Remote ischemia precondition protects against renal IRI through apoptosis associated vesicles carrying MIF protein via modulating DUSP6/JNK signaling axis [0.03%]
远程缺血预处理通过携带MIF蛋白的凋亡小体调节DUSP6 / JNK信号轴来预防肾IRI
Nieke Zhang,Zhicong Huang,Yi Xia et al.
Nieke Zhang et al.
Background: Remote ischemic preconditioning (rIPC) has been reported to protect against kidney ischemia-reperfusion injury (IRI) through the delivery of extracellular vesicles (EVs). Among these, apoptosis-induced compens...
Polypyrrole-ferric phosphate-methotrexate nanoparticles enhance apoptosis/ferroptosis of M1 macrophages via autophagy blockage for rheumatoid arthritis treatment [0.03%]
聚吡咯-三氧化二铁-甲氨蝶呤纳米颗粒通过阻断自噬促进M1巨噬细胞凋亡/铁死亡以治疗类风湿关节炎
Hui Liu,Haoyu Wan,Anbiao Zhang et al.
Hui Liu et al.
Rheumatoid arthritis (RA) is an inflammatory disease that progresses from synovial inflammation to cartilage and bone destruction. Eliminating pro-inflammatory M1 macrophages is a promising strategy for RA treatment, but is impeded by cytop...
The effects of Klotho delivering mesenchymal stem cell-derived small extracellular vesicles on acute kidney injury [0.03%]
克洛托多能间充质干细胞来源的小细胞外囊泡对急性肾损伤的影响
Xiao-Hui Deng,Zi-Cong Wu,Qi Sun et al.
Xiao-Hui Deng et al.
Acute kidney injury (AKI) is a life-threating syndrome characterized by sudden loss of kidney function, and its management is challenging and often suboptimal. Mesenchymal stem cells (MSCs) have shown promise in AKI therapy in pre-clinical ...
Genetically engineered T cell membrane-camouflaged nanoparticles triggered cuproptosis for synergistic bladder cancer photothermal-immunotherapy [0.03%]
基因工程T细胞膜伪装的纳米颗粒触发铜死用于协同膀胱癌光热-免疫治疗
Wen Deng,Yuan Chen,Yongke Bai et al.
Wen Deng et al.
Immunotherapy has become a promising and transformative approach for treating advanced or treatment-resistant bladder cancer (BCa). However, its efficacy remains limited due to the immunosuppressive tumor microenvironment (TME) and insuffic...
Automatic target-seeking nanoparticle inhibiting orthotopic drug-resistant colon cancer and liver metastases via regulating cancer cell adhesion and proliferation [0.03%]
一种可自动定位的纳米药物载体颗粒通过调节癌细胞黏附和增殖抑制原位耐药结肠癌及肝转移病灶
Shaobo Bai,Yang Sun,Miao Liu et al.
Shaobo Bai et al.
Galectin-3 (Gal-3) plays an important role in adhesion and proliferation of cancer cells. The level of Gal-3 in blood and the expression of Gal-3 in colon cancer tissue are significantly increased in patient with colon cancer. The elevated ...
Orchestrated Cu2+-coordinated tetracycline-porphyrin self-assembly remodels tumor microenvironment for photo-enhanced immuno-chemodynamic therapy [0.03%]
铜离子调控四环素-卟啉自组装重构肿瘤微环境增强光免疫化学动力学治疗
Xianbin Sun,Xinyi Wang,Xudong Li et al.
Xianbin Sun et al.
An ultra-sensitive and point-of-care time-resolved fluorescence immunochromatographic platform for trace-level brucellosis antibody rapid on-site detection [0.03%]
一种超灵敏的时间分辨荧光免疫层析平台技术用于布鲁氏病抗体现场快速检测
Bin Wang,Shusen Ji,Boya Li et al.
Bin Wang et al.
Tumor-microenvironment responsive nanomodulator for near infrared photothermal immunotherapy of hepatocellular carcinoma [0.03%]
肝癌近红外光热免疫治疗的肿瘤微环境响应型纳米调控剂
Fei Kong,Tian Xia,Xiaorong Zhu et al.
Fei Kong et al.
Recurrence and metastasis remain significant challenges in the clinical treatment of hepatocellular carcinoma (HCC). The integration of photodynamic therapy and immunotherapy has emerged as a promising strategy for treating cancer in terms ...
Advancing immunomodulation in organ transplantation: the therapeutic potential of self-assembled rapamycin nanoparticles in allograft rejection [0.03%]
器官移植中免疫调节的新进展：雷帕霉素纳米颗粒在预防同种异体移植排斥中的治疗潜力研究
Ruiqi Sun,Zhi Liang,Ning Wang et al.
Ruiqi Sun et al.
Background: Transplant rejection remains a significant challenge, necessitating effective post-transplant interventions. Although rapamycin (RAPA) is a recognized immunosuppressant, its utility is limited by poor solubili...
Cell-laden biomimetic microneedles reconstruct skin rete ridge and stem cell niche [0.03%]
含细胞的类组织微针重建皮肤乳头状突和干细胞生态位
Xiaohong Zhao,Zongze Wu,Yicheng Guo et al.
Xiaohong Zhao et al.
The traditional skin graft wound repair strategy for burns is unable to reconstruct the normal anatomy of the skin, resulting in quality problems such as scarring, which have always been the bottleneck of burn medicine. The skin rete ridge ...