Macrophage-derived mitochondria-rich extracellular vesicles aggravate bone loss in periodontitis by disrupting the mitochondrial dynamics of BMSCs [0.03%]
巨噬细胞衍生的富线粒体胞外囊泡通过破坏BMSCs的线粒体动态平衡加剧牙周炎的骨质流失
Jiayin Yan,Tian Yang,Siyuan Ma et al.
Jiayin Yan et al.
Background: Periodontitis is the leading cause of tooth loss in adults due to progressive bone destruction, which is closely related to the dysfunction of bone mesenchymal stem cells (BMSCs). Existing evidence suggests th...
Acid-responsive aggregated carrot-derived nanoantioxidants alleviate oxidative stress and restore osteoblast activity [0.03%]
响应酸性的胡萝卜衍生聚集纳米抗氧化剂，缓解氧化应激并恢复骨细胞活性
Jiao Peng,Rongyan Liu,Junyi Xu et al.
Jiao Peng et al.
Background: Excessive generation of reactive oxygen species is a hallmark of the osteoporotic bone microenvironment, which leads to the damage of mitochondrial function and the deactivation of osteoblasts. Fruits and vege...
Mesenchymal stem cell-derived extracellular vesicles alleviate autism by regulating microglial glucose metabolism reprogramming and neuroinflammation through PD-1/PD-L1 interaction [0.03%]
间充质干细胞衍生的细胞外囊泡通过PD-1/PD-L1相互作用调节小胶质细胞糖代谢重编程和神经炎症，从而缓解自闭症
Qian Qin,Linlin Fan,Xin Zeng et al.
Qian Qin et al.
Neuroinflammation triggered by microglia activation is hallmark of autism spectrum disorder (ASD), and this process includes crucial metabolic reprogramming from oxidative phosphorylation to glycolysis, which may cause neuron loss and funct...
Young fibroblast-derived migrasomes alleviate keratinocyte senescence and enhance wound healing in aged skin [0.03%]
年轻成纤维细胞衍生的迁移体可缓解老年皮肤角质细胞衰老并促进伤口愈合
Hanlin Tu,Yingliang Shi,Yi Guo et al.
Hanlin Tu et al.
Background: Alterations in intercellular communication driven by cellular senescence constitute an important factor in skin aging. Migrasome, a newly discovered vesicular organelle, efficiently participates in intercellul...
Mitochondria-targeted nanovesicles for ursodeoxycholic acid delivery to combat neurodegeneration by ameliorating mitochondrial dysfunction [0.03%]
针对线粒体的牛磺胆酸纳米载体通过改善线粒体功能障碍来对抗神经退行性疾病
Shizheng Zhang,Mengmeng Li,Yuan Li et al.
Shizheng Zhang et al.
Mitochondria are pivotal in sustaining oxidative balance and metabolic activity within neurons. It is well-established that mitochondrial dysfunction constitutes a fundamental pathogenic mechanism in neurodegeneration, especially in the con...
Regulation of immune microenvironments by polyetheretherketone surface topography for improving osseointegration [0.03%]
聚醚醚酮表面形态对免疫微环境的调控作用及其对骨整合的影响
Yuqing Zhao,Yanxin An,Fan Wu et al.
Yuqing Zhao et al.
Optimizing the immune microenvironment is essential for successful implant osseointegration. In this study, four different nano/microstructures were fabricated on polyetheretherketone (PEEK) substrates by varying the agitation speed during ...
CREB1/CRTC2 regulated tubular epithelial-derived exosomal miR-93-3p promotes kidney injury induced by calcium oxalate via activating M1 polarization and macrophage extracellular trap formation [0.03%]
CREB1/CRTC2调控的管状上皮源性外泌体miR-93-3p通过激活M1极化和巨噬细胞胞外诱捕结构的形成促进草酸钙诱导的肾脏损伤
Yushi Sun,Bojun Li,Baofeng Song et al.
Yushi Sun et al.
Background: Calcium oxalate (CaOx) crystals are known to cause renal injury and trigger inflammatory responses. However, the role of exosome-mediated epithelial-macrophage communication in CaOx-induced kidney injury remai...
MXene-based nanosheet for enhanced glioma therapy via photonic hyperthermia to boost the abscopal effect of radioimmunotherapy [0.03%]
基于MXene纳米片通过光子热疗增强胶质瘤疗法以促进放免疫疗法的旁观者效应
Huan Zhu,Zhaoyuan Zhang,Rong Jiang et al.
Huan Zhu et al.
Radiotherapy (RT) effectiveness is limited by low DNA damage in tumor cells, surrounding tissue harm, and tumor radioresistance with active DNA repair. Herein, we have engineered a two-dimensional nanomaterial consisting of MXene nanosheets...
Ginseng exosomes modulate M1/M2 polarisation by activating autophagy and target IKK/IкB/NF-кB to alleviate inflammatory bowel disease [0.03%]
人参外泌体通过激活自噬作用调节M1/M2极化，并靶向IKK/IкB/NF-кB以减轻炎症性肠病
Song Yang,Liangliang Fan,Lijia Yin et al.
Song Yang et al.
Background: Exosomes are involved in intercellular communication and regulation of the inflammatory microenvironment. In a previous study, we demonstrated that fresh ginseng exosomes (GEs) alleviated inflammatory bowel di...
Renal-clearable and tumor-retained nanodots overcoming metabolic reprogramming to boost mitochondrial-targeted photodynamic therapy in triple-negative breast cancer [0.03%]
可被肾脏清除并可在肿瘤内保留的纳米点克服代谢重编程以提升三阴性乳腺癌线粒体光动力治疗效果
Defan Yao,Yanshu Wang,Xue Dong et al.
Defan Yao et al.
Background: Targeting tumor metabolism reprogramming has demonstrated a synergistic antitumor effect in photodynamic therapy of triple-negative breast cancer (TNBC). However, such a combination therapeutic regimen has enc...