Multidimensional applications of prussian blue-based nanoparticles in cancer immunotherapy [0.03%]
普鲁士蓝基纳米颗粒在癌症免疫治疗中的多维应用
Jiayi Zhang,Fang Wang,Zhaogang Sun et al.
Jiayi Zhang et al.
Immunotherapy holds notable progress in the treatment of cancer. However, the clinical therapeutic effect remains a significant challenge due to immune-related side effects, poor immunogenicity, and immunosuppressive microenvironment. Nanop...
Conditioning period impacts the morphology and proliferative effect of extracellular vesicles derived from rat adipose tissue derived stromal cell [0.03%]
条件培养期对大鼠脂肪间充质干细胞来源的细胞外囊泡形态及增殖效果的影响
Borger Anton,Haertinger Maximilian,Millesi Flavia et al.
Borger Anton et al.
A serum-free conditioning period is a crucial step during small extracellular vesicle (sEV) preparation ranging from 12 to 72h. There is a paucity of knowledge about downstream effects of serum-free conditioning on sEVs and the optimal dura...
3D printed porous magnesium metal scaffolds with bioactive coating for bone defect repair: enhancing angiogenesis and osteogenesis [0.03%]
具有生物活性涂层的3D打印多孔镁金属支架用于骨缺损修复：促进血管生成和成骨作用
Jianting Ye,Bozun Miao,Yingjie Xiong et al.
Jianting Ye et al.
In orthopedics, the effective treatment of bone defects remains a major challenge. Magnesium (Mg) metals, with their excellent biocompatibility and favorable osteoconductivity, osteoinductivity, and osseointegration properties, hold great p...
Exploring the link between M1 macrophages and EMT of amniotic epithelial cells: implications for premature rupture of membranes [0.03%]
M1型巨噬细胞和羊膜上皮细胞的EMT之间的联系的研究：对胎膜早破的意义
Yuhua Gao,Yanan Zhang,Ningning Mi et al.
Yuhua Gao et al.
Background: Despite increasing evidence supporting the role of an amniotic epithelial-mesenchymal transition (EMT) in the premature rupture of membranes (PROMs), it remains unclear if extracellular vesicle (EV) derived fr...
Nanomedicine's shining armor: understanding and leveraging the metal-phenolic networks [0.03%]
纳米医学的坚固护甲：了解和利用金属酚网络
Zhengming Tang,Zhijie Huang,Yisheng Huang et al.
Zhengming Tang et al.
Metal-phenolic networks (MPNs), which comprise supramolecular amorphous networks formed by interlinking polyphenols with metal ions, garner escalating interest within the realm of nanomedicine. Presently, a comprehensive synthesis of the cu...
Metal-organic framework-based smart stimuli-responsive drug delivery systems for cancer therapy: advances, challenges, and future perspectives [0.03%]
用于癌症治疗的基于金属有机框架的智能刺激响应药物递送系统：进展、挑战和未来展望
Ziliang Guo,Yuzhen Xiao,Wenting Wu et al.
Ziliang Guo et al.
Cancer treatment is currently one of the most critical healthcare issues globally. A well-designed drug delivery system can precisely target tumor tissues, improve efficacy, and reduce damage to normal tissues. Stimuli-responsive drug deliv...
Exosomal lncRNA Mir100hg from lung cancer stem cells activates H3K14 lactylation to enhance metastatic activity in non-stem lung cancer cells [0.03%]
肺癌干细胞中的exosomal lncRNA Mir100hg通过激活H3K14乳酰化来增强非干性肺癌细胞的转移活性
Lei Shi,Bowen Li,Jiyu Tan et al.
Lei Shi et al.
The mean survival of metastatic lung adenocarcinoma is less than 1 year, highlighting the urgent need to understand the mechanisms underlying its high mortality rate. The role of Extracellular vesicles (EVs) in facilitating the interactions...
Astragaloside IV- loaded biomimetic nanoparticles target IκBα to regulate neutrophil extracellular trap formation for sepsis therapy [0.03%]
黄酮茋IV负载的生物模拟纳米颗粒通过靶向IκBα调节中性粒细胞外陷阱形成以用于脓毒症治疗
Shujuan Wu,Mengqi Zhou,Huimin Zhou et al.
Shujuan Wu et al.
This study explored the novel mechanism of Astragaloside IV (As) in treating sepsis and its application through a biomimetic nano-delivery system (As@ZM). Sepsis, a condition of organ dysfunction caused by an abnormal host response to infec...
pH-responsive cationic polymer-functionalized poly-ε-caprolactone microspheres scavenge cell-free-DNA to alleviate intestinal ischemia/reperfusion injury by inhibiting M1 macrophage polarization [0.03%]
pH响应的阳离子聚合物功能化的聚-ε-己内酯微球通过抑制M1型巨噬细胞极化来清除无细胞DNA从而减轻肠道缺血再灌注损伤
Hanbin Xie,Cong Wei,Chang Xiong et al.
Hanbin Xie et al.
Intestinal ischemia/reperfusion (I/R) injury is a common life-threatening condition. Inflammatory dysregulation plays a crucial role in the pathological progression of intestinal I/R injury, indicating that controlling excessive inflammator...
Black phosphorus nanosheets encapsulated microneedle for multifunctional therapy for androgenic alopecia [0.03%]
用于多功能治疗雄性脱发的封装黑磷纳米片微针
Sha Xiong,Zhongjun Li,Siwen Jiao et al.
Sha Xiong et al.
Background: Androgenetic alopecia (AGA), a chronic and progressive disease, significantly impacts the patients' social, emotional, and mental well-being. Current treatment for AGA are mainly limited by drug side effects a...