Enhanced mRNA vaccine combined with immune checkpoint blockade efficiently suppresses tumor growth and metastasis [0.03%]
Yufeng Zhang,Xinghuan Ma,Danni Jin et al.
Yufeng Zhang et al.
Recently, mRNA vaccines have successfully prevented infectious diseases but remain only adjuvant therapies for cancer due to limited immune killing efficacy. The efficacy of tumor vaccines depends on both the immunogenicity of associated an...
Nanomedicine in immunotherapy of urinary system tumors: advances, synergistic strategies, and translational challenges [0.03%]
Wenpeng Huang,Ayushi Chaudhary,Zhaonan Sun et al.
Wenpeng Huang et al.
Urological malignancies impose a substantial global health burden, underscoring the urgent need for more effective therapeutic strategies. Although immunotherapy has transformed cancer management, its benefit in urological tumors remains in...
Targeted hyperthermia therapy (THT) using gold nanorods remodels the tumor microenvironment to sensitize murine microsatellite-stable colorectal cancer to immune checkpoint blockade [0.03%]
Barry E Kennedy,Julie L Jordan,Geetha Subramanian et al.
Barry E Kennedy et al.
Microsatellite-stable (MSS) colorectal cancers are refractory to immune checkpoint blockade (ICB) due to limited baseline inflammation, inefficient antigen presentation, and impaired T cell priming. We investigated whether nanomaterial-enab...
Yadong Guo,Wenbo Du,Shuguang Cheng et al.
Yadong Guo et al.
Apoptotic extracellular vesicles (ApoEVs), natural bilayer nanoparticles released during programmed cell death, have emerged as pivotal regulators and promising therapeutic agents for bone regeneration. They function as innate multimodal si...
A dual-transformable MgGa-MOF nanoplatform for HCC therapy via lactate metabolism blockade and immune reactivation [0.03%]
Yajie Li,Yingying Wei,Shaoshi Ma et al.
Yajie Li et al.
Microwave ablation (MWA) has emerged as one of the preferred modalities for treating hepatocellular carcinoma (HCC). However, its therapeutic efficiency is restricted by lactate accumulation after MWA. Lactate serves as a metabolic fuel for...
Yaqi Yao,Zhenna Xu,Haoran Ding et al.
Yaqi Yao et al.
Acute liver injury (ALI) represented a significant clinical challenge due to its high mortality rate and the absence of specific therapeutic interventions. Plant-derived exosome-like nanoparticles (ELNs) had recently garnered increasing att...
Injectable pH-responsive carboxymethyl cellulose hydrogel for sustained delivery of IL-22 in the treatment of alcoholic liver disease [0.03%]
Huan Zhou,Dashuai Yang,Rongrong Gu et al.
Huan Zhou et al.
Alcoholic liver disease (ALD) is a major chronic liver disorder that poses a significant global health burden due to its severe health risks and limited therapeutic options. Although recombinant interleukin-22 (IL-22) is an available therap...
LILRB3 inhibition reverses immunosuppression in glioma: a nanoparticle-based therapeutic strategy [0.03%]
Jiefu Yu,Xiangguo Cui,Guangcai Shao et al.
Jiefu Yu et al.
Glioma is a highly aggressive brain tumor characterized by a profoundly immunosuppressive tumor microenvironment dominated by M2-polarized tumor-associated macrophages (TAMs). This study utilized machine learning and single-cell multi-omics...
Dual-loaded homotypic exosomes with endogenous IR808 and pH-responsive DOX drive sequenced chemo-PDT and convert "cold" OSCC tumors "hot" [0.03%]
He Wang,Yang Yu,Wenbin Zhou et al.
He Wang et al.
Background: Chemotherapy remains central to oral squamous cell carcinoma (OSCC) management but is constrained by poor specificity, systemic toxicity, multidrug resistance, and limited durability. Tumor-derived exosomes (T...
Responsive nanoparticles modulating microglia lactate transport alleviate M1-type polarization and neuroinflammation for brain injury therapy [0.03%]
Yuxiao Ma,Guojie Chen,Pengcheng Xu et al.
Yuxiao Ma et al.
Neuroinflammation mediated by microglia and excessive oxidative stress are key pathological processes driving the progression of brain injuries such as intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Modulating lactate tran...