Copper-coordinated engineered nanoreactors with self-amplifying O2 and cascade chem-drug synthesis for enhanced sonodynamic-mediated oncotherapy [0.03%]
一种铜配位的工程纳米反应器 自行放大氧气和级联化学药物合成 用于增强超声动力学介导的肿瘤治疗
Zhongxiong Fan,Lijun Ding,Fukai Zhu et al.
Zhongxiong Fan et al.
Efficient synthesis of chemotherapeutic drugs within the tumor microenvironment (TME) holds great potential for enhancing sonodynamic-mediated synergistic oncotherapy. Herein, an engineered nanoreactor composed of Cu2+, indocyanine green (I...
Triple-targeting miRNA-loaded core-shell nanoparticles in injectable hydrogel enable coordinated diabetic wound repair [0.03%]
可注射水凝胶中的三重靶向miRNA载核壳纳米粒子实现糖尿病创面的协同修复
Ziyan Guo,Lele Wu,Yu Niu et al.
Ziyan Guo et al.
Diabetic wound healing is critically impaired by dysregulated macrophage polarization, compromised endothelial angiogenic function, and diminished fibroblast proliferation/migration under persistent hyperglycemia. Current therapies, predomi...
Macrophage membrane-coated nanoparticles in inflammatory diseases: from bioinspired design to translational potential [0.03%]
炎症性疾病中的巨噬细胞膜包被的纳米颗粒：从仿生设计到转化潜力
Yuyue Hou,Ruolin Wu,Yan Zhou et al.
Yuyue Hou et al.
Inflammatory diseases, including autoimmune, infectious, and metabolic disorders, remain major global health challenges due to their complex pathogenesis and limited therapeutic options. In recent years, bioinspired nanotechnology has emerg...
Cost-effective and flexible preimplantation genetic testing (PGT) by nanopore adaptive sampling [0.03%]
通过纳米孔自适应采样进行经济且灵活的胚胎植入前遗传学检测(PGT)
Zhiqiang Zhang,Shujing He,Taoli Ding et al.
Zhiqiang Zhang et al.
Genetic diseases encompass a spectrum of disorders resulting from DNA variations. Preimplantation genetic testing (PGT) is a critical strategy for preventing recurrent miscarriage, fetal malformations, and the birth of children affected by ...
Synergistic effect study on the co-delivery of paclitaxel and SiRNA targeting STMN1 based on MPDA nanoparticles in the therapy of ovarian cancer [0.03%]
基于MPDA纳米粒的包载紫杉醇及STMN1靶向siRNA协同递送抗卵巢癌药效学研究
Xueqian Qian,Yi Yuan,Yaning Zhang et al.
Xueqian Qian et al.
Background: Ovarian cancer is one of the most prevalent gynecologic malignancies and ranks as a leading cause of death in female cancers. Chemotherapy remains the primary treatment modality, however, the development of ch...
Dual-pathway nanoengineering: spatiotemporal control of immunogenic apoptosis and macrophage phenotype reprogramming for augmented antitumor immunity [0.03%]
双重途径纳米工程学：免疫原性细胞凋亡的时空控制及巨噬细胞表型重编以增强抗肿瘤免疫反应
Yunfeng Tang,Xiangtian Deng,Min Yi et al.
Yunfeng Tang et al.
Damage-associated molecular patterns (DAMPs) are released by cells through immunogenic cell death (ICD), reshaping the tumor microenvironment and demonstrating significant potential in cancer immunotherapy. We report a type of nanoparticle ...
Tumor targeting dendritic nanocarrier with immunogenic cell death inducing and TIGIT blockade for synergistic chemo-immunotherapy against TNBC [0.03%]
一种靶向肿瘤的树突状纳米载体用于诱导免疫性细胞死亡和阻断TIGIT以协同治疗三阴性乳腺癌化学免疫疗法
Jia Wang,Zhiji Wang,Kaiming Li et al.
Jia Wang et al.
The clinical therapeutic effect of immune-checkpoint blockade (ICB) on triple-negative breast cancer (TNBC) is limited due to low tumor immunogenicity and tumor immunosuppressive microenvironment. Combination therapies of chemotherapy and I...
Targeted nanodelivery strategies for atrial fibrillation: concomitant targeting of fibrosis suppression and electrical conduction restoration through advanced nanobiotechnology [0.03%]
利用高级纳米生物技术靶向输送策略治疗房颤：同时抑制纤维化和恢复电传导
Yanxiao Liang,Haoyuan Zheng,Yuan Tian
Yanxiao Liang
Atrial fibrillation (AF), the most common form of cardiac arrhythmia, is closely associated with atrial fibrosis and electrophysiological remodeling, both of which contribute to its persistence and recurrence. Current treatment strategies r...
Advances in nanomedicine-based retinal drug delivery: mechanisms and translational applications [0.03%]
基于纳米医学的视网膜药物递送进展：机制和转化应用
Helia Nafar,Pouya Mahdavi Sharif,Nima Rezaei
Helia Nafar
Retinal diseases like age-related macular degeneration (AMD), diabetic retinopathy (DR), and diabetic macular edema (DME), alongside optic neuropathies such as glaucoma, are primary contributors to irreversible visual impairment and blindne...
Charge-mediated directed assembly of Pt nanoshell on PDA: colorimetric-catalytic co-enhanced lateral flow immunoassay for point-of-care testing [0.03%]
基于电荷介导的Pt纳米壳定向组装：用于现场快速检测的比色-催化协同增强型免疫层析试纸条
Xingsheng Yang,Lei Ren,Jing Liang et al.
Xingsheng Yang et al.
Effectively enhancing the detection sensitivity of lateral flow immunoassay (LFIA) without dependence on instruments has crucial implications for point-of-care diagnostics. Herein, we introduce a core-shell structured polydopamine (PDA)@pla...