Iron-based MOF with Catalase-like activity improves the synergistic therapeutic effect of PDT/ferroptosis/starvation therapy by reversing the tumor hypoxic microenvironment [0.03%]
类过氧化氢酶铁基MOF通过逆转肿瘤低氧微环境改善光动力/铁死亡/饥饿协同治疗效果
Yukun Chen,Yuanyuan Chen,Zhenzhi Wang et al.
Yukun Chen et al.
Reversing the hypoxic microenvironment of tumors is an important method to enhance the synergistic effect of tumor treatment. In this work, we developed the nanoparticles called Ce6@HGMOF, which consists of a photosensitizer (Ce6), glucose ...
Magnetic nanoradiotracers for targeted neutrophil detection in pulmonary arterial hypertension [0.03%]
用于靶向检测肺动脉高压中中性粒细胞的磁性纳米放射示踪剂
Lucía Fadón-Padilla,Claudia Miranda-Pérez de Alejo,Ana Beatriz Miguel-Coello et al.
Lucía Fadón-Padilla et al.
Background: Pulmonary arterial hypertension (PAH) is a severe disease characterized by elevated blood pressure in the pulmonary artery that can ultimately damage the right ventricle of the heart. PAH is pathophysiological...
FeS2@COF based nanocarrier for photothermal-enhanced chemodynamic/thermodynamic tumor therapy and immunotherapy via reprograming tumor-associated macrophages [0.03%]
基于FeS2@COF的纳米载体用于光热增强的化学动力学/热动力学肿瘤治疗和通过重新编程肿瘤相关巨噬细胞进行免疫治疗
Xiangtian Deng,Renliang Zhao,YunFeng Tang et al.
Xiangtian Deng et al.
Developing high-performance nanomedicines to enhance antitumor efficacy remains a hot point in the field of biomedicine. In this study, we designed a versatile nanocomposite (FeS₂@COF-HA/AIPH) integrating covalent organic frameworks (COF) ...
De novo strategy of organic semiconducting polymer brushes for NIR-II light-triggered carbon monoxide release to boost deep-tissue cancer phototheranostics [0.03%]
用于近红外光触发一氧化碳释放的从头设计有机半导体聚合物刷子以增强深层组织癌症光诊疗
Caijun Zhu,Mingdian Yu,Jingqi Lv et al.
Caijun Zhu et al.
The integration of photoacoustic imaging (PAI) and photothermal therapy (PTT) within the second near-infrared (NIR-II) window, offering a combination of high-resolution imaging and precise non-invasive thermal ablation, presents an attracti...
Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach [0.03%]
定制用于RNA疗法靶向递送的脂质纳米颗粒的体内旅程的质量设计方法导航
Elahe Haghighi,Samira Sadat Abolmaali,Ali Dehshahri et al.
Elahe Haghighi et al.
RNA therapeutics, such as mRNA, siRNA, and CRISPR-Cas9, present exciting avenues for treating diverse diseases. However, their potential is commonly hindered by vulnerability to degradation and poor cellular uptake, requiring effective deli...
Metal-phenolic nanoparticles enhance low temperature photothermal therapy for bacterial biofilm in superficial infections [0.03%]
金属酚纳米粒子增强低体温光热疗法治疗浅表感染的细菌生物膜
Yang Ye,Qinqin Zheng,Ziqi Wang et al.
Yang Ye et al.
Bacterial infections, especially induced by multidrug-resistant pathogens, have become a significant global health concern. In the infected tissues, biofilms not only serve as a source of nutrients but also act as protective barriers that i...
Succinate exacerbates mastitis in mice via extracellular vesicles derived from the gut microbiota: a potential new mechanism for mastitis [0.03%]
琥珀酸通过来源于肠道微生物的外泌体加重小鼠乳腺炎：乳腺炎的新机制研究
Min Qiu,Cong Ye,Xiaotong Zhao et al.
Min Qiu et al.
Background: A high grain diet causes an ecological imbalance in the gut microbiota and serves as an important endogenous trigger of mastitis in dairy cows, but the underlying mechanisms are unclear. Our previous study rev...
Microneedle patches incorporating zinc-doped mesoporous silica nanoparticles loaded with betamethasone dipropionate for psoriasis treatment [0.03%]
一种用于银屑病治疗的新型微针贴片及其制备方法
Jun Li,Zhiguo Yuan,Shuyu Shi et al.
Jun Li et al.
Treating psoriasis presents a major clinical challenge because of the limitations associated with traditional topical glucocorticoid therapy. This study introduced a drug delivery system utilizing zinc-doped mesoporous silica nanoparticle (...
Zihan Feng,Yuexin Guo,Yicong Zhang et al.
Zihan Feng et al.
As novel multifunctional materials that merge enzyme-like capabilities with the distinctive traits of nanomaterials, nanozymes have made significant strides in interdisciplinary research areas spanning materials science, bioscience, and bey...
Targeting glutamine synthetase with AS1411-modified exosome-liposome hybrid nanoparticles for inhibition of choroidal neovascularization [0.03%]
靶向谷氨酰胺合成酶的AS1411修饰的外泌体-脂质体杂合纳米颗粒抑制脉络膜新生血管形成
Miaomiao Zhang,Xinyue Lu,Lifu Luo et al.
Miaomiao Zhang et al.
Choroidal neovascularization (CNV) is a leading cause of visual impairment in wet age-related macular degeneration (wAMD). Recent investigations have validated the potential of reducing glutamine synthetase (GS) to inhibit neovascularizatio...