Targeted nanoparticle delivery unleashes synergistic photothermal and immunotherapeutic effects against hepatocellular carcinoma [0.03%]
靶向纳米颗粒递送释放协同光热和免疫治疗效应以治疗肝细胞癌
Amal Babu,Sathiyamoorthy Padmanaban,Sahil Chahal et al.
Amal Babu et al.
The substantial mortality and morbidity of hepatocellular carcinoma, representing 90% of liver cancers, poses a significant health burden. The effectiveness of traditional hepatocellular carcinoma treatments such as surgical resection, radi...
Adipose-derived stem cell exosomes attenuates myofibroblast transformation via inhibiting autophagy through TGF-β/Smad2 axis in oral submucosal fibrosis [0.03%]
脂肪来源干细胞外泌体通过TGF-β/Smad2轴抑制自噬从而减轻口腔黏膜纤维化中肌成纤维细胞转化
Jinhao Xu,Yujing Wang,Zifei Shao et al.
Jinhao Xu et al.
Oral submucous fibrosis (OSF) is a precancerous condition that poses substantial health risks. OSF is mainly caused by betel nut chewing behavior, but its pathogenesis is still unclear and there is no effective treatment strategy. The trans...
Zinc-based radioenhancers to activate tumor radioimmunotherapy by PD-L1 and cGAS-STING pathway [0.03%]
基于锌的放射增效剂通过PD-L1和cGAS-STING途径激活肿瘤放射免疫治疗
Mengjiao Xu,Chao Xu,Yu Qiu et al.
Mengjiao Xu et al.
Radiotherapy and immunotherapy have already become the primary form of treatment for non-small-cell lung cancer (NSCLC), but are limited by high radiotherapy dose and low immune response rate. Herein, a multi-pronged strategy using a radio-...
Circulating plasma derived exosomes from systemic lupus erythematosus aggravate lupus nephritis through miR-122-5p/FOXO3-mediated macrophage activation [0.03%]
系统性红斑狼疮循环血浆来源的外泌体通过miR-122-5p/FOXO3介导的巨噬细胞活化加重狼疮性肾炎
Juan Ji,Qian He,Yunfei Xia et al.
Juan Ji et al.
Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease characterized by dysregulation in both innate and adaptive immunity. Polarization of macrophages into M1/M2 macrophages affects the development of lupus. Exosom...
Bacteria-activated macrophage membrane coated ROS-responsive nanoparticle for targeted delivery of antibiotics to infected wounds [0.03%]
一种细菌激活的巨噬细胞膜包被的ROS响应型载抗生素纳米颗粒用于感染伤口治疗研究
Ying Luo,Xiaoli Jia,Xiaozhuo Wu et al.
Ying Luo et al.
Bacterial infections and antibiotic resistance represent significant global public health challenges, necessitating the development of innovative antibacterial agents with targeted delivery capabilities. Our study utilized macrophages' natu...
Cartilage-targeting peptide-modified cerium oxide nanoparticles alleviate oxidative stress and cartilage damage in osteoarthritis [0.03%]
软骨靶向肽修饰的纳米氧化铈通过减轻氧化应激和软骨损伤治疗骨关节炎
Huangming Zhuang,Xunshan Ren,Huajie Li et al.
Huangming Zhuang et al.
Background: Osteoarthritis (OA) is a degenerative joint disease that leads to a substantial decline in the well-being of older individuals. Chondrocyte senescence and the resultant damage to cartilage tissue, induced by e...
Regulation of dynamic spatiotemporal inflammation by nanomaterials in spinal cord injury [0.03%]
纳米材料调节脊髓损伤的动态时空炎症反应
Zeping Liu,Chunyu Xiang,Xu Zhao et al.
Zeping Liu et al.
Spinal cord injury (SCI) is a common clinical condition of the central nervous system that can lead to sensory and motor impairment below the injury level or permanent loss of function in severe cases. Dynamic spatiotemporal neuroinflammati...
Sparstolonin B potentiates the antitumor activity of nanovesicle-loaded drugs by suppressing the phagocytosis of macrophages in vivo [0.03%]
Sparstolonin B通过体内抑制巨噬细胞的吞噬作用来增强纳米囊载药物抗肿瘤活性
Yuefeng Zhang,Zuo Mou,Wei Song et al.
Yuefeng Zhang et al.
Background: Extracellular vesicles (EVs) and extruded nanovesicles (ENVs) are promising nanovesicles (NVs) for drug delivery. However, the application of these NVs is strongly hindered by their short half-life in the circ...
Development and evaluation of a single domain antibody targeting folate receptor alpha for radioligand therapy [0.03%]
靶向叶酸受体α的单结构城抗体的开发及放射配体治疗评估
Jonatan Dewulf,Sam Massa,Laurent Navarro et al.
Jonatan Dewulf et al.
Background: Folate receptor alpha (FRα) overexpression is seen in many cancers. Radioligand therapy (RLT) has emerged as a promising tool to target FRα and has been investigated previously, but further progression was l...
Osteoblastic ferroptosis inhibition by small-molecule promoting GPX4 activation for peri-prosthetic osteolysis therapy [0.03%]
小分子活化GPX4治疗假体周围骨溶解诱导的成骨细胞铁死亡抑制研究
Xin Liu,Wei Wang,Feng Zhu et al.
Xin Liu et al.
Peri-prosthesis osteolysis (PPO) represents the most severe complication of total joint arthroplasty (TJA) surgery and imposes the primary cause of prosthesis failure and subsequent revision surgery. Antiresorptive therapies are usually pre...