CuOTeDsP nanotherapeutics enhance cuproptosis-mediated immunotherapy by modulating cholesterol metabolism in bladder cancer [0.03%]
CuOTeDsP纳米疗法通过调节胆固醇代谢增强膀胱癌中的铜死亡介导的免疫治疗
Hai Cai,Panpan Xue,Siyuan Liu et al.
Hai Cai et al.
Metal-organic nanostructures based on sono/chemo-nanodynamic synergy of TixOy/Ru reaction units: for ultrasound-induced dynamic cancer therapy [0.03%]
基于TixOy/Ru反应单元的声化学纳米动力协同金属有机纳米结构：用于超声波诱导的癌症动态治疗
Tao Jiang,Zixiang Tang,Shumiao Tian et al.
Tao Jiang et al.
Sonodynamic therapy (SDT) exhibits clinical potential for deep-tissue tumor treatment due to its deep tissue penetration and spatiotemporal controllability. Its core mechanism relies on ultrasound-activated sonosensitizers to generate react...
An adeno-associated virus gene therapy strategy for anti-obesity treatment by nanocarrier-based delivery systems [0.03%]
基于纳米载体的递送系统进行腺相关病毒肥胖治疗基因疗法策略
Li Li,Wang Wang,Rong Li et al.
Li Li et al.
Gut microbiota is increasingly recognized for its profound influence on host metabolism. However, the mechanisms underlying the distinct metabolic phenotype observed in germ-free (GF) mice are not fully understood. Here, the serum levels of...
Multifunctional nanoagent for enhanced cancer radioimmunotherapy via pyroptosis and cGAS-STING activation [0.03%]
一种多功能纳米剂通过激活细胞焦亡和cGAS-STING途径增强癌症放射免疫治疗的功效
Ziting Xu,Yang Gao,Li Zhang et al.
Ziting Xu et al.
The immunosuppressive tumor microenvironment (ITME) and inherent radioresistance of tumor cells limit the effectiveness of radioimmunotherapy and exacerbate immune evasion. To address these challenges, PEGylated Azacitidine-loaded and Mn2+-...
Injectable HAMA-CPC hydrogels loaded with high-yield 3D bioprinted adipose-derived stem cell small extracellular vesicles for increased bone repair [0.03%]
负载高收率3D生物打印脂肪源干细胞小细胞外囊泡的HAMA-CPC水凝胶促进骨修复增强效应
Wenbin Xu,Wenling Gao,Yi Zhang et al.
Wenbin Xu et al.
In the field of bone tissue engineering, the development of effective strategies for bone defect repair remains a major challenge. Herein, we report a novel approach involving the integration of high-yield 3D bioprinted adipose-derived stem...
Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review [0.03%]
利用天然聚合物增强外泌体稳定性及递送防治宫腔粘连和促进子宫内膜修复的研究进展综述
Wei Sun,Wei Xu,Miaomiao Xiao et al.
Wei Sun et al.
Intrauterine adhesions (IUAs) are defined as the formation of fibrotic scar tissue within the uterine cavity. They can lead to a range of complications, including hypomenorrhea, amenorrhea, infertility, and recurrent pregnancy loss. Convent...
Prunus mume derived extracellular vesicle-like particles alleviate experimental colitis via disrupting NEK7-NLRP3 interaction and inflammasome activation [0.03%]
梅花衍生的细胞外囊泡样颗粒通过破坏NEK7-NLRP3相互作用和凋亡小体活化来缓解实验性结肠炎
Qi Lv,Hongqiong Yang,Ying Xie et al.
Qi Lv et al.
Edible plant derived extracellular vesicle-like particles (EVLPs) have garnered attention as potential therapeutic agents for chronic inflammatory diseases. Prunus mume (PM) is a functional fruit known for its gastrointestinal benefits, yet...
Biomimetic phosphorus dendrimer multi-epitope nanovaccine enhances humoral and cellular immune response against African swine fever virus [0.03%]
类磷树形递呈多表位纳米疫苗可增强 ASFV 的体液和细胞免疫应答
Hong Duan,Aijuan Shen,Min Wang et al.
Hong Duan et al.
Using nanoparticles (NPs) as a platform for multivalent antigen display is an effective strategy to increase the immunogenicity of subunit vaccines, which can induce high levels of humoral and cellular immunity. In addition, antigens that t...
Recent advances in engineered exosome-based therapies for ocular vascular disease [0.03%]
工程化外体治疗眼血管疾病的新进展
Jian Guan,Fanhe Meng,Chuanzhuo Wang et al.
Jian Guan et al.
Ocular neovascular diseases (ONDs), including corneal neovascularization (CoNV), age-related macular degeneration (AMD) and diabetic retinopathy (DR), are among the leading causes of visual impairment worldwide. Current therapeutic strategi...
Delivery of an ERK inhibitor using bioactive lipid nanoparticles reduces angiogenesis and prevents oral squamous cell carcinoma development [0.03%]
利用生物活性脂质纳米颗粒输送ERK抑制剂可减少血管生成并预防口腔鳞状细胞癌的发生
Zixian Huang,Junyue Fang,Li Lin et al.
Zixian Huang et al.
Extracellular regulated protein kinases (ERK) signaling is aberrantly activated in oral squamous cell carcinoma (OSCC), and targeting ERK signaling with ERK1/2 inhibitors is a potential strategy for OSCC treatment. However, methods for the ...