Adipose-derived stem cell exosomes loaded with icariin alleviates rheumatoid arthritis by modulating macrophage polarization in rats [0.03%]
载淫羊藿素脂肪源干细胞外泌体通过调节巨噬细胞极化缓解大鼠类风湿性关节炎
Qiqi Yan,Haixia Liu,Shiyue Sun et al.
Qiqi Yan et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by synovitis and cartilage destruction. The active compound, icariin (ICA), derived from the herb Epimedium, exhibits potent anti-inflammatory properties. However, its clinica...
Polymeric nanocarriers delivery systems in ischemic stroke for targeted therapeutic strategies [0.03%]
聚meric纳米载体递送系统在缺血性卒中的靶向治疗策略中发挥的作用
Lin Zhu,Weijie Zhong,Xuchen Meng et al.
Lin Zhu et al.
Ischemic stroke is a complex, high-mortality disease with multifactorial etiology and pathogenesis. Currently, drug therapy is mainly used treat ischemic stroke in clinic, but there are still some limitations, such as limited blood-brain ba...
Correction: Extracellular vesicles from senescent mesenchymal stromal cells are defective and cannot prevent osteoarthritis [0.03%]
correction:衰老间充质干细胞来源的细胞外囊泡有缺陷且无法预防骨关节炎
Jérémy Boulestreau,Marie Maumus,Giuliana M Bertolino et al.
Jérémy Boulestreau et al.
Published Erratum
Journal of nanobiotechnology. 2024 Jul 16;22(1):418. DOI:10.1186/s12951-024-02655-6 2024
A pH-triggered N-oxide polyzwitterionic nano-drug loaded system for the anti-tumor immunity activation research [0.03%]
一种用于抗肿瘤免疫激活研究的pH触发型N-氧化物双性离子纳米载药系统
Yan Zhao,Yuansong Bai,Mei Li et al.
Yan Zhao et al.
Triple negative breast cancer (TNBC) has the characteristics of low immune cell infiltration, high expression of tumor programmed death ligand 1 (PD-L1), and abundant cancer stem cells. Systemic toxicity of traditional chemotherapy drugs du...
Modulating cell stiffness for improved vascularization: leveraging the MIL-53(fe) for improved interaction of titanium implant and endothelial cell [0.03%]
利用MIL-53(Fe)调节细胞刚度改善血管化：提高钛种植体与内皮细胞的相互作用
Jie Wu,Leyi Liu,Weidong Du et al.
Jie Wu et al.
Vascularization plays a significant role in promoting the expedited process of bone regeneration while also enhancing the stability and viability of artificial bone implants. Although titanium alloy scaffolds were designed to mimic the poro...
Optimization of micelle-encapsulated extremely small sized iron oxide nanoparticles as a T1 contrast imaging agent: biodistribution and safety profile [0.03%]
优化超小型铁氧化铁纳米颗粒作为T1对比成像剂的研究：生物分布和安全性研究
Minseok Suh,Ji Yong Park,Guen Bae Ko et al.
Minseok Suh et al.
Background: Iron oxide nanoparticles (IONPs) have been cleared by the Food and Drug Administration (FDA) for various clinical applications, such as tumor-targeted imaging, hyperthermia therapy, drug delivery, and live-cel...
Endogenous and exogeneous stimuli-triggered reactive oxygen species evoke long-lived carbon monoxide to fight against lung cancer [0.03%]
内源性和外源性刺激触发的活性氧诱导长期存活的一氧化碳以对抗肺癌
Yujia Fang,Jianjun Yang,Xiayi Liang et al.
Yujia Fang et al.
Reactive oxygen species (ROS)-associated anticancer approaches usually suffer from two limitations, i.e., insufficient ROS level and short ROS half-life. Nevertheless, no report has synchronously addressed both concerns yet. Herein, a multi...
Integration of photomagnetic bimodal imaging to monitor an autogenous exosome loaded platform: unveiling strong targeted retention effects for guiding the photothermal and magnetothermal therapy in a mouse prostate cancer model [0.03%]
集成光磁双模式成像监测自动体外囊泡加载平台：在前列腺癌小鼠模型中揭示强烈的靶向滞留效应以指导光热和磁疗
Songlu Liu,Wenting Shang,Jian Song et al.
Songlu Liu et al.
Background: Prostate cancer (PCa) is the most prevalent cancer among males, emphasizing the critical need for precise diagnosis and treatment to enhance patient prognosis. Recent studies have extensively utilized urine ex...
Preparation and in vivo and ex vivo studies of sirolimus nano-in-situ gel ophthalmic formulation [0.03%]
雷帕霉素纳米原位凝胶滴眼剂的制备及其在体、离体研究
Ye Liu,Xu Chen,Xinghao Chen et al.
Ye Liu et al.
Sirolimus (SR) is a macrolide with antifungal and antitumor immunosuppressant properties, classified as a selective inhibitor of mammalian target of rapamycin (mTOR). In this study, an ionic in situ gel of SR (SR-SUS-ISG) was formulated usi...
Controllable self-cleaning FET self-assembled RNA-cleaving DNAzyme based DNA nanotree for culture-free Staphylococcus aureus detection [0.03%]
一种可控自清洁的场效应晶体管以及基于其对培养基无关型金黄色葡萄球菌检测的DNA纳米树传感器
Hui Wang,Ruipeng Chen,Yue He et al.
Hui Wang et al.
Staphylococcus aureus (SA) poses a serious risk to human and animal health, necessitating a low-cost and high-performance analytical platform for point-of-care diagnostics. Cellulose paper-based field-effect transistors (FETs) with RNA-clea...