Biological nanoparticles from Brucella abortusΔeipB∆perΔwadC elicit protective immunity against brucellosis [0.03%]
缺失eipB、per和wadC基因的布鲁氏菌生物纳米颗粒具有保护免疫性
Yike Huang,Hengtai Wang,Xiaowei Peng et al.
Yike Huang et al.
Brucellosis, caused by bacteria of the genus Brucella, is a globally prevalent zoonotic disease that poses serious risks to both animal and human health. Brucella abortus releases the biological nanoparticles (outer-membrane-vesicles, OMVs)...
Gut microbiome restoring biogenic ferritin mineral as an effective oral iron supplement for iron deficiency anemia [0.03%]
一种有效的口服补铁剂治疗缺铁性贫血的肠道微生物恢复生物铁蛋白矿物质
Yingchun Yang,Luqiu Yang,Rong Yang et al.
Yingchun Yang et al.
Traditional iron supplements for iron deficiency anemia (IDA) have several limitations, including suboptimal absorption, gastrointestinal discomfort, and concerns regarding long-term safety. In this study, we synthesized monodisperse 6-line...
Nanopore assay for fingerprinting DNA binding and quantifying real-time cleavage by catalytically active Cas9 enzyme [0.03%]
用于表征DNA结合并实时量化由催化活性Cas9酶介导的切割的纳米孔测定法
Punitkumar Nagpure,Sarangi Suresh,Divya Shet et al.
Punitkumar Nagpure et al.
Nanopore sensing, a high-resolution DNA sequencing technology, is rapidly expanding into novel and exciting directions of probing specific DNA-enzyme interactions. Although proven excellent for the detecting structural features of bare DNA,...
Recent advances in electric-stimulus assisted microneedle patches for skin disease treatment [0.03%]
用于皮肤疾病治疗的电刺激辅助微针贴片最新进展
Xiao-Nan Tao,Lin Yao,Xiujun Cheng et al.
Xiao-Nan Tao et al.
Due to the natural barrier of skin structure, traditional topical drug utilization for skin disease management has been severely constrained by low bioavailability. While current microneedle (MN)-based systems confront challenges related to...
Simple-synthesis VO₂ nanoparticles as robust nanozymes for synergistic antibacterial therapy and abscess repair [0.03%]
简单合成的VO₂纳米颗粒作为抗菌联合治疗和脓肿修复的稳健纳米酶
Weicong Fu,Tian Huang,Yi-Xin Wang et al.
Weicong Fu et al.
Multidrug resistant (MDR) bacterial infections, particularly those involving methicillin-resistant Staphylococcus aureus (MRSA), pose a grave threat to global population health, necessitating novel therapeutic approaches capable of circumve...
3D bioprinted microneedle patches loaded with gambogic acid-iron-doxorubicin nanozymes for postoperative glioma in situ therapy via ferroptosis synergistic chemosensitization [0.03%]
负载 gambogic 酸-铁-多柔比星纳米酶的 3D 生物打印微针贴片通过促进铁死亡协同化疗作用进行术后胶质瘤原位治疗
Menghui Liu,Yang Qiao,Sheng Cheng et al.
Menghui Liu et al.
Background: Postoperative chemotherapy is essential for glioma treatment but faces two major limitations: the blood-brain barrier (BBB) restricts drug delivery, and tumor chemoresistance reduces therapeutic efficacy. To c...
Surface-engineered hyaluronic acid-coated lyotropic liquid crystalline nanoparticles for CD44-targeting of 3-Acetyl-11-keto-β-boswellic acid in rheumatoid arthritis treatment [0.03%]
表面工程透明质酸涂覆的向列型液晶纳米颗粒，用于CD44靶向输送3-乙酰-11-酮-β-乳香酸治疗类风湿性关节炎
Sakshi Priya,Vagesh Verma,Aniruddha Roy et al.
Sakshi Priya et al.
Background: In the current era of the global increase in autoimmune and inflammatory disorders, predominantly rheumatoid arthritis (RA), there is mounting interest in developing advanced, safe, and patient-compliant treat...
Multifunctional nanoagonist enhances photodynamic therapy-driven in situ cancer vaccination by inhibiting tumor thrombosis [0.03%]
多功能纳米 agonist通过抑制肿瘤血栓促进光动力治疗驱动的原位癌症疫苗接种
Cheng Liu,Xinyu Wang,Mingzhi Wang et al.
Cheng Liu et al.
Converting autologous tumors into therapeutic cancer vaccines represents an attractive strategy for achieving personalized antitumor immunity. However, the antitumor immune response is significantly compromised by the tumor microenvironment...
Chinese leek-derived extracellular vesicles ameliorate sarcopenia by regulating mitochondrial biogenesis and autophagy via AMPK and maintaining myosin homeostasis [0.03%]
通过AMPK调节线粒体生物合成和自噬并维持肌球蛋白稳态以缓解肌肉减少症：来自中国韭菜的外泌体的作用
Weihui Qi,Libin Yang,Yanli Pan et al.
Weihui Qi et al.
Sarcopenia, a prevalent age-related degenerative disorder, poses significant challenges in geriatric care. Chinese leek demonstrates therapeutic potential against sarcopenia progression, with emerging evidence suggesting its extracellular v...
Inhalable targeted CD8 + T cell nanoparticles loaded ferroptosis inhibitor ferrostatin-1 alleviate acute lung injury [0.03%]
可吸入靶向CD8+T细胞纳米颗粒装载铁死亡抑制剂Fer-1缓解急性肺损伤
Chunhua Ma,Zhaocong Yang,Jing Wang et al.
Chunhua Ma et al.
Acute lung injury (ALI) is a common clinical complication of sepsis and ferroptosis plays an important role in ALI. The aim of this study was to evaluate the effects of CD8 antibodies modified PD-1 engineered CD8+ T lymphocytes (CTL) membra...