Asymmetrically PEGylated and amphipathic heptamethine indocyanine dyes potentiate radiotherapy of renal cell carcinoma via mitochondrial targeting [0.03%]
通过线粒体靶向增强肾细胞癌放射治疗的不对称PEG化和两亲性庚甲川吲哚青染料
Zifei Wu,Xie Huang,Chuan Wu et al.
Zifei Wu et al.
Enhancing the sensitivity of radiotherapy (RT) towards renal cell carcinoma (RCC) remains a challenge because RCC is a radioresistant tumor. In this work, we design and report asymmetrically Polyethylene Glycol (PEG)ylated and amphipathic h...
Apoptotic body based biomimetic hybrid nanovesicles to attenuate cytokine storms for sepsis treatment [0.03%]
基于凋亡小体的仿生杂化纳米囊泡用于减轻细胞因子风暴以治疗脓毒症
Hongbing Lan,Zhanhao Zhou,Qian Hu et al.
Hongbing Lan et al.
Sepsis is a severe immune response to pathogens that is associated with high mortality rate and a paucity of efficacious treatment options. It is characterized by the hyperactivation of macrophages and the occurrence of cytokine storms. Giv...
Shedding light on vascular imaging: the revolutionary role of nanotechnology [0.03%]
血管成像照进光明：纳米技术的革命性作用
Peisen Zhang,Yao Li,Xiaoqi Li et al.
Peisen Zhang et al.
Vascular dysfunction, characterized by changes in anatomy, hemodynamics, and molecular expressions of vasculatures, is closely linked to the onset and development of diseases, emphasizing the importance of its detection. In clinical practic...
Temperature induces brain-intake shift of recombinant high-density lipoprotein after traumatic brain injury [0.03%]
温度可使创伤性脑损伤后重组高密度脂蛋白从血液向脑内转运
Jialin Huang,Yidong Peng,Xin Wang et al.
Jialin Huang et al.
Traumatic brain injury (TBI) is one of the leading public health concerns in the world. Therapeutic hypothermia is routinely used in severe TBI, and pathophysiological hyperthermia, frequently observed in TBI patients, has an unclear impact...
Biomimetic astrocyte cell membrane-fused nanovesicles for protecting neurovascular units in hypoxic ischemic encephalopathy [0.03%]
仿生外泌体负载的星形胶质细胞膜融合纳米囊泡保护脑缺氧缺血损伤中的神经血管单元
Zihao Liu,Qian Xia,Chanyue Wang et al.
Zihao Liu et al.
Hypoxic ischemic encephalopathy (HIE) refers to neonatal hypoxic brain injury caused by severe asphyxia during the perinatal period. With a high incidence rate and poor prognosis, HIE accounts for 2.4% of the global disease burden, imposing...
3D cryo-printed hierarchical porous scaffolds provide immobilization of surface-functionalized sleep-inspired small extracellular vesicles: synergistic therapeutic strategies for vascularized bone regeneration based on macrophage phenotype modulation and angiogenesis-osteogenesis coupling [0.03%]
用于血管化骨再生的协同治疗策略基于巨噬细胞表型调节和成血管/成骨偶联：基于表面功能化的睡眠启发的小细胞外囊泡的固定化三维冷冻打印分级多孔支架
Xu-Ran Li,Qing-Song Deng,Shu-Hang He et al.
Xu-Ran Li et al.
Bone defect healing is a multi-factorial process involving the inflammatory microenvironment, bone regeneration and the formation of blood vessels, and remains a great challenge in clinical practice. Combined use of three-dimensional (3D)-p...
HDACi combination therapy with IDO1i remodels the tumor microenvironment and boosts antitumor efficacy in colorectal cancer with microsatellite stability [0.03%]
表观遗传治疗联合IDO抑制剂改变结直肠癌微环境中的免疫抑制从而提高治疗效果
Rongpu Liang,Dongbing Ding,Yiquan Li et al.
Rongpu Liang et al.
Background: Immunotherapy for colorectal cancer (CRC) with microsatellite stability (MSS) and mismatch repair proficiency (pMMR) has shown limited success in clinical trials. The combination of immunomodulators and immune...
Correction: Age-dependent changes in phagocytic activity: in vivo response of mouse pulmonary antigen presenting cells to direct lung delivery of charged PEGDA nanoparticles [0.03%]
订正：与年龄有关的吞噬细胞活性变化：鼠肺直接递送带电PEGDA纳米颗粒后抗原呈递细胞的体内反应
Emma R Sudduth,Aida López Ruiz,Michael Trautmann-Rodriguez et al.
Emma R Sudduth et al.
Published Erratum
Journal of nanobiotechnology. 2024 Dec 12;22(1):751. DOI:10.1186/s12951-024-03040-z 2024
Fu-Xing-Zi Li,Jun-Jie Liu,Li-Min Lei et al.
Fu-Xing-Zi Li et al.
Published Erratum
Journal of nanobiotechnology. 2024 Dec 12;22(1):752. DOI:10.1186/s12951-024-03039-6 2024
A minimalist multifunctional nano-prodrug for drug resistance reverse and integration with PD-L1 mAb for enhanced immunotherapy of hepatocellular carcinoma [0.03%]
一种治疗肝细胞癌的针对药敏性和PD-L1的多功能纳米前药体系
Ting Zou,Yun Huang,Zongtao Zhou et al.
Ting Zou et al.
Clinical treatment of hepatocellular carcinoma (HCC) with 5-fluorouracil (5-FU), the primary anticancer agent, remains unsatisfactory due to the glutathione (GSH)-associated drug resistance and immunosuppressive microenvironment of HCC. To ...