Reprogramming tumor-associated macrophages and blocking PD-L1 via engineered outer membrane vesicles to enhance T cell infiltration and cytotoxic functions [0.03%]
通过工程化外泌体重编肿瘤相关巨噬细胞和阻断PD-L1以增强T细胞浸润及杀伤功能
Zhiqiang Chen,Bo Wang,Jianwei Zheng et al.
Zhiqiang Chen et al.
The immunosuppressive tumor microenvironment (TME) critically undermines the efficacy of T cell-based tumor immunotherapy by impeding CD8+ T cell infiltration and cytotoxic function, primarily through tumor-associated macrophages (TAMs) and...
Engineered protein corona sustains stealth functionality of nanocarriers in plasma [0.03%]
工程化的蛋白质冠可持续纳米载体在血浆中的隐身功能
Xueqing Zhang,Shutian Si,Ingo Lieberwirth et al.
Xueqing Zhang et al.
Pre-adsorption of selective proteins is instrumental in forming functionally important protein coronas that allow for achieving long circulation in blood stream. This is an important prerequisite for subsequent specific uptake into target c...
Hyaluronic acid-tailored prodrug nanoplatforms for efficiently overcoming colorectal cancer chemoresistance and recurrence by synergistic inhibition of cancer cell stemness [0.03%]
透明质酸修饰的前药递送平台协同抑制结直肠癌细胞干性以克服耐药和复发
Xirui Duan,Hailong Tian,Peilan Peng et al.
Xirui Duan et al.
A subset of residual colorectal cancer (CRC) cells with stemness features exhibits a transient adaptive resistance after chemotherapy, limiting durable therapeutic benefits and even accelerating tumor recurrence. To tackle this problem, we ...
Engineered Panax notoginseng polysaccharide micelles inhibit macrophage polarization and delay the progression of rheumatoid arthritis via JAK2-STAT3 signaling pathway [0.03%]
工程化伪玄麦冬聚糖胶束通过JAK2-STAT3信号通路抑制巨噬细胞极化并延缓类风湿性关节炎的进展
Yang Yu,Liang Kong,Rui-Bo Guo et al.
Yang Yu et al.
Background: The imbalance of macrophage polarization plays a pivotal role in the progression of rheumatoid arthritis (RA). Reprogramming macrophages from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 pheno...
Molecular mechanism differences between nanoplastics and microplastics in colon toxicity: nanoplastics induce ferroptosis-mediated immunogenic cell death, while microplastics cause cell metabolic reprogramming [0.03%]
纳米塑料和微塑料诱导结肠毒性的分子机制差异：纳米塑料诱导铁死亡介导的免疫原性细胞死亡，而微塑料导致细胞代谢重编程
Yixian Cheng,Junjie Chen,Rui Fu et al.
Yixian Cheng et al.
This study investigates the size-dependent mechanisms by which polystyrene (PS) microplastics (MPs) cause intestinal epithelial injury, focusing on the differential effects of nanoscale (100 nm) and microscale (10 μm) particles. Using both...
N-doped carbon dots for dual-modality NIR fluorescence imaging and photothermal therapy [0.03%]
N掺杂碳点用于近红外荧光成像和光热治疗的双模式成像
Hui-Xian Shi,Xuan Qu,Tong-Tong Zhao et al.
Hui-Xian Shi et al.
Photothermal therapy (PTT), a rapidly advancing non-invasive cancer treatment modality, utilizes photothermal agents to convert light energy into thermal energy, enabling precise and localized destruction of cancer cells. Recent development...
FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise [0.03%]
富含FNDC5/irisin的骨靶向适配体修饰的外泌体用于缓解骨质疏松症：运动疗法的潜在替代方案
Min-Zhi Mao,Ming-Hui Zheng,Bei Guo et al.
Min-Zhi Mao et al.
Exercise maintains bone health and produces protective effects on bone loss. In this study, we investigated the potential protective effects of circulating small extracellular vesicles (sEVs) generated under endurance exercise training (Exe...
Near-infrared organic nanoparticles (6BQ NPs) enhance the random flaps survival by modulating the HSP90/HIF-1α axis through mild photothermal therapy [0.03%]
近红外有机纳米粒子（6BQ NPs）通过轻微光热疗法调节HSP90 / HIF-1α轴以增强随机皮瓣的存活率
Feng Wu,Jin Zhang,Jiangtian Ye et al.
Feng Wu et al.
Random flaps are primarily employed in clinical practice for wound repair; however, the ischemic necrosis following surgery remains a significant challenge. To address this issue, we developed high-performance near-infrared (NIR) phototherm...
Extracellular vesicles derived from Schwann cells to enhance bone and dental tissue regeneration: a literature review [0.03%]
雪旺细胞源外泌体促进骨和牙组织再生：文献回顾研究
Xinyi Li,Minjia Zhu,Le Xiao et al.
Xinyi Li et al.
Background: Recently, the importance and innovative applications of extracellular vesicles in bone and dental pulp tissue engineering have attracted more attention. Moreover, the use of extracellular vesicles derived from...
Curcumin-based polymer prodrug nanoplatform for high-efficiency immunotherapy by synergistically suppression of head and neck cancer cell stemness [0.03%]
一种新型藤黄根提取物聚合物前药纳米平台协同抑制头颈癌细胞干性高效免疫治疗研究
Zhisen Shen,Hao Jiang,Shuaijun Lu et al.
Zhisen Shen et al.
Background: Immunotherapy represents a transformative advance in cancer treatment; however, its efficacy in head and neck cancer (HNC) remains constrained by tumor cell stemness and profound immunosuppression within the t...