An oral nanocombinatorial agent exhibits pleiotropic improvement in diabetic nephropathy via modulation of the SCAP/SREBPs pathway [0.03%]
Yu Su,Haobo Wen,Ke Hu et al.
Yu Su et al.
The multifaceted pathogenesis and multi-cellular involvement of diabetic nephropathy (DN) stand in stark contrast to the inadequacy of conventional single-target therapeutic strategies. This disparity underscores the urgent need for novel d...
Plant-derived nanocarriers & nanostructures for barrier-defined translation: a comprehensive review of mechanisms, targets, and translation [0.03%]
Ling Lv,Yue Yu,Jinlu Liu et al.
Ling Lv et al.
Plant-derived nanocarriers (PDNs) constitute a heterogeneous family of bioinspired delivery platforms, including plant-derived extracellular vesicles, lipid-based nanovectors, and plant viral nanoparticles, that have attracted growing inter...
Fengyu Tan,Wangrui Liu,Tongfei Li et al.
Fengyu Tan et al.
Inflammatory diseases remain a major clinical challenge due to their complex pathologies and the limitations of current anti-inflammatory therapies. Conventional treatments, such as non-steroidal anti-inflammatory drugs and biologics, often...
Tetrahedral framework nucleic acid delivery of emodin enables precision antibacterial and anti-inflammatory therapy for drug-resistant Staphylococcus aureus [0.03%]
Peitong Jiang,Li Wang,Yun Sun et al.
Peitong Jiang et al.
Background: Staphylococcus aureus skin infections represent a persistent clinical challenge owing to their high pathogenicity, multidrug resistance, and biofilm-associated recurrence, which collectively impair antibiotic ...
A degradable multi-metal-chelating stealth nanoplatform for dual ferroptosis/cuproptosis-enhanced metalloimmunotherapy in leukemia [0.03%]
Yingying Wang,Jianxiang Xu,Wenhui Bai et al.
Yingying Wang et al.
Acute myeloid leukemia (AML) remains a challenging hematologic malignancy with limited treatment options and poor prognosis. Here, we report the development of a multifunctional, pH-responsive, and biodegradable nanoparticle system, Membran...
Biogenesis, preparation, characterization, therapeutic mechanisms and safety evaluation of plant-derived exosome-like nanovesicles in the treatment of ulcerative colitis [0.03%]
Cailan Li,Luyou Zhao,Xuefei Wang et al.
Cailan Li et al.
Ulcerative colitis remains a challenging clinical condition due to its complex etiology and the limitations of current therapies. Plant-derived exosome-like nanovesicles (PDELNs) represent a new class of natural nanotherapeutics with signif...
Yue Na,Jinku Bai,Ning Zhang et al.
Yue Na et al.
Alzheimer's disease (AD) is a prevalent and progressive neurodegenerative disease characterized by behavioral abnormalities, memory loss, and cognitive decline, presenting significant challenges for early diagnosis and effective treatment. ...
Coupled mesoporous silica nanoparticles and limonene-chitosan Pickering emulsions: enhanced insecticidal delivery and selectivity [0.03%]
Nannan Lv,Zhixuan Xu,Qingyang Zhang et al.
Nannan Lv et al.
Background: Nanodelivery represents a promising strategy to enhance pesticide efficacy while reducing associated environmental risks. Mesoporous silica nanospheres (MSNs) can serve as effective nanocarriers but improvemen...
Recent advances in application of hydrogel-based nanomaterials in breast cancer: from drug delivery, immunotherapy mechanisms to clinical applications [0.03%]
Yuanbing Xu,Dai Pan,Qinlian Yang et al.
Yuanbing Xu et al.
Breast cancer remains one of the most prevalent malignant tumors affecting women worldwide and continues posing a major threat to global health. Current clinical treatments include surgery, chemotherapy, radiotherapy, targeted therapy, and ...
Prussian blue analogue-mineralized ginseng-derived vesicles promote PPARγ nuclear translocation to suppress tumor vasculogenic mimicry and reverse the immunosuppressive microenvironment [0.03%]
Chaoqin Guo,Xiaoyan Zhang,Qiyi Liu et al.
Chaoqin Guo et al.
Highly aggressive tumor cells fulfill their metabolic demands by forming vascular-like channels through a process of cellular deformation and extracellular matrix (ECM) remodeling, known as vasculogenic mimicry (VM). This phenomenon contrib...