NIR-responsive smart hydrogel incorporating LF-decorated nanosheets recalibrating the immune-vascular-osteogenic microenvironment for enhanced bone regeneration [0.03%]
Xiaozhu Liao,Xuzheng Liu,Jiarong Yan et al.
Xiaozhu Liao et al.
Critical-sized bone defects possess inherently limited self-healing potential, posing a persistent challenge in clinical bone repair. In recent years, numerous hydrogel systems have been developed for bone defect repair and have made remark...
Engineering BiTE-inspired IPSC-exosomes to potentiate CAR-T cell therapy against lung cancer [0.03%]
Ronghao Wang,Guining Fu,Haozhao Dou et al.
Ronghao Wang et al.
Chimeric antigen receptor T (CAR-T) cell therapy faces critical barriers in solid tumors, including poor infiltration, T cell exhaustion, and immunosuppressive microenvironments, resulting in response rates below 10%. Herein, we engineered ...
A core-shell microneedle platform for the spatiotemporal codelivery of dual-agent therapeutics precisely orchestrates diabetic wound healing [0.03%]
Yuhang Zhan,Zhihan Zhang,Zhiyue Zhang et al.
Yuhang Zhan et al.
Chronic non-healing of diabetic wound (DW) remains a critical clinical challenge worldwide. Sustained oxidative stress and prolonged inflammatory responses disrupt the wound microenvironment, while bacterial colonization and biofilm formati...
Human umbilical cord-derived mesenchymal stem cell exosomes ameliorate hepatocyte ferroptosis and sepsis-associated liver injury by restoring iron homeostasis in hepatocytes [0.03%]
Yiqi Wu,Lu Wang,Zihui Deng et al.
Yiqi Wu et al.
Mesenchymal stem cells-derived exosomes (MSCs-Exo) constitute critical mediators of intercellular communication between stem cells and other cell types. Among these, exosomes derived from human umbilical cord mesenchymal stem cells (HUMSCs-...
Dual-targeted hybrid nanovesicles coordinated bone-muscle regeneration via regulating the DUSP4/p38 MAPK pathway to reverse osteosarcopenia [0.03%]
Benchi Che,Yongzhi Cui,Zhengsheng Chen et al.
Benchi Che et al.
Osteosarcopenia (OSP), a degenerative syndrome characterized by concurrent osteoporosis and sarcopenia, exhibits persistently high global prevalence due to aging and disuse, yet lacks targeted therapies. p38 MAPK plays a key regulatory role...
Transcriptomics and metabolomics reveal functional nanoplastics-induced male reproductive damage and resveratrol antagonistic effects [0.03%]
Fang Zhang,Nenghua Zhang,Chunji Wang et al.
Fang Zhang et al.
Polystyrene nanoparticles (PS-NPs) can undergo surface functionalization under environmental conditions, and their accumulation in living organisms may pose a potential reproductive toxicity risk to males, though the underlying mechanisms r...
tLyP-1 peptide-modified MnO₂ co-delivering si-SLC16A1 and temozolomide synergistically suppresses glioblastoma via hypoxia modulation and metabolic stress [0.03%]
Haiting Zhao,Li Meng,Peng Du et al.
Haiting Zhao et al.
Glioblastoma (GBM) is a highly lethal brain tumor with limited treatment efficacy due to therapy resistance and the blood-brain barrier (BBB). Here, we developed tLyP-1-modified polyethylene glycol (PEG)-coated hollow catalase-mimicking MnO...
A 'two-in-one' tumor-specific-hydrogel-assisted strategy for intravesical chemotherapy and protection of normal tissues [0.03%]
Xiaowen Qin,Bin Zheng,Dingyi Liu et al.
Xiaowen Qin et al.
Intravesical therapy is commonly administered after transurethral resection to treat bladder cancer, but it frequently induces chemical cystitis as a side effect. To address this issue, we propose a 'two-in-one' strategy designed to simulta...
Bifidobacterium breve inhibits colorectal cancer via extracellular vesicles containing formate acetyltransferase [0.03%]
Yuefeng Zhang,Qian Zhang,Yue Luo et al.
Yuefeng Zhang et al.
Background: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. The gut microbiota exerts unique therapeutic advantages against CRC, and the probiotic Bifidobacterium breve (B. breve...
Multi-functional self-powered nanofiber conduit for peripheral nerve regeneration and muscle atrophy prevention [0.03%]
Renjie Tan,Ke Zhang,Yifan Si et al.
Renjie Tan et al.
Peripheral nerve injury (PNI) often leads to limited functional recovery in over 50% of patients, with current clinical strategies primarily relying on nerve grafts or conduits to bridge injury gaps. In the search of alternative solutions, ...