Plain DNA and cationic aromatics: a platform to simplify carrier-free delivery systems [0.03%]
不含载体的基因传递体系的简化平台：DNA与阳性感光性芳香烃体系
Shiji Fang,Zhongwei Zhao,Huaping Li et al.
Shiji Fang et al.
DNA nanotechnology offers a powerful alternative in biomedical areas yet a simple and general strategy to engineer DNA-based nanomedicine bearing high and adjustable drug-loading capacity and stability remains challenging. Herein, we report...
Bidirectional regulation of liver sinusoidal clearance by amino acid nanofibers and IGFBP4 complex: effects on HbA1c [0.03%]
氨基酸纳米纤维和IGFBP4复合物对肝脏窦隙清除的双向调节作用：对HbA1c的影响
Aejin Lee,Silvia de Lamo Castelli,Patrick Sellers et al.
Aejin Lee et al.
Therapies for type 2 diabetes primarily target hyperglycemia; however, complications are also triggered by advanced glycation end products (AGEs). We hypothesize that the anti-diabetic efficacy of insulin-like growth factor-binding protein ...
Platinum-doped emodin carbon dots mitigate sepsis-induced lung injury by targeting the gut-lung axis [0.03%]
铂掺杂的大黄素碳点通过靶向肠-肺轴缓解脓毒症引起的肺损伤
Honghao Song,Yuqing Ma,Lei Peng et al.
Honghao Song et al.
Spatiotemporally controlled delivery of biomacromolecules via injectable hydrogels for precision modulation of the tumor immune microenvironment [0.03%]
基于注射型水凝胶的生物大分子时空可控递送精确调控肿瘤免疫微环境
Hongxu Zhou,Hao Zheng,Wenbo Yao et al.
Hongxu Zhou et al.
The pronounced heterogeneity and immunosuppressive characteristics of the tumor immune microenvironment (TIME) substantially impede the clinical efficacy of immune checkpoint blockade (ICB) therapies. Biomacromolecules-such as antibodies, c...
Ultrasound-responsive micro/nanobubbles based intelligent theranostic systems for precision tumor therapy [0.03%]
一种基于智能诊疗系统的超声波响应微/纳米泡技术进行精准肿瘤治疗
Deng Liu,Yi Ling,Wanqian Liu et al.
Deng Liu et al.
Ultrasound-targeted micro/nanobubble cavitation (UTMC/UTNC) has emerged as a highly promising ultrasound-based strategy for precision tumor therapy. This technique harnesses microbubbles and nanobubbles as cavitation nuclei that respond to ...
Yue Gao,Jiahao Xu,Yuanqiu Lai et al.
Yue Gao et al.
Cancer therapy faces significant challenges due to the resistance of traditional apoptosis-based treatments. Ferroptosis, an iron-dependent, lipid peroxidation-driven form of programmed cell death, has emerged as a novel therapeutic strateg...
Mesenchymal stem cell-derived apoptotic extracellular vesicles loaded with Prussian blue nanoparticles attenuate severe acute pancreatitis via neutrophil extracellular traps resolution and acinar-ductal metaplasia promotion [0.03%]
间充质干细胞源性凋亡外泌体负载普鲁士蓝纳米颗粒通过促进中性粒细胞胞外陷阱消解及胰腺腺泡上皮化促进作用缓解重症急性胰腺炎
Wenjie Xu,Wenwu Cai,Junyong Wu et al.
Wenjie Xu et al.
Nowadays, severe acute pancreatitis (SAP) remains a critical clinical disease with a high mortality rate. Current treatments are mainly supportive, lacking specific therapies targeting the core pathological mechanisms including neutrophil e...
Charge-dependent mitochondrial targeting of cerium-doped polypyrrole nanoparticles to injured renal tubules for acute kidney injury therapy [0.03%]
电荷依赖的掺铈聚吡咯纳米粒子靶向损伤肾小管治疗急性肾损伤
Mengjie Huang,Yuanqi Liu,Tuo Xiao et al.
Mengjie Huang et al.
Yawen Zhu,Dongxue Ge,Jinglin Wang et al.
Yawen Zhu et al.
The liver is the largest parenchymal organ in the human body, crucial for overall health. However, hepatic diseases have become a global epidemic, causing significant burdens. While traditional therapies for liver diseases such as hepatic f...
DNA-guided 3D pathway reconfiguration of composite nanopores for ion transport regulation [0.03%]
基于DNA引导的复合纳米孔三维路径重构用于离子传输调控
Jiarong Guo,Tao Gao,Ying Ma et al.
Jiarong Guo et al.
Ion current rectification (ICR) is essential for understanding analyte-driven nanofluid transport within nanopores. However, the rapid flow rates and limited reaction times in this process can impede electrochemical reactions at electrode i...