Nitric oxide-releasing nanocarriers integrated with ginsenoside compound K in dissolvable microneedles for androgenetic alopecia [0.03%]
一氧化氮释放纳米载体与人参皂苷CK可降解微针贴片联合治疗雄激素性脱发
Guanghui Sun,Jianlin Liu,Guorui Jin et al.
Guanghui Sun et al.
Androgenetic alopecia (AGA) is recognized as a prevalent androgen-mediated disorder characterized by progressive follicular miniaturization and irreversible hair loss, primarily driven by the pathological elevation of dihydrotestosterone (D...
Aptamer-engineered NIR-II Ru-doped carbon quantum dot nanozyme for photoacoustic imaging-guided synergistic photothermal and catalytic cancer therapy [0.03%]
一种用于光声成像引导的协同光热和催化癌症治疗的近红外II区Ru掺杂碳量子点纳米酶/aptamer诊疗体系
Yumin Hao,Zihan Wang,Yihong Chen et al.
Yumin Hao et al.
Carbon quantum dot (CQD)-based nanozymes have attracted growing interest for advanced biomedical applications owing to their superior catalytic activity, photostability, and biocompatibility. However, the rational design of a multifunctiona...
Bioinspired smart catalytic microneedle patch with structural color for infected wound management [0.03%]
一种生物启发的智能催化微针贴片，可管理感染伤口并具有结构色彩功能
Yuting Huang,Yuqi Wu,Peipei Xi et al.
Yuting Huang et al.
Infected wounds remain a major clinical challenge due to persistent inflammation, excessive reactive oxygen species (ROS), and bacterial colonization. Here, we present a bioinspired catalytic microneedle (MN) patch that integrates antibacte...
Manganese-enriched nanoboron agent amplifies BNCT efficacy via pyroptosis-mediated immune activation and STING pathway synergy [0.03%]
富锰纳米硼剂通过焦亡介导的免疫激活和STING途径协同作用增强BNCT疗效
Zhicheng Zhang,Xiaoyan Sun,Yaxin Qin et al.
Zhicheng Zhang et al.
Boron Neutron Capture Therapy (BNCT) offers selective tumor cell ablation with minimal damage to normal tissues, but its efficacy is limited by therapy-induced immunosuppression and high intratumoral H2O2 levels, restricting synergy with im...
AI-engineered multifunctional nanoplatforms: synergistically bridging precision diagnosis and intelligent therapy in next-generation oncology [0.03%]
人工智能工程多功能纳米平台：下一代肿瘤学精准诊断和智能治疗的协同桥梁
Lin Zhao,Xinglong Liu,Xiangying Deng
Lin Zhao
The integration of artificial intelligence (AI) and nanotechnology is reshaping cancer diagnosis and treatment. In this context, intelligent nanoplatforms are multifunctional nanoscale systems designed or optimized with the help of AI, capa...
Conductive hydrogel combined with electrical stimulation remodels the microenvironment for nerve regeneration to promote spinal cord injury repair [0.03%]
导电水凝胶结合电刺激修复脊髓损伤中促进神经再生及微环境重塑的作用研究
Haorui Du,Xinting Yang,Zhiping Qi et al.
Haorui Du et al.
The secondary inflammatory response and disruption of electrical signaling following spinal cord injury (SCI) present significant challenges to neurological recovery. Modulating the inflammatory microenvironment and reconstructing the spina...
Dual-function TA@CaCO3 nanomedicine targeting M2 macrophage lipid peroxidation sensitivity in rheumatoid arthritis therapy [0.03%]
双功能TA@CaCO3纳米药物靶向M2型巨噬细胞脂质过氧化敏感性治疗类风湿关节炎
Qin Zhang,Ziliang Dong,Yanglin Wu et al.
Qin Zhang et al.
Rheumatoid arthritis (RA) is a globally prevalent autoimmune musculoskeletal disease that requires early-stage treatment. Initially, patients with RA exhibit elevated reactive oxygen species (ROS) levels and acidic conditions within the art...
Atosiban-conjugated 3WJ-pRNA nanoparticles delivering GAS1-enhanced extracellular vesicles: targeting the decidua to combat recurrent miscarriage [0.03%]
阿托西班结合的3WJ-pRNA纳米颗粒递送GAS1增强型细胞外囊泡：靶向子宫内膜以对抗复发性流产
Yuan-Xing Li,Si-Qi Wei,Peng-Sheng Zheng
Yuan-Xing Li
Background: Recurrent miscarriage (RM) remains a significant clinical challenge due to insufficient understanding of decidual microenvironment dysfunction and limited effective therapeutic options. Current treatments prim...
Metabolically hijacked Listeria monocytogenes synergizes STING activation and dual cell death for enhanced antitumor immunotherapy [0.03%]
代谢劫持的李斯特菌单核细胞增生性李斯特菌与STING激活及双重细胞死亡协同作用以增强抗肿瘤免疫治疗
Tao Liu,Qunfang Yang,Jianhua Huang et al.
Tao Liu et al.
Background: Listeria monocytogenes (LM) holds promise as a microbial vector for cancer immunotherapy, yet its clinical translation requires precise engineering to achieve an optimal balance between attenuation and immunog...
Correction: Inhibition of post-surgery tumour recurrence via a sprayable chemo-immunotherapy gel releasing PD-L1 antibody and platelet-derived small EVs [0.03%]
更正：通过喷洒式化疗免疫凝胶释放PD-L1抗体和血小板源小型EV抑制术后肿瘤复发
Jian Zhao,Hao Ye,Qi Lu et al.
Jian Zhao et al.
Published Erratum
Journal of nanobiotechnology. 2025 Dec 20;23(1):779. DOI:10.1186/s12951-025-03867-0 2025