Myocardial mechanics displaying on visual structural color hydrogel microcolumn arrays [0.03%]
可视化结构色水凝胶微柱阵列的心肌力学展示技术研究
Lingyu Sun,Minhui Lu,Zezun Xie et al.
Lingyu Sun et al.
Cellular mechanics play significant roles in biological processes from cellular level to tissue level. Great efforts have been committed to developing simple and reliable mechanical sensing strategies. Here, we present the concept of cellul...
Self-supplying hydrogen peroxide-driven gold nanoparticle aggregation via bio-orthogonal click reaction activates cGAS-STING-PERK pathway for multimodal tumor therapy [0.03%]
一种用于多模态肿瘤治疗的自给过氧化氢驱动型金纳米颗粒生物正交聚集激活cGAS-STING-PERK通路方法
Junyou Li,Kaiqi Hu,Man Lung Lee et al.
Junyou Li et al.
We developed an effective nanoplatform, T+EPAuNPLu&Lap, that concurrently harnesses Type I photodynamic therapy (PDT), chemodynamic therapy (CDT), photothermal therapy (PTT), and immunomodulation to remodel the immunosuppressive tumor micro...
A zinc-coordinated cascade-responsive therapeutic nanoassembly for remodeling the pathological microenvironment and restoring mitochondrial homeostasis in spinal cord injury [0.03%]
一种锌配位的级联响应型治疗纳米组装体系用于重塑脊髓损伤病理微环境和恢复线粒体稳态
Chunyu Xiang,Xiaodong He,Fengshuo Guo et al.
Chunyu Xiang et al.
Secondary injury after spinal cord injury (SCI) is sustained by coupled oxidative stress and inflammation, which drives neuronal apoptosis and bioenergetic failure. Here, a cascade-responsive Zn2+-centered nanoassembly (Zn-PC/PA@Gel) is con...
In situ sol-gel-sol transformation formed by sodium alginate realizes folic acid-modified chitosan nanoparticles to deliver hops β-acids for colorectal cancer therapy [0.03%]
原位溶胶-凝胶-溶胶转化形成的海藻酸钠实现大肠癌治疗 entrega 葛氏 β-酸
Xia Qiao,Jiayue Liu,Jing Bai et al.
Xia Qiao et al.
Oral administration can deliver targeted nanoparticles directly to colorectal cancer (CRC) lesions, bypassing systemic circulation. However, orally administered nanoparticles may become physically entrapped in the small intestine, compromis...
Metal-organic framework-based fuel-driven chemical reaction network for ferroptosis therapy [0.03%]
一种用于铁死亡治疗的基于金属有机骨架的燃料驱动化学反应网络疗法
Ding Guo,Qian Lin,Quanyi Jin et al.
Ding Guo et al.
Ferroptosis is a prospective approach for cancer treatment. However, the efficacy of ferroptosis therapy is limited by three parallel ferroptosis defense pathways: the glutathione (GSH)-glutathione peroxidase 4 (GPX4) pathway, the ferroptos...
Hydrogen peroxide self-supplied nanozyme system for synergistic prostate cancer therapy via ferroptosis/pyroptosis and Ca2+ overload-induced apoptosis [0.03%]
基于铁死亡/细胞焦亡和钙超载诱导的细胞凋亡的协同治疗前列腺癌的过氧化氢供给型纳米酶系统
Sixu Chen,Linnan Yang,Peng Wang et al.
Sixu Chen et al.
Ferroptosis, an iron-dependent and non-apoptotic regulated cell death mode, has garnered increasing attention in treating cancers with apoptosis resistance. However, the insufficient hydrogen peroxide (H2O2) supply impedes the sustained gen...
Machine learning-assisted nanozyme nanosensor for instantaneous quantitative analysis of antitubercular drugs [0.03%]
基于机器学习的纳米酶传感器用于抗结核药物的瞬时定量分析
Chendi Qin,Xuehong Min,Linjian Fang et al.
Chendi Qin et al.
The dynamic concentration of drugs in the blood reflect pharmacokinetic characteristics and serves as crucial indicators of therapeutic efficacy and medication safety. This underscores the necessity of real-time monitoring to guide individu...
A magnetic-acoustic dual-fesponsive nanoplatform for targeted PPARδ activation attenuates adolescent idiopathic scoliosis progression [0.03%]
一种磁声双响应的纳米平台通过靶向激活PPARδ来抑制青少年特发性脊柱侧弯的发展
Chong Zhao,Shuaiqi Zhu,Yonghao Wu et al.
Chong Zhao et al.
Paraspinal muscle asymmetry is a characteristic feature of adolescent idiopathic scoliosis (AIS), yet the underlying molecular mechanisms driving this degeneration remain unclear. Here, we identify the suppression of the FNDC5-associated PP...
A pH‑responsive hydrogel delivering ISOC1 modRNA attenuates disc degeneration by promoting BIRC6‑mediated MYC degradation and inhibiting SBSN expression [0.03%]
响应pH变化的水凝胶递送ISOC1模RNA通过促进BIRC6介导的MYC降解和抑制SBSN表达来缓解椎间盘退变
Kun Wang,Zhiqiang Wang,Yanzheng Gao et al.
Kun Wang et al.
Intervertebral disc degeneration (IDD), a principal cause of chronic low back pain, is characterized by nucleus pulposus cell (NPC) apoptosis and currently lacks effective therapies. Through integrated multi-omics and Mendelian randomizatio...
Engineering smart polymeric lipid nanoparticles for breast cancer: AI-guided formulation design, biological barriers, and translational constraints [0.03%]
人工智能引导的乳腺癌聚合物脂质纳米粒制剂设计、生物屏障及转化限制
Tianzhao Du,Ye Yuan,Ruihan Shen et al.
Tianzhao Du et al.
Breast cancer is a biologically heterogeneous disease in which tumor-intrinsic diversity and the tumor immune microenvironment jointly shape therapeutic resistance and variable clinical outcomes. Although nanomedicine has improved the safet...