Extracellular vesicles from alveolar macrophages promotes pulmonary fibrosis through suppression of lung alveolar regeneration [0.03%]
Jiali Min,Yu Zhang,Jiahui Yang et al.
Jiali Min et al.
Pulmonary fibrosis (PF) is a type of progressive interstitial lung disease characterized by varying degrees of lung interstitial fibrosis. Lung alveolar regeneration failure in PF is critical for mediating this incurable disease. Here, we r...
Li Chen,Yang Li,Jingwen Yu et al.
Li Chen et al.
Single-atom Pt doped nanoceria for enhanced cell phagocytosis and nanozyme activities in keratitis immune regulation [0.03%]
Jianguo Zhao,Wanqing Lou,Yixin Wang et al.
Jianguo Zhao et al.
During keratitis treatment, oxidative stress and inflammation often result in corneal neovascularisation, scarring, and reduced light transmittance. In this study, single-atom Pt/CeO2 is synthesized, exhibiting significantly enhanced catala...
Schwann cell-derived extracellular vesicles inhibit osteoclastogenesis through the PTEN/AKT axis in peripheral nerve-bone crosstalk [0.03%]
施万细胞源性外泌体通过PTEN/AKT信号轴抑制外周神经-骨交叉 talk 中破骨细胞的生成
Huijian Yang,Biao Yu,Ruiyang Li et al.
Huijian Yang et al.
Osteoclasts, the sole bone-resorbing cells, play a central part in bone homeostasis, and their overactivation is implicated in bone diseases such as osteoporosis. Schwann cells (SCs), the primary glial cells of the peripheral nervous system...
Improved X-ray absorption capability of Core-shell nano-transducer in situ enhances γ-ray-excited radioluminescence imaging in vivo [0.03%]
核壳纳米换能器增强γ射线激发的放射发光在体成像的能力
Rong Guo,Tianye Cao,Shaowen Yang et al.
Rong Guo et al.
Background: Radioluminescence imaging (RLI) using nanoscintillators offers great potential for biomedical applications, yet remains constrained by low quantum efficiency and the reliance of Cerenkov imaging on high-energy...
Dual-engineered Treg-Exosome-IKVAV nanovesicles spatiotemporally sequentially regulate neuro-immune microenvironment to promote spinal cord injury repair [0.03%]
双工程Treg-外泌体-IKVAV纳米囊泡时空序贯调节神经免疫微环境促进脊髓损伤修复
Su Xinjin,Gu Changjiang,Zeng Feihui et al.
Su Xinjin et al.
Spinal cord injury (SCI) repair remains a significant clinical challenge due to the imbalance of inflammatory microenvironment and insufficient neural regenerative ability. Current therapeutic approaches, such as pharmaceuticals, stem cell ...
Lung-targeted RNA delivery systems: strategies and therapeutic applications [0.03%]
肺部靶向RNA传递系统：策略与治疗应用
Shenrui Xu,Min Li,Tingting Wang et al.
Shenrui Xu et al.
Pulmonary diseases, encompassing asthma, lung cancer, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis, constitute major contributors to global morbidity and mortality, imposing substantial burdens on healthcare systems ...
Pathology-tailored nanotherapy via Galectin-3-targeted and triple-responsive nanoparticles enables multimodal therapy against aortic dissection [0.03%]
通过Galectin-3靶向和三重刺激响应型纳米颗粒实现针对主动脉夹层的多模式治疗病理学指导的纳米疗法
Chi Lin,Min-Lang Tsai,Hsin-Yi Chao et al.
Chi Lin et al.
Aortic dissection (AD) is a life‑threatening vascular disorder with high mortality and no effective pharmacological treatment. Addressing its multicellular and dynamic pathology requires strategies that precisely modulate inflammatory and ...
pH-responsive and dual-dynamically crosslinked metal-phenolic hydrogel for synergistic macrophage and Th17/Treg reprogramming in diabetic wounds [0.03%]
用于糖尿病伤口的PH响应型和双动态交联金属酚类水凝胶，可协同巨噬细胞和Th17/Treg重编程
Yuheng Liao,Yanzhi Zhao,Chenyan Yu et al.
Yuheng Liao et al.
In recent years, there has been a progressive increase in the cumulative number of individuals afflicted with diabetic wounds, elevating this condition to a global public health concern of significant magnitude. The disruption of the immune...
Degradable scaffold-mediated synergistic matrix formation by endogenous cells: an in vivo manufacturing strategy for off-the-shelf vascular grafts to address clinical shortages [0.03%]
可降解支架介导的内源性细胞协同基质形成：现货血管移植物的体内制造策略，以解决临床短缺问题
Yijie He,Yunfei Mo,Xiaoyan Shen et al.
Yijie He et al.