In-situ ²²³Ra-doped calcium-alginate composite microspheres: a high-LET and immunoactivating platform for α-particle radioembolization in hepatocellular carcinoma [0.03%]
原位掺杂²²³Ra的钙-海藻酸盐复合微球：一种用于肝细胞癌α粒子放射栓塞的高线性能量传递和免疫激活平台
Jinming Tian,Zeyu Zhang,Chao Cheng et al.
Jinming Tian et al.
Transarterial radioembolization (TARE) with β-emitting radionuclides is widely used for hepatocellular carcinoma (HCC), but its clinical efficacy remains to be further improved. α-particle-emitting radionuclides possess high linear energy...
Bacteria-powered LA@CaDGP biomotor: a multi-modal weapon integrating calcium overload, chemotherapy, and starvation for breast cancer therapy [0.03%]
细菌驱动的LA@CaDGP生物马达：一种集钙超载、化疗和饥饿为一体的治疗乳腺癌的多模态武器
Jingrong Huang,Yongcheng Tang,Kewei Xiang et al.
Jingrong Huang et al.
Chemotherapy remains a cornerstone in breast cancer treatment, but poor drug targeting compromises its efficacy and exacerbates side effects. To optimize drug delivery, we developed a novel bacteria-propelled biomotor system, designated as ...
RVG-targeted extracellular vesicles loaded with echinatin attenuate dopaminergic neurodegeneration via the IGF-2/PI3K/Akt pathway in Parkinson's disease mice [0.03%]
靶向递送岩白菜素的外泌体通过Igf-2/PI3K/AKT通路缓解帕金森病小鼠多巴胺能神经元损伤
Liuyan Ding,Yuchen Xiao,Zongtang Xu et al.
Liuyan Ding et al.
Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons. The development of effective neuroprotective therapies is severely hampered by the b...
Emerging nano-immunotherapeutic strategies achieve metastatic colorectal cancer precision therapy [0.03%]
新兴的纳米免疫治疗策略实现转移性结直肠癌的精准治疗
Songsong Jiang,Ziheng Zhang,Yongfei Mao et al.
Songsong Jiang et al.
Metastatic colorectal cancer (mCRC) poses significant therapeutic challenges due to its low immunogenicity, complex metastatic patterns, and highly immunosuppressive tumor microenvironment. Despite the success of immune checkpoint blockade ...
Targeted Inhibition of P. gingivalis OMV-derived TsRNA by tetrahedral framework nucleic acids promotes periodontal regeneration [0.03%]
靶向抑制四面体框架核酸介导的牙龈卟啉单胞菌OMVs衍生的小tsRNA促进牙周组织再生
Yumeng Cao,Xuan Li,Lin Jing et al.
Yumeng Cao et al.
Outer membrane vesicles (OMVs) derived from Porphyromonas gingivalis (P. gingivalis) exhibit substantially greater pathogenic potential than their parent bacteria, thereby contributing significantly to the pathogenesis of periodontitis. Her...
Endothelial-targeted modification of ginseng-derived exosomes for IL-6 SiRNA delivery ameliorates hepatic ischemia-reperfusion injury [0.03%]
人参外泌体靶向内皮细胞递送IL-6 siRNA缓解肝脏缺血再灌注损伤
Kaijun Huang,Xuanlin Zhang,Xufeng Yan et al.
Kaijun Huang et al.
Liver ischemia-reperfusion injury (IRI) serves as a critical pathological basis for post-hepatectomy liver failure and graft dysfunction following liver transplantation. Excessive inflammatory responses, oxidative stress, and cell death are...
Reinvigorating CD8+ T cells through ADRB1 blockade using copper-propranolol nanoparticles for enhanced immune checkpoint blockade therapy [0.03%]
利用铜质普萘洛尔纳米颗粒通过ADRB1阻滞活化CD8⁺T细胞增强免疫检查点阻滞疗法
Binshu Weng,Nan Zhu,Huirong Li et al.
Binshu Weng et al.
Currently, colorectal cancer ranks third in terms of global cancer incidence and second in terms of cancer-related mortality, posing a significant therapeutic challenge. However, the efficacy of immunotherapy is limited by the immunosuppres...
Biomimetic "Tendon Band-Aid" regulates inflammatory microenvironment and tenogenic differentiation for tendinopathy regeneration [0.03%]
模拟肌腱贴片调节炎症微环境和肌腱分化以治疗肌腱病
Tongtong Zhang,Chao Li,Jiakuo Yu et al.
Tongtong Zhang et al.
Tendinopathy (TDP) is a common yet challenging chronic degenerative condition characterized by disrupted inflammatory microenvironments, cellular dysfunction and tissue structural degradation. Drawing inspiration from the protective and dru...
Correction: Transcranial and precise optical neuromodulation mediated by NIR photoactive nanosheets [0.03%]
纠正：近红外光活性纳米片介导的颅内和精确光学神经调控
Deqi Yang,Ya Zhang,Yun Yuan et al.
Deqi Yang et al.
Published Erratum
Journal of nanobiotechnology. 2026 Jan 2;24(1):2. DOI:10.1186/s12951-025-03886-x 2026
Covalent organic framework-based electrochemical nanosensing: an emerging paradigm for early cancer diagnosis and longitudinal surveillance [0.03%]
基于共价有机框架的电化学纳米传感：一种新兴的癌症早期诊断和长期监测范式
Yue Zhang,Shuyi Chen,Jie Ma et al.
Yue Zhang et al.
The management of cancer relies crucially on early diagnosis and personalized treatment. Real-time analysis of tumor markers within the tumor microenvironment via liquid biopsy opens potential pathways for effective cancer treatment and imp...