Engineered exosomes: a promising approach for overcoming challenges in pancreatic cancer therapy [0.03%]
工程化外泌体在克服胰腺癌治疗难题中的应用前景不容小觑
Mo Sha,Yang Gao,Xu Yin et al.
Mo Sha et al.
Pancreatic cancer (PC) is among the deadliest types of cancer, with very low chances of survival. It is often asymptomatic in the early stage, making diagnosis difficult. Therefore, it is typically found at an advanced stage, resulting in p...
MiR-7683-3p from M2-exosomes attenuated atherosclerosis by activating the PPARγ-LXRα-ABCG1 pathway mediated cholesterol efflux of vascular smooth muscle cell derived foam cells [0.03%]
M2源外泌体中miR-7683-3p通过激活PPARγ-LXRα-ABCG1通路介导的血管平滑肌细胞源泡沫细胞胆固醇流出抑制动脉粥样硬化形成
Shuo Wang,Yunhui Lv,Xiaohu Wang et al.
Shuo Wang et al.
Background: Impaired excretion of lipid deposits within vascular smooth muscle cell-derived foam cells (VSMC-FCs) contributes to the ongoing expansion of the plaque necrotic core. This study aims to explore the effects an...
Aligned nanofiber-based responsive sponge scaffolds for peripheral nerve regeneration [0.03%]
用于周围神经再生的定向纳米纤维基响应性海绵支架
Sizhe Song,Ying Zhang,Dongyu Xu et al.
Sizhe Song et al.
Nerve conduits have demonstrated tremendous value in advancing nerve regeneration. The current research focuses on improving their neuro regenerative effects through structural optimization and functional enhancement. Here, an original resp...
Exosomes/MoS2 complex for targeting and effective photothermal therapy [0.03%]
用于靶向及有效光热治疗的外泌体/钼二硫化物复合材料
Liyan Wang,Huizhi Chen,Haiyan Qiu et al.
Liyan Wang et al.
Photothermal therapy (PTT) has been an attractive tumor treatment strategy in recent years. Two-dimensional molybdenum disulfide (MoS2)-based nanomaterials with high photothermal conversion efficiency is a promising candidate for PTT. Howev...
Lactobacillus johnsonii-derived extracellular vesicles restore mucosal immunity via taurine-linked Th17/Treg and IgA/IgG regulation in colitis [0.03%]
乳酸菌约翰逊氏菌来源的外泌体通过牛磺酸连接的Th17/Treg和IgA/IgG调节恢复结肠炎黏膜免疫功能
Hailan Zhao,Ningning Yue,Zhiliang Mai et al.
Hailan Zhao et al.
Background: Aberrant mucosal immune responses to gut microbiota contribute to inflammatory bowel disease (IBD), yet the mechanisms linking immunoglobulin-coated bacteria to mucosal inflammation remain unclear. Microbial e...
A two-stage transdermal drug delivery system comprising sono-phase-change transfersomes for non-invasive deep dermal delivery [0.03%]
一种经皮给药系统，该系统包含声敏相变转移体，可实现非侵入性真皮深层递送
Yi Zhang,Xiong He,Xiang Mao et al.
Yi Zhang et al.
Non-invasive deep transdermal drug delivery is required for conditions such as keloids. However, the skin's stratum corneum barrier is the primary obstacle for transdermal drug delivery methods. Most energy sources and operational controls ...
Magnetic field-induced plasmonic enhancement of near infrared fluorescence from a Magnetoplasmonic nanoplatform for bioimaging applications [0.03%]
磁場誘導等離子體近紅外光譜發射增強的磁等離子體納米影像平台
Siqi Gao,Jiantao Liu,Iuliia Golovynska et al.
Siqi Gao et al.
A phenomenon of plasmon-enhanced fluorescence (PEF) arises from interactions between fluorophores and metal nanostructures, leading to a substantial amplification of the fluorescence signal. Herein, we report a magnetic field (MF) induced o...
Dimensional control of DNA nanostructures enhances cellular uptake and guides tissue-regenerative responses [0.03%]
尺寸控制的DNA纳米结构增强细胞内吞并指导组织再生反应
Xinyue Tang,Tingting Zhai,Tiancheng Li et al.
Xinyue Tang et al.
Precise regulation of cellular functions is fundamental for advancing tissue regeneration and drug delivery systems. Structural DNA nanotechnology enables the design of well-defined nanostructures, emerging as a promising platform in these ...
Novel drug-free cascaded nanoparticles induce tumor-specific ROS storms via multimodal synergistic anticancer therapy [0.03%]
一种新型无药物纳米粒子协同诱导特异性肿瘤ROS风暴用于多模态联合抗肿瘤治疗
Mingsen Wen,Hongwei Chen,Song Xu et al.
Mingsen Wen et al.
Reactive oxygen species (ROS), generated by sonosensitizers, play a pivotal role in tumor cell apoptosis during sonodynamic therapy (SDT), particularly for tumors located deep within tissues. Nevertheless, conventional sonosensitizers prese...
Biomimetic Cu2-xSe nanoplatforms for efficient glioblastoma treatment: overcoming the blood-brain barrier and boosting Immunogenetic cell death [0.03%]
仿生Cu2-xSe纳米平台高效治疗胶质母细胞瘤：克服血脑屏障并增强免疫遗传性细胞死亡
Sijia Lin,Haiyan Xing,Yu Zeng et al.
Sijia Lin et al.
Glioblastoma (GBM) is an aggressive and highly heterogeneous brain tumor that continues to pose a significant clinical challenge. Current therapeutic strategies, including surgical resection, radiotherapy, and chemotherapy, are hindered by ...