Nootkatone confers MAOB-dependent neuroprotection against ferroptotic injury via brain-targeted nanoparticle delivery in ischemic stroke [0.03%]
Yonggang Zhang,Shi Feng,Kai Yu et al.
Yonggang Zhang et al.
Background: Despite advances in reperfusion therapy, effective neuroprotective interventions for ischemic stroke that can be reliably translated into clinical benefit are lacking. A persistent obstacle is the frequent dis...
Design and evaluation of a bifunctional fusion polypeptide for targeted delivery of tigecycline against drug-resistant Klebsiella pneumoniae [0.03%]
Meiling Zhou,Yuming Yao,Shuo Ma et al.
Meiling Zhou et al.
The overuse of antibiotics and the continuous evolution of drug-resistant bacteria present substantial obstacles to the clinical treatment of Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections. This study reports the rational desi...
Peptidylarginine deiminase in Porphyromonas gingivalis-derived outer membrane vesicles exacerbates metabolic dysfunction-associated steatotic liver disease through the NPAS2/CYP4A10 pathway [0.03%]
Yanqing Liu,Xiaomeng Xue,Zhaorong Li et al.
Yanqing Liu et al.
This study investigated the relationship between periodontitis and metabolic dysfunction-associated steatotic liver disease (MASLD), with a specific focus on the role of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) carried by ...
A multi species autophagy-inducing nano-vaccine platform: uncovering immunoenhancement properties of PCV2 cap nanoparticles [0.03%]
Zhuofan Deng,He Qiu,Xudong Yin et al.
Zhuofan Deng et al.
Cap VLPs (virus-like-particles) are self-assembling nanoparticles (NPs) derived from PCV2 ORF2 with ordered and repetitive antigen display, which have been widely used as a landmark veterinary vaccine in the swine industry. Building upon th...
Targeted inhibition of ATP synthase subunit c by pp10-loaded inhalable albumin nanoparticles ameliorates airway inflammation in asthma [0.03%]
Decai Wang,Tong Zhou,Yalan Cui et al.
Decai Wang et al.
The persistent opening of the mitochondrial permeability transition pore (mPTP) plays a critical role in bronchial asthma pathogenesis. The ATP synthase c subunit (c subunit) constitutes a core component of mPTP. A novel c subunit inhibitor...
An intelligent nano-engineered PLGA@IGF-1 hydrogel for programmed immune modulation and tendon regeneration via IGF-1R/AKT signaling [0.03%]
Xiaojun Yan,Yulin Zhang,Wen Zeng et al.
Xiaojun Yan et al.
Tendon repair remains a major clinical challenge, largely because current strategies often fail to simultaneously achieve early inflammatory control and subsequent matrix remodeling. To address this problem, we developed a dynamically respo...
Apigenin based nanoplatform achieves non-small cell lung cancer immunotherapy through glycolysis inhibition and photodynamic co-perturbation of organelles [0.03%]
Guoyang Zhang,Guanghui Zhu,Wei Yan et al.
Guoyang Zhang et al.
Effective treatment of non-small cell lung cancer (NSCLC) remains challenging due to its immunosuppressive tumor microenvironment, metabolic adaptability, and resistance to conventional therapies. To improve the treatment efficiency of NSCL...
Modular assembly of nanocomposite hydrogel with NIR-responsive black phosphorus release and mild photothermal synergy for enhanced regenerative microenvironment and accelerated infectious bone repair [0.03%]
Xiangru Chen,Zhiwei Sun,Zhi Zheng et al.
Xiangru Chen et al.
Infectious bone defects remain a clinical challenge due to the lack of spatiotemporal control over bacterial infection, immune microenvironment modulation, vascular regeneration, and osteogenic differentiation. Herein, we engineered a modul...
Yue-Yi Ren,Xin-Yi Yang,Yue-Ting Lin et al.
Yue-Yi Ren et al.
Chronic wound healing represents a significant clinical challenge, requiring multi-target intervention strategies due to the complex pathological microenvironment. Traditional Chinese Medicine (TCM) has a long wound care history and TCM-bas...
Autophagy-enhanced hybrid pyroptotic vesicles as personalized vaccines for cancer immunotherapy [0.03%]
Han Yan,Ling Wu,Jun Liu et al.
Han Yan et al.
Tumor vaccines represent a promising strategy for mobilizing the immune system against malignancies, however, their efficacy is limited by poor antigen immunogenicity, inefficient lymph nodes (LNs) accumulation, and inadequate antigen prese...