Biomimetic nanocomplexes loading with evolocumab and curcumin for synergistic anti-atherosclerosis therapy in ApoE-/- mice [0.03%]
一种用于协同治疗动脉粥样硬化的仿生纳米复合物（evolocumab和姜黄素）的构建及评价研究
Yi Liu,Shengchao Ma,Feng Li et al.
Yi Liu et al.
Atherosclerosis (AS), a leading contributor to global cardiovascular mortality, is primarily driven by the dual pathological processes of chronic persistent inflammation and dysregulated lipid metabolism. Current clinical interventions are ...
Targeting CD39 boosts PD-1 blockade antitumor therapeutic efficacy via strengthening CD8 + TILs function and recruiting B cells in cervical cancer [0.03%]
靶向CD39通过增强宫颈癌中CD8+t细胞的功能和募集B细胞来提高PD-1阻断的抗肿瘤疗效
Lili Jiang,Tong Wu,Xinyu Qu et al.
Lili Jiang et al.
Although the programmed cell death protein 1 (PD-1) blockade has been authorized for the treatment of recurrent and metastatic cervical cancer (CC) patients, a significant proportion of CC patients show low objective response rates (ORR) to...
Sirtuin-3 activation by honokiol attenuated anesthesia/surgery-induced cognitive impairment and neuronal ferroptosis via inhibiting mitochondrial GPX4 acetylation [0.03%]
Honokiol通过抑制线粒体GPX4乙酰化激活Sirtuin-3来缓解麻醉/手术引起的认知障碍和神经元铁死亡
Lian Zeng,Pengchao Hu,Xuan Wang et al.
Lian Zeng et al.
Background: Perioperative neurocognitive disorder (PND), a prevalent neurological complication in elderly patients following anesthesia and surgery, has recently been linked to ferroptosis as a central pathogenic mechanis...
An integrated multi-mode detection platform based on CRISPR/Cas 12a and aptamers for ultra-sensitive identification of sulfamethazine and genes associated with sulfonamide resistance [0.03%]
基于CRISPR / Cas 12a和适配体的集成多功能检测平台超灵敏鉴定磺胺二甲嘧啶和耐磺胺类药物基因相关平台
Tao Zhang,Zongwu Meng,Haoyu Yu et al.
Tao Zhang et al.
The production and buildup of sulfamethazine (SMZ) and resistance genes for sulfonamide antibiotics (sul1) pose a serious risk to environmental and public health safety. Creating advanced sensing systems that are both highly sensitive and s...
In situ and dynamic screening of extracellular vesicles as predictive biomarkers in immune-checkpoint inhibitor therapies [0.03%]
免疫检查点抑制剂治疗中外泌体的原位和动态筛查以预测生物标志物
Yihe Wang,Yue Sun,Mengqi Liu et al.
Yihe Wang et al.
Extracellular vesicles (EVs) is promising in predicting the efficacy of immune checkpoint inhibitor (ICI) therapies. But it is challenging to determine the level of circulating EVs due to their variations in spatial and temporal distributio...
Gastrointestinal exposure to silica nanoparticles induced Alzheimer's disease-like neurotoxicity in mice relying on gut microbiota and modulation through TLR4/NF-κB and HDAC [0.03%]
基于肠道菌群介导的TLR4/NF-κB和HDAC调制的小鼠类似阿尔茨海默病的大脑神经毒性诱导了硅纳米颗粒的胃肠道暴露
Lisha Du,Benjie Wang,Xinyi Wang et al.
Lisha Du et al.
Background: Silica nanoparticles (SiO2 NPs) are widely used in the food and pharmaceutical industries and dramatically increase the health risks associated with gastrointestinal exposure. However, the neurotoxicological e...
Targeted tumor cell-intrinsic CTRP6 biomimetic codelivery synergistically amplifies ferroptosis and immune activation to boost anti-PD-L1 immunotherapy efficacy in lung cancer [0.03%]
靶向肿瘤细胞固有的CTRP6仿生共输送协同增强铁死亡和免疫激活以增强肺癌抗PD-L1免疫治疗效果
Songhua Cai,Jing Huang,Hongjie Fan et al.
Songhua Cai et al.
Background: Lung adenocarcinoma (LUAD) is a refractory tumor with high incidence, high mortality, and easy development of drug resistance. Represented by PD-L1, the rise of immunotherapy and multidrug combinations offers ...
In situ radiochemical doping of functionalized inorganic nanoplatforms for theranostic applications: a paradigm shift in nanooncology [0.03%]
用于治疗诊断应用的原位放射化学掺杂功能性无机纳米平台：纳米肿瘤学中的一个范式转变
Sanchita Ghosh,Yutong Liang,Weibo Cai et al.
Sanchita Ghosh et al.
In situ radiochemical doping presents a transformative approach for synthesizing radiolabeled inorganic nanoparticles (NPs) for cancer theranostics. Traditional radiolabeling techniques rely on bifunctional chelators, which often require ha...
A minimalist self-assembly nanosystem for cancer immunotherapy via multiple immune activation [0.03%]
一种用于癌症免疫治疗的最小化自组装纳米系统实现多重免疫激活作用
Weizhe Xu,Shiyuan Wang,Jiayi Zhang et al.
Weizhe Xu et al.
In recent years, anti-tumor immunity has emerged as a central focus in cancer research, with the rapid advancement of immunotherapy heralding a new era in cancer treatment. Despite the significant potential of immunotherapy, the use of sing...
Fucoidan-decorated metal-zoledronic acid nanocomplexes suppress tumor metastasis by inducing ferroptotic cell death and enhancing cancer immunotherapy [0.03%]
岩藻糖素修饰的金属-唑来磷酸纳米复合物通过诱导铁死亡和增强癌症免疫治疗来抑制肿瘤转移
Hsin-Ting Tsai,Chi Lin,Chu-Hung Chung et al.
Hsin-Ting Tsai et al.
Metastatic tumor cells that escape from immune surveillance are a dilemma in cancer treatment, and thus developing selective targeting agents to treat metastatic tumor and reinstate immune perception is imperative for clinical applications....