Mucus and tumor penetrating paclitaxel micelles for potent local therapy of cervical cancer [0.03%]
用于局部治疗宫颈癌的粘液和肿瘤穿透性紫杉醇胶束
Yijie Chen,Yangla Xie,Jiaping Wu et al.
Yijie Chen et al.
The therapeutic efficacy for cervical cancer treatment is limited by insufficient drug accumulation and penetration due to physiological barriers such as mucin-rich environments after systemic administration. Thus, developing a local drug d...
Virosome-masked ratiometric nanoprobes for in vivo dynamic imaging of influenza a virus infection [0.03%]
用于体内检测流感病毒感染的病毒体掩蔽比率纳米探针
Ruiqi Ming,Yue Wang,Zewei Yan et al.
Ruiqi Ming et al.
In vivo fluorescent in situ visualization of viral infection dynamics is crucial for elucidating the mechanisms of viral pathogenesis. However, current approaches lack sufficient specificity and sensitivity for spatiotemporal monitoring of ...
Oral delivery of anti-mCD80 nanobody-engineered probiotic bacterial nanovesicles for macrophage-targeted Il17ra silencing in colitis [0.03%]
口服抗mCD80纳米抗体工程益生菌细菌纳米囊泡以靶向巨噬细胞在结肠炎中沉默IL17RA
Manli Zhang,Yonggang Zhu,Feng Hu et al.
Manli Zhang et al.
Inflammatory bowel disease remains challenging to treat because effective intervention requires localized suppression of mucosal inflammation together with restoration of tissue homeostasis. Here, a hierarchically engineered oral nanotherap...
Tumor microenvironment-responsive nanocarriers for enhanced glioblastoma immunotherapy [0.03%]
用于增强胶质母细胞瘤免疫治疗的肿瘤微环境响应型纳米载体
Cuicui Wang,Zhihong Sun,Jun Sun et al.
Cuicui Wang et al.
The glioblastoma (GBM) microenvironment exhibits a profoundly immunosuppressive state, which constitutes the major barrier limiting the efficacy of immunotherapy. It is intricately intertwined with aberrant physicochemical characteristics i...
Discriminating single-amino acid differences and post-translational modifications in negatively charged peptides with α-hemolysin nanopores [0.03%]
利用α-溶血素纳米孔区分负电荷肽中的单氨基酸差异和翻译后修饰
Liting Kang,Linting Wang,Xuefei Fan et al.
Liting Kang et al.
Effective and precise detection of peptides and their post-translational modifications (PTMs) is crucial for biomedical research but remains technically challenging. Here, we present a nanopore sensing strategy that enables label-free analy...
An integrative multi-omics landscape of multi-dimensional cellular stress and metabolic reprogramming in melanoma treated with targeted alpha therapy [0.03%]
靶向α疗法治疗黑色素瘤的多维度细胞应激和代谢重编程的整合多组学景观
Jiajia Zhang,Zhiling Song,Zhengguo Chen et al.
Jiajia Zhang et al.
Purpose: This study aimed to elucidate the biological mechanisms underlying the therapeutic effects of targeted alpha therapy (TAT) using a novel 211At-labeled single-domain antibody drug ([211At]At-AuNP-sdAb). By integra...
Colon-targeting pH-responsive Bletilla striata polysaccharide coacervate microdroplets for ulcerative colitis therapy via macrophage reprogramming [0.03%]
通过巨噬细胞重编程治疗溃疡性结肠炎的结肠靶向pH响应型Bletilla striata多糖凝聚体微滴
Qiantao Zhang,Lai Chai,Hui Liu et al.
Qiantao Zhang et al.
Ulcerative colitis (UC) is an immune-mediated chronic inflammatory bowel disease that severely impairs patients' quality of life. Efficient oral colon-targeted delivery systems are urgently needed to improve local therapeutic efficacy while...
Kidney‑enriched lipid nanoparticles delivering ANXA2 alleviate renal ischemia-reperfusion injury via CHMP2A-mediated necroptosis inhibition [0.03%]
肾脏丰富型脂质纳米颗粒递送ANXA2通过CHMP2A介导的抑制坏死性凋亡来缓解肾缺血再灌注损伤
Dong Lai,Qing Bi,Jichen Wang et al.
Dong Lai et al.
Background: Renal ischemia-reperfusion injury (IRI) is a major complication following nephron-sparing surgery, with limited preventive strategies. Annexin A2 (ANXA2) is upregulated after renal IRI, but its functional role...
A novel nanosensor for in situ detection of EV-miR-107 enables noninvasive tuberculosis diagnosis and treatment monitoring [0.03%]
一种新型纳米传感器实现原位检测EV-miR-107用于无创结核病诊断和治疗监测
Yuan Wu,Shihua Luo,Jin Gu et al.
Yuan Wu et al.
Tuberculosis (TB) remains a leading cause of infectious death globally, creating an urgent need for rapid and non-invasive diagnostics. Extracellular vesicles (EVs) have emerged as promising carriers of disease-specific microRNAs with bioma...
Quaternary ammonium carbon dots for membrane perforation-immunity synergistic therapy against drug-resistant cancer metastasis [0.03%]
季铵化碳点用于膜穿孔-免疫协同治疗药物耐受性癌转移
Qi Wu,Shanshan Wang,Jingchun Wang et al.
Qi Wu et al.
Multidrug resistance and invasive metastasis constitute pivotal clinical bottlenecks that severely compromise curative outcomes of malignant tumors. Conventional chemotherapy and immunotherapy frequently fail to achieve satisfactory efficac...