Separable cryo-microneedle patches delivery with capsaicin integrated mesoporous dopamine for obesity treatment [0.03%]
一种用于肥胖症治疗的可分离冷冻微针贴片，其含有融合了介孔多巴胺的辣椒素
Jingjing Gan,Lingyu Sun,Wenjuan Tang et al.
Jingjing Gan et al.
Microneedle patch encapsulated with active medication holds significant potential promise in the realm of anti-obesity therapy. Nevertheless, the improvement of actives delivery efficiency remains a significant challenge. In this paper, we ...
Mechanically tunable fiber-based hydrogel activates PIEZO1-integrin axis for enhanced bone repair [0.03%]
机械调节的纤维基水凝胶激活PIEZO1-整合素轴以增强骨修复
Jinghong Yang,Runli Li,Xiaoshuang Wang et al.
Jinghong Yang et al.
Irregular alveolar bone defects pose persistent clinical challenges due to their complex morphology and the lack of biomaterials that simultaneously provide structural integrity, biocompatibility, and dynamic osteoinductive potential. Herei...
Spleen-targeted NeoPol-mL242 mRNA vaccine induces robust T-cell responses in a hepatocellular carcinoma model [0.03%]
脾靶向NeoPol-mL242 mRNA疫苗在肝细胞癌模型中诱导强大的T细胞反应
Yufei Wu,Gongrui Sun,Wendan Ren et al.
Yufei Wu et al.
Personalized neoantigen peptide vaccines have shown remarkable anti-tumor activity across diverse cancer types. With the rapid advancement of messenger RNA (mRNA) delivery technologies during the coronavirus disease of 2019 (COVID-19) pande...
Intraoperative application of an antioxidant nanoparticle-hydrogel targeting microglia regulates neuroinflammation in traumatic brain injury [0.03%]
术中应用针对小胶质细胞的抗氧化纳米颗粒-水凝胶可调节创伤性脑损伤中的神经炎症
Yuhan Han,Jiacheng Gu,Miaomiao Xu et al.
Yuhan Han et al.
Microglia play a critical role in neuroinflammation, a key secondary injury mechanism following traumatic brain injury (TBI). The colony-stimulating factor 1 receptor (CSF-1R) inhibitor PLX5622 has shown promise in suppressing neuroinflamma...
Circadian disruption and ROS-NLRP3 signaling mediate sleep deprivation-enhanced silica nanoparticle toxicity in lacrimal glands [0.03%]
昼夜节律紊乱和ROS-NLRP3信号介导的睡眠剥夺增强的纳米硅毒性对泪腺的影响
Wenxiao Zhang,Di Qi,Xiaoting Pei et al.
Wenxiao Zhang et al.
Sleep deprivation (SD) and exposure to engineered nanomaterials such as silica nanoparticles (SiNPs) are emerging risk factors for ocular surface disorders, particularly dry eye disease. However, the molecular mechanisms underlying their co...
Nanoscale metal-organic frameworks as a versatile platform for synergistic combination tumor therapy [0.03%]
纳米金属有机骨架在协同综合肿瘤治疗中的多功能平台作用研究
Mengru Cai,Yuqing Yang,Jiahui Kong et al.
Mengru Cai et al.
As the second most common cause of death globally, tumor significantly impacts human health and quality of life. Although monotherapy has achieved remarkable progress, its therapeutic effectiveness remains less than ideal. The current strat...
Polymerase-based DNA reactions for molecularly computing cancerous diagnostic valences of multiple miRNAs [0.03%]
基于聚合酶的DNA反应，用于计算多种miRNA癌症诊断值分子式
Yumin Yan,Hongyang Zhao,Lijie Xing et al.
Yumin Yan et al.
Conventional miRNA-based diagnostic methods often treat all biomarkers equally, overlooking the fact that each miRNA contributes differently to disease classification. This differential diagnostic importance is captured by the concept of Ca...
Dectin-1-targeted pH-responsive liposomal nanoplatform delivering Plantago Asiatica L. acidic polysaccharide for immunomodulation and immunosuppressive breast cancer microenvironment reprogramming [0.03%]
以酸性多糖为目标的针对Dectin-1的pH响应型脂质体纳米递药平台用于免疫调节和免疫抑制型乳腺癌微环境重编程
Wanbing Pan,Can Li,Xiaoyu Zhou et al.
Wanbing Pan et al.
Background: The limited tumor-specific delivery and insufficient dendritic cell (DC) activation remain critical challenges in cancer immunotherapy. This research aimed to improve antitumor efficacy by developing a novel p...
Defect-engineered amorphous-like nanointerceptors for T2 MRI-Guided treatment of reperfusion injury [0.03%]
用于再灌注损伤T2 MRI引导治疗的缺陷工程类无定形纳米拦截剂
Xiaotong Ma,Xin Liang,Yixin Yu et al.
Xiaotong Ma et al.
Ischemic reperfusion (I/R) injury is dominated by excessive reactive oxygen species (ROS)-mediated oxidative damage and uncontrolled inflammation, yet effective strategies for simultaneous diagnosis and treatment remain elusive. Herein, we ...
Lipid nanoparticles-mRNA based on the consensus sequences of avian coronavirus S1 and N genes protect animals against multiple viral infections [0.03%]
基于禽冠状病毒S1和N基因共识序列的脂质纳米颗粒-mRNA对多种病毒感染具有保护作用
Hongtao Xiao,Wanyan Wu,Siyao Yu et al.
Hongtao Xiao et al.
Lipid nanoparticles-mRNA play important roles in SARS-CoV-2 infection control. Avian coronavirus infectious bronchitis virus (IBV) comprises eight genotypes with a lack of cross-protection, causing severe economic losses to the poultry indu...