Black phosphorus-based photothermal-responsive hydrogel enhanced osteoporotic bone injury regeneration by alleviating oxidative stress and remodeling bone homeostasis [0.03%]
基于黑磷的光热响应性水凝胶通过减轻氧化应激和重塑骨稳态增强骨质疏松性骨损伤修复
Yufeng Zhang,Guilin Qi,Liang Zhang et al.
Yufeng Zhang et al.
Diabetes-induced osteoporosis significantly elevates the risk of fracture-related disability and mortality. Developing effective therapeutic strategies for diabetic-related bone defects has become a pressing concern in both clinical and res...
Ramesh Koduru,Somedutta Maity,Dibakar Das et al.
Ramesh Koduru et al.
The advancement of nanotechnology has revolutionized reproductive healthcare worldwide. It has enabled the treatment of various conditions, such as infertility, endometriosis, ectopic pregnancies, erectile dysfunction, sexually transmitted ...
Zinc peroxide-copper bimetallic nanozyme with self-activated ROS and cuproptosis for superficial antifungal therapy [0.03%]
具有自激活ROS和铜依赖性细胞死亡的氧化锌-铜纳米酶用于浅表真菌治疗
Fuyao Chen,Yang Ye,Yitao Yao et al.
Fuyao Chen et al.
Fungal infections, particularly intractable cases such as fungal keratitis (FK) and skin wound infections, remain a pressing global health challenge, further exacerbated by rising antifungal resistance and treatment-associated cytotoxicity....
Piezoelectric scaffold with enhanced effect drives the healing of osteochondral defects through electromechanical-immune coupling [0.03%]
压电支架通过机电免疫偶联机制增强软骨下骨缺损修复效果
Xin Liu,Congyang Xue,Jun Guo et al.
Xin Liu et al.
Silk fibroin scaffolds (SFCs) that exploit piezoelectricity for osteochondral repair have been hampered by both insufficient electromechanical output and a pro‑inflammatory joint microenvironment that erodes therapeutic efficacy. To overco...
A novel nanotherapeutic strategy: rescuing nucleus pulposus cells from fatty acid metabolic disorder and pyroptosis through ACOT13 by Chinese herbal formula nanoparticles [0.03%]
一种新的纳米治疗策略：通过中药配方纳米颗粒利用ACOT13从脂肪酸代谢紊乱和细胞焦亡中拯救椎间盘髓核细胞
Weihui Qi,Mingchao Yuan,Du He et al.
Weihui Qi et al.
Low back pain (LBP) is a widespread global health concern that profoundly impairs patients' quality of life and productivity. Intervertebral disc degeneration (IVDD) is considered a major pathological factor in low back pain, yet the underl...
A biohybrid platform integrating bacterial propulsion and photoresponsive nanomedicine for adequate intratumoral drug delivery [0.03%]
一种生物杂化平台集成细菌推进和光响应纳米药物用于肿瘤内给药
Zhe Yu,Jingwei Wang,Youbei Qiao et al.
Zhe Yu et al.
Efficient and uniform delivery of nanomedicine into deep tumors remains challenging due to the limited targeting efficiency and the dense stromal barrier of solid tumors. Here, we report a bacterial biohybrid platform that integrates tumor-...
Citrate-coated Prussian blue nanozyme hitchhikes neutrophils to ameliorate calcium oxalate crystal-induced kidney injury via inhibiting pyroptosis and NETosis [0.03%]
苹果酸涂布的普鲁士蓝纳米酶劫持中性粒细胞通过抑制细胞焦亡和NETosis改善钙 oxalate晶体诱导的肾脏损伤
Xiaozhuo Ba,Xiaoqi Yang,Yu He et al.
Xiaozhuo Ba et al.
Kidney stones are among the most common renal diseases with high global incidence and recurrence rates, with calcium oxalate (CaOx) stones constituting 65.9% to 80% of all cases. Minimally invasive surgery remains the primary approach for k...
A single-dose of PDGFB circular RNA enables sustained growth factor expression to accelerate diabetic wound healing [0.03%]
单剂量PDGFB环状RNA通过持续生长因子表达促进糖尿病伤口愈合
Yi-Qi Shen,Yan Zhang,Liu-Yi Yao et al.
Yi-Qi Shen et al.
Diabetic foot ulcer (DFU) is one of the most serious complications of diabetes and lack effective treatment options. Although platelet-derived growth factor-B (PDGFB) has been approved for the treatment of diabetic wounds, it is difficult t...
Exercise-derived exosomes: molecular mediators of systemic health and disease therapy [0.03%]
运动诱导的外泌体：全身健康和疾病治疗的分子介导体
Hui Kong,Jing Luo,Zhihui Zou et al.
Hui Kong et al.
Exosomes serve as pivotal nanoscale messengers in intercellular communication by transporting bioactive molecules such as miRNAs, proteins, and lipids that regulate physiological and pathological processes. Emerging evidence highlights exer...
Selenium-doped carbon dots nanozymes hitchhiking tailored liposomes block neuronal pyroptosis through GPX4/ROS/NLRP3/GSDMD axis to attenuate ischemic stroke [0.03%]
硒掺杂碳点纳米酶 hitchhiking 脂质体制备用于阻断缺血性脑卒中神经元焦亡通过 GPX4/ROS/NLRP3/GSDMD 轴的作用研究
Jiaxuan Hou,Li Yao,Yane Li et al.
Jiaxuan Hou et al.
Ischemia-reperfusion (I/R) injury is a critical contributor to adverse outcomes following stroke. During I/R injury, excessive production of reactive oxygen species (ROS) leads to various forms of neuronal cell death. Moreover, the blood-br...