Single-atom Ca nanozyme induces glioma death through Ca2+-overload-enhanced catalytic tumor nanotherapy, ferroptosis and synergistic remodeling of the immune microenvironment [0.03%]
单原子钙纳米酶通过钙超载增强的催化肿瘤纳米疗法、铁死亡和协同重塑免疫微环境诱导胶质瘤细胞死亡
Zhizhong Jin,Xinqiao Li,Xiaoyu Hou et al.
Zhizhong Jin et al.
In recent years, nanozyme-based catalytic therapy for tumors has garnered extensive attention. They combine the properties of nanomaterials and enzymes, precisely mimicking the structure of natural enzymes and exhibiting highly efficient ca...
Retraction Note: Carbon dot nanozymes as free radicals scavengers for the management of hepatic ischemia-reperfusion injury by regulating the liver inflammatory network and inhibiting apoptosis [0.03%]
撤回 notice: 碳点纳米酶作为自由基清除剂通过调节肝脏炎性网络和抑制肝缺血再灌注损伤的凋亡来对其进行管理
Haoge Geng,Jiayu Chen,Kangsheng Tu et al.
Haoge Geng et al.
Reengineering glycyrrhetinic acid into a therapeutic oligomer for targeted tumor therapy with cardioprotection [0.03%]
甘草酸衍生治疗寡糖类化合物用于心脏保护的靶向肿瘤治疗研究
Zixin Wang,Bo Su,Alu Ouyang et al.
Zixin Wang et al.
To overcome the inherent limitations of conventional nanocarriers such as therapeutic inefficacy and suboptimal drug loading capacity, a novel "polymeric nanodrug" strategy was developed. This approach redefines nanodrug design by employing...
pH-responsive Oral liposomal delivery of hydrogen sulfide donor GYY4137 enables colon-targeted therapy for inflammatory bowel disease [0.03%]
口服递送PH值响应型载有氢硫化物供体GYY4137的脂质体用于炎症性肠病的结肠靶向治疗
Chiwoo Oh,Jee-Eun Hwang,Hyunjoon Yim et al.
Chiwoo Oh et al.
Background: Although therapeutic options for inflammatory bowel disease (IBD) have advanced, many patients still experience suboptimal clinical response, systemic side effects, or difficulty maintaining long-term treatmen...
Advanced nitric oxide-activated calcium overload and zinc ion-amplified oxidative imbalance in ferroptosis/apoptosis [0.03%]
NO介导的钙超载和Zn2+放大的氧化损伤在铁死亡/凋亡中的作用机制研究
Hongmei Zhou,Yujia Liang,Lijuan Liu et al.
Hongmei Zhou et al.
Background: Ferroptosis, a programmed cell death driven by lipid peroxidation, relies on an oxidative imbalance. However, tumor cells counteract the effects of oxidative imbalance through adaptive defense mechanisms and m...
Synergistic gambogic acid/Ga³⁺ remodels the immunosuppressive tumor microenvironment to enhance triple-negative breast cancer therapy [0.03%]
gambogic酸/Ga³⁺重塑免疫抑制肿瘤微环境以增强三阴性乳腺癌治疗的协同作用
Chong Qiu,Pengbo Guo,Chen Wang et al.
Chong Qiu et al.
The immunosuppressive tumor microenvironment (TME) is a pivotal contributor to therapeutic resistance in triple-negative breast cancer (TNBC). Immunogenic cell death (ICD), which activates antitumor immunity through damage-associated molecu...
Yanping Feng,JinYi Chen,Congqin Ning
Yanping Feng
Selenium (Se) is an essential trace element for the human body, serving as a component of several natural enzymes and playing a crucial role in a variety of biological functions. However, the extraction of natural selenoenzymes presents sig...
Multifunctional metal-phenolic network coatings drive immunocompetent osseointegration via marrow microenvironment remodeling [0.03%]
金属酚网络多功能涂层通过骨髓微环境重塑促进免疫 competent的骨整合
Yu-Wei Ge,Nai-Sheng Zhai,Chen-Jun Liu et al.
Yu-Wei Ge et al.
Surface modification is crucial for improving bone-implant integration, but current coating technologies lack simplicity, efficiency, and multifunctionality needed for clinical use. Metal-phenolic networks (MPNs) are emerging as a promising...
Targeting bone marrow adipocyte-driven fatty acid metabolism to overcome drug resistance in lung cancer bone metastasis [0.03%]
靶向骨髓脂肪细胞驱动的脂代谢以克服肺癌骨转移引起的药物耐药性
Jian Dong,Huaze Ding,Shuoer Wang et al.
Jian Dong et al.
Lung cancer remains a leading cause of cancer-related mortality worldwide, with bone metastasis presenting a significant challenge due to its association with severe skeletal complications and therapy resistance. This study investigates the...
Cinobufagin loaded Prussian blue-like nanoparticles for chemo/gas therapy of multidrug resistant cancer [0.03%]
用于耐药肿瘤化疗/气体治疗的携带 Cinobufagin 的类似普鲁士蓝纳米粒子
Wensheng Qiu,Jialong Fan,Weifeng Tao et al.
Wensheng Qiu et al.