Microneedle-mediated delivery of Coptis chinensis-derived nanovesicles orchestrating antibacterial and macrophage reprogramming for comprehensive wound healing [0.03%]
基于黄连素的纳米囊泡介导的微针协同杀菌和巨噬细胞重编程促进创面全面修复
Ke-Min Xu,Jia-Qi Lin,Xin-Xiang-Yi Zhuo et al.
Ke-Min Xu et al.
Conventional antibiotic treatments for infected wounds often inadequately regulate the complex inflammatory cascade and fail to sufficiently promote tissue regeneration, leading to delayed healing and potential secondary tissue damage. Cons...
Correction: PDLIM4 drives gastric cancer malignant progression and cisplatin resistance by inhibiting HSP70 ubiquitination and degradation via competitive interaction with STUB1 [0.03%]
PDLIM4通过与STUB1竞争性结合抑制HSP70泛素化降解驱动胃癌恶性进展和顺铂耐药的机制研究纠正版
Chao Zhu,Meng Chen,Linwei Fan et al.
Chao Zhu et al.
Published Erratum
Journal of nanobiotechnology. 2026 Feb 26;24(1):196. DOI:10.1186/s12951-026-04118-6 2026
Engineering integrin αvβ8-targeted extracellular vesicles to deliver BDNF mRNA for motor recovery in spinal cord injury [0.03%]
工程化整合素αvβ8靶向的细胞外囊泡递送BDNF信使核糖核酸促进脊髓损伤后运动功能恢复
Ming-You Shie,Cheng-Di Chiu,Yeh Chen et al.
Ming-You Shie et al.
Spinal cord injury (SCI) remains difficult to treat, and current interventions provide limited functional restoration and often require invasive procedures. Existing cell- or extracellular vesicles (EV)-based approaches are frequently admin...
PD1 cell membrane-coated Ru(ll)-Pt(lV) complex nanoparticles inhibit liver metastatic melanoma via cascade immune activation [0.03%]
程序化死亡配体1细胞膜包被的钌(II)-铂(IV)复合物纳米颗粒通过级联免疫活化抑制肝转移性黑色素瘤
Cong Huang,Thuy Thu Phann,Feijun OuYang et al.
Cong Huang et al.
Chemotherapy and photodynamic therapy (PDT) can indirectly increase T cell infiltration in metastatic melanoma by inducing immunogenic cell death (ICD) effects that activate the innate immune system. However, this indirect adaptive immune a...
Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheimer's disease via cGAS-STING inhibition [0.03%]
通过cGAS-STING抑制改善阿尔茨海默病的siSTING传递六螺旋DNA束锁装备件
Manqing Zhang,Yufei Lan,Qu Yue et al.
Manqing Zhang et al.
Alzheimer's disease (AD) pathological progression is intimately linked to microglial inflammatory activation mediated by the cGAS-STING pathway. Small interfering RNA targeting STING (siSTING) is a precise therapeutic to silence STING and i...
Nanotherapeutic strategy via ADSC-mitoEVs rescues ischaemic angiogenesis through mitophagy and mitochondrial metabolic reprogramming [0.03%]
基于ADSC-mitoEVs的纳米治疗策略通过线粒体自噬和线粒体代谢重编程拯救缺血性血管生成
Yuan-Zheng Zhu,Min-Chen Zhang,Xue-Er Li et al.
Yuan-Zheng Zhu et al.
Ischaemic vascular diseases are critically linked to mitochondrial dysfunction in endothelial cells, which impairs angiogenesis and tissue repair. Although mitochondrial transplantation has emerged as a promising regenerative strategy, its ...
Ergostane steroid, as one of the major contributor to cranberry derived extracellular vesicle nanoparticles, restores ovarian function of murine premature ovarian failure [0.03%]
Ergostane固醇作为促进小鼠早发性卵巢功能不全的大豆衍生的细胞外囊泡纳米颗粒的主要贡献者，可恢复卵巢功能
Zeyu Cui,Yanchen Lai,Te Liu et al.
Zeyu Cui et al.
Background: A high-fat and high-sugar (HFHS) diet can induce ovarian insufficiency and premature ovarian failure (POF) by inducing the abnormal expression of multiple metabolic pathways that makes treatment difficult. We ...
Programmable trivalent nanocage vaccine confers durable cross-species protection against Bordetella bronchiseptica infection [0.03%]
一种可编程的纳米笼疫苗能够对副嗜血杆菌感染产生持久的交叉物种保护作用
Wenna He,Lingli Wang,Xiaoyu Zhang et al.
Wenna He et al.
Bordetella bronchiseptica (B. bronchiseptica), a respiratory pathogen endemic in companion animals, poses an escalating zoonotic threat to humans due to intensified human-pet contact, particularly among immunocompromised individuals. Here, ...
f-SPION-mediated magnetic stimulation induces reparative Schwann cell reprogramming via cytoskeletal dynamics - gated activation of Piezo1 [0.03%]
磁性刺激通过细胞骨架动力学门控激活Piezo1诱导施万细胞再生重编程
Ting Liu,Mingxi Yang,Wantao Tian et al.
Ting Liu et al.
The remarkable intrinsic regenerative capacity of peripheral nerves following injury is largely attributed to the phenotypic plasticity of Schwann cells (SCs) and their ability to transition into a repair-supportive state (rSCs). Transcript...
Chlorine-coordinated iron single-atom nanozymes for amplified ferroptosis in triple-negative breast cancer therapy [0.03%]
用于三阴性乳腺癌治疗的单原子纳米酶协同诱导铁死亡放大效应
Mingming Yin,Bing-Hao Wang,Huijuan Wang et al.
Mingming Yin et al.
Triple-negative breast cancer (TNBC) represents an aggressive breast cancer subtype with limited therapeutic options and poor prognosis. Although single-atom nanozymes (SAzymes) show promise in cancer therapy, their ferroptosis-inducing cap...