Engineered GLP-1R-targeting nanoplatforms: multimodal therapeutics in human diseases [0.03%]
工程化的GLP-1R靶向纳米平台：人类疾病的多模态治疗方案
Juan Zeng,Xinxin Tang,Dalian Qin et al.
Juan Zeng et al.
Glucagon-like peptide-1 receptor (GLP-1R) is a versatile therapeutic target that regulates glucose homeostasis, cardiovascular function, neuroprotection, and immune responses. Native GLP-1 undergoes rapid enzymatic degradation, limiting its...
Investigation of the effects of Si-A/PUE@HA hydrogels on the osteochondral defect microenvironment based on single-cell RNA sequencing [0.03%]
基于单细胞RNA测序的Si-A/PUE@HA水凝胶对软骨缺损微环境影响的研究
Zhipeng Xi,Ning Xu,Xiaobo Zhou et al.
Zhipeng Xi et al.
Osteochondral defects pose significant challenges in joint health, leading to pain, decreased mobility, and substantial healthcare costs due to surgical interventions. This study aimed to develop and evaluate Si-A/PUE@HA composite hydrogels...
Mesenchymal stem cell-derived apoptotic vesicles: emerging cell-free strategy for periodontitis treatment [0.03%]
间充质干细胞来源的凋亡小体：治疗牙周病的新策略
Jingru Han,Yinyin Huang,Yadong Guo et al.
Jingru Han et al.
Periodontitis is a chronic infectious disease characterized by the destruction of periodontal supporting tissues. Traditional treatment methods, including scaling and root planing, have limited effectiveness in restoring damaged periodontal...
A novel ligustrazine-based nanodelivery system protects against doxorubicin-induced cardiotoxicity by targeting the SIRT5-DUSP1 axis for mitochondrial repair [0.03%]
一种新型川芎嗪纳米递送系统通过靶向SIRT5-DUSP1轴修复线粒体来抵抗多柔比星引起的心脏毒性
Hongshuo Shi,Boxian Pang,Fenglei Zhang et al.
Hongshuo Shi et al.
Background: Doxorubicin (DOX)-induced cardiotoxicity (DIC) injury primarily contributes to anthracycline-associated end-stage cardiovascular mortality. Ligustrazine (LIG), a natural compound extracted from Ligusticum chua...
Dendritic cell-targeted liposomes for cancer immunotherapy via inhibition of aryl hydrocarbon receptor [0.03%]
通过抑制芳香烃受体针对树突状细胞的脂质体用于癌症免疫治疗
Chen-Guang Zhang,Chen-Yun Yeh,Sheng-Yun Hsu et al.
Chen-Guang Zhang et al.
Ligands for the aryl hydrocarbon receptor (AhR), such as kynurenine derived from the tumor microenvironment, are well-known immunosuppressants. Although systemic AhR inhibition has demonstrated antitumor activity in previous studies, the sp...
Decellularized extracellular matrix bio-patch with strong and biodegradable wet adhesive interface for sutureless soft tissue defect repair [0.03%]
一种用于无缝线修复软组织缺损的高强度可降解湿粘接界面脱细胞基质生物补片
Xiaoya Chen,Binbin Guan,Wei Jing et al.
Xiaoya Chen et al.
Decellularized extracellular matrix-based bio-patches offer superior biocompatibility and bioactivity, making them an ideal implantation material for soft tissue defect repair. However, the fixation of these patches typically relies on sutu...
Nanotechnology-driven biofortification of Fe, Zn, and Se in edible plants [0.03%]
纳米技术在植物食品中铁、锌和硒的增补富集作用
Luana Vanessa Peretti Minello,Suelen Goettems Kuntzler,Emílio Berghahn et al.
Luana Vanessa Peretti Minello et al.
Iron (Fe) and zinc (Zn) are essential micronutrients for both plants and humans, whereas selenium (Se) is essential for human health and beneficial for plants. Nevertheless, deficiencies in these elements remain a global concern. Nanopartic...
Integrating artificial intelligence with nanodiagnostics for early detection and precision management of neurodegenerative diseases [0.03%]
结合人工智能的纳米诊断技术在神经退行性疾病早期检测及精准治疗中的应用
Youssef M Hassan,Ahmed Wanas,Ayat A Ali et al.
Youssef M Hassan et al.
Background: Neurodegenerative diseases—including Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS)—as well as autoimmune disorders with neurodegenerative features such as multiple sclerosis (MS), prese...
Neuron-targeted ROS-responsive liposomes for puerarin delivery remodel ischemic microenvironment via microglial modulation and neurovascular regeneration [0.03%]
神经元靶向ROS响应性脂质体递送葛根素通过调节微胶质细胞和神经血管再生重塑缺血微环境
Di Chen,Hui Jiang,Lu Sun et al.
Di Chen et al.
Ischemic stroke triggers the "ischemic cascade," which encompasses vascular injury, oxidative stress, inflammatory responses, and mitochondrial dysfunction, ultimately leading to neuronal death and impaired brain function. Conventional phar...
Advances of extracellular vesicles isolation and detection frontier technology: from heterogeneity analysis to clinical application [0.03%]
外泌体等细胞外小囊泡的分离检测前沿技术进展：从异质性分析到临床应用
Bei Li,Wei Wu,Wenrong Xu et al.
Bei Li et al.
Extracellular vesicles (EVs) play a crucial role in intercellular communication, participating in various physiological and pathological processes, and showing great application potential in disease diagnosis, therapy and prognosis. Neverth...