Ion-interference amplifier nano-system enhances radiotherapy via mitochondrial dysfunction and efferocytosis Inhibition [0.03%]
离子干扰放大纳米系统通过线粒体功能障碍和抑制凋亡细胞吞噬作用增强放射治疗效果
Shuting Zheng,Yinfei Zheng,Honglei Hu et al.
Shuting Zheng et al.
Background: The efficacy of radiotherapy (RT) is often compromised by tumor radioresistance and an immunosuppressive microenvironment. Two key limitations are the clearance of apoptotic cells (efferocytosis), which can pr...
Mesoporous multimetallic PdPtBi nanozymes target redox imbalance and glutamine deprivation for immuno-chemodynamic therapy [0.03%]
中空多金属PdPtBi纳米酶靶向氧化还原失衡和谷氨酰胺剥夺的免疫化学动力学治疗
Guanhua Qiu,Jie Long,Feng Lin et al.
Guanhua Qiu et al.
Therapeutic resistance remains a formidable challenge in oncology, mainly due to the chaotic tumor microenvironment (TME), which drive tumor progression and adaptive resistance via a self-sustaining metabolic-oxidative feedback loop. Herein...
Image-guided therapy of colorectal cancer using a zirconium coordinated nanosensitizer [0.03%]
一种锆配位纳米光敏剂引导的结直肠癌治疗新方法
Shuyang Yang,Xiaodan Jiao,Xuan Lou et al.
Shuyang Yang et al.
Sonodynamic therapy (SDT) has gained attention as a promising non-invasive cancer treatment strategy due to its localized effects and superior tissue penetration. SDT induces apoptosis and immunogenic cell death (ICD) via the generation of ...
Collagenase-mediated extracellular matrix targeting for enhanced drug penetration and therapeutic efficacy in nanoscale delivery systems for cancer therapy [0.03%]
用于癌症治疗的纳米级递送系统中胶原酶介导的细胞外基质靶向以增强药物渗透和治疗效果
Pengyu Gong,Fei Wang,Yixin Hua et al.
Pengyu Gong et al.
The highly fibrotic extracellular matrix (ECM) constitutes a major barrier that restricts the penetration and delivery efficiency of anticancer drugs, particularly in fibrotic tumors such as pancreatic cancer, in which cancer-associated fib...
Correction: MiR-7683-3p from M2-exosomes attenuated atherosclerosis by activating the PPARγ-LXRα-ABCG1 pathway mediated cholesterol efflux of vascular smooth muscle cell derived foam cells [0.03%]
纠正：M2来源的MiR-7683-3p通过激活PPARγ-LXRα-ABCG1通路介导的血管平滑肌细胞源泡沫细胞胆固醇流出缓解动脉粥样硬化
Shuo Wang,Yunhui Lv,Xiaohu Wang et al.
Shuo Wang et al.
Published Erratum
Journal of nanobiotechnology. 2025 Nov 23;23(1):731. DOI:10.1186/s12951-025-03780-6 2025
Cu-doping site regulation in carbon dots for concurrent cuproptosis-like death anti-bacteria and osteogenesis of infected bone defects [0.03%]
铜掺杂位点调控的碳点协同诱导细菌类杯铂式死亡用于感染性骨缺损修复及成骨刺激
Bo Yuan,Yifan Tang,Lang Yan et al.
Bo Yuan et al.
Infected bone defect repair suffers frequently from the insufficient bone differentiation activity and the stubborn biofilm formation resulting from bacterial infections. In addition, the incorporation of non-biocompatible antibiotics into ...
Size control of lipid nanoparticles via simulation-based design of a microfluidic chip and its effect on mRNA delivery in vitro and in vivo [0.03%]
基于模拟的微流控芯片设计实现脂质纳米颗粒粒径控制及其对体内和体外mRNA递送的影响研究
Bookun Kim,Cheol Hui Park,In-Young Jung et al.
Bookun Kim et al.
The emergence of mRNA-containing lipid nanoparticles (LNPs) during the COVID-19 pandemic has revolutionized vaccine technology and is now being explored for protein replacement therapies. This study aimed to test the hypothesis that LNP siz...
Multienzymatic nanocatalysts attenuate acute pancreatitis via dual modulation of pyroptotic pathways and autodigestion blockade [0.03%]
多酶纳米催化剂通过双重调节焦亡途径和自动消化阻断来缓解急性胰腺炎
Xiulin Dong,Weigang Gu,Sijia Hua et al.
Xiulin Dong et al.
Acute pancreatitis (AP) is associated with a high mortality rate, and thereby its therapy is still a challenge. At the molecular level, single-cell RNA sequencing (scRNA-seq) analysis revealed a marked upregulation of pyroptosis (a recently...
A novel sono-activatable nanoreactor induces precision intratumoral juglone generation and caspase 3/GSDME-mediated pyroptosis for treatment of bladder cancer [0.03%]
一种新型声敏活化纳米反应器诱导精确的肿瘤内 Juglone 生成及半胱天冬酶 3/GSDME 介导的焦亡用于治疗膀胱癌
Yuanfeng Zhang,Enguang Yang,Xinyu Zhang et al.
Yuanfeng Zhang et al.
Background: Juglone, a natural naphthoquinone compound, exhibits potent anticancer activity but faces clinical limitations due to poor solubility, low bioavailability, and systemic toxicity. While tumor microenvironment-r...
Targeting CAD with a tumor microenvironment-responsive nano-heterojunction for synergistic induction of cuproptosis and inhibition of colorectal cancer progression [0.03%]
一种针对肿瘤微环境的纳米异质结靶向CAD，协同诱导铜依赖性细胞死亡并抑制结直肠癌进展
Yuanchu Xiang,Yujie Liao,Mi Yao et al.
Yuanchu Xiang et al.
Carbamoyl-phosphate synthetase II/Aspartate transcarbamylase/Dihydroorotase (CAD) is a multifunctional enzyme with demonstrated oncogenic potential across various cancers, emerging as a promising therapeutic target. However, its functional ...