Optimization of M1 macrophage targeting using a glucosylated albumin nanoplatform for ROS scavenging and mitochondrial rescue in acute kidney injury [0.03%]
一种糖基化白蛋白纳米平台用于急性肾损伤中的M1型巨噬细胞靶向优化：抗氧化和线粒体保护作用
Ji Yong Park,Jung Nam An,Seong Min Lee et al.
Ji Yong Park et al.
Background: Acute kidney injury (AKI) remains a major clinical challenge resulting from the intertwined processes of oxidative stress and macrophage-driven inflammation, both converging on mitochondrial dysfunction. We de...
3D-bioprinted adipose-derived stem cell-secreted GAS6+-sEVs reprogram microglia polarization and alleviate neuroinflammation in traumatic brain injury [0.03%]
用于重编创伤性脑损伤中微胶质细胞极化和缓解神经炎症的3D生物打印脂肪源干细胞分泌的GAS6+sEVs
Qian Zhang,Tiange Chen,Jianwei Chen et al.
Qian Zhang et al.
Traumatic brain injury (TBI)-induced neuroinflammation, driven by inflammatory microglial polarization, continues to pose a significant regenerative and clinical challenge. Small extracellular vesicles (sEVs) have demonstrated great potenti...
Synergistic chemodynamic-photothermal therapy of super-resistant Enterobacter asburiae-infected sepsis using multifunctional mesoporous nanocomposite [0.03%]
利用多功能介孔纳米复合材料对泛耐药阴沟肠杆菌感染所致脓毒症进行化学动力-光热联合治疗
Anlai Zou,Xiaoxue Zhu,Feng Zhao et al.
Anlai Zou et al.
Multidrug-resistant bacterial infections pose a severe threat to sepsis, where uncontrolled bacterial proliferation and the accompanying inflammatory response lead to multiorgan dysfunction. Recent clinical isolation of a super-resistant En...
An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis [0.03%]
一种可注射的双靶向诱导PANoptosis和抗炎纳米复合物水凝胶用于治疗骨关节炎
Qingchen Li,Lixue Chen,Yi Sun et al.
Qingchen Li et al.
PANoptosis, a distinct type of inflammation-associated programmed cell death that integrates features of apoptosis, necroptosis and pyroptosis, is closely related to the pathogenesis and progression of articular cartilage degeneration in os...
CD8a antibody-functionalized biomimetic red blood cell membrane ectosomes delivering C646 reverse CD8⁺ T Cell exhaustion via H3K18la histone delactylation in gastric cardia adenocarcinoma [0.03%]
通过组蛋白H3K18去乳酸化逆转胃贲门腺癌中CD8⁺ T细胞耗竭的C646递送仿生红细胞膜外体免疫疗法（CD8a抗体功能化）
Zheng Xiang,Xinxin Zhang,Xinlei Liu et al.
Zheng Xiang et al.
The functional exhaustion of CD8+ T cells in the tumor microenvironment (TME) severely limits anti-tumor immunity in gastric cardia adenocarcinoma (GCA). Here, we developed CD8a antibody-functionalized biomimetic red blood cell membrane ect...
Singlet oxygen-precharged injectable hydrogel triggers ferroptosis and lactate metabolism reprogramming for enhanced colorectal cancer immunotherapy [0.03%]
单线态氧预充注式水凝胶触发铁死亡和乳酸代谢重编程以增强结直肠癌免疫治疗
Hao Zhang,Xiaoyu Song,Leilei Zhao et al.
Hao Zhang et al.
Photodynamic therapy (PDT) holds significant potential for tumor treatment, yet its immunotherapeutic efficacy is severely constrained by the immunosuppressive tumor microenvironment (TME) marked by lactate accumulation, hypoxia, and glutat...
Correction: Multifunctional Fe-based coordination polymer nano-bomb modified with β-lapachone and CaO2 for targeted tumor dual chemodynamic therapy with enhanced ferroptosis and H2O2 self-supply [0.03%]
纠正：多功能Fe基配位聚合物纳米炸弹负载β- lapachone和CaO2用于增强铁死亡的肿瘤靶向双重化学动力学治疗及过氧化氢的原位生成
Pan Zhao,Liyang Gong,Le Chang et al.
Pan Zhao et al.
Published Erratum
Journal of nanobiotechnology. 2026 Jan 28;24(1):87. DOI:10.1186/s12951-025-03917-7 2026
Adolescent exposure to polystyrene nanoplastics induces male reproductive damage via the microbiome-gut-testis axis [0.03%]
聚苯乙烯纳米塑料通过微生物组-肠道-睾丸轴诱导雄性生殖损害
Jiaochen Luan,Xu Zhang,Tong Chen et al.
Jiaochen Luan et al.
Polystyrene nanoplastics (PS-NPs), are increasingly associated with reduced male fertility, yet the underlying mechanisms remain poorly defined. Here, we systematically unraveled a novel microbiome-gut-testis axis mediating PS-NPs-induced r...
OCTN2-targeted and ROS-responsive hybrid polymeric micelles for oral delivery of docetaxel [0.03%]
口服递送多西他赛的OCTN2靶向和ROS响应型杂化聚合物胶束
Haihan Sun,Jingxin Gou,Xiaoshuang Bi et al.
Haihan Sun et al.
Our previous research identified that an oral mPEG-b-PCL polymeric micelle (PM) maintained satisfactory integrity but exhibited limited transcytosis efficiency. To enhance transcytosis and enable ROS-responsive release, we developed a serie...
Tanshinone IIA&Icaritin -MPs regulated vascular normalization and restored tumor-infiltrating T lymphocyte function to boost anti-PD-1 therapy in melanoma lung metastasis [0.03%]
丹参酮IIA和淫羊藿素微粒调控血管正常化并恢复肿瘤浸润淋巴细胞的功能以增强抗PD-1疗法在黑色素瘤肺转移中的作用
Xiaoyu Che,Yaqin Li,Wenjing Chen et al.
Xiaoyu Che et al.
Background: PD-1 inhibitors are a promising treatment for melanoma, but over 50% of patients with metastatic melanoma do not respond well. This limited efficacy is partly due to the aberrant vascular structure and immunos...