A bismuth-based nanoplatform with synergistic fibrin/NET disruption and antioxidant/anti-inflammatory capabilities for enhanced thrombolysis and prevention of deep vein thrombosis recurrence [0.03%]
Lian Xu,Jiangwei Chen,Wenli Zhang et al.
Lian Xu et al.
Deep vein thrombosis (DVT) is a serious medical condition that can lead to life-threatening complications. Conventional or nanotechnology-based antithrombotic therapies frequently lead to incomplete thrombolysis and may result in DVT recurr...
NIR-controlled photothermal intelligent nanozyme synergizes catalysis and gas therapy for multidimensional treatment of inflammatory bowel disease [0.03%]
Xiaoya Liang,Xin Yu,Yilin Liu et al.
Xiaoya Liang et al.
The vicious feedback loop between reactive oxygen species (ROS)-triggered mucosal inflammation and intestinal epithelial barrier disruption represents a critical mechanism driving the onset and progression of inflammatory bowel disease (IBD...
Peptide-modified phase-transition nanoparticles co-deliver FTO siRNA and Ce6 for sonodynamic metabolism-immunotherapy of melanoma [0.03%]
Xintong Li,Weinan Sun,Weidong Yu et al.
Xintong Li et al.
Background: Melanoma, the most aggressive skin cancer, remains challenging to treat due to limited therapeutic options. Sonodynamic therapy (SDT) has emerged as a promising strategy for combating malignant tumors. However...
Carbon dot sensitized Cu3P sonozymes for cuproptosis-enhanced and heterojunction-amplified sono-immunotherapy through activating cGAS-STING pathway [0.03%]
Shangwei Xu,Yue Wu,Jinming Cai et al.
Shangwei Xu et al.
It is believed that the poor response of patients and the immunosuppressive tumor microenvironment (TME) severely limit the clinical application of lung cancer immunotherapy. Herein, the cascade amplification of anticancer immune response i...
Sono-triggered endoplasmic reticulum-targeted ROS burst silencing CD300ld to alleviate polymorphonuclear myeloid-derived suppressor cells for breast cancer treatment [0.03%]
Xuejun Chen,Shaoyue Li,Qing Lu et al.
Xuejun Chen et al.
Immunogenic cell death (ICD) significantly boosts anti-tumor immunotherapy effectiveness; however, the recruitment of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), driven by factors such as adenosine accumulation and oxyge...
A simple and effective hydrogel dressing for advanced management of full-thickness skin wound by multi-functional strategies [0.03%]
Deqiao Dong,Lujia Mao,Zhenmiao Qin et al.
Deqiao Dong et al.
In clinical practice, wound treatment continues to be a significant concern. The wound healing process is intricate and continuous. Hemostasis is the initial stage and the primary variables influencing wound healing include bacterial infect...
Hongjae Kim,Hayoon Jeong,Young A Kim et al.
Hongjae Kim et al.
In this study, we synthesized an ionizable lipidoid, Cdoids, composed of carbon dots (Cdots) conjugated with oleic acid that exhibits superior biocompatibility compared to conventional ionizable lipids while retaining intrinsic fluorescence...
Exploring the multi-repair effects of advanced biomimetic rapamycin nanoparticles on cerebral ischemia-reperfusion injury [0.03%]
Yanyun Wang,Yufan Ma,Tieying Cai et al.
Yanyun Wang et al.
Ischemic stroke, an intractable neurovascular disease with high lethality, disability and recurrence rates, poses a serious challenge to human health. The only effective treatment for acute stroke is reperfusion therapy. However, the inflam...
Peptide-functionalized periodic mesoporous silica nanoparticles for monocyte-specific TET3 Silencing enhance cardiac repair after acute myocardial infarction [0.03%]
Hao Jin,Jiandong Ding,Xiaoguo Zhang et al.
Hao Jin et al.
Modulating the balance between pro- and anti-inflammatory monocyte subsets holds therapeutic promise in acute myocardial infarction (AMI); however, effective and selective strategies are still lacking. In this study, we are the first to ide...
Publisher Correction: amorphous layered double hydroxide-based nano-enzyme eye drops against dry eye disease by inhibiting mitochondrial damage and pyroptosis [0.03%]
Dandan Chu,Tingting Hu,Haohao Cui et al.
Dandan Chu et al.
Published Erratum
Journal of nanobiotechnology. 2025 Nov 26;23(1):742. DOI:10.1186/s12951-025-03820-1 2025