Synergistic SDT/cuproptosis therapy for liver hepatocellular carcinoma: enhanced antitumor efficacy and specific mechanisms [0.03%]
协同SDT/铜死亡疗法治疗肝细胞癌：增强的抗肿瘤功效和特异性机制研究
Yucao Sun,Yichi Chen,Bolin Wu et al.
Yucao Sun et al.
The efficacy of sonodynamic therapy (SDT), an emerging approach for tumor treatment, is hindered by the high levels of the antioxidant glutathione (GSH) in the tumor microenvironment (TME). In this study, we constructed nanobubbles loaded w...
In situ size amplification strategy reduces lymphatic clearance for enhanced arthritis therapy [0.03%]
原位尺寸放大策略减少淋巴结清除以增强关节炎治疗效果
Xianyan Qin,Luhan Zhang,Yang-Bao Miao et al.
Xianyan Qin et al.
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by painful swelling and inflammation, arising from the immune system attacking on healthy cells. However, arthritic sites often experience increased lymph flow, hastening dru...
Exosome-delivered NR2F1-AS1 and NR2F1 drive phenotypic transition from dormancy to proliferation in treatment-resistant prostate cancer via stabilizing hormonal receptors [0.03%]
外泌体递送的NR2F1-AS1和NR2F1通过稳定激素受体驱动治疗抵抗性前列腺癌从休眠向增殖的表型转变
Wenbin Chen,Yiyou Mao,YiYuan Zhan et al.
Wenbin Chen et al.
Cancer cells acquire the ability to reprogram their phenotype in response to targeted therapies, yet the transition from dormancy to proliferation in drug-resistant cancers remains poorly understood. In prostate cancer, we utilized high-pla...
Asymmetrically PEGylated and amphipathic heptamethine indocyanine dyes potentiate radiotherapy of renal cell carcinoma via mitochondrial targeting [0.03%]
通过线粒体靶向增强肾细胞癌放射治疗的不对称PEG化和两亲性庚甲川吲哚青染料
Zifei Wu,Xie Huang,Chuan Wu et al.
Zifei Wu et al.
Enhancing the sensitivity of radiotherapy (RT) towards renal cell carcinoma (RCC) remains a challenge because RCC is a radioresistant tumor. In this work, we design and report asymmetrically Polyethylene Glycol (PEG)ylated and amphipathic h...
Apoptotic body based biomimetic hybrid nanovesicles to attenuate cytokine storms for sepsis treatment [0.03%]
基于凋亡小体的仿生杂化纳米囊泡用于减轻细胞因子风暴以治疗脓毒症
Hongbing Lan,Zhanhao Zhou,Qian Hu et al.
Hongbing Lan et al.
Sepsis is a severe immune response to pathogens that is associated with high mortality rate and a paucity of efficacious treatment options. It is characterized by the hyperactivation of macrophages and the occurrence of cytokine storms. Giv...
Shedding light on vascular imaging: the revolutionary role of nanotechnology [0.03%]
血管成像照进光明：纳米技术的革命性作用
Peisen Zhang,Yao Li,Xiaoqi Li et al.
Peisen Zhang et al.
Vascular dysfunction, characterized by changes in anatomy, hemodynamics, and molecular expressions of vasculatures, is closely linked to the onset and development of diseases, emphasizing the importance of its detection. In clinical practic...
Temperature induces brain-intake shift of recombinant high-density lipoprotein after traumatic brain injury [0.03%]
温度可使创伤性脑损伤后重组高密度脂蛋白从血液向脑内转运
Jialin Huang,Yidong Peng,Xin Wang et al.
Jialin Huang et al.
Traumatic brain injury (TBI) is one of the leading public health concerns in the world. Therapeutic hypothermia is routinely used in severe TBI, and pathophysiological hyperthermia, frequently observed in TBI patients, has an unclear impact...
Biomimetic astrocyte cell membrane-fused nanovesicles for protecting neurovascular units in hypoxic ischemic encephalopathy [0.03%]
仿生外泌体负载的星形胶质细胞膜融合纳米囊泡保护脑缺氧缺血损伤中的神经血管单元
Zihao Liu,Qian Xia,Chanyue Wang et al.
Zihao Liu et al.
Hypoxic ischemic encephalopathy (HIE) refers to neonatal hypoxic brain injury caused by severe asphyxia during the perinatal period. With a high incidence rate and poor prognosis, HIE accounts for 2.4% of the global disease burden, imposing...
3D cryo-printed hierarchical porous scaffolds provide immobilization of surface-functionalized sleep-inspired small extracellular vesicles: synergistic therapeutic strategies for vascularized bone regeneration based on macrophage phenotype modulation and angiogenesis-osteogenesis coupling [0.03%]
用于血管化骨再生的协同治疗策略基于巨噬细胞表型调节和成血管/成骨偶联：基于表面功能化的睡眠启发的小细胞外囊泡的固定化三维冷冻打印分级多孔支架
Xu-Ran Li,Qing-Song Deng,Shu-Hang He et al.
Xu-Ran Li et al.
Bone defect healing is a multi-factorial process involving the inflammatory microenvironment, bone regeneration and the formation of blood vessels, and remains a great challenge in clinical practice. Combined use of three-dimensional (3D)-p...
HDACi combination therapy with IDO1i remodels the tumor microenvironment and boosts antitumor efficacy in colorectal cancer with microsatellite stability [0.03%]
表观遗传治疗联合IDO抑制剂改变结直肠癌微环境中的免疫抑制从而提高治疗效果
Rongpu Liang,Dongbing Ding,Yiquan Li et al.
Rongpu Liang et al.
Background: Immunotherapy for colorectal cancer (CRC) with microsatellite stability (MSS) and mismatch repair proficiency (pMMR) has shown limited success in clinical trials. The combination of immunomodulators and immune...