Silk-based biomimetic nanocomposite for precision eradication of Helicobacter pylori and gut microbiome preservation [0.03%]
丝蛋白基仿生纳米复合材料精准根除幽门螺旋杆菌及保护肠道菌群平衡
Guangcheng Huang,Chi Tian,Qingsong Liu et al.
Guangcheng Huang et al.
Antibiotics remain the recommended first-line therapy for eradicating Helicobacter pylori infection. However, the harsh gastric physicochemical environment severely limits drug bioavailability, contributing to treatment failure (~10%), gut ...
Emerging potential of engineered nanozymes in periodontitis treatment: from monotherapy to hierarchical therapy [0.03%]
工程纳米酶在牙周炎治疗中的潜力：从单一疗法到分层疗法
Jiazhuo Song,Lin Sun,Fang Li et al.
Jiazhuo Song et al.
The unique pathological microenvironment of periodontitis poses significant challenges to conventional therapies and drives the development of advanced treatment strategies. Engineered nanozymes as multifunctional nanomaterials offer promis...
Inflammation-responsive biomimetic hybrid nanovesicles reverse stem cell senescence by up-regulating SIRT1 to treat periodontitis [0.03%]
炎症响应仿生杂化纳米囊泡通过上调SIRT1逆转干细胞衰老以治疗牙周炎
Jiaming Bi,Yan Chai,Hong Wang et al.
Jiaming Bi et al.
Periodontitis is a chronic inflammatory condition affecting billions globally, posing a significant public health challenge due to its high prevalence and associated tooth loss. The inflammatory microenvironment engendered by periodontitis ...
Migrasomes constrained by a homologous-targeting photodynamic nanoplatform: enhancing intratumoral CD8+ T-cell-associated antitumor immunity in oral squamous cell carcinoma [0.03%]
受同源靶向光动力纳米平台约束的迁移体：增强口腔鳞状细胞癌瘤内CD8+T细胞相关的抗肿瘤免疫能力
Lejia Zhang,Hui Gao,Wanting Jia et al.
Lejia Zhang et al.
Photodynamic therapy (PDT) is an effective adjunct treatment for oral squamous cell carcinoma (OSCC). Enhancing photosensitizer targeting and inducing effective cytotoxic T-cell responses through photoimmunotherapy have become key strategie...
Hydrogel microspheres loaded with sinomenine and Drynaria rhizome enhance the treatment of rheumatoid arthritis via immune regulation and promoting bone repair [0.03%]
载防己甲素和木贼茎枯草芽孢杆菌微球的水凝胶通过免疫调节和促进骨修复增强类风湿性关节炎治疗
Li Cai,Jian Gao,Kai Zhang et al.
Li Cai et al.
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovial inflammation, cartilage destruction, and bone loss. Current therapeutic approaches are often limited by short drug half-life, insufficient local drug relea...
Synergistic regulation of TGF-β1/Smad2/3 signaling and inflammatory pathways via SA/NAC-based nanoplatforms: a novel strategy to enhance anti-fibrotic therapeutic outcomes in idiopathic pulmonary fibrosis [0.03%]
基于SA/NAC的纳米平台协同调节TGF-β1/Smad2/3信号通路和炎症途径：一种增强特发性肺纤维化抗纤维化治疗效果的新策略
Ce Li,Yichao Yuan,Yaqing Bao et al.
Ce Li et al.
Idiopathic pulmonary fibrosis (IPF), a chronic interstitial lung disease, is characterized by progressive fibrosis and poor prognosis, with no current therapies capable of reversing the fibrotic changes. The aberrant repair driven by fibrob...
A multifunctional injectable nanocomposite hydrogel for precision keloid therapy via ECM remodeling and local pruritus relief [0.03%]
一种多功能可注射纳米复合水凝胶通过基质重塑和局部止痒进行精准瘢痕治疗
Jingyu Jin,Chengjie Zhu,Nuoya Wang et al.
Jingyu Jin et al.
Keloids are refractory fibroproliferative disorders. Their treatment faces multiple clinical challenges, including the coexistence of multiple pathological mechanisms, low drug bioavailability, and keloid-related pruritus. This study develo...
Microneedle-delivered ROS-adaptive asiatic acid nanoparticles promote scarless repair via remodeling the pathological microenvironment [0.03%]
ROS适配的羟基姜黄素纳米粒微针促进瘢痕修复的临床前研究：重塑病理微环境以实现无瘢痕修复
Yawen Zhang,Xuanyu Tang,Yijing Ma et al.
Yawen Zhang et al.
Hypertrophic scar (HS) is a pathologic fibrotic disease caused by aberrant wound healing following severe skin injury. Despite advances in clinical treatments, the therapeutic outcomes remain suboptimal, mainly due to inadequate penetration...
Recent advances in nanomaterial-based precision medicine for orthotopic tumor therapy [0.03%]
基于纳米材料的精准医学在原位肿瘤治疗中的新进展
Min Luo,Fu-Kun Zhao,Cang-Hong Ouyang et al.
Min Luo et al.
The escalating global burden of cancer, marked by high incidence and mortality, necessitates more effective therapeutic strategies. A major bottleneck in clinical translation is the long-standing reliance on subcutaneous tumor models, which...
Conjugate electrospinning dermal-adipose bilayered skin: structural integration promoting regenerative skin remodeling [0.03%]
共轭静电纺丝真皮-脂肪双层皮肤：结构整合促进再生皮肤重塑
Zhuolun Hao,Yaqi Guo,Junjin Jie et al.
Zhuolun Hao et al.
The skin is a three-dimensional organ composed of multilayered tissues, in which the epidermis, dermis, and subcutaneous adipose layer cooperate to maintain protection, thermoregulation, and repair. Although recent advances in tissue-engine...