Biomimetic nanocarriers in cancer therapy: based on intercellular and cell-tumor microenvironment communication [0.03%]
仿生纳米载体在癌症治疗中的应用基于细胞间及细胞与肿瘤微环境的交流沟通
He Mengyuan,Li Aixue,Gu Yongwei et al.
He Mengyuan et al.
Inspired by the concept of "natural camouflage," biomimetic drug delivery systems have emerged to address the limitations of traditional synthetic nanocarriers, such as poor targeting, susceptibility to identification and clearance, inadequ...
Co-freezing localized CRISPR-Cas12a system enables rapid and sensitive nucleic acid analysis [0.03%]
共冷冻局部化CRISPR-Cas12a系统可实现快速灵敏的核酸检测
Lifeng Zhang,Shihua Luo,Wenbin Li et al.
Lifeng Zhang et al.
Rapid and sensitive nucleic acid detection is vital in disease diagnosis and therapeutic assessment. Herein, we propose a co-freezing localized CRISPR-Cas12a (CL-Cas12a) strategy for sensitive nucleic acid detection. The CL-Cas12a was obtai...
Personalized mRNA vaccines in glioblastoma therapy: from rational design to clinical trials [0.03%]
个性化mRNA疫苗在胶质母细胞瘤治疗中的应用：从理性设计到临床试验
Iman Karimi-Sani,Zahra Molavi,Samaneh Naderi et al.
Iman Karimi-Sani et al.
Glioblastomas (GBMs) are the most common and aggressive malignant brain tumors, presenting significant challenges for treatment due to their invasive nature and localization in critical brain regions. Standard treatment includes surgical re...
3D-printing hydrogel programmed released exosomes to restore aortic medial degeneration through inhibiting VSMC ferroptosis in aortic dissection [0.03%]
用于抑制主动脉夹层平滑肌细胞铁死亡从而通过程序化释放外泌体来修复主动脉中膜退行性变的3D打印水凝胶
Weitie Wang,Qing Liu,Qiwei Yang et al.
Weitie Wang et al.
Aortic dissection (AD) is a devastating disease with a high mortality rate. Exosomes derived from mesenchymal stem cells (exo-MSCs) offer a promising strategy to restore aortic medial degeneration and combat ferroptosis in AD. However, thei...
Targeted blood-brain barrier penetration and precise imaging of infiltrative glioblastoma margins using hybrid cell membrane-coated ICG liposomes [0.03%]
利用混合细胞膜包被的吲哚菁绿脂质体实现浸润性胶质母细胞瘤边界的靶向血脑屏障递送与精准成像
Ping Liu,Siyi Lan,Duyang Gao et al.
Ping Liu et al.
Surgical resection remains the primary treatment modality for glioblastoma (GBM); however, the infiltrative nature of GBM margins complicates achieving complete tumor removal. Additionally, the blood-brain barrier (BBB) poses a formidable c...
Jiasheng Yuan,Huquan Zhu,Shixinyi Li et al.
Jiasheng Yuan et al.
Background: The urgent need for affordable and rapid detection methodologies for foodborne pathogens, particularly Escherichia coli (E. coli), highlights the importance of developing efficient and widely accessible diagno...
Modification of transvaginal polypropylene mesh with co-axis electrospun nanofibrous membrane to alleviate complications following surgical implantation [0.03%]
通过同轴静电纺纳米纤维膜对经阴道聚丙烯网片进行改性以减轻植入后的手术并发症
Tao Guo,Xuechun Hu,Zhe Du et al.
Tao Guo et al.
Background: Surgeries for treating pelvic organ prolapse involving the utilization of synthetic mesh have been associated with complications such as mesh erosion, postoperative pain, and dyspareunia. This work aimed to re...
Integrated triple signal amplification strategy for ultrasensitive electrochemical detection of gastric cancer-related microRNA utilizing MoS2-based nanozyme, hybridization chain reaction, and horseradish peroxidase [0.03%]
利用二硫化钼纳米酶、杂交链反应和辣根过氧化物酶的一体化三信号放大策略用于胃癌相关microRNA的超灵敏电化学检测
Jianfeng Ma,Qunyan Yao,Suo Lv et al.
Jianfeng Ma et al.
Early diagnosis and treatment of gastric cancer (GC) play a vital role in improving efficacy, reducing mortality and prolonging patients' lives. Given the importance of early detection of gastric cancer, an electrochemical biosensor was dev...
NIR-activatable nitric oxide generator based on nanoparticles loaded small-molecule photosensitizers for synergetic photodynamic/gas therapy [0.03%]
基于负载小分子光敏剂的纳米粒子的近红外激活一氧化氮发生器用于协同光动力/气体治疗
Lili Fu,Yan Huang,Xin Shan et al.
Lili Fu et al.
Background: Therapeutic approaches that combine conventional photodynamic therapy (PDT) with gas therapy (GT) to sensitize PDT are an attractive strategy, but the molecular structure design of the complex lacks effective ...
Superior antitumor immune response achieved with proton over photon immunoradiotherapy is amplified by the nanoradioenhancer NBTXR3 [0.03%]
纳米放疗增强剂NBTXR3可放大质子治疗较光子治疗所达到的更强的抗肿瘤免疫反应
Yun Hu,Sébastien Paris,Narayan Sahoo et al.
Yun Hu et al.
Recent findings suggest that immunoradiotherapy (IRT), combining photon radiotherapy (XRT) or proton radiotherapy (PRT) with immune checkpoint blockade, can enhance systemic tumor control. However, the comparative efficacy of XRT and PRT in...