Ethosomes-mediated tryptanthrin delivery as efficient anti-psoriatic nanotherapy by enhancing topical drug absorption and lipid homeostasis [0.03%]
以角鲨烷为载体的喜树素抗银屑病纳米药物传输体系的研究及其作用机制探讨
Pengyu Wang,Shihao Hong,Can Cao et al.
Pengyu Wang et al.
Psoriasis is a chronic, relapsing, and refractory immune-mediated skin disease with the etiology and pharmaceutical targets remaining unsatisfactorily addressed. Topical herbal-derived compounds, such as tryptanthrin (Tryp), have been consi...
Bei Li,Chen Qi,Yifan Zhang et al.
Bei Li et al.
Kidney diseases represent a diverse range of conditions that compromise renal function and structure which characterized by a progressive deterioration of kidney function, may ultimately necessitate dialysis or kidney transplantation as end...
β-Cyclodextrin-optimized supramolecular nanovesicles enhance the droplet/foliage interface interactions and inhibition of succinate dehydrogenase (SDH) for efficient treatment of fungal diseases [0.03%]
优化的超分子纳米囊泡增强液滴/叶界面相互作用和琥珀酸脱氢酶（SDH）抑制以有效治疗真菌病
Deng-Xuan Guo,Li Song,Jing-Han Yang et al.
Deng-Xuan Guo et al.
Background: Plant fungal diseases present a major challenge to global agricultural production. Despite extensive efforts to develop fungicides, particularly succinate dehydrogenase inhibitors (SDHIs), their effectiveness ...
Encapsulated lactiplantibacillus plantarum improves Alzheimer's symptoms in APP/PS1 mice [0.03%]
包被的植物乳杆菌改善APP / PS1小鼠阿尔茨海默病症状
Fangfang Hu,Qian Gao,Caiyun Zheng et al.
Fangfang Hu et al.
Background: Alzheimer's disease (AD) is a neurodegenerative disorder that can result in neurotoxicity and an imbalance in gut microbiota. Probiotics have been shown to play an important role in regulating the gut microbio...
An antimicrobial microneedle patch promotes functional healing of infected wounds through controlled release of adipose tissue-derived apoptotic vesicles [0.03%]
一种抗菌微针贴片通过控制释放脂肪组织来源的凋亡小体促进感染伤口的功能愈合
Yue Ma,Jia Dong,Maojiao Li et al.
Yue Ma et al.
The high incidence and mortality rates associated with acute and chronic wound infections impose a significant burden on global healthcare systems. In terms of the management of wound infection, the reconstruction and regeneration of skin a...
Apoptotic vesicles rescue impaired mesenchymal stem cells and their therapeutic capacity for osteoporosis by restoring miR-145a-5p deficiency [0.03%]
凋亡小体通过恢复miR-145a-5p缺陷来挽救受损间充质干细胞及其治疗骨质疏松症的潜力
Rong Zhang,Xiaodan Mu,Dawei Liu et al.
Rong Zhang et al.
Apoptotic vesicles (apoVs) play a vital role in various physiological and pathological conditions. However, we have yet to fully understand their precise biological effects in rescuing impaired mesenchymal stem cells (MSCs). Here, we proved...
A multifunctional composite scaffold responds to microenvironment and guides osteogenesis for the repair of infected bone defects [0.03%]
一种多功能复合支架响应微环境并引导成骨修复感染性骨缺损
Jiajia Sun,Haidi Zhu,Huan Wang et al.
Jiajia Sun et al.
Treating bone defect concomitant with microbial infection poses a formidable clinical challenge. Addressing this dilemma necessitates the implementation of biomaterials exhibiting dual capabilities in anti-bacteria and bone regeneration. Of...
Multifunctional carbomer based ferulic acid hydrogel promotes wound healing in radiation-induced skin injury by inactivating NLRP3 inflammasome [0.03%]
基于卡波姆的富马酸水凝胶通过灭活NLRP3炎性小体促进放射引起的皮肤损伤愈合
Congshu Huang,Chaoji Huangfu,Zhijie Bai et al.
Congshu Huang et al.
Background: Radiation-induced skin injury is a significant adverse reaction to radiotherapy. However, there is a lack of effective prevention and treatment methods for this complication. Ferulic acid (FA) has been identif...
Macrophage membrane-camouflaged biomimetic nanoparticles for rheumatoid arthritis treatment via modulating macrophage polarization [0.03%]
通过调节巨噬细胞极化治疗类风湿性关节炎的巨噬细胞膜伪装仿生纳米粒子
Renpeng Zhou,Song Xue,Yuanzhi Cheng et al.
Renpeng Zhou et al.
Rheumatoid arthritis (RA) is a debilitating autoimmune disease characterized by chronic joint inflammation and cartilage damage. Current therapeutic strategies often result in side effects, necessitating the development of targeted and safe...
A new strategy of using low-dose caffeic acid carbon nanodots for high resistance to poorly differentiated human papillary thyroid cancer [0.03%]
一种低剂量咖啡酸碳点用于治疗分化不良的人乳头状甲状腺癌的新策略
Jingwei Xin,Meiwei Song,Xiangling Liu et al.
Jingwei Xin et al.
Thyroid cancer is one of the most common endocrine malignancies in clinical practice. Traditional surgery and radioactive iodine ablation have poor treatment results for poorly differentiated thyroid cancer, and there is a risk of metastasi...