Plant-derived exosome-like nanovesicles: a novel therapeutic perspective for skin diseases [0.03%]
植物来源的类外泌体纳米囊泡：皮肤疾病的新型治疗视角
Hui Liu,Tingru Dong,Can Dong et al.
Hui Liu et al.
Plant-derived exosome-like nanovesicles (PENs) are emerging as a unique class of bioactive nanocarriers with transformative potential in dermatology. Characterized by intrinsic biocompatibility, the ability to traverse biological barriers, ...
Scientometric analysis of extracellular vesicles in vision science (up to 2024) [0.03%]
视觉科学中外泌体的科学计量分析（截至2024年）
Fei Liao,Francisco Germain,Li Ma et al.
Fei Liao et al.
Background: Extracellular vesicles (EVs) in vision science have gained significant attention. However, a comprehensive scientometric analysis of the key major contributors, the current research landscape, and development ...
Outer membrane vesicles-based nano-regulator for cancer immunotherapy by modulating neutrophils N1 polarization and hitchhiking delivery [0.03%]
基于外膜囊泡的纳米调控器通过调节中性粒细胞N1极化和搭便车递送进行癌症免疫治疗
Xiaoning Liu,Qun Niu,Haoxiang Yang et al.
Xiaoning Liu et al.
Efficient eradication of cancer cells and enhanced tumor accumulation of drug via immune cells represent promising strategies for cancer treatment, yet they remain significant challenges. Inspired by neutrophils (NEs), we designed a novel n...
Photosensitive small intestinal submucosal hydrogels loaded with the KR-12-a5 peptide promote periodontal osteogenesis and antimicrobial activity [0.03%]
载有KR-12-a5肽的感光性小型肠黏膜下水凝胶促进牙周成骨和抗菌活性
Shiqing Ma,Qiquan Yan,Le Li et al.
Shiqing Ma et al.
Background: Periodontitis, a chronic inflammatory condition, causes progressive loss of oral soft and hard tissues. Current treatments struggle to balance antimicrobial efficacy with bone regeneration. This study aimed to...
ROS-degradable hydrogel delivering LOXL2-LNPs rescues disc degeneration by synchronously suppressing cellular senescence and oxidative damage [0.03%]
一种可降解的携带LOXL2-LNPs的水凝胶通过同步抑制细胞衰老和氧化损伤来拯救椎间盘退变
Jian Zhang,Yang Li,Rui Ding et al.
Jian Zhang et al.
Background: Intervertebral disc degeneration (IDD) is a chronic degenerative disorder marked by nucleus pulposus cells (NPCs) senescence and extracellular matrix (ECM) degradation, which is a key pathological factor leadi...
Neuroprotective effects of Berberine-loaded BMSCs-apoptotic extracellular vesicles on retinal ganglion cells: therapeutic potential for glaucomatous injury [0.03%]
载小檗碱的BMSCs凋亡外泌体对视网膜神经节细胞的神经保护作用：治疗青光眼损伤的潜力
Mengling You,Xuan Zhang,Zhou Zeng et al.
Mengling You et al.
Glaucoma is a leading cause of irreversible blindness, primarily driven by the progressive degeneration of retinal ganglion cells (RGCs). In this study, we report the novel application of bone marrow mesenchymal stem cells (BMSCs)-derived a...
Plastic tableware use, microplastic accumulation, and sperm quality: from epidemiological evidence to FOXA1/p38 mechanistic insights [0.03%]
关于塑料食具使用、微塑性蓄积及精子质量的流行病学证据与FOXA1/p38机制见解之间的关系研究
Jiayuan Qu,Jiayue Zeng,Li Mou et al.
Jiayuan Qu et al.
Microplastics (MPs), as emerging contaminants, may adversely affect male reproductive health. This study investigated the potential association between MP accumulation in human semen and sperm quality. Furthermore, the molecular mechanisms ...
Mitochondria-targeting polymer cLipG/CuET activates the cGAS/STING pathway to enhance cholangiocarcinoma immunotherapy [0.03%]
线粒体靶向聚合物cLipG/CuET激活cGAS/STING通路以增强肝内胆管癌免疫治疗
Ge Bai,Hongwen Liu,Wei Li et al.
Ge Bai et al.
Background: The remodeling of extracellular matrix often fails chemotherapeutic agents to fight intrahepatic cholangiocarcinoma (ICC). The cGAS/STING pathway can trigger the innate immune response to obtain better immunot...
Hybrid metallic nanozyme with nitric oxide-releasing photothermal coating for accelerated infected diabetic wound healing [0.03%]
一种用于加速糖尿病感染伤口愈合的含一氧化氮释放光热涂层的金属纳米酶杂化材料
Sri Ganga Padaga,Milan Paul,Tonmoy Banerjee et al.
Sri Ganga Padaga et al.
Infected diabetic wounds are prone to developing bacterial biofilms and are difficult to treat due to a lack of strategies that can eliminate drug-resistant bacteria. Conventional antibiotics can't achieve the desired antibacterial effect d...
Bispecific self-assembled peptides as supra-growth factors for preventing endotheliopathy and improving survival of traumatic brain injury in mice [0.03%]
双特异肽自组装体在预防内皮细胞病变和改善小鼠创伤性脑损伤存活率方面的功效研究
Yichi Zhang,Lanxing Wang,Dandan Li et al.
Yichi Zhang et al.
Traumatic brain injury (TBI) causes endothelial injury (endotheliopathy), which contributes to a cascade of adverse events, including cerebral hemorrhage, edema and acute lung injury (ALI), and leads to poor clinical outcomes. Protecting en...