotherapy-induced pyroptosis for eliciting antitumor immunity [0.03%]
空心锰氧化物纳米载药剂增强放射治疗诱导的细胞焦亡以激发抗肿瘤免疫响应
Yifan Zhang,Yuqian Liu,Bin Hu et al.
Yifan Zhang et al.
Radiotherapy (RT) is a primary modality in clinical cancer treatment. However, its ability to induce tumor cell apoptosis offers limited activation of anti-tumor immunity. Pyroptosis, characterized by cell swelling, membrane rupture, and th...
Folate-modified biomimetic nanovesicles loaded with a PU.1 inhibitor alleviate atherosclerosis by suppressing inflammation [0.03%]
叶酸修饰的生物仿生纳米囊泡载运PU.1抑制剂通过抑炎缓解动脉粥样硬化
Leye Yan,Xinyan Hu,Jianan He et al.
Leye Yan et al.
Atherosclerosis is a chronic inflammatory disease affecting arterial walls and remains a leading cause of morbidity and mortality worldwide. While anti-inflammatory therapy is widely recognized as a critical component in the management of a...
Kupffer cells biomimetic nanoparticles alleviate sepsis related liver injury [0.03%]
模拟枯氏细胞的纳米颗粒可改善脓毒症相关肝损伤
Chunhua Ma,Yingzhi Zhou,Zhaocong Yang et al.
Chunhua Ma et al.
The mechanism of sepsis related liver injury (SRLI) is unclear and its treatment method is unsatisfactory. The aim of this study was to investigate the effects of BRCC3 on SRIL and preparation of kupffer cells membrane encapsulated ZIF-8 lo...
Hypoxia-activated paclitaxel prodrugs enable PD-L1 degradation to potentiate cancer chemo-immunotherapy [0.03%]
缺氧激活的紫杉醇前药能够降解PD-L1以增强化学免疫疗法的作用
Shiyu Zhou,Qiang Zhang,Hui Han et al.
Shiyu Zhou et al.
The combination of chemotherapy and immune checkpoint blockade therapy shows great potential in tumor treatment, but their integration remains a great challenge. Herein, hypoxia-responsive prodrugs integrating paclitaxel (PTX) and bromodoma...
Qinze Rong,Zibin Chu,Ye Xu et al.
Qinze Rong et al.
Nucleic acid nanotechnology (NAN) has emerged as a powerful platform for constructing programmable molecular architectures, with broad applications spanning biomedicine, materials science, and molecular computing. While numerous reviews hav...
Structurally and functionally optimized silk fibroin-alginate-based biomimetic scaffolds reinforced with nanobioceramics for bone tissue engineering applications [0.03%]
结构和功能最佳化的丝素-海藻酸盐仿生骨支架用于骨组织工程中
Thanh-Mai Ngoc Nguyen,Ngoc-Han Hoai Le,Mohanapriya Murugesan et al.
Thanh-Mai Ngoc Nguyen et al.
In this study, we prepared chemically crosslinked silk fibroin (SF) and sodium alginate (Alg) biomimetic scaffolds reinforced with bioceramic nanohydroxyapatite (nHAp) for bone tissue engineering (BTE) applications. The pore sizes of these ...
Correction: NIR-responsive Cu2-xSe@Fc nanoparticles for photothermal- ferroptosis combination therapy in esophageal cancer [0.03%]
纠正：用于食道癌光热-铁死亡联合治疗的近红外响应Cu2-xSe@Fc纳米粒子
Linlin Shi,Ying Yu,Jiayi Li et al.
Linlin Shi et al.
Published Erratum
Journal of nanobiotechnology. 2025 Dec 2;23(1):753. DOI:10.1186/s12951-025-03809-w 2025
Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation [0.03%]
代谢调节急性肾损伤治疗用生长激素释放肽6（GHRP-6）水凝胶
Xiaotong Zhao,Kai Pan,Rui Li et al.
Xiaotong Zhao et al.
Renal tubular epithelial cells (TECs), which are highly susceptible to injury during acute kidney injury (AKI), have notable regenerative effects on renal recovery after AKI. AKI-driven metabolic reprogramming of TECs plays a critical role ...
3D dynamic magnetic microfluidic chip for efficient plasma extracellular vesicle enrichment and machine learning-based multiparametric diagnosis of hepatocellular carcinoma [0.03%]
一种高效的三维磁性微流控芯片及其结合机器学习的肝癌多参数诊断方法
Xiaodan Xi,Kezhen Yi,Lili Xu et al.
Xiaodan Xi et al.
Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide, with early diagnosis critical for improving outcomes. Current diagnostic tools, including serum biomarkers and...
Meta-surface plasmon resonance microscopy for sensitive, high-throughput, and long-term label-free analysis of cell adhesion dynamics [0.03%]
用于细胞粘附动力学敏感、高通量和长期无标签分析的元表面等离激元共振显微镜
Mingqian Chen,Wen Li,Taoyu Hu et al.
Mingqian Chen et al.
Quantitative, label-free monitoring of dynamic cell adhesion remains challenging. Meta-Surface Plasmon Resonance Microscopy (Meta-SPRM) is a novel platform integrating bright-field microscopy with engineered Meta-SPR nanocup arrays. This sy...