Glucose oxidase-mineralized scaffolds with multiple bioactivities for accelerated diabetic bone regeneration [0.03%]
用于加速糖尿病骨再生的葡萄糖氧化酶-矿化支架的多种生物活性研究
Yancheng Zhu,Xiaohao Liu,Zhuyun Cai et al.
Yancheng Zhu et al.
Diabetic bone defects pose a significant clinical challenge due to impaired healing under hyperglycemia. However, no effective therapy is available to treat diabetic bone defect in clinic. This study engineers a biomimetic 3D-printed scaffo...
Exosome-enabled bone defect repair: mechanistic foundations, bioengineered delivery, and artificial intelligence-driven translation [0.03%]
外泌体介导的骨缺损修复：机制基础、生物工程递送及人工智能驱动转化研究
Shen Yang,Siliang Ge,Zhongyang Liu et al.
Shen Yang et al.
Bone defects remain a substantial clinical burden. Exosomes have been extensively investigated as cell-free therapeutic candidates, exhibiting favorable biocompatibility and potential applicability in bone defect repair. Mechanisms relevant...
3D printed HAMA/GelMA/lignosulfonate hydrogel integrating oxygen-releasing and antioxidative modules for liver regeneration [0.03%]
一种集放氧和抗氧化模块于一体的3D打印HAMA/GelMA/木质素磺酸钠水凝胶用于肝再生
Sang Luo,Longbao Feng,Bingren Tian et al.
Sang Luo et al.
A multifunctional polysaccharide-based hydrogel was developed for liver regeneration by integrating sodium alginate (SA), sodium lignosulfonate (SL), and 3D bioprinting technology. The hydrogel incorporated FH1@SA microspheres and CaO2@ZIF-...
Cell-free DNA in precision medicine: overcoming biological barriers through integrated nanoparticle platforms for simultaneous diagnosis and therapy [0.03%]
基于集成纳米粒子平台的游离DNA在精准医疗中的应用：克服生物屏障，实现同时诊断和治疗
Neda Esfandiari,Amirhossein Kaffash Arani,Armineh Jamshidi et al.
Neda Esfandiari et al.
Cell-free DNA (cfDNA), released into the bloodstream through cell death and cellular stress, has emerged as a highly promising noninvasive biomarker with broad diagnostic and therapeutic potential. However, clinical translation of cfDNA rem...
A DNA nanoflowers-based microneedle patch for transdermal gene and photodynamic therapy against melanoma [0.03%]
一种DNA纳米花贴片用于黑色素瘤的透皮基因和光动力治疗
Yuchen Qi,Zhe Wang,Yaguang Wu et al.
Yuchen Qi et al.
DNA nanostructures show great potential as drug carriers in biomedicine, however, biological barriers and stability issues limit their applications, particularly for aggressive melanoma shielded by the skin barrier. This study presents a hy...
Targeted inhibition of RGS19 alleviates renal fibrosis by restoring autophagy and modulating immune cell infiltration [0.03%]
靶向抑制RGS19通过恢复自噬和调节免疫细胞浸润来缓解肾纤维化
Xinhao Niu,Yufeng Zhao,Long Li et al.
Xinhao Niu et al.
Renal fibrosis, a progressive pathological feature of chronic kidney disease (CKD), is driven by impaired autophagic processes and persistent immune activation. The molecular mechanisms that interconnect these pathways remain inadequately u...
Fisetin-loaded nanoparticles as a novel approach for cholesterol regulation in hypercholesterolemia: targeting the ASGR1-mediated mTORC1/AMPK pathway [0.03%]
金丝桃素载药纳米颗粒通过靶向ASGR1介导的mTORC1/AMPK信号通路为高胆固醇血症的治疗提供新思路
Ziyang Zhang,Xi Chen,Xiaoshuang Hu et al.
Ziyang Zhang et al.
Hypercholesterolemia is a major risk factor for the development of atherosclerotic cardiovascular disease. The flavonoid fisetin shows potential cholesterol-regulating effects. Nevertheless, poor solubility and low bioavailability limit its...
Research advances and future perspectives of nanomaterials for depression therapy: a scientometric review [0.03%]
纳米材料抑郁症治疗研究进展与未来展望：科学计量学综述
Dong Xu,Chao Guo,Wang-Ting Li et al.
Dong Xu et al.
Background: Depressive disorder is one of the most common mental health conditions with significant repercussions on both the physical and psychological health of affected individuals. In recent years, an increasing numbe...
Tissue-derived extracellular vesicles-mediated delivery of a hepatic enzyme living panorama (HELP) for treating multifactorial liver diseases [0.03%]
一种由组织来源的细胞外囊泡介导递送的治疗多因素肝病的肝脏酶全景图(Portrait of Liver Enzymes via Living Panorama，HELP)疗法
Xin Zeng,Wei Jiang,Baohong He et al.
Xin Zeng et al.
Background: Dysregulation of hepatic drug-metabolizing enzymes is a hallmark of liver injury and contributes to treatment failure. Current strategies often overlook the complexity of the integrated enzyme network. This st...
Microneedle-mediated delivery of Coptis chinensis-derived nanovesicles orchestrating antibacterial and macrophage reprogramming for comprehensive wound healing [0.03%]
基于黄连素的纳米囊泡介导的微针协同杀菌和巨噬细胞重编程促进创面全面修复
Ke-Min Xu,Jia-Qi Lin,Xin-Xiang-Yi Zhuo et al.
Ke-Min Xu et al.
Conventional antibiotic treatments for infected wounds often inadequately regulate the complex inflammatory cascade and fail to sufficiently promote tissue regeneration, leading to delayed healing and potential secondary tissue damage. Cons...