Proton nanomodulators for enhanced Mn2+-mediated chemodynamic therapy of tumors via HCO3- regulation [0.03%]
通过调节HCO3-增强Mn2+介导的化疗动力学疗法的质子纳米调控剂
Peng Yang,Shaojie Liu,Zhuang Chen et al.
Peng Yang et al.
Background: Mn2+-mediated chemodynamic therapy (CDT) has been emerged as a promising cancer therapeutic modality that relies heavily on HCO3- level in the system. Although the physiological buffers (H2CO3/HCO3-) provide c...
Self-assembly antimicrobial peptide for treatment of multidrug-resistant bacterial infection [0.03%]
用于治疗多重耐药细菌感染的抗菌肽自组装体系
Xuanxuan Ma,Na Yang,Ruoyu Mao et al.
Xuanxuan Ma et al.
The wide-spreading of multidrug resistance poses a significant threat to human and animal health. Although antimicrobial peptides (AMPs) show great potential application, their instability has severely limited their clinical application. He...
Losartan-based nanocomposite hydrogel overcomes chemo-immunotherapy resistance by remodeling tumor mechanical microenvironment [0.03%]
基于洛萨坦的纳米复合水凝胶通过重塑肿瘤机械微环境来克服化疗免疫治疗耐药性
Xiaodong Hou,Yuting Shen,Bin Huang et al.
Xiaodong Hou et al.
Preclinical studies demonstrating high cure rates with PD1/PD-L1 combinations have led to numerous clinical trials, but emerging results are disappointing. These combined immunotherapies are commonly employed for patients with refractory tu...
Magnetic vagus nerve stimulation ameliorates contrast-induced acute kidney injury by circulating plasma exosomal miR-365-3p [0.03%]
磁性迷走神经刺激通过循环血浆外泌体miR-365-3p改善对比剂介导的急性肾损伤
Tianyu Wu,Wenwu Zhu,Rui Duan et al.
Tianyu Wu et al.
Background: Contrast-induced acute kidney injury (CI-AKI) is manifested by a rapid decline in renal function occurring within 48-72 h in patients exposed to iodinated contrast media (CM). Although intravenous hydration is...
Magnetic targeting enhances the neuroprotective function of human mesenchymal stem cell-derived iron oxide exosomes by delivering miR-1228-5p [0.03%]
磁性靶向通过递送miR-1228-5p增强人间充质干细胞源铁氧体外泌体的神经保护功能
Wei-Jia Hu,Hong Wei,Li-Li Cai et al.
Wei-Jia Hu et al.
Background: Treating mitochondrial dysfunction is a promising approach for the treatment of post-stroke cognitive impairment (PSCI). HuMSC-derived exosomes (H-Ex) have shown powerful therapeutic effects in improving mitoc...
Macrophage membrane-functionalized manganese dioxide nanomedicine for synergistic treatment of atherosclerosis by mitigating inflammatory storms and promoting cholesterol efflux [0.03%]
用于缓解炎症风暴和促进胆固醇流出协同治疗动脉粥样硬化的巨噬细胞膜功能化锰 dioxide 纳米药物
Sijin Chen,Wenli Zhang,Chun Tang et al.
Sijin Chen et al.
Atherosclerosis (AS) poses a significant threat to human life and health. However, conventional antiatherogenic medications exhibit insufficient targeting precision and restricted therapeutic effectiveness. Moreover, during the progression ...
Engineering dendritic cell biomimetic membrane as a delivery system for tumor targeted therapy [0.03%]
工程化仿树突状细胞膜作为肿瘤靶向治疗的输送系统
Huiyang Liu,Yiming Lu,Jinbao Zong et al.
Huiyang Liu et al.
Targeted immunotherapies make substantial strides in clinical cancer care due to their ability to counteract the tumor's capacity to suppress immune responses. Advances in biomimetic technology with minimally immunogenic and highly targeted...
S-RBD-modified and miR-486-5p-engineered exosomes derived from mesenchymal stem cells suppress ferroptosis and alleviate radiation-induced lung injury and long-term pulmonary fibrosis [0.03%]
来源于间充质干细胞经S-RBD修饰和miR-486-5p工程化的外泌体通过抑制铁死亡改善放射性肺损伤及长期肺纤维化
Wei-Yuan Zhang,Li Wen,Li Du et al.
Wei-Yuan Zhang et al.
Background: Radiation-induced lung injury (RILI) is associated with alveolar epithelial cell death and secondary fibrosis in injured lung. Mesenchymal stem cell (MSC)-derived exosomes have regenerative effect against lung...
Asim Mushtaq,Muhammad Zubair Iqbal,Jianbin Tang et al.
Asim Mushtaq et al.
Global mortality data indicates cancer as the second-leading cause of death worldwide. Therefore, there's a pressing need to innovate effective treatments to address this significant medical and societal challenge. In recent years, X-ray-in...
Multifunctional nanoplatform with near-infrared triggered nitric-oxide release for enhanced tumor ferroptosis [0.03%]
具有近红外触发一氧化氮释放的多功能纳米平台促进肿瘤铁死亡增强效应
Min Wang,Zhuangli Zhang,Qianqian Li et al.
Min Wang et al.
Ferroptosis has emerged as a promising strategy for cancer treatment. Nevertheless, the efficiency of ferroptosis-mediated therapy remains a challenge due to high glutathione (GSH) levels and insufficient endogenous hydrogen peroxide in the...