Nanoplatforms for EGFR-TKI resistance reversion and immunoactivation in NSCLC by ER stress and siRNA intervention [0.03%]
通过内质网应激和siRNA干预逆转非小细胞肺癌中EGFR-TKI耐药性并激活免疫反应的纳米平台
Yingshan Qu,Yuping Jiang,Zhenzhen Zhu et al.
Yingshan Qu et al.
Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are considered as classic targeted drugs for EGFR-mutated non-small cell lung cancer (NSCLC), but induce EGFR-TKI-resistance and immunosu...
Artesunate-based macromolecular therapy attenuates neutrophilic asthma by targeting the BCAT1/Succinate/NLRP3 metabolite-immunity cascade [0.03%]
基于艺术赛特的宏观分子疗法通过靶向BCAT1/琥珀酸/NLRP3代谢-免疫级联反应来减轻中性粒细胞哮喘
Jing Gong,Min Zhou,Yue Huang et al.
Jing Gong et al.
Asthma is a chronic inflammatory respiratory disease worldwide. Its severe phenotypes, particularly the glucocorticoid-resistant ones, pose a major challenge, with neutrophilic inflammation being the key driver. However, no effective treatm...
High glucose-primed HUVEC-derived extracellular vesicles encapsulated in microgels boost diabetic ischaemic flap regeneration via HIF-1α/VEGF pathway [0.03%]
高糖预处理的HUVEC源性外泌体微凝胶通过HIF-1α/VEGF途径促进糖尿病缺血皮瓣再生
Sheng Ding,Siyu Liu,Shaoyang Kang et al.
Sheng Ding et al.
Diabetic wound healing poses a major clinical challenge. One of the promising therapy, the flap transplantation surgery exhibited unsatisfactorily low flap survival due to the intertwined pathological barriers: impaired angiogenesis, excess...
Nano-hydrogel-based delivery system for dihydroartemisinin to enhance cuproptosis and synergize with anti-PD-1 therapy in triple-negative breast cancer [0.03%]
纳米水凝胶递送系统通过增强铜死亡及与抗PD-1疗法协同作用来提高双氢青蒿素治疗三阴性乳腺癌的疗效
Qiaoli Yi,Fada Xia,Tong-Fei Li et al.
Qiaoli Yi et al.
As an aggressive subtype of breast cancer, triple-negative breast cancer (TNBC) displays limited therapeutic options and poor clinical prognosis. Thus, there is an urgent need for developing more effective treatment strategies to optimize t...
Clinical evaluation of photochromic nanoparticle tattoo ink: safety, tolerability, and performance of rewritable intradermal implants [0.03%]
光致变色纳米颗粒纹身墨水的临床评估：可重写皮下植入物的安全性、耐受性和性能
Keith McCurdy,Jesse L Butterfield,Hyejin Kwon et al.
Keith McCurdy et al.
'Smart tattoos' based on stimulus-responsive nanoparticles have emerged as a promising platform for intradermal biosensing and dynamic optical interfaces, yet translation to safe and sustained use in human skin remains largely untested. We ...
Jian-Bin Guan,Shan-Xi Wang,Ying-Guang Wang et al.
Jian-Bin Guan et al.
Objective: To develop and evaluate a mitochondria-targeted biomimetic nanoplatform (nMitoQ-SNA-CMT) for the treatment of intervertebral disc degeneration (IVDD). ...
ISL@mTOMV nanoparticles: a promising approach for VM-targeted therapy in breast cancer [0.03%]
ISL@mTOMV纳米粒：乳腺癌线粒体靶向治疗的新策略
Chengxiao Fu,Zhimin Li,Bowen Tang et al.
Chengxiao Fu et al.
Vasculogenic mimicry (VM) in breast cancer is recognized as an important non-endothelium-dependent vascular mechanism that promotes tumor invasiveness, survival, and metastatic potential; however, effective and specific intervention strateg...
Platelet concentrates integrated with tissue engineering scaffolds: a promising approach for wound healing application [0.03%]
用于伤口愈合的富含血小板血浆与组织工程支架集成：一种有前景的方法
Yinglin Xu,Chunlei Dai,Jianlin Huang et al.
Yinglin Xu et al.
Wound healing is a complex process involving various factors and reconstruction of tissue structures. Platelets and their bioactive substances play an indispensable role in various stages of wound healing. Tissue engineering scaffolds are i...
Restoration of macrophage mitochondrial dynamics and trafficking with enzymatic magnesium-manganese layered double hydroxide for osteoporotic therapy [0.03%]
用于骨质疏松治疗的酶诱导镁锰层状双氢氧化物修复巨噬细胞线粒体动态及运输能力
Wenwen Mao,Kehan Wang,Jingxian Mao et al.
Wenwen Mao et al.
Macrophages play pivotal roles at the interface of immune regulation and bone metabolism and frequently exhibit a proinflammatory phenotype that contributes to the osteoporotic microenvironment. We found that dysfunctional macrophages in th...
Cartilage targeted grape skin-derived extracellular vesicles ameliorate osteoarthritis by attenuating chondrocyte senescence [0.03%]
葡萄皮来源的细胞外囊泡靶向软骨并通过抑制软骨细胞衰老改善骨关节炎
Wanzhuo Chen,Luyu Niu,Yuezhou Wu et al.
Wanzhuo Chen et al.
Osteoarthritis (OA) is predominantly driven by chondrocyte senescence, accompanied by progressive cartilage degradation. Facing the substantial worldwide impact of this condition, creating sustainable and economical therapies has become inc...