A bismuth-based nanoplatform with synergistic fibrin/NET disruption and antioxidant/anti-inflammatory capabilities for enhanced thrombolysis and prevention of deep vein thrombosis recurrence [0.03%]
一种基于铋的纳米平台具有协同破坏纤维蛋白/ NET和抗氧化/抗炎作用，可增强溶栓并预防深静脉血栓复发
Lian Xu,Jiangwei Chen,Wenli Zhang et al.
Lian Xu et al.
Deep vein thrombosis (DVT) is a serious medical condition that can lead to life-threatening complications. Conventional or nanotechnology-based antithrombotic therapies frequently lead to incomplete thrombolysis and may result in DVT recurr...
NIR-controlled photothermal intelligent nanozyme synergizes catalysis and gas therapy for multidimensional treatment of inflammatory bowel disease [0.03%]
基于近红外调控的智能纳米酶协同催化和气体治疗多维度炎症性肠病
Xiaoya Liang,Xin Yu,Yilin Liu et al.
Xiaoya Liang et al.
The vicious feedback loop between reactive oxygen species (ROS)-triggered mucosal inflammation and intestinal epithelial barrier disruption represents a critical mechanism driving the onset and progression of inflammatory bowel disease (IBD...
Peptide-modified phase-transition nanoparticles co-deliver FTO siRNA and Ce6 for sonodynamic metabolism-immunotherapy of melanoma [0.03%]
多肽修饰的相变纳米粒共递送FTO siRNA和Ce6协同超声动力代谢免疫治疗黑色素瘤
Xintong Li,Weinan Sun,Weidong Yu et al.
Xintong Li et al.
Background: Melanoma, the most aggressive skin cancer, remains challenging to treat due to limited therapeutic options. Sonodynamic therapy (SDT) has emerged as a promising strategy for combating malignant tumors. However...
Carbon dot sensitized Cu3P sonozymes for cuproptosis-enhanced and heterojunction-amplified sono-immunotherapy through activating cGAS-STING pathway [0.03%]
碳点敏化Cu3P超声酶引发 cups 关闭小体增强的异质结放大的免疫疗法通过激活cGAS-STING途径
Shangwei Xu,Yue Wu,Jinming Cai et al.
Shangwei Xu et al.
It is believed that the poor response of patients and the immunosuppressive tumor microenvironment (TME) severely limit the clinical application of lung cancer immunotherapy. Herein, the cascade amplification of anticancer immune response i...
Sono-triggered endoplasmic reticulum-targeted ROS burst silencing CD300ld to alleviate polymorphonuclear myeloid-derived suppressor cells for breast cancer treatment [0.03%]
声触发的内质网靶向ROS爆发沉默CD300ld以缓解多形核髓源性抑制细胞治疗乳腺癌
Xuejun Chen,Shaoyue Li,Qing Lu et al.
Xuejun Chen et al.
Immunogenic cell death (ICD) significantly boosts anti-tumor immunotherapy effectiveness; however, the recruitment of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), driven by factors such as adenosine accumulation and oxyge...
A simple and effective hydrogel dressing for advanced management of full-thickness skin wound by multi-functional strategies [0.03%]
一种简单有效的用于全层皮肤伤口修复的多功能水凝胶敷料
Deqiao Dong,Lujia Mao,Zhenmiao Qin et al.
Deqiao Dong et al.
In clinical practice, wound treatment continues to be a significant concern. The wound healing process is intricate and continuous. Hemostasis is the initial stage and the primary variables influencing wound healing include bacterial infect...
Carbon dot-lipidoid nanocarriers for superiorly biocompatible nasal mRNA cancer vaccination [0.03%]
用于鼻粘膜给药的优异生物相容性脂质载体纳米颗粒递送mRNA癌症疫苗研究
Hongjae Kim,Hayoon Jeong,Young A Kim et al.
Hongjae Kim et al.
In this study, we synthesized an ionizable lipidoid, Cdoids, composed of carbon dots (Cdots) conjugated with oleic acid that exhibits superior biocompatibility compared to conventional ionizable lipids while retaining intrinsic fluorescence...
Exploring the multi-repair effects of advanced biomimetic rapamycin nanoparticles on cerebral ischemia-reperfusion injury [0.03%]
用于脑缺血再灌注损伤的仿生雷帕霉素纳米粒的多修复作用研究
Yanyun Wang,Yufan Ma,Tieying Cai et al.
Yanyun Wang et al.
Ischemic stroke, an intractable neurovascular disease with high lethality, disability and recurrence rates, poses a serious challenge to human health. The only effective treatment for acute stroke is reperfusion therapy. However, the inflam...
Peptide-functionalized periodic mesoporous silica nanoparticles for monocyte-specific TET3 Silencing enhance cardiac repair after acute myocardial infarction [0.03%]
用于心脏特异性沉默TET3的肽功能化周期性介孔硅纳米粒子在急性心肌梗死后促进心脏修复中的应用
Hao Jin,Jiandong Ding,Xiaoguo Zhang et al.
Hao Jin et al.
Modulating the balance between pro- and anti-inflammatory monocyte subsets holds therapeutic promise in acute myocardial infarction (AMI); however, effective and selective strategies are still lacking. In this study, we are the first to ide...
Publisher Correction: amorphous layered double hydroxide-based nano-enzyme eye drops against dry eye disease by inhibiting mitochondrial damage and pyroptosis [0.03%]
出版更正：基于无定形双氢氧化物纳米酶的眼药水通过抑制线粒体损伤和细胞焦亡治疗干眼病
Dandan Chu,Tingting Hu,Haohao Cui et al.
Dandan Chu et al.
Published Erratum
Journal of nanobiotechnology. 2025 Nov 26;23(1):742. DOI:10.1186/s12951-025-03820-1 2025