Multilevel synergistic mechanisms of a nanocarrier-enabled topramezone herbicide against invasive weeds [0.03%]
Jingyi Chen,Heng Qiao,Xiao Ran et al.
Jingyi Chen et al.
The rapid proliferation of invasive weeds has emerged as an escalating "major threat", and the inefficient utilization and environmental dispersion of conventional herbicides pose persistent challenges in agricultural production. Herein, an...
Monocyte-hitchhiking system for the targeted delivery of paclitaxel-loaded PLGA nanoparticles to glioblastoma in mice [0.03%]
Xanthippi Koutsoumpou,Vincent Lenders,Akshaya Lakshmi Krishnamoorthy et al.
Xanthippi Koutsoumpou et al.
Cell-based therapy for the treatment of glioblastoma (GBM) has gained a lot of attention as a minimally invasive drug delivery strategy because of its potential to overcome the blood-brain barrier (BBB) impediment and target the tumor micro...
Shi Tang,Ling Lv,Na Liu et al.
Shi Tang et al.
Dopamine deficiency is a non-vascular neurodegenerative disorder that involves the destruction of dopaminergic neurons, aggregation of α-synuclein, mitochondrial dysfunction, oxidative stress, and chronic neuroinflammation. The prolonged p...
Hee Jung Choi,Kyung Min Jung,Yujin Han et al.
Hee Jung Choi et al.
Avian embryos present substantial barriers to early-stage genetic manipulation due to the rigid eggshell and opaque yolk, underscoring the need for alternative in vivo germline delivery systems. Extracellular vesicles (EVs), particularly ex...
Bioengineered anti-EpCAM-guided exosome nanocarriers delivering Foxp3 agonist butyrate achieve tissue-specific immunomodulation in autoimmune Sjögren's syndrome [0.03%]
Bailing Tian,Qiyu Li,Bohan Chang et al.
Bailing Tian et al.
Primary Sjögren's syndrome (pSS) is characterized by salivary gland-centered immune dysregulation, in which an imbalanced T follicular helper (Tfh)/T follicular regulatory (Tfr) axis drives aberrant follicular responses and glandular dysfu...
Mg/Mn bi-single-atom carbon dot nanozymes with enhanced SOD-like activity and fluorescence for hepatoprotection [0.03%]
Xuejiao Wang,Yu Zhang,Jing Li et al.
Xuejiao Wang et al.
Maria Bravo,Guillermo Solís-Fernandez,Sandra Krzyzowska et al.
Maria Bravo et al.
Nanoparticles (NPs) are a promising tool for cancer therapy, yet few have successfully reached clinical application. Current nanomedicine development pipelines are focused on optimizing the physical properties of NPs, overlooking the impact...
Simple and rapid profiling of tumor EVs for differential diagnosis of NSCLC via orthogonal barcode-driven CRISPR/Cas12a [0.03%]
Pan Yang,Ruijia Ma,Jiangnan Zeng et al.
Pan Yang et al.
Platinum nanozymes pursue cellular redox homeostasis: playing dual roles as pro-oxidants and antioxidants [0.03%]
Jiajie Liu,Long Zhao,Jiani Xie et al.
Jiajie Liu et al.
A Cu-based metal-organic framework based on desloratadine and siHIF-1α for achievement of genes/drugs/CDT combination therapy in hepatocellular carcinoma [0.03%]
Ding Ding,Zhe Huang,Lu Wang et al.
Ding Ding et al.
Background: Desloratadine (DL) has been demonstrated to inhibit NMT1 enzymatic activity, thereby promoting oxidative stress and endoplasmic reticulum (ER) stress to induce cancer cell death. However, the lack of tumor tar...