Novel cocktail therapy based on multifunctional supramolecular hydrogel targeting immune-angiogenesis-nerve network for enhanced diabetic wound healing [0.03%]
针对免疫-血管-神经网络的多功能超分子水凝胶新型鸡尾酒疗法促进糖尿病伤口愈合增强效应
Ruiyin Zeng,Yuan Xiong,Ze Lin et al.
Ruiyin Zeng et al.
Diabetes-associated chronic skin wounds present a formidable challenge due to inadequate angiogenesis and nerve regeneration during the healing process. In the present study, we introduce a groundbreaking approach in the form of a novel coc...
Engineering extracellular vesicles to transiently permeabilize the blood-brain barrier [0.03%]
工程化细胞外囊泡以暂时渗透血脑屏障
Francesca Tomatis,Susana Rosa,Susana Simões et al.
Francesca Tomatis et al.
Background: Drug delivery to the brain is challenging due to the restrict permeability of the blood brain barrier (BBB). Recent studies indicate that BBB permeability increases over time during physiological aging likely ...
A supervised machine learning tool to predict the bactericidal efficiency of nanostructured surface [0.03%]
一种预测纳米结构表面杀菌效率的监督机器学习工具
Yaxi Chen,Hongyi Chen,Anthony Harker et al.
Yaxi Chen et al.
The emergence and rapid spread of multidrug-resistant bacterial strains is a growing concern of public health. Inspired by the natural bactericidal surfaces of lotus leaves and shark skin, increasing attention has been focused on the use of...
A green, versatile, and facile strategy for anti-biofouling surface with ultra-high graft density polyethylene glycol [0.03%]
一种绿色、通用和简便的抗生物污染超高聚乙二醇接枝密度表面策略
Wenjie Liu,Suqin He,Hao Liu et al.
Wenjie Liu et al.
Implantable catheters are susceptible to severe complications due to non-specific protein adhesion on their surfaces. Polyethylene glycol (PEG) coatings, the gold standard for resistance to non-specific protein adhesion, present a challenge...
Advanced siRNA delivery in combating hepatitis B virus: mechanistic insights and recent updates [0.03%]
先进的siRNA递送技术在抗击乙肝病毒方面的机制见解和最新进展
Linh Nguyen,Tiep Tien Nguyen,Ju-Yeon Kim et al.
Linh Nguyen et al.
Hepatitis B virus (HBV) infection is a major health problem, causing thousands of deaths each year worldwide. Although current medications can often inhibit viral replication and reduce the risk of liver carcinoma, several obstacles still h...
Enhancing radiotherapy in triple-negative breast cancer with hesperetin-induced ferroptosis via AURKA targeting nanocomposites [0.03%]
纳米复合材料通过靶向AURKA诱导hesperetin介导的铁死亡增强三阴性乳腺癌放疗疗效
Yang Guo,Huan Wang,Xinlei Wang et al.
Yang Guo et al.
Triple-negative breast cancer (TNBC) is an aggressive cancer type that lacks targeted treatment options. Ferroptosis, a novel therapeutic strategy, induces cell death by disrupting the oxidative-reductive balance. Hesperetin, a potential TN...
A novel pan-epitope based nanovaccine self-assembled with CpG enhances immune responses against flavivirus [0.03%]
一种新型基于泛表位的卡介苗自组装CpG增强对黄病毒的免疫反应
Jiuxiang He,Xiaoyan Ding,Jing Zhao et al.
Jiuxiang He et al.
Background: Flavivirus is a highly prevalent and outbreak-prone disease, affecting billions of individuals annually and posing substantial public health challenges. Vaccination is critical to reducing the global impact of...
From dansyl-modified biofilm disruptors to β-cyclodextrin-optimized multifunctional supramolecular nanovesicles: their improved treatment for plant bacterial diseases [0.03%]
从丹磺酰修饰的生物被膜瓦解剂到β-环糊精优化的多功能超分子纳米囊泡：改善植物细菌病害的治疗方案
Hui-Ling Zhang,Hong-Wei Wang,Jing-Han Yang et al.
Hui-Ling Zhang et al.
Background: Bacterial diseases caused by phytopathogenic Xanthomonas pose a significant threat to global agricultural production, causing substantial economic losses. Biofilm formation by these bacteria enhances their res...
Oral creatine-modified selenium-based hyaluronic acid nanogel mediated mitochondrial energy recovery to drive the treatment of inflammatory bowel disease [0.03%]
口服改良型硒化透明质酸纳米凝胶介导的线粒体能量恢复驱动炎症性肠病治疗
Manxiu Huai,Mingliang Pei,Jie Chen et al.
Manxiu Huai et al.
The damnification of mitochondrion is often considered to be an important culprit of inflammatory bowel disease (IBD), however, there are fewer reports of mechanisms of mitochondria-mediated IBD treatment. Therefore, we first proposed to re...
Accurate HER2 determination in breast cancer: a prominent COF-immobilized enzyme-enhanced electrochemical aptasensor employing 4-acetamidophenol as an efficient mediator [0.03%]
一种高效的赫尔普林霉素介导的电化学适配子传感器用于准确测定乳腺癌中的HER2分子
Yue Zhang,Shuyi Chen,Jie Ma et al.
Yue Zhang et al.
An effective strategy for enzyme-enhanced electrochemical detection of human epidermal growth factor receptor 2 (HER2) is proposed for breast cancer diagnosis. This strategy utilizes a three-dimensional mesoporous covalent organic framework...