A dual-action core-shell microneedle system restores mitochondrial function and accelerates healing in diabetic wounds [0.03%]
一种双效核-壳微针系统可恢复糖尿病创面线粒体功能并加速伤口愈合
Xinyu Li,Haojie Fu,Chenghao Yang et al.
Xinyu Li et al.
Diabetic wounds remain a significant clinical challenge due to persistent oxidative stress, chronic inflammation, and vascular dysfunction. Leveraging single-cell RNA sequencing, we identified voltage-dependent anion channel 1 (VDAC1) as a ...
Carbon-based quantum dots enhance platelets aggregation through migrasomes biogenesis [0.03%]
碳基量子点通过迁移体生成促进血小板聚集作用
Ang Li,Leiliang Zhang
Ang Li
While previous research has primarily focused on nanoparticles larger than 20 nm for promoting migrasome formation, this study shifts the emphasis to nanoparticles smaller than 10 nm. Our findings reveal the significant impact of these sub-...
Intravesical instillation of pirfenidone/polydopamine nanoparticles for managing neurogenic bladder post-spinal cord injury by alleviating bladder inflammation and fibrosis [0.03%]
通过减轻脊髓损伤后的膀胱炎症和纤维化进行膀胱给药pirfenidone/聚多巴胺纳米颗粒治疗神经源性膀胱障碍
Jizheng Zhang,Hui Li,Lekai Zhang et al.
Jizheng Zhang et al.
Neurogenic bladder (NB) secondary to spinal cord injury (SCI) progresses from early-stage bladder inflammation to late-stage fibrosis, ultimately resulting in renal dysfunction. However, effective therapeutic options for NB remain limited, ...
All-natural medicine food homology herb-based self-gelling hemostatic powder for rapid hemostasis and diabetic wound management [0.03%]
天然药物食物同源止血生肌散的研发及其治疗糖尿病足溃疡的研究
Mijia Zhang,Jianhua Peng,Xin Peng et al.
Mijia Zhang et al.
Diabetic wound management is characterized by a significantly delayed healing process and the induction of severe complications due to the significant alteration of the immune microenvironment. Additionally, uncontrolled bleeding after trau...
Self-assembled nanonetworks of highly stable gemini surfactant-like peptides: antibacterial mechanisms, self-assembly characteristics, and in vivo anti-infection potential [0.03%]
高度稳定的双头肽衍生物类似物Gemini表面活性剂的自组装纳米网络：抗菌机制，自组装特性及体内抗感染潜力
Ruoshi Zhang,Jing Sun,Chendi Fu et al.
Ruoshi Zhang et al.
The escalating prevalence of bacterial resistance underscores the critical demand for developing non-antibiotic therapeutic candidates. Antimicrobial peptides (AMPs) with potent efficacy and low toxicity have emerged as a promising alternat...
Alkali-controlled one-pot synthesis of ultrasmall pegylated polydopamine nanoparticles for diverse biological applications [0.03%]
一种用于多样化生物学应用的超小型聚多巴胺PEG纳米粒子的一锅法合成方法及其碱控制技术
Yujie Tong,Jingjing Guo,Danfeng Wu et al.
Yujie Tong et al.
Background: Polydopamine nanoparticles (PDA NPs) hold considerable significance in biomedical field due to their diverse multifunctionality, including efficient metal ion chelation, intrinsic antioxidant activity, and rob...
A programmable peptide interface for on-demand neural culturing platforms [0.03%]
一种可编程肽界面，用于按需神经培养平台
Hongyong Zhang,Xixi Song,Nan Huang et al.
Hongyong Zhang et al.
The precise spatial organization of neural cells into two-dimensional networks or three-dimensional spheroids is crucial for advancing neuroscience research and drug discoveries, yet remains challenging with conventional, single-function co...
NGO ameliorates psoriasis by modulating mitochondrial function and suppressing pSTAT3-IL-17-expressing CD8+ TRM cells [0.03%]
非编码RNA通过调节线粒体功能及抑制pSTAT3-IL-17表达的CD8⁺记忆T细胞治疗银屑病
Tae Ho Kim,Chae Rim Lee,Kyoung Min Choi et al.
Tae Ho Kim et al.
Psoriasis is a chronic autoimmune skin disorder characterized by keratinocyte hyperproliferation, persistent inflammation, and frequent relapse. Tissue-resident memory T (TRM) cells, particularly IL-17- and phosphorylated STAT3 (pSTAT3)-exp...
Machine learning for extracellular vesicles enables diagnostic and therapeutic nanobiotechnology [0.03%]
机器学习在外泌体领域的应用开启了诊断和治疗纳米生物学技术的新纪元
Ashutosh Tiwari,Widodo,Dyah Ika Krisnawati et al.
Ashutosh Tiwari et al.
Extracellular vesicles (EVs) are emerging as naturally bioactive nanomaterials with intrinsic biocompatibility and targeting potential. Recent integration of machine learning (ML) into EV research has accelerated advances in molecular profi...
Low-dose X-ray-activated radiodynamic therapy via a lutetium-coordinated nanoplatform synergizing PARP inhibition and ferroptosis [0.03%]
一种镥配位的纳米平台通过低剂量X射线激活协同PARP抑制和铁死亡的放射动力学疗法
Wanli Song,Chuanyi Zhao,Youqing Mai et al.
Wanli Song et al.
Low-dose X-ray-activated radiodynamic therapy (RDT) is a promising strategy for precision oncology. However, its therapeutic efficacy is limited by tumor radioresistance and insufficient generation of reactive oxygen species (ROS). Here, we...