Responsive nanoparticles synergize with Curcumin to break the "reactive oxygen Species-Neuroinflammation" vicious cycle, enhancing traumatic brain injury outcomes [0.03%]
响应型纳米颗粒与姜黄素协同作用，打破“活性氧-神经炎症”恶性循环，改善创伤性脑损伤结果
Xianhua Fu,Yongkang Zhang,Guojie Chen et al.
Xianhua Fu et al.
Traumatic brain injury (TBI) disrupts oxygen homeostasis in the brain, leading to excessive reactive oxygen species (ROS) production and dysregulated antioxidant mechanisms, which fail to clear excess ROS. This ROS overload promotes the exp...
An anti-CD19-exosome delivery system navigates the blood-brain barrier for targeting of central nervous system lymphoma [0.03%]
抗CD19-外泌体传输系统穿越血脑屏障靶向中枢神经系统淋巴瘤
Meifang Zhao,Qi Li,Yali Chai et al.
Meifang Zhao et al.
Background: High-dose methotrexate (HD-MTX) serves as the cornerstone of central nervous system lymphoma (CNSL) treatment, but its efficacy is limited due to low blood-brain barrier (BBB) penetration and adverse effects. ...
Nanophotonic-enhanced photoacoustic imaging for brain tumor detection [0.03%]
用于脑肿瘤检测的纳米光子增强型光电声成像技术
Ali Rizwan,Badrinathan Sridharan,Jin Hyeong Park et al.
Ali Rizwan et al.
Photoacoustic brain imaging (PABI) has emerged as a promising biomedical imaging modality, combining high contrast of optical imaging with deep tissue penetration of ultrasound imaging. This review explores the application of photoacoustic ...
Regulation of cancer-associated fibroblasts for enhanced cancer immunotherapy using advanced functional nanomedicines: an updated review [0.03%]
使用先进的功能纳米药物调控癌症相关成纤维细胞以增强癌症免疫治疗：一项最新的回顾
Tingting Liao,Xiaoxiao Chen,Fengkai Qiu et al.
Tingting Liao et al.
The tumor microenvironment (TME) is a complex and dynamic ecosystem that plays a critical role in cancer progression. It comprises various cell types, including immune cells, tumor cells, and stromal cells. Among these, cancer-associated fi...
Naringenin cationic lipid-modified nanoparticles mitigate MASLD progression by modulating lipid homeostasis and gut microbiota [0.03%]
奈林芸香碱阳离子脂质修饰的纳米粒通过调节脂质稳态和肠道微生物群来减轻MASLD的进展
Lu Dong,Wenyong Lou,Congfei Xu et al.
Lu Dong et al.
Naringenin (NAR) possesses various pharmacological activities including antioxidant, anti-inflammatory, and hepatoprotective effects. However, its therapeutic efficacy is limited by its hydrophobic and crystalline nature. This study aimed t...
Graphdiyne biomaterials: from characterization to properties and applications [0.03%]
石图炔生物材料：从特征分析到性质和应用
Ling-Xiao Zhao,Yong-Gang Fan,Xue Zhang et al.
Ling-Xiao Zhao et al.
Graphdiyne (GDY), the sole synthetic carbon allotrope with sp-hybridized carbon atoms, has been extensively researched that benefit from its pore structure, fully conjugated surfaces, wide band gaps, and more reactive C≡C bonds. In additio...
Spermine delivered by ZIF90 nanoparticles alleviates atherosclerosis by targeted inhibition of macrophage ferroptosis in plaque [0.03%]
通过ZIF90纳米颗粒靶向抑制斑块内巨噬细胞铁死亡来缓解动脉粥样硬化中的左旋孢胺
Yuwu Chen,Biyi Xu,Quan Lin et al.
Yuwu Chen et al.
Background: Nowadays, emerging evidence have suggested that the ferroptosis of macrophages could contribute to the progression of atherosclerosis (AS). Meanwhile, Spermine (Sp) could serve as an endogenous small molecule ...
Cascade-recharged macrophage-biomimetic ruthenium-based nanobattery for enhanced photodynamic-induced immunotherapy [0.03%]
级联式宏噬细胞仿生钌基纳米电池用于增强光动力免疫治疗
Guoyu Xia,Zhongxiong Fan,Qingluo Wang et al.
Guoyu Xia et al.
Photodynamic-induced immunotherapy (PDI) is often hampered by low reactive oxygen species (ROS) yield, intra-tumor hypoxia, high glutathione (GSH) concentration, and immunosuppressive microenvironment. In view of this, a ruthenium (Ru)-base...
Infertility treatment using polysaccharides-based hydrogels: new strategies in tissue engineering and regenerative medicine [0.03%]
使用多糖水凝胶进行不孕症治疗：组织工程和再生医学的新策略
Maryam Ghahremani-Nasab,Soraya Babaie,Sara Bazdar et al.
Maryam Ghahremani-Nasab et al.
Infertility is a primary health issue affecting about 15% of couples of reproductive ages worldwide, leading to physical, mental, and social challenges. Advances in nanobiotechnology and regenerative medicine are opening new therapeutic hor...
Specific muscle targeted delivery of miR-130a loaded lipid nanoparticles: a novel approach to inhibit lipid accumulation in skeletal muscle and obesity [0.03%]
负载miR-130a的脂质纳米颗粒靶向特定肌肉传递：一种新颖的抑制骨骼肌中脂质积累和肥胖的方法
Yingqian Wang,Zeqiang Ma,Lehua Jiang et al.
Yingqian Wang et al.
Background: Skeletal muscle lipid deposition is a key manifestation of obesity, often accompanied by decreased exercise capacity and muscle atrophy. Skeletal muscle as the largest organ in the body, makes it challenges fo...