Yadong Guo,Wenbo Du,Shuguang Cheng et al.
Yadong Guo et al.
Apoptotic extracellular vesicles (ApoEVs), natural bilayer nanoparticles released during programmed cell death, have emerged as pivotal regulators and promising therapeutic agents for bone regeneration. They function as innate multimodal si...
A dual-transformable MgGa-MOF nanoplatform for HCC therapy via lactate metabolism blockade and immune reactivation [0.03%]
Yajie Li,Yingying Wei,Shaoshi Ma et al.
Yajie Li et al.
Microwave ablation (MWA) has emerged as one of the preferred modalities for treating hepatocellular carcinoma (HCC). However, its therapeutic efficiency is restricted by lactate accumulation after MWA. Lactate serves as a metabolic fuel for...
Yaqi Yao,Zhenna Xu,Haoran Ding et al.
Yaqi Yao et al.
Acute liver injury (ALI) represented a significant clinical challenge due to its high mortality rate and the absence of specific therapeutic interventions. Plant-derived exosome-like nanoparticles (ELNs) had recently garnered increasing att...
Injectable pH-responsive carboxymethyl cellulose hydrogel for sustained delivery of IL-22 in the treatment of alcoholic liver disease [0.03%]
Huan Zhou,Dashuai Yang,Rongrong Gu et al.
Huan Zhou et al.
Alcoholic liver disease (ALD) is a major chronic liver disorder that poses a significant global health burden due to its severe health risks and limited therapeutic options. Although recombinant interleukin-22 (IL-22) is an available therap...
LILRB3 inhibition reverses immunosuppression in glioma: a nanoparticle-based therapeutic strategy [0.03%]
Jiefu Yu,Xiangguo Cui,Guangcai Shao et al.
Jiefu Yu et al.
Glioma is a highly aggressive brain tumor characterized by a profoundly immunosuppressive tumor microenvironment dominated by M2-polarized tumor-associated macrophages (TAMs). This study utilized machine learning and single-cell multi-omics...
Dual-loaded homotypic exosomes with endogenous IR808 and pH-responsive DOX drive sequenced chemo-PDT and convert "cold" OSCC tumors "hot" [0.03%]
He Wang,Yang Yu,Wenbin Zhou et al.
He Wang et al.
Background: Chemotherapy remains central to oral squamous cell carcinoma (OSCC) management but is constrained by poor specificity, systemic toxicity, multidrug resistance, and limited durability. Tumor-derived exosomes (T...
Responsive nanoparticles modulating microglia lactate transport alleviate M1-type polarization and neuroinflammation for brain injury therapy [0.03%]
Yuxiao Ma,Guojie Chen,Pengcheng Xu et al.
Yuxiao Ma et al.
Neuroinflammation mediated by microglia and excessive oxidative stress are key pathological processes driving the progression of brain injuries such as intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Modulating lactate tran...
Nanobody-based bioPROTAC for viral protein degradation provides an antiviral strategy for porcine arterivirus [0.03%]
Shibo Su,Mingxia Sun,Haiwei Wang et al.
Shibo Su et al.
Background: Proteolysis-targeting chimeras (PROTACs) are powerful tools for targeted protein degradation and are expected to contribute to a promising strategy for next-generation precision therapeutic antiviral drug deve...
Smart logistics of perishable goods: emerging nanomaterial-based sensing technologies for real-time monitoring and analytical control [0.03%]
Haibin Liu,Gao Zhou,Zhili Wang et al.
Haibin Liu et al.
Perishable supply chains lose substantial value because product deterioration is rarely measured directly during distribution, while static date labels and temperature records provide only indirect assurance of quality. This review surveys ...
Lactobacillus-derived extracellular vesicles provide multi-target acne treatment by enriched proteins and skin microbiota protection [0.03%]
Ke Liu,Zhiqi Zhang,Yuting Su et al.
Ke Liu et al.
Numerous studies have highlighted the therapeutic potential of probiotics in acne. Given the complex and multifactorial nature of the disease, probiotic-based multi-target therapies may be promising. Additionally, due to their non-replicati...