Dehong Tan,Wenxiang Zhu,Shilei Liu et al.
Dehong Tan et al.
Postoperative complications such as tumor recurrence, wound infections, and delayed tissue regeneration persist as critical challenges in melanoma management. In this study, we designed a temperature-tunable photothermal immunotherapy hydro...
Immune-modified exosome vaccine loaded with liver cancer epitope peptides induces potent and specific antitumor immunity [0.03%]
Shumin Luo,Li Xiao,Fang Xu et al.
Shumin Luo et al.
Background: Dendritic cell-derived exosomes (DEXs) are emerging as effective platforms for cancer vaccines due to their capacity to present tumor antigens and regulate immune responses. Here, we developed a multifunctiona...
Peptide nanofibers and PAMP agonist combinations enhance pulmonary CD4+T cell functionality of immune recall to vaccination [0.03%]
Megan A Files,Anirban Das,Darren Kim et al.
Megan A Files et al.
Vaccine adjuvants typically contain pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) that activate innate immune cells. The FDA's approval of multiple PAMP-DAMP combinations for clinical use has...
Application of an intercellular adhesion molecule-1-targeted nanoparticles loaded with irisin in postoperative neurocognitive disorder through metabolic axis activation and barrier restoration [0.03%]
Huisheng Wu,Wenlong Dai,Jun Cheng et al.
Huisheng Wu et al.
Postoperative neurocognitive disorder (PND) is a frequent complication in elderly surgical patients and is closely associated with blood-brain barrier (BBB) disruption and cerebral metabolic imbalance. The present study explores a metabolis...
Esraa Dakrory Mahmoud,Hoda Elkhenany,Tarek M Bedair
Esraa Dakrory Mahmoud
Strontium (Sr)-based nanofibers have gained great attention in biomedical and tissue engineering applications due to their unique ability to combine nanoscale structural features with the biological activity of Sr ions (Sr2+). Nanofibers of...
Ultrasound-activated nanoregulator enables Cu2+ directional enrichment and enhances cuproptosis via energy-gated feedback loop [0.03%]
Haiyan Huang,Rui Zhang,Yu Luo et al.
Haiyan Huang et al.
Modulating intratumoral copper homeostasis to trigger cuproptosis is a promising copper‑based anticancer strategy, but its clinical translation is hindered by the absence of precise spatiotemporal control over intracellular copper levels a...
DSCAML1+ extracellular vesicles revealed by single-vesicle proteomics as a novel biomarker and therapeutic target in myocardial infarction [0.03%]
Nan Liu,Guoyue Wei,Haoran Wang et al.
Nan Liu et al.
The early and accurate diagnosis of acute myocardial infarction (AMI) remains a significant clinical challenge. To this end, we profiled the surface proteome of individual plasma extracellular vesicles (EVs) from AMI patients using single-v...
Oral colon targeted curcumin-based nanocomposite inulin hydrogel for alleviating intestinal inflammation and dysbiosis [0.03%]
Qiangyuan Fan,Chen Kan,Kesheng Wang et al.
Qiangyuan Fan et al.
Scavenging excess reactive oxygen species (ROS) and positively improving intestinal dysbiosis is a promising therapeutic strategy for alleviating inflammatory bowel disease (IBD). However, conventional clinical drugs and probiotic-based adj...
An oral nanocombinatorial agent exhibits pleiotropic improvement in diabetic nephropathy via modulation of the SCAP/SREBPs pathway [0.03%]
Yu Su,Haobo Wen,Ke Hu et al.
Yu Su et al.
The multifaceted pathogenesis and multi-cellular involvement of diabetic nephropathy (DN) stand in stark contrast to the inadequacy of conventional single-target therapeutic strategies. This disparity underscores the urgent need for novel d...
Plant-derived nanocarriers & nanostructures for barrier-defined translation: a comprehensive review of mechanisms, targets, and translation [0.03%]
Ling Lv,Yue Yu,Jinlu Liu et al.
Ling Lv et al.
Plant-derived nanocarriers (PDNs) constitute a heterogeneous family of bioinspired delivery platforms, including plant-derived extracellular vesicles, lipid-based nanovectors, and plant viral nanoparticles, that have attracted growing inter...