Neutrophil-mediated delivery of curcumin-loaded manganese-doped zeolitic imidazolate framework-8 nanozymes for pulmonary arterial hypertension [0.03%]
负载姜黄素的锰掺杂咪唑酸盐框架-8纳米酶的中性粒细胞介导递送用于肺动脉高压治疗
Chun Dai,Xiang Li,Tian-Shu Chu et al.
Chun Dai et al.
Background: Pulmonary arterial hypertension (PAH) is a severe vascular disease characterized by oxidative stress, inflammation, vascular remodeling, and endothelial‑to‑mesenchymal transition (EndoMT), leading to high pu...
Resveratrol‒loaded self‒assembled tetrahedral framework nucleic acids reshape the epileptic microenvironment by regulating oxidative stress and neuroinflammation via the SIRT3/SOD2 pathway [0.03%]
白藜芦醇负载的自组装四面体框架核酸通过SIRT3/SOD2信号通路重塑氧化应激和神经炎症以治疗癫痫
Jingwen Cui,Qilong Zhai,Zixiao Tan et al.
Jingwen Cui et al.
Background: Epilepsy management remains a significant clinical challenge, as conventional antiseizure medications primarily mitigate symptoms without addressing the core pathological drivers, specifically the vicious cycl...
Carnosic acid-loaded stimuli-responsive hydrogel promotes wound healing through PGP-1 mediated immune remodeling [0.03%]
载有杨梅素的刺激响应性水凝胶通过PGP-1介导的免疫重塑促进伤口愈合
Renshuai Zhang,Rufei Wang,Yixiao Wang et al.
Renshuai Zhang et al.
Persistent inflammation is a major barrier to effective wound healing. The local immune microenvironment, closely associated with the inflammatory state, exerts central regulatory control throughout repair. Pyroglutamyl aminopeptidase 1 (PG...
ROS-responsive Ganoderma lucidum polysaccharide nanocomposite targeting prosenescent oxidative stress niche for structural and functional diabetic tendon regeneration [0.03%]
响应ROS的灵芝多糖纳米复合材料针对促衰老氧化应激生态位进行结构和功能糖尿病肌腱再生
Yucheng Gao,Hao Wang,Renwang Sheng et al.
Yucheng Gao et al.
Diabetic patients exhibit higher tendon injury incidence, with elevated risks of healing failure and re-rupture than healthy individuals, posing major clinical challenges. Tendon stem/progenitor cells (TSPCs) are crucial for tendon homeosta...
Garlic-derived exosome-like nanovesicle core-shell platform for sequential infection treatment and tissue repair [0.03%]
一种用于序贯感染治疗和组织修复的大蒜衍生类外泌体纳米囊泡核-壳平台技术
Yuqi Gao,Yang Gao,Jie Shan et al.
Yuqi Gao et al.
Infectious tissue damage evolves through a stage-dependent cascade, progressing from initial pathogen invasion and immune dysfunction to subsequent failure in tissue regeneration. While nanotechnology offers promising strategies for infecti...
Macrophage-delivered Nifuroxazide reprograms immunosuppressive microenvironment and synergizes with oxaliplatin for enhanced anti-hepatocellular carcinoma therapy [0.03%]
巨噬细胞递送洛哌丁胺重塑免疫抑制微环境并协同奥沙利铂增强抗肝癌效应
Zhentao Yang,Hong Tang,Ning Wang et al.
Zhentao Yang et al.
Nifuroxazide (NFX), an antibacterial agent, also exhibits notable antitumor effects by inhibiting STAT3 signaling, which is often aberrantly activated and linked to chemoresistance in tumors such as hepatocellular carcinoma (HCC). Combining...
Targeting redox metabolism and low-dose radiotherapy synergistically activate cGAS-STING pathway to improve NK cell therapy efficacy in hepatocellular carcinoma [0.03%]
靶向红氧代谢和低剂量放疗协同激活cGAS-STING通路以增强NK细胞治疗在肝癌中的疗效
Bo Liu,Wenjia Kong,Xijie Zhang et al.
Bo Liu et al.
Adoptive natural killer (NK) cell therapy (ANKCT) is a promising strategy for hepatocellular carcinoma (HCC); however, its efficacy is hampered by insufficient NK cell homing and the immunosuppressive activity of M2-polarized tumor-associat...
Electro-controlled assembled of biphasic guided bone regeneration membrane for healing of diabetic periodontal bone defects [0.03%]
电控双相导骨再生膜的构建及在糖尿病牙周骨缺损修复中的应用
Dan Li,Yan Wang,Yujia Tian et al.
Dan Li et al.
Background: Regeneration of periodontal bone defects has long posed a significant challenge to clinicians. Traditional guided bone regeneration (GBR) membranes have a single function, making it difficult to achieve immuno...
Bioengineered probiotics derived bacterial extracellular vesicle as bioactive nanocarrier for the local VEGF expression to accelerate wound healing [0.03%]
一种用于局部表达VEGF促进伤口愈合的工程益生菌来源细菌外泌体生物纳米载体
Zelin Zheng,Xi Liu,Kailu Guo et al.
Zelin Zheng et al.
Nanobodies targeting the Epstein-Barr virus EBNA1 DNA binding domain inhibit tumor growth [0.03%]
针对EB病毒EBNA1 DNA结合域的纳米抗体可抑制肿瘤生长
Fang Wu,Yuzhe Wu,Yongyue Han et al.
Fang Wu et al.