Targeting YTHDF2 with pH-responsive siRNA nanoparticles suppresses MYC m6A modification and restores antitumor immunity in hepatocellular carcinoma [0.03%]
基于pH响应的siRNA纳米颗粒靶向肝癌中YTHDF2以抑制MYC mRNA去甲基化并恢复抗肿瘤免疫功能
Ziqi Guo,Qiuling Huang,Zhenzhen Cui et al.
Ziqi Guo et al.
Hepatocellular carcinoma (HCC) is a highly heterogeneous and immunosuppressive malignancy that frequently exhibits poor responses to immunotherapy, primarily due to immune evasion mediated by myeloid-derived suppressor cells (MDSCs) in the ...
Advanced wound healing with Stimuli-Responsive nanozymes: mechanisms, design and applications [0.03%]
具有刺激响应性的nanozymes的伤口治疗：机制、设计和应用
Xiaoyang Liu,Huihui Zhang,Lianglong Chen et al.
Xiaoyang Liu et al.
Wound healing outcomes critically depend on precise regulation of oxidative and antimicrobial microenvironments. Traditional dressings have limited wound responsiveness, insufficient infection control, and limited treatment accuracy. In con...
Biomaterials mediated 3R (remove-remodel-repair) strategy: holistic management of Helicobacter pylori infection [0.03%]
用于治疗幽门螺旋杆菌感染的材料介导的3R(清除-重塑-修复)策略：整体管理
Tinglin Zhang,Yating Zheng,Tielou Chen et al.
Tinglin Zhang et al.
Helicobacter pylori (HP) is a major etiological agent of gastric cancer, with a global prevalence of around 50%. Current treatments, primarily based on antibiotics, face challenges such as increasing drug resistance and disruption of the gu...
Nanomaterial isolated extracellular vesicles enable high precision identification of tumor biomarkers for pancreatic cancer liquid biopsy [0.03%]
纳米材料隔离的细胞外囊泡能够用于高精度识别胰腺癌液体活检肿瘤生物标志物
Zachary F Greenberg,Samantha Ali,Andrew Brock et al.
Zachary F Greenberg et al.
Pancreatic cancer has the highest mortality rate among all major cancers, which highlights the urgent needs of non-invasive early detection. Circulating extracellular vesicles (EVs) have gained significant attention for discovering tumor bi...
Advanced strategy for cancer detection based on volatile organic compounds in breath [0.03%]
基于呼吸中挥发性有机化合物的癌症检测先进策略研究
Ziqi Jia,Yiwen Jiang,Tongxuan Shang et al.
Ziqi Jia et al.
The analysis of volatile organic compounds (VOCs) in exhaled breath has emerged as a promising non-invasive approach for cancer diagnosis, offering advantages in speed, safety, cost-effectiveness, and real-time monitoring. Two primary metho...
Early-life exposure to polypropylene nanoplastics induces neurodevelopmental toxicity in mice and human iPSC-derived cerebral organoids [0.03%]
聚丙烯纳米塑料的早期暴露诱导小鼠和人多能干细胞来源脑类器官的神经发育毒性
Fangfang Huang,Haizhen You,Xiaogang Tang et al.
Fangfang Huang et al.
Nanoplastics (NPs) are emerging environmental pollutants that pose growing concerns due to their potential health risks. However, the effects of inhaled NP exposure during pregnancy on fetal brain development remain poorly understood. In th...
A novel tetrahedral framework nucleic acid-based antibiotic delivery system: overcoming biofilm barriers to combat chronic infections [0.03%]
一种新型四面体笼状核酸载药体系：克服生物被膜屏障以治疗慢性感染
Yue Hu,Zhou Chen,Xinggang Mao et al.
Yue Hu et al.
Background: Overcoming bacterial biofilm barriers to enhance the efficacy of antibiotics remains a major therapeutic challenge, necessitating the development of efficient and biocompatible drug delivery systems. While fra...
Stimuli-responsive smart materials enabled high-performance biosensors for liquid biopsies [0.03%]
基于刺激响应型智能材料的高性能液体活检生物传感器
Xiaoqi Gao,Bayinqiaoge Bayinqiaoge,Ming Li et al.
Xiaoqi Gao et al.
Liquid biopsies have emerged as a key tool that enables personalized medicine, enabling precise detection of biochemical parameters to tailor treatments to individual needs. Modern biosensors enable real-time detection, precise diagnosis, a...
Correction: Co-delivery of axitinib and PD-L1 siRNA for the synergism of vascular normalization and immune checkpoint Inhibition to boost anticancer immunity [0.03%]
纠正：阿昔替尼和PD-L1siRNA的共递送，以实现血管正常化和免疫检查点抑制的协同作用，以增强抗癌免疫力
Yanhong Liu,Liming Gong,Jing Feng et al.
Yanhong Liu et al.
Published Erratum
Journal of nanobiotechnology. 2025 Jun 24;23(1):461. DOI:10.1186/s12951-025-03532-6 2025
Delivery of LOXL1-AS1-siRNAs using targeting peptide-engineered extracellular vesicles with focused ultrasound to suppress medulloblastoma metastasis [0.03%]
利用聚焦超声引导的靶向肽工程外泌体递送LOXL1-AS1-siRNA抑制髓母细胞瘤转移
Anh Duy Do,Shing-Shung Chu,Le Hien Giang et al.
Anh Duy Do et al.
Background: Metastasis of medulloblastomas (MBs) is difficult to treat and remains the primary cause of death in children with this brain tumor. Current treatment focuses on radiotherapy to limit metastatic recurrence and...