A TEMPO-loaded DNA hydrogel enabling integrated early diagnosis and treatment of osteoarthritis [0.03%]
一种用于软骨组织精准修复的智能DNA水凝胶材料研究
Hong Huang,Mingze Tang,Pengcheng Hu et al.
Hong Huang et al.
Osteoarthritis (OA) is a chronic inflammatory disease characterized primarily by cartilage degradation. Current imaging techniques often detect OA only after irreversible cartilage damage has occurred, and no drugs are available to halt dis...
Programmed nanozyme hydrogel enabling spatiotemporal modulation of wound healing achieves skin regeneration after biofilm infection [0.03%]
程序化纳米酶水凝胶实现时空调节伤口愈合以实现生物膜感染后的皮肤再生
Ze-Ming Zhuang,Yi Wang,Fa-Wei Xu et al.
Ze-Ming Zhuang et al.
Skin regeneration after wound healing is challenging, especially following infection. Wound repair is a staged yet continuous program, necessitating distinct therapeutic approaches at each stage. Regulation of infection-induced excessive re...
Transcranial and precise optical neuromodulation mediated by NIR photoactive nanosheets [0.03%]
由近红外光活性纳米片介导的颅内和精确光学神经调控技术
Deqi Yang,Ya Zhang,Yun Yuan et al.
Deqi Yang et al.
Remote modulation of specific neurons is critical for neural circuit dissection and neurological disease therapy. Traditional neuromodulation strategies applying electrodes and external stimuli may suffer from invasive injuries and insuffic...
Enhanced atherosclerosis molecular imaging and therapy with collagen hybridizing peptide functionalized albumin nanoparticles [0.03%]
一种用于动脉粥样硬化分子影像及治疗的胶原亲和性白蛋白纳米颗粒
Jianan He,Jianxun Cai,Jingjing Zhang et al.
Jianan He et al.
Intraluminal drug coated devices, such as paclitaxel (PTX)-coated balloons, are commonly used to treat arterial occlusive diseases caused by atherosclerosis. However, their efficacy is limited by drug loss, poor drug retention, insufficient...
Recent advances in theranostic nanomaterials for overcoming traumatic brain injury [0.03%]
用于治疗创伤性脑损伤的诊疗纳米材料最新进展
Nam Cheol Hwang,Dong Min Lim,Tae Sik Goh et al.
Nam Cheol Hwang et al.
Traumatic brain injury (TBI) is a major global health challenge characterized by complex secondary injury mechanisms involving oxidative stress, inflammation, and blood-brain barrier (BBB) disruption. Traditional biosensing and therapy stra...
Dual-function MgSrCeAl-LDH nanosheets enable both ROS clearance and enhanced angiogenesis for myocardial ischemia/reperfusion injury therapy [0.03%]
双功能MgSrCeAl-LDH纳米片同时清除ROS和促进血管生成治疗心肌缺血再灌注损伤
Jiayi Shen,Yuwen Luo,Wuming Hu et al.
Jiayi Shen et al.
Myocardial ischemia/reperfusion (I/R) injury represents a major global health concern, driven by excessive reactive oxygen species (ROS), which closely correlates with subsequent myocardial infarction and fibrosis. Combining ROS scavenging ...
An endoplasmic reticulum stress-responsive nanocomposite hydrogel for diabetic wound healing through a fibroblast-immune cell dual regulation hub [0.03%]
一种通过成纤维细胞-免疫细胞双调节节点响应内质网压力的用于糖尿病伤口愈合的纳米复合水凝胶
Shaoying Gao,Tao Chen,Chengliang Deng et al.
Shaoying Gao et al.
Diabetic wounds exhibit excessive endoplasmic reticulum stress (ERS), which can lead to fibroblast dysfunction, abnormal natural killer (NK) cell activation, and imbalanced macrophage polarization. ERS exerts a bidirectional regulatory effe...
Amorphous layered double hydroxide-based nano-enzyme eye drops against dry eye disease by inhibiting mitochondrial damage and pyroptosis [0.03%]
一种非晶层状双氢氧化物基纳米酶眼药水通过抑制线粒体损伤和细胞焦亡治疗干眼病
Dandan Chu,Tingting Hu,Haohao Cui et al.
Dandan Chu et al.
Chronic inflammation serves as a prominent contributor to the progression of dry eye disease (DED). Reactive oxygen species (ROS) and the downstream NLRP3 inflammasome mediate pyroptosis, which induces the inflammatory response by releasing...
Platelet-derived biomimetic nanoplatforms: a promising drug delivery strategy for cardiovascular disease [0.03%]
血小板衍生的仿生纳米平台：心血管疾病治疗的药物递送新策略
Simin Zhang,Mei Han,Shan Li et al.
Simin Zhang et al.
Over the past few decades, research has demonstrated that the progression of cardiovascular diseases is related to platelets, and the associated pathological responses include bleeding and hemostasis, antithrombotic and prothrombotic effect...
Electron-injected Pd@CeO2 nanozymes for multifaceted ROS scavenging and protection against ischemia-reperfusion injury in skin flaps [0.03%]
用于皮肤皮瓣缺血再灌注损伤防护的电子注入型Pd@CeO2纳米酶及其多功能ROS清除性能
Lingling Zhou,Jiayuan Sun,Tianxiang Lu et al.
Lingling Zhou et al.
Ischemia-reperfusion (I/R) injury in skin flap transplantation causes acute oxidative damage and inflammation, leading to high failure rates and tissue necrosis. Herein, we present a core-shell Pd@CeO2 nanozymes that addresses this challeng...