Microglia-derived iron-overloaded exosomes induce neuronal ferroptosis and aggravate neurological impairment after subarachnoid hemorrhage [0.03%]
蛛网膜下腔出血后小胶质细胞源性铁过载外泌体诱导神经元铁死亡及加重神经功能缺损
Yuchen Li,Bowen Sun,Zurong Yao et al.
Yuchen Li et al.
Subarachnoid hemorrhage (SAH) is a devastating stroke subtype often leading to poor neurological outcomes. Iron homeostasis imbalance is a key contributor to cognitive dysfunction in neurological diseases. Extracellular vesicles, including ...
Multimodal electroconductive PLGA-based scaffold orchestrates neuroprotection and regeneration following severe spinal cord injury [0.03%]
多模式电导性PLGA基支架在严重脊髓损伤后协同神经保护和再生作用
So-Yeon Park,Gyubin Kim,Yanting Liu et al.
So-Yeon Park et al.
Spinal cord injury (SCI) is a devastating neurological condition that has limited therapeutic options; thus, developing innovative regenerative strategies to treat SCI is necessary. This study presents a multifunctional scaffold system that...
Pathogen-microenvironment-responsive and antioxidant-buffered propiconazole nanofungicide for safe and effective fungal disease control [0.03%]
一种针对病原菌微环境响应的和具备抗氧化缓冲作用的丙硫菌唑纳米杀菌剂用于安全且高效的真菌病害防治
Xin Shi,Qizhen Zhang,Xunian Chang et al.
Xin Shi et al.
Pan Liang,Chenyan Zhao,Xin Peng et al.
Pan Liang et al.
Organ adhesions pose a significant clinical challenge, arising from factors such as congenital adhesions caused by embryonic developmental abnormalities, as well as acquired adhesions resulting from inflammation or surgery. This phenomenon ...
Nano-PROTACs for precision medicine: engineering strategies for enhanced targeting and potency [0.03%]
用于精准医疗的纳米PROTACs：增强靶向性和效力的工程策略
Xiaoping Yang,Dongmei Wang,Chunxiao Li et al.
Xiaoping Yang et al.
Proteolysis-targeting chimeras (PROTACs) represent a transformative therapeutic modality that leverages the endogenous ubiquitin-proteasome system (UPS) to achieve targeted protein degradation. These heterobifunctional molecules facilitate ...
Design and mechanistic insights into ZMF59/CpG: a complementary adjuvant system boosting immunity and safety in herpes zoster vaccines [0.03%]
ZMF59/CpG佐剂系统在带状疱疹疫苗中的设计及其机制研究与免疫原性及安全性评价
Lijun Bian,Dongdong Li,Jingying Zhou et al.
Lijun Bian et al.
Targeting TRIM25 as a therapeutic strategy to enhance ferroptosis in glioblastoma cells [0.03%]
靶向TRIM25以增强胶质母细胞瘤细胞铁死亡的治疗策略
Maorong Zhu,Yuxin Wu,Huihui Ou et al.
Maorong Zhu et al.
Background: Glioblastoma (GBM) is the most common malignant brain tumor with a dismal prognosis (< 7% 5-year survival) under current first-line treatment. While inducing programmed cell death (PCD) is a promising antitumo...
Cocrystal-inspired glycyrrhizic acid-azole nanoassemblies for synergistic biofilm disruption and immune modulation in fungal infections [0.03%]
甘草酸-唑类纳米组装体协同抗真菌生物被膜及免疫调控用于真菌感染治疗
Chen Wang,Chang Gao,Linna Qian et al.
Chen Wang et al.
Fungal biofilms represent a major therapeutic hurdle due to their drug resistance and immune evasion. Here, we report a cocrystal-inspired nano-assembly strategy that co-assembles glycyrrhizic acid (GA), a natural triterpenoid saponin, with...
Biomimetic PD-1-nanovesicles inducing tri-modal sonodynamic-chemo-immunotherapy for breast cancer therapy and lung metastasis inhibition [0.03%]
用于乳腺癌治疗和肺转移抑制的仿生PD-1-纳米囊泡诱导三模式声动力-化疗-免疫疗法
Wenjin Lin,Zhenhu Lin,Fen Fu et al.
Wenjin Lin et al.
Background: Current cancer therapeutic approaches demonstrate constrained efficacy and fail to effectively address tumor metastasis, underscoring the critical need for innovative treatment modalities. ...
A novel protein B2URF3 from Akkermansia muciniphila increased by intermittent fasting alleviates vascular calcification [0.03%]
间歇性禁食引起的肠道菌Akkermansia muciniphila分泌的蛋白B2URF3缓解血管钙化
Shi-Yu Zeng,Jiang-Hua Liu,Ying-Ying Xiang et al.
Shi-Yu Zeng et al.
Vascular calcification (VC) is a major contributor to cardiovascular morbidity and mortality, yet effective therapies are lacking. Here, we show that alternate-day intermittent fasting (IF1:1) attenuates vitamin D-induced VC in mice, wherea...