Singlet oxygen-precharged injectable hydrogel triggers ferroptosis and lactate metabolism reprogramming for enhanced colorectal cancer immunotherapy [0.03%]
单线态氧预充注式水凝胶触发铁死亡和乳酸代谢重编程以增强结直肠癌免疫治疗
Hao Zhang,Xiaoyu Song,Leilei Zhao et al.
Hao Zhang et al.
Photodynamic therapy (PDT) holds significant potential for tumor treatment, yet its immunotherapeutic efficacy is severely constrained by the immunosuppressive tumor microenvironment (TME) marked by lactate accumulation, hypoxia, and glutat...
Correction: Multifunctional Fe-based coordination polymer nano-bomb modified with β-lapachone and CaO2 for targeted tumor dual chemodynamic therapy with enhanced ferroptosis and H2O2 self-supply [0.03%]
纠正：多功能Fe基配位聚合物纳米炸弹负载β- lapachone和CaO2用于增强铁死亡的肿瘤靶向双重化学动力学治疗及过氧化氢的原位生成
Pan Zhao,Liyang Gong,Le Chang et al.
Pan Zhao et al.
Published Erratum
Journal of nanobiotechnology. 2026 Jan 28;24(1):87. DOI:10.1186/s12951-025-03917-7 2026
Adolescent exposure to polystyrene nanoplastics induces male reproductive damage via the microbiome-gut-testis axis [0.03%]
聚苯乙烯纳米塑料通过微生物组-肠道-睾丸轴诱导雄性生殖损害
Jiaochen Luan,Xu Zhang,Tong Chen et al.
Jiaochen Luan et al.
Polystyrene nanoplastics (PS-NPs), are increasingly associated with reduced male fertility, yet the underlying mechanisms remain poorly defined. Here, we systematically unraveled a novel microbiome-gut-testis axis mediating PS-NPs-induced r...
OCTN2-targeted and ROS-responsive hybrid polymeric micelles for oral delivery of docetaxel [0.03%]
口服递送多西他赛的OCTN2靶向和ROS响应型杂化聚合物胶束
Haihan Sun,Jingxin Gou,Xiaoshuang Bi et al.
Haihan Sun et al.
Our previous research identified that an oral mPEG-b-PCL polymeric micelle (PM) maintained satisfactory integrity but exhibited limited transcytosis efficiency. To enhance transcytosis and enable ROS-responsive release, we developed a serie...
Tanshinone IIA&Icaritin -MPs regulated vascular normalization and restored tumor-infiltrating T lymphocyte function to boost anti-PD-1 therapy in melanoma lung metastasis [0.03%]
丹参酮IIA和淫羊藿素微粒调控血管正常化并恢复肿瘤浸润淋巴细胞的功能以增强抗PD-1疗法在黑色素瘤肺转移中的作用
Xiaoyu Che,Yaqin Li,Wenjing Chen et al.
Xiaoyu Che et al.
Background: PD-1 inhibitors are a promising treatment for melanoma, but over 50% of patients with metastatic melanoma do not respond well. This limited efficacy is partly due to the aberrant vascular structure and immunos...
Synthetic nanoparticles for cell-type specific, spatially resolved loading and export of MiRNAs in neural cells [0.03%]
合成纳米颗粒在神经细胞中用于特定细胞类型的空间分辨的miRNA装载和释放
Marianna Mignanelli,Giacomo Siano,Vincenzo Iannone et al.
Marianna Mignanelli et al.
Background: Brain development and plasticity depend on specific microRNA (miRNA) expression patterns across cell types and subcellular compartments. Nevertheless, comprehensive profiling of localized brain miRNAs is still...
Exosomes displaying native EGF enhance doxorubicin's therapeutic efficacy and reduce cardiotoxicity [0.03%]
表达天然EGF的外泌体增强多柔比星的治疗效果并降低心脏毒性
Liang Mao,Longtao Qian,Xin Zhou et al.
Liang Mao et al.
Background: Doxorubicin (DOX) is one of the most potent chemotherapeutic agents for cancer treatment. However, its cumulative and often irreversible, life-threatening cardiotoxicity significantly limits its clinical appli...
Silk-based biomimetic nanocomposite for precision eradication of Helicobacter pylori and gut microbiome preservation [0.03%]
丝蛋白基仿生纳米复合材料精准根除幽门螺旋杆菌及保护肠道菌群平衡
Guangcheng Huang,Chi Tian,Qingsong Liu et al.
Guangcheng Huang et al.
Antibiotics remain the recommended first-line therapy for eradicating Helicobacter pylori infection. However, the harsh gastric physicochemical environment severely limits drug bioavailability, contributing to treatment failure (~10%), gut ...
Emerging potential of engineered nanozymes in periodontitis treatment: from monotherapy to hierarchical therapy [0.03%]
工程纳米酶在牙周炎治疗中的潜力：从单一疗法到分层疗法
Jiazhuo Song,Lin Sun,Fang Li et al.
Jiazhuo Song et al.
The unique pathological microenvironment of periodontitis poses significant challenges to conventional therapies and drives the development of advanced treatment strategies. Engineered nanozymes as multifunctional nanomaterials offer promis...
Inflammation-responsive biomimetic hybrid nanovesicles reverse stem cell senescence by up-regulating SIRT1 to treat periodontitis [0.03%]
炎症响应仿生杂化纳米囊泡通过上调SIRT1逆转干细胞衰老以治疗牙周炎
Jiaming Bi,Yan Chai,Hong Wang et al.
Jiaming Bi et al.
Periodontitis is a chronic inflammatory condition affecting billions globally, posing a significant public health challenge due to its high prevalence and associated tooth loss. The inflammatory microenvironment engendered by periodontitis ...