Advances in extracellular vesicle-based nanomedicine for regenerative orthopaedics [0.03%]
基于细胞外囊泡的纳米医学在外科再生医学中的进展
Sara Gil Izquierdo,Andrés Fernández Pilar,Jaqueline Lourdes Rios et al.
Sara Gil Izquierdo et al.
The increasing prevalence of bone and cartilage injuries presents a persistent clinical challenge in orthopaedic medicine. Current standard-of-care approaches and regenerative strategies, including cell-based therapies and conventional biom...
Ultrasound-enhanced and cell-traction-induced piezoelectric scaffolds for repairing bone defects [0.03%]
一种用于骨骼修复的超声和细胞牵引驱动的压电支架
Xing Zhang,Meifei Lian,Juncen Zhou et al.
Xing Zhang et al.
The global increase in traumatic accidents and aging population has brought bone tissue injury and disease to the forefront of global health concerns. Traditional treatment methods face significant challenges, emphasizing the urgent need fo...
Endothelial mitochondrial-derived vesicles (EMDVs) with retinal targeted homing properties dynamically modulate the eIF2α-ATF4-CHOP signaling pathway and efficiently restore mitochondrial homeostasis in diabetic retina [0.03%]
具有视网膜靶向归巢特性的内皮细胞线粒体来源的囊泡（EMDVs）可动态调节eIF2α-ATF4-CHOP信号通路并有效恢复糖尿病视网膜病变中的线粒体稳态
Siyu Gui,Jie Gao,Tianchang Tao et al.
Siyu Gui et al.
mRNA based vaccines and therapeutics for parasitic infections: a comprehensive review [0.03%]
基于mRNA的寄生虫感染疫苗和治疗药物：全面回顾
Hasan Muhammad Waqqas,Jiajia Pan,Ningbo Xia et al.
Hasan Muhammad Waqqas et al.
The success of mRNA vaccines during the COVID-19 pandemic has revealed a revolutionary platform for addressing neglected parasite zoonosis, which represent a continual and significant threat to world health, especially in resource-constrain...
Apoptotic vesicles rectify senile bone-fat imbalance by activating Thy1-ERK-TAZ axis [0.03%]
凋亡小体通过激活Thy1-ERK-TAZ轴纠正衰老骨髓脂肪失衡
Yuhe Jiang,Jianqi She,Zeying Wang et al.
Yuhe Jiang et al.
Background: Senile bone-fat imbalance poses a significant public health burden in aging populations. This study investigates how aging affects the heterogeneity of mesenchymal stem cell (MSC)-derived apoptotic vesicles (a...
Diselenide-bridged hybrid mesoporous silica for radiosensitization and radioprotection in the radioimmunotherapy of colorectal cancer [0.03%]
用于结直肠癌放射免疫治疗的二硒代桥杂化介孔二氧化硅的增敏和防护作用
Fan Zhang,Xiaochun Xie,Junna Lu et al.
Fan Zhang et al.
Radioimmunotherapy has been recognized as a promising strategy for the treatment of colorectal cancer; however, it faces several challenges, including limited efficacy, weak immune activation, and severe radiation-induced colitis. To addres...
HPDA-based tubule-targeting nanoplatform alleviates oxidative stress and ferroptosis for the reversal of renal interstitial fibrosis [0.03%]
基于HPDA的管型靶向纳米平台缓解氧化应激和铁死亡以逆转肾间质纤维化
Zheng Xiao,Peng Luo,Guoli Li et al.
Zheng Xiao et al.
Background: Renal interstitial fibrosis (RIF) is a hallmark pathological process in the progression of chronic kidney disease (CKD). However, effective therapies to halt or reverse RIF remain limited. Emerging evidence im...
Engineered extracellular vesicles-mediated curcumin delivery in brain microenvironment modulating lysosomes, mitochondria, and microglia reprogram for parkinson's disease therapy [0.03%]
工程化的细胞外囊泡介导的姜黄素递送调节脑内溶酶体、线粒体和小胶质细胞重编程治疗帕金森病
Ming-You Shie,Mei-Chih Chen,Yeh Chen et al.
Ming-You Shie et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons, aggregation of α-synuclein (α-Syn), lysosomal dysfunction, and mitochondrial impairment. Curcumin has demonstrated neu...
Enzymes assembled pickering emulsion as self-cascade bioreactor to reprogram inflammatory microenvironment for gouty arthritis therapy [0.03%]
基于Pickering乳液的酶组装级联生物反应器重构炎症微环境治疗痛风性关节炎
Yuanru Liu,Jingqing Gan,Zunfu Hu et al.
Yuanru Liu et al.
Background: Gouty arthritis (GA) is characterized by the deposition of monosodium urate (MSU) crystals within synovial joints, triggering a vicious cycle of intense inflammation and progressive tissue damage. Although co-...
Dual-targeted bacterial outer membrane vesicles enhance glioblastoma immunotherapy by regulating tumor microenvironment and inducing IFN-γ-mediated ferroptosis [0.03%]
双靶向细菌外膜囊泡通过调节肿瘤微环境和诱导IFN-γ介导的铁死亡来增强胶质母细胞瘤免疫治疗
Chen Chen,Xiaojing Zhu,Zefeng Song et al.
Chen Chen et al.
Glioblastoma (GBM) immunotherapy is limited by the blood-brain barrier (BBB) and the tumor immune resistance. Here, we develop an engineered bacterial outer membrane vesicle (OMV) through safe and straightforward genetic modification of Esc...