Extracellular vesicles: a new frontier in diagnosing and treating graft-versus-host disease after allogeneic hematopoietic cell transplantation [0.03%]
胞外囊泡：同种异体造血细胞移植后诊断和治疗移植物抗宿主病的新领域
Peipei Wu,Zhangfei Wang,Yongping Sun et al.
Peipei Wu et al.
Graft-versus-host disease (GvHD) is a prevalent complication following allogeneic hematopoietic stem cell transplantation (HSCT) and is characterized by relatively high morbidity and mortality rates. GvHD can result in extensive systemic da...
Correction: Near-infrared light triggered in situ release of CO for enhanced therapy of glioblastoma [0.03%]
修正：近红外光触发原位释放一氧化碳增强胶质母细胞瘤治疗效果
Juan Ge,Miaomiao Zuo,Qirong Wang et al.
Juan Ge et al.
Published Erratum
Journal of nanobiotechnology. 2025 Mar 25;23(1):245. DOI:10.1186/s12951-025-03162-y 2025
Biomimetic gene delivery system coupled with extracellular vesicle-encapsulated AAV for improving diabetic wound through promoting vascularization and remodeling of inflammatory microenvironment [0.03%]
仿生基因递送系统结合细胞外囊泡包裹的AAV通过促进血管化和重塑炎症微环境来改善糖尿病伤口
Shan He,Zhenhao Li,Lei Xie et al.
Shan He et al.
Adeno-associated virus (AAV)-mediated gene transfer has demonstrated potential in effectively promoting re-epithelialization and angiogenesis. AAV vector has a safety profile; however, the relatively low delivery efficacy in chronic wound w...
Dual-modality immune nano-activator harnessing Mn2⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy [0.03%]
双模免疫纳米激活剂利用Mn2⁺和檞皮素增强cGAS-STING通路用于先进癌症金属免疫治疗
Shanshan Ma,Xuequan Zhang,Xiaoqi Zhu et al.
Shanshan Ma et al.
Manganese ions (Mn2+) have emerged as promising activators of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway. However, their clinical application was hindered by low bioavailability and limited immune activa...
Reduction of colitis in mice by chemically programmed supramolecular nanoassemblies of vitamin-lipid conjugates [0.03%]
维生素-脂质偶联物的化学程序超分子纳米组件对小鼠结肠炎的改善作用
Shiyun Xian,Fanchao Meng,Xiaona Chen et al.
Shiyun Xian et al.
Inflammatory bowel disease (IBD) is a relapsing disorder characterized by uncontrolled chronic inflammation of the gastrointestinal tract, posing a significant therapeutic challenge owing to the limited efficacy and undesirable side effects...
3D printed shape-memory piezoelectric scaffolds with in-situ self-power properties for bone defect repair [0.03%]
用于骨缺损修复的具有原位自供电性能的3D打印形状记忆压电支架
Bing Li,Yichao Ma,Kanwal Fatima et al.
Bing Li et al.
Electrical stimulation has been shown to regulate early immunity and late-stage osteogenesis in bone repair. However, achieving in-situ electrical stimulation in the form of self-power in vivo during the initial postoperative stages when th...
Single-atom Zr doped heterojunction enhanced piezocatalysis for implant infection therapy through synergistic metal immunotherapy with sonodynamic and physical puncture [0.03%]
单原子Zr掺杂异质结增强压电催化通过协同金属免疫疗法与声动力和物理穿刺治疗植入感染
Xing Zhou,Jingbo Xie,Xingchen Zhou et al.
Xing Zhou et al.
Recent common clinical treatments for implant bacterial infections involve replacing inert implants and using antibiotics. However, these methods remain limited in their effectiveness for pathogen clearance, immune regulation, and osteogene...
In situ construction of heterojunctions to regulate the biodegradation behavior of copper carriers for tumor-specific cuproptosis-enhanced sono-immunotherapy [0.03%]
原位构建异质结以调控铜载体的生物降解行为实现肿瘤特异性铜死亡增强型声动力免疫治疗
Xiqian Cao,Lingwei Mao,Yijun Tian et al.
Xiqian Cao et al.
Cuproptosis, a novel approach utilizing copper carriers to trigger programmed cell death, exhibits promise for enhancing traditional therapies and activating robust adaptive immune responses. However, the uncontrolled release of Cu ions ris...
Recombinant human collagen hydrogels with different stem cell-derived exosomes encapsulation for wound treatment [0.03%]
用于伤口处理的不同干细胞衍生外泌体包封的重组人胶原水凝胶
Xiaoman Zeng,Jingjing Gan,Danqing Huang et al.
Xiaoman Zeng et al.
Exosomes-loaded hydrogels have potential value in wound treatment. Current studies focus on improving hydrogels' biocompatibility and optimizing different stem cell-derived exosomes for better therapeutic effect. Herein, we present a novel ...
Nanocomposite-based PCR reactors to enhance thermal rate and fluorescence intensity in hand-held qPCR device [0.03%]
基于纳米复合材料的PCR反应器可提升手持式qPCR设备中的热速率和荧光强度
Jiyeon Han,Tiara A M,Seongryeong Kim et al.
Jiyeon Han et al.
A photonic quantitative polymerase chain reaction (qPCR) has usually implemented a polydimethylsiloxane (PDMS) based disposable inexpensive PCR reactor, worked as the photothermal cycler, to show potential as a point-of-care test (PoCT) for...