Mesenchymal stem cell-derived extracellular vesicles attenuate periductal fibrosis by inhibiting Th17 differentiation in human liver multilineage organoids and Mdr2-/- mice [0.03%]
人肝多能类器官和Mdr2-/-小鼠模型中，间充质干细胞源性外泌体通过抑制Th17分化缓解导管周围纤维化
Wenyi Chen,Xinyi Chen,Feiqiong Gao et al.
Wenyi Chen et al.
Primary sclerosing cholangitis (PSC) pathogenesis involves immune dysregulation, genetic factors, and bile duct pathology; however, a comprehensive pathogenesis model and effective therapeutic strategies remain limited. Here, we develop a n...
Nanomedicine in cardiovascular and cerebrovascular diseases: targeted nanozyme therapies and their clinical potential and current challenges [0.03%]
纳米医学在心血管和脑血管疾病中的应用：靶向纳酶治疗及其临床潜力与当前挑战
Yanhua Jiang,Yongjian Zhou,Zhe Li et al.
Yanhua Jiang et al.
Extracellular vesicles from ovarian cancer cells induce senescent lipid-laden macrophages to facilitate omental metastasis [0.03%]
卵巢癌细胞源外泌体可诱导衰老巨噬细胞促腹膜转移
Guoqing Li,Xiaoling Zhou,Wenhan Li et al.
Guoqing Li et al.
Background: Ovarian cancer exhibits striking metastatic tropism for the omentum, where lipid-laden macrophages are key mediators that fuel disease progression. However, the mechanisms governing their formation and pro-met...
Advanced therapeutic scaffolds of biomimetic periosteum for functional bone regeneration [0.03%]
功能性骨组织再生的仿生periosteum高级治疗支架
Archita Gupta,Kyung Wook Kim,Amal George Kurian et al.
Archita Gupta et al.
Treating chronic bone injuries and defects remains a significant challenge in orthopedic medicine, impacting patient mobility, recovery time, and healthcare costs. The periosteum, a specialized, vascularized connective tissue covering the o...
Bandgap-engineered proteinic near-infrared nanodots for localized precision cancer theranostics [0.03%]
基于能带隙工程的蛋白质近红外纳米点用于癌症精确诊断与治疗
Mou Seung Kim,In Ho Nam,Hyung Joon Cha et al.
Mou Seung Kim et al.
Hypoxia-augmented chemotherapy potentiates imaging-guided combinatorial radionuclide-sonodynamic therapy for pancreatic cancer [0.03%]
缺氧增强的化疗联合影像引导的放射性核素-声动力学治疗胰腺癌
Jie An,Kaile Chu,Xirong Li et al.
Jie An et al.
Radionuclide therapy and chemotherapy are effective for pancreatic cancer, yet their efficacy is often limited by tumor hypoxia. In this study, manganese porphyrin (MnTTP) and tirapazamine (TPZ) were encapsulated in polylactic-co-glycolic a...
Internalized polystyrene nanoplastics trigger testicular damage and promote ferroptosis via CISD1 downregulation in mouse spermatocyte [0.03%]
内源性聚苯乙烯纳米塑料通过下调CISD1诱导小鼠精母细胞睾丸损伤和促进铁死亡
Jing Lv,Guangyu Liu,Ziqi Wang et al.
Jing Lv et al.
Background: There is a growing body of research regarding the potential reproductive toxicity of microplastics and nanoplastics. However, the underlying mechanisms by which nanoplastics exposure adversely affects the test...
A comprehensive review of unlocking the potential of lignin-derived biomaterials: from lignin structure to biomedical application [0.03%]
全面解析 lignin 生物质材料的潜在应用：从结构到生物医学应用综述
Jixiang Zhao,Minyu Zhu,Wei Jin et al.
Jixiang Zhao et al.
Inspired by natural organisms, biomimetic materials with exceptional biocompatibility, degradability, and multifunctionality have emerged as promising candidates for biomedical applications. Lignin, a plant-derived organic polymer, has gain...
Quercetin combined with shTERT induces apoptosis in ovarian cancer via the P53/Bax pathway, and RGD-MSN/QR/shTERT nanoparticles enhance the therapeutic efficacy [0.03%]
槲皮素联合shTERT通过P53/Bax途径诱导卵巢癌细胞凋亡及RGD-MSN/QR/shTERT纳米颗粒增强其治疗效果
Guojie Chen,Weiwei Song,Xing Wang et al.
Guojie Chen et al.
Background: Ovarian cancer (OC) is a highly malignant gynecological tumor with poor current treatment effects. Telomerase reverse transcriptase (TERT) is an important component of telomerase and plays an important role in...
A fibrin gel-loaded Gouqi-derived nanovesicle (GqDNV) repairs the heart after myocardial infarction by inhibiting p38 MAPK/NF-κB p65 pathway [0.03%]
载地黄纳米囊泡通过抑制p38 MAPK/NF-κB p65通路修复心肌梗死后心脏组织损伤
Huan-Huan Zhou,Xiaolei Zhou,Jianqiu Pei et al.
Huan-Huan Zhou et al.
The restoration of cardiac function post-myocardial infarction (MI) remains a significant clinical challenge. Emerging evidence indicates that Goji berries ("Gouqi" in Chinese) and their extracts exhibit substantial cardioprotective propert...