Repolarizing neutrophils via MnO2 nanoparticle-activated STING pathway enhances Salmonella-mediated tumor immunotherapy [0.03%]
二氧化锰纳米粒子激活STING途径再极化中性粒细胞可增强沙门菌介导的肿瘤免疫治疗
Shan Lu,Ze Mi,Peng Liu et al.
Shan Lu et al.
Engineered Salmonella has emerged as a promising microbial immunotherapy against tumors; however, its clinical effectiveness has encountered limitations. In our investigation, we unveil a non-dose-dependent type of behavior regarding Salmon...
HiViPore: a highly viable in-flow compression for a one-step cell mechanoporation in microfluidics to induce a free delivery of nano- macro-cargoes [0.03%]
HiViPore：微流控中一步细胞机理穿孔的高活性随流压缩以诱导纳米至宏观载荷的自由递送
Maria Isabella Maremonti,Valeria Panzetta,Paolo Antonio Netti et al.
Maria Isabella Maremonti et al.
Background: Among mechanoporation techniques for intracellular delivery, microfluidic approaches succeed in high delivery efficiency and throughput. However, especially the entry of large cargoes (e.g. DNA origami, mRNAs,...
PD-L1 siRNA hitched polyethyleneimine-elastase constituting nanovesicle induces tumor immunogenicity and PD-L1 silencing for synergistic antitumor immunotherapy [0.03%]
基于聚乙烯亚胺和弹性酶的siRNA纳米囊泡递送系统诱导肿瘤免疫原性及PD-L1沉默协同抗肿瘤免疫治疗
Li Du,Yao Gong,Xiaoying Zhang et al.
Li Du et al.
Background: PD-1/PD-L1 blockade has become a powerful method to treat malignant tumors. However, a large proportion of patients still do not benefit from this treatment, due to low tumor immunogenicity and low tumor penet...
A multifunctional injectable, self-healing, and adhesive hydrogel-based wound dressing stimulated diabetic wound healing with combined reactive oxygen species scavenging, hyperglycemia reducing, and bacteria-killing abilities [0.03%]
一种多功能注射型、自修复性和黏附性的基于水凝胶的创面敷料，能刺激糖尿病创面愈合并兼具清除活性氧、降血糖和杀细菌等多种功能
Rong Chen,Pinkai Wang,Jiajun Xie et al.
Rong Chen et al.
The proficient handling of diabetic wounds, a rising issue coinciding with the global escalation of diabetes cases, poses significant clinical difficulties. A range of biofunctional dressings have been engineered and produced to expedite th...
Enzyme/ROS dual-sensitive nanoplatform with on-demand Celastrol release capacity for enhanced ulcerative colitis therapy by ROS scavenging, microbiota rebalancing, inflammation alleviating [0.03%]
一种酶/ROS双敏感的纳米平台，通过抗氧化、重塑肠道菌群和消炎能力实现增强型溃疡性结肠炎治疗及按需雷斯坦发布功能
Jinfeng Shi,Jiahui Zhou,Bo Liu et al.
Jinfeng Shi et al.
Background: The oral administration of drugs for treating ulcerative colitis (UC) is hindered by several factors, including inadequate gastrointestinal stability, insufficient accumulation in colonic lesions, and uncontro...
Extracellular matrix hydrogels with fibroblast growth factor 2 containing exosomes for reconstructing skin microstructures [0.03%]
含有成纤维细胞生长因子2的外泌体用于重构皮肤微细结构的细胞外基质水凝胶
Zheng Zhou,Ziheng Bu,Shiqiang Wang et al.
Zheng Zhou et al.
Decellularized extracellular matrix hydrogel (ECM hydrogel), a natural material derived from normal tissue with unique biocompatibility properties, is widely used for tissue repair. However, there are still problems such as poor biological ...
Targeted nanoparticles triggered by plaque microenvironment for atherosclerosis treatment through cascade effects of reactive oxygen species scavenging and anti-inflammation [0.03%]
由斑块微环境触发的用于级联抗氧化和抗炎治疗动脉粥样硬化的纳米粒子
Xianghong Luo,Mengjiao Zhang,Waicong Dai et al.
Xianghong Luo et al.
Inflammatory factors and reactive oxygen species (ROS) are risk factors for atherosclerosis. Many existing therapies use ROS-sensitive delivery systems to alleviate atherosclerosis, which achieved certain efficacy, but cannot eliminate exce...
Fast fabrication of "all-in-one" injectable hydrogels as antibiotic alternatives for enhanced bacterial inhibition and accelerating wound healing [0.03%]
快速制造“一体化”可注射水凝胶作为抗生素替代品以增强细菌抑制和加速伤口愈合
Juan Xin,Zhangyou Yang,Shurong Zhang et al.
Juan Xin et al.
Skin wound infection has become a notable medical threat. Herein, the polysaccharide-based injectable hydrogels with multifunctionality were developed by a simple and fast gelation process not only to inactivate bacteria but also to acceler...
NANO.PTML model for read-across prediction of nanosystems in neurosciences. computational model and experimental case of study [0.03%]
用于神经科学研究中纳米系统的类推预测的NANO.PTML模型。计算模型及实验案例研究
Shan He,Karam Nader,Julen Segura Abarrategi et al.
Shan He et al.
Neurodegenerative diseases involve progressive neuronal death. Traditional treatments often struggle due to solubility, bioavailability, and crossing the Blood-Brain Barrier (BBB). Nanoparticles (NPs) in biomedical field are garnering growi...
Differentiated management of ROS level in tumor and kidney to alleviate Cis-platinum induced acute kidney injury with improved efficacy [0.03%]
差异化调控肿瘤ROS水平与肾脏ROS水平以缓解顺铂致急性肾损伤并提高抗肿瘤疗效
Shiqi Zhu,Linlin Huo,Jie Zeng et al.
Shiqi Zhu et al.
Cisplatin (DDP) is a prevalent chemotherapeutic agent used in tumor therapy, yet DDP-induced acute kidney injury (AKI) severely limits its clinical application. Antioxidants as reactive oxygen species (ROS) scavengers can circumvent this ad...