Dual-targeted lipid nanoparticles for TET3 siRNA delivery: nanobiotechnology strategy to remodel tumor immune microenvironment in hepatocellular carcinoma [0.03%]
Wei Peng,Jin Zhou,Zhiliang Chen et al.
Wei Peng et al.
Background: Hepatocellular carcinoma (HCC) is characterized by a highly immunosuppressive tumor microenvironment (TME), where M2-polarized tumor-associated macrophages (TAMs) and exhausted CD8+ T cells limit immunotherapy...
GSH-responsive triple-action photosensitizer nanoplatforms orchestrate cuproptosis-ferroptosis synergy to potentiate antitumor PDT efficacy [0.03%]
Luyao Xu,Jing Feng,Shihao Xu et al.
Luyao Xu et al.
Multimodal targeted combination therapy that harnesses synergistic effects has emerged as a transformative paradigm in cancer therapy, progressively replacing traditional monotherapy. Herein, we report a tumor microenvironment (TME)-respons...
Synchronous PET/MR imaging and visualizing penetration of nanomedicine within tumor based on 68Ga-NaGdF4 probes [0.03%]
Sitong Wu,Wenyue Li,Qi Yang et al.
Sitong Wu et al.
Magnetic resonance imaging (MRI) and nuclear medicine imaging are widely used for cancer detection due to their high soft tissue resolution and sensitivity. Each modality has inherent limitations; therefore, integrated techniques such as po...
Functionalized metal-organic framework-based photosensitive hydrogel eye drops for inhibition of corneal neovascularization and promotion of epithelial repair [0.03%]
Can Meng,Weijin Nan,Meiliang Wu et al.
Can Meng et al.
Background: Corneal neovascularization is a common pathological feature of various corneal disorders, often leading to severe visual impairment or blindness. Current therapeutic approaches are limited by low bioavailabili...
Leveraging the crosstalk between cGAS-STING and pyroptosis by nanomedicine to enhance antitumor immunity [0.03%]
Yumin Wang,Jinxia Chen,Xuan Zhang et al.
Yumin Wang et al.
Intratumoral vascular damage-dependent drug permeability and anticancer effect of nano drug carriers: significant anticancer enhancement of combination therapy [0.03%]
Dohyeon Moon,Doyun Kim,Sandip Gangadhar Balwe et al.
Dohyeon Moon et al.
Determining how anticancer drug-induced intratumor vascular damage alters drug permeability and enhances therapeutic efficacy is crucial for optimizing cancer treatment. This study successfully quantified anticancer drug encapsulated-MnO2 (...
Zinc-coordination-driven mitochondrial nanodisruptors to ablate cancer stemness for potentiating immunotherapy in colorectal malignancies [0.03%]
Yun Long,Wenting Cheng,Hailong Tian et al.
Yun Long et al.
Cancer stemness, sustained by mitochondrial metabolic plasticity, drives immunotherapy resistance in colorectal cancer (CRC). We reengineer zeolitic imidazolate framework-8 (ZIF-8), a zinc-coordination-driven metal-organic framework, from i...
Zesheng Wang,Weiling Lu,Zhenjun Guo et al.
Zesheng Wang et al.
Extracellular vesicles (EVs) are nanoscale, membrane-bound particles that carry nucleic acids, proteins, metabolites, and lipids. Their omics profiles can reflect tumor and microenvironmental states, making EVs a promising source of liquid ...
pH-responsive virus-drug conjugates for targeted PD-L1 silencing and enhanced cancer immunotherapy [0.03%]
S-Ja Tseng,Ivan M Kempson,Yi-Cheng Ho et al.
S-Ja Tseng et al.
Clinical efficacy of virotherapy is often limited by poor transduction and off-target effects. To overcome these hurdles, we engineered a multi-stage, pH-responsive virus-drug conjugate (VDC) for targeted, cancer immunotherapy. Our VDC comp...
Dual induction of tissue-resident T and B cell immunity for broad influenza protection with a nanofiber-VLP vaccine [0.03%]
Xiuyu Wang,Haoran Luo,Zhenyu Fan et al.
Xiuyu Wang et al.