High-temperature PTT/CDT coordination nanoplatform realizing exacerbated hypoxia for enhancing hypoxia-activated chemotherapy to overcome tumor drug resistance [0.03%]
一种高温下活化的PTT/CDT协同作用的纳米调控平台用于加剧肿瘤低氧微环境以增强低氧型化疗药物的治疗效果来克服耐药性问题的研究
Peng Chang,Yingying Guo,Dan Chen et al.
Peng Chang et al.
Background: Hypoxia-activated prodrugs present new opportunities for safe and effective tumor drug resistance therapy due to their high selectivity for hypoxic cells. However, the uneven distribution of oxygen in solid tu...
Self-assembled copper-based nanoparticles for enzyme catalysis-enhanced chemodynamic/photodynamic/antiangiogenic tritherapy against hepatocellular carcinoma [0.03%]
自组装的铜基纳米粒子用于酶催化增强的化学动力学/光动力学/抗血管生成三联疗法治疗肝细胞癌
Yaping Wang,Xun Zhang,Yunfeng Ma et al.
Yaping Wang et al.
As an emerging cancer treatment strategy, reactive oxygen species-based tumor catalytic therapies face enormous challenges due to hypoxia and the overexpression of glutathione (GSH) in the tumor microenvironment. Herein, a self-assembled co...
Microfluidics-enabled mesenchymal stem cell derived Neuron like cell membrane coated nanoparticles inhibit inflammation and apoptosis for Parkinson's Disease [0.03%]
微流体技术制备的间质干细胞来源类似神经细胞膜涂层纳米颗粒抑制炎症及凋亡治疗帕金森病
Tong Lei,Caifeng Li,Yang Liu et al.
Tong Lei et al.
Parkinson's disease (PD) is the second largest group of neurodegenerative diseases, and its existing drug treatments are not satisfactory. Natural cell membrane drugs are used for homologous targeting to enhance efficacy. In this study, mic...
Phage-based delivery systems: engineering, applications, and challenges in nanomedicines [0.03%]
基于噬菌体的递送系统：纳米药物中的工程设计、应用及挑战
Hui Wang,Ying Yang,Yan Xu et al.
Hui Wang et al.
Bacteriophages (phages) represent a unique category of viruses with a remarkable ability to selectively infect host bacteria, characterized by their assembly from proteins and nucleic acids. Leveraging their exceptional biological propertie...
M6A demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p/FOXO1 axis [0.03%]
M6A去甲基化酶FTO稳定化的外泌体circBRCA1通过miR-642a-5p/FOXO1轴缓解氧化应激诱导的颗粒细胞损伤
Xiaolan Zhu,Wenxin Li,Minjun Lu et al.
Xiaolan Zhu et al.
Background: Premature ovarian insufficiency (POI) is an important cause of female infertility and seriously impacts the physical and psychological health of patients. Human umbilical cord mesenchymal stem cell-derived exo...
Diagnosis and treatment status of inoperable locally advanced breast cancer and the application value of inorganic nanomaterials [0.03%]
不可手术局部晚期乳腺癌的诊断治疗现状及无机纳米材料的应用价值
Linxuan Wu,Chuan He,Tingting Zhao et al.
Linxuan Wu et al.
Locally advanced breast cancer (LABC) is a heterogeneous group of breast cancer that accounts for 10-30% of breast cancer cases. Despite the ongoing development of current treatment methods, LABC remains a severe and complex public health c...
Ultrasonic-responsive piezoelectric stimulation enhances sonodynamic therapy for HER2-positive breast cancer [0.03%]
超声响应压电刺激增强HER2阳性乳腺癌体声动力学治疗效果研究
Zhiguang Chen,Lizhi Yang,Zhimin Yang et al.
Zhiguang Chen et al.
Introduction: Breast cancer ranks second as the most common malignancy globally, after lung cancer. Among the various subtypes of breast cancer, HER2 positive breast cancer (HER2 BC)poses a particularly challenging progno...
Microneedle delivery system with rapid dissolution and sustained release of bleomycin for the treatment of hemangiomas [0.03%]
一种用于治疗血管瘤的博莱霉素速溶缓释微针输送系统
Bin Sun,Tikai Zhang,Hongrui Chen et al.
Bin Sun et al.
Hemangioma of infancy is the most common vascular tumor during infancy and childhood. Despite the proven efficacy of propranolol treatment, certain patients still encounter resistance or face recurrence. The need for frequent daily medicati...
Breaking barriers: bacterial-microalgae symbiotic systems as a probiotic delivery system [0.03%]
突破壁垒：细菌-微藻共生系统作为益生菌递送系统
Hui Huang,Xiaoyang Liu,Yutong Lang et al.
Hui Huang et al.
The gut microbiota is one of the essential contributors of the pathogenesis and progress of inflammatory bowel disease (IBD). Compared with first-line drug therapy, probiotic supplementation has emerged as a viable and secure therapeutic ap...
Magnesium malate-modified calcium phosphate bone cement promotes the repair of vertebral bone defects in minipigs via regulating CGRP [0.03%]
马来酸镁修饰的钙磷骨水泥通过调节CGRP促进 miniature swine椎体骨缺损修复
Hailiang Xu,Fang Tian,Youjun Liu et al.
Hailiang Xu et al.
Active artificial bone substitutes are crucial in bone repair and reconstruction. Calcium phosphate bone cement (CPC) is known for its biocompatibility, degradability, and ability to fill various shaped bone defects. However, its low osteoi...