Synergistic gambogic acid/Ga³⁺ remodels the immunosuppressive tumor microenvironment to enhance triple-negative breast cancer therapy [0.03%]
gambogic酸/Ga³⁺重塑免疫抑制肿瘤微环境以增强三阴性乳腺癌治疗的协同作用
Chong Qiu,Pengbo Guo,Chen Wang et al.
Chong Qiu et al.
The immunosuppressive tumor microenvironment (TME) is a pivotal contributor to therapeutic resistance in triple-negative breast cancer (TNBC). Immunogenic cell death (ICD), which activates antitumor immunity through damage-associated molecu...
Yanping Feng,JinYi Chen,Congqin Ning
Yanping Feng
Selenium (Se) is an essential trace element for the human body, serving as a component of several natural enzymes and playing a crucial role in a variety of biological functions. However, the extraction of natural selenoenzymes presents sig...
Multifunctional metal-phenolic network coatings drive immunocompetent osseointegration via marrow microenvironment remodeling [0.03%]
金属酚网络多功能涂层通过骨髓微环境重塑促进免疫 competent的骨整合
Yu-Wei Ge,Nai-Sheng Zhai,Chen-Jun Liu et al.
Yu-Wei Ge et al.
Surface modification is crucial for improving bone-implant integration, but current coating technologies lack simplicity, efficiency, and multifunctionality needed for clinical use. Metal-phenolic networks (MPNs) are emerging as a promising...
Targeting bone marrow adipocyte-driven fatty acid metabolism to overcome drug resistance in lung cancer bone metastasis [0.03%]
靶向骨髓脂肪细胞驱动的脂代谢以克服肺癌骨转移引起的药物耐药性
Jian Dong,Huaze Ding,Shuoer Wang et al.
Jian Dong et al.
Lung cancer remains a leading cause of cancer-related mortality worldwide, with bone metastasis presenting a significant challenge due to its association with severe skeletal complications and therapy resistance. This study investigates the...
Cinobufagin loaded Prussian blue-like nanoparticles for chemo/gas therapy of multidrug resistant cancer [0.03%]
用于耐药肿瘤化疗/气体治疗的携带 Cinobufagin 的类似普鲁士蓝纳米粒子
Wensheng Qiu,Jialong Fan,Weifeng Tao et al.
Wensheng Qiu et al.
Targeted delivery of the GPX4 activator via HUCMSC-derived exosomes inhibits ferroptosis in spinal cord injury [0.03%]
人脐带间质干细胞来源的外泌体靶向递送GPX4激活剂抑制脊髓损伤铁死亡
Baoyou Fan,Xiang Gao,Xiaoyang Chen et al.
Baoyou Fan et al.
Spinal cord injury (SCI) is a severe and multifaceted neurological trauma characterized by neuronal loss, axonal disruption, and limited regenerative potential, often causing lasting neurological deficits. Ferroptosis promotes neural cell d...
Ultrasound-responsive Janus patch with mechanical anisotropy, pro-healing, and anti-adhesion properties for abdominal wall defect repair [0.03%]
一种各向异性机械性能的超声波响应Janus补片促进腹壁缺损修复及防止粘连
Binying Peng,Binghua Ma,Hao Lu et al.
Binying Peng et al.
Abdominal wall exhibits a complex anisotropic architecture with region-specific mechanical gradients, essential for maintaining biomechanical integrity during physiological deformations. However, most clinical patches possess isotropic stru...
Retraction Note: Graphene oxide (GO)-based nanosheets with combined chemo/photothermal/photodynamic therapy to overcome gastric cancer (GC) Paclitaxel resistance by reducing mitochondria-derived adenosine-triphosphate (ATP) [0.03%]
撤回 notice: 基于 graphene oxide (GO) 的纳米片通过减少线粒体衍生的三磷酸腺苷(ATP)克服胃癌(GC) Paclitaxel 耐药性综合化疗/光热/光动力疗法
Weihong Guo,Zhian Chen,Xiaoli Feng et al.
Weihong Guo et al.
Anthocyanin-functionalized selenocysteine nanotherapeutics alleviate cisplatin nephrotoxicity by inhibiting oxidative stress and ferroptosis [0.03%]
花青素功能硒半胱氨酸纳米药物通过抑制氧化应激和铁死亡来缓解顺铂肾毒性
Hongyan Zhu,Xingyuan Wu,Yulin Tan et al.
Hongyan Zhu et al.
Although cisplatin (CDDP) remains a widely used chemotherapeutic agent in clinical cancer treatment, severe oxidative stress and inflammatory responses induced by CDDP are still major causes of acute kidney injury (AKI) in patients. Our pre...
A mitochondria-targeted nanomedicine for myocardial ischemia/reperfusion injury with synergistic antioxidant and anti-inflammatory properties [0.03%]
一种针对线粒体的纳米药物用于心肌缺血/再灌注损伤，具有协同抗氧化和抗炎作用
Congcong Li,Zhengfeng Zhang,Chao Luo et al.
Congcong Li et al.
Acute myocardial infarction (AMI) remains the leading cause of mortality worldwide, posing a significant threat to global public health. Although revascularization strategies such as percutaneous coronary intervention represent the standard...