Visualizing spatiotemporal pattern of vascularization by SWIR fluorescence imaging in a mouse model of perforator flap transplantation [0.03%]
通过SWIR荧光成像在穿支皮瓣移植小鼠模型中可视化血管化的时空模式
Sijia Feng,Mo Chen,Huizhu Li et al.
Sijia Feng et al.
Vascularization as a spatiotemporally interlaced process involving angiogenesis and vascular remodeling, has seldom been investigated comprehensively regarding the interrelationship of the two intertwining but sequential processes. Here, a ...
A novel perspective on the regulation of cardiac cell beating: cardiac cell under mechanical stimulation acts as "cell activation button" to activate adjacent cardiac cell [0.03%]
心脏细胞搏动调节的新观点：机械刺激下的心脏细胞作为“细胞激活按钮”来激活相邻的心脏细胞
Zhaotong Chu,Yujie Zhang,Yidi Zhang et al.
Zhaotong Chu et al.
The regulation of cardiac cell beating is of great significance for understanding cardiac coordination mechanisms and the treatment of cardiovascular diseases. Inspired by this natural "cell regulates cell" mode in which sinoatrial node cel...
MSCs-EVs harboring OA immune memory reprogram macrophage phenotype via modulation of the mt-ND3/NADH-CoQ axis for OA treatment [0.03%]
携带OA免疫记忆的MSCs-EVs通过调节mt-ND3/NADH-CoQ轴来重新编程巨噬细胞表型以治疗OA
Jingdi Zhan,Jing Zou,Qiming Pang et al.
Jingdi Zhan et al.
Background: Osteoarthritis (OA) is a prevalent degenerative joint disease and current therapies are insufficient to halt its progression. Mesenchymal stem cells-derived extracellular vesicles (MSCs-EVs) offer promising th...
Frontier applications of retinal nanomedicine: progress, challenges and perspectives [0.03%]
视网膜纳米药物的前沿应用：进展、挑战与展望
Zhimin Tang,Fuxiang Ye,Ni Ni et al.
Zhimin Tang et al.
The human retina is a fragile and sophisticated light-sensitive tissue in the central nervous system. Unhealthy retinas can cause irreversible visual deterioration and permanent vision loss. Effective therapeutic strategies are restricted t...
Influences of lead-based perovskite nanoparticles exposure on early development of human retina [0.03%]
铅基钙钛矿纳米颗粒暴露对人类视网膜早期发育的影响
Cao Yang,Zhulin Du,Linqiang Mei et al.
Cao Yang et al.
Background: Lead-based perovskite nanoparticles (Pb-PNPs) are widely utilized in the photovoltaic industry. However, due to their poor stability and high water solubility, lead often gets released into the environment, wh...
Li Yan,Zeyang Liu,Yulian Zeng et al.
Li Yan et al.
Long-term exposure to ultraviolet B (UVB) radiation induces the accumulation of free radicals in the skin, resulting in oxidative damage and accelerated aging. As a natural anti-oxidant, squalene has been applied as a cosmetic additive. Non...
Emerging strategies against accelerated blood clearance phenomenon of nanocarrier drug delivery systems [0.03%]
针对纳米载药系统加速血液清除现象的策略进展
Jianquan Pan,Yanyan Wang,Yunna Chen et al.
Jianquan Pan et al.
Nanocarrier drug delivery systems (NDDS) have gained momentum in the field of anticancer or nucleic acid drug delivery due to their capacity to aggrandize the targeting efficacy and therapeutic outcomes of encapsulated drugs. A disadvantage...
Decellularized tissue matrices hydrogels functionalized with extracellular vesicles promote macrophage reprogramming and neural stem cell differentiation for spinal cord injury repair [0.03%]
负载细胞外囊泡的脱细胞组织基质水凝胶通过促进巨噬重编程和神经干细胞分化修复脊髓损伤
Ming Deng,Ping Xie,Hongyang Xue et al.
Ming Deng et al.
This study investigates the application of decellularized tissue matrices (DSCM) hydrogels functionalized with extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) for spinal cord injury (SCI) treatment. The primary fo...
Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cGAS-STING activation for enhancing triple-negative breast cancer immunotherapy [0.03%]
锌铜双金属纳米平台触发光热放大铜死亡和cGAS-STING激活以增强三阴性乳腺癌免疫治疗
Bangyi Zhou,Mengyao Chen,Zhixing Hao et al.
Bangyi Zhou et al.
Triple-negative breast cancer (TNBC) is characterized by high rates of metastasis and recurrence, along with a low sensitivity to immunotherapy, resulting in a paucity of effective therapeutic strategies. Herein, we have developed polydopam...
RSL3-loaded nanoparticles amplify the therapeutic potential of cold atmospheric plasma [0.03%]
负载RSL3的纳米粒子增强了冷大气等离子体的治疗潜力
Xiaona Cao,Mo Chen,Tianxu Fang et al.
Xiaona Cao et al.
Cold atmospheric plasma (CAP) has exhibited exciting potential for cancer treatment. Reactive oxygen and nitrogen species (RONS), the primary constituents in CAP, contribute to cancer cell death by elevating oxidative stress in cells. Howev...