Tumor-homing cerium nanozyme platform enables coordinated drug release and STING activation for bladder cancer treatment [0.03%]
肿瘤靶向铈纳米酶平台用于协同药物释放和STING活化以治疗膀胱癌
Zhiming Wu,Jiamin Zeng,Longbao Feng et al.
Zhiming Wu et al.
Non-muscle-invasive bladder cancer (NMIBC) carries 70% incidence yet remains plagued by high recurrence because single-modality chemotherapy or immunotherapy is crippled by rapid urinary clearance, poor tumor specificity, and narrow therape...
Gated MoS2/SiN nanochannel for tunable ion transport and protein translocation [0.03%]
具有可调离子传输和蛋白质转运功能的MoS2 / SiN纳米通道的大门
Shukun Weng,Ali Douaki,Makusu Tsutsui et al.
Shukun Weng et al.
Porphyromonas gingivalis-derived outer membrane vesicles promote vascular endothelial glycocalyx injury via the PPAD/CitH3/B3GAT1 pathway [0.03%]
牙龈卟啉单胞菌来源的外泌体通过PPAD/CitH3/B3GAT1途径促进血管内皮细胞糖萼损伤
Shoucheng Yin,Qihui Qiao,Zhaorong Li et al.
Shoucheng Yin et al.
Background: The glycocalyx serves as the skeletal structure of the outer layer of endothelial cells and regulates the function of endothelial cells. Porphyromonas gingivalis (P. gingivalis) outer membrane vesicles (OMVs) ...
In situ encapsulation of Cu-MOF in wax gourd sponge for integrated smart treatment of diabetic wounds [0.03%]
冬瓜海绵中Cu-MOF的原位封装技术在糖尿病伤口智能治疗中的应用研究
Qiliang Zhai,Xiaoling Deng,Yubo Gao et al.
Qiliang Zhai et al.
Unraveling the structure-activity relationship of alloying in nanozyme design for synergistic tumor metabolic-immunotherapy [0.03%]
解密纳米酶设计中合金结构活性关系的协同肿瘤代谢免疫疗法研究
Chaoran Liu,Wenyu Zhang,Qingbin He et al.
Chaoran Liu et al.
Catalyzing the glucose cascade reaction to impair tumor cell energy metabolism represents a promising strategy for tumor therapy. However, the application of natural enzymes as therapeutic agents remains limited by various challenges. Altho...
Microglia-derived iron-overloaded exosomes induce neuronal ferroptosis and aggravate neurological impairment after subarachnoid hemorrhage [0.03%]
蛛网膜下腔出血后小胶质细胞源性铁过载外泌体诱导神经元铁死亡及加重神经功能缺损
Yuchen Li,Bowen Sun,Zurong Yao et al.
Yuchen Li et al.
Subarachnoid hemorrhage (SAH) is a devastating stroke subtype often leading to poor neurological outcomes. Iron homeostasis imbalance is a key contributor to cognitive dysfunction in neurological diseases. Extracellular vesicles, including ...
Multimodal electroconductive PLGA-based scaffold orchestrates neuroprotection and regeneration following severe spinal cord injury [0.03%]
多模式电导性PLGA基支架在严重脊髓损伤后协同神经保护和再生作用
So-Yeon Park,Gyubin Kim,Yanting Liu et al.
So-Yeon Park et al.
Spinal cord injury (SCI) is a devastating neurological condition that has limited therapeutic options; thus, developing innovative regenerative strategies to treat SCI is necessary. This study presents a multifunctional scaffold system that...
Pathogen-microenvironment-responsive and antioxidant-buffered propiconazole nanofungicide for safe and effective fungal disease control [0.03%]
一种针对病原菌微环境响应的和具备抗氧化缓冲作用的丙硫菌唑纳米杀菌剂用于安全且高效的真菌病害防治
Xin Shi,Qizhen Zhang,Xunian Chang et al.
Xin Shi et al.
Pan Liang,Chenyan Zhao,Xin Peng et al.
Pan Liang et al.
Organ adhesions pose a significant clinical challenge, arising from factors such as congenital adhesions caused by embryonic developmental abnormalities, as well as acquired adhesions resulting from inflammation or surgery. This phenomenon ...
Nano-PROTACs for precision medicine: engineering strategies for enhanced targeting and potency [0.03%]
用于精准医疗的纳米PROTACs：增强靶向性和效力的工程策略
Xiaoping Yang,Dongmei Wang,Chunxiao Li et al.
Xiaoping Yang et al.
Proteolysis-targeting chimeras (PROTACs) represent a transformative therapeutic modality that leverages the endogenous ubiquitin-proteasome system (UPS) to achieve targeted protein degradation. These heterobifunctional molecules facilitate ...