Mitochondria-targeting polymer cLipG/CuET activates the cGAS/STING pathway to enhance cholangiocarcinoma immunotherapy [0.03%]
线粒体靶向聚合物cLipG/CuET激活cGAS/STING通路以增强肝内胆管癌免疫治疗
Ge Bai,Hongwen Liu,Wei Li et al.
Ge Bai et al.
Background: The remodeling of extracellular matrix often fails chemotherapeutic agents to fight intrahepatic cholangiocarcinoma (ICC). The cGAS/STING pathway can trigger the innate immune response to obtain better immunot...
Hybrid metallic nanozyme with nitric oxide-releasing photothermal coating for accelerated infected diabetic wound healing [0.03%]
一种用于加速糖尿病感染伤口愈合的含一氧化氮释放光热涂层的金属纳米酶杂化材料
Sri Ganga Padaga,Milan Paul,Tonmoy Banerjee et al.
Sri Ganga Padaga et al.
Infected diabetic wounds are prone to developing bacterial biofilms and are difficult to treat due to a lack of strategies that can eliminate drug-resistant bacteria. Conventional antibiotics can't achieve the desired antibacterial effect d...
Bispecific self-assembled peptides as supra-growth factors for preventing endotheliopathy and improving survival of traumatic brain injury in mice [0.03%]
双特异肽自组装体在预防内皮细胞病变和改善小鼠创伤性脑损伤存活率方面的功效研究
Yichi Zhang,Lanxing Wang,Dandan Li et al.
Yichi Zhang et al.
Traumatic brain injury (TBI) causes endothelial injury (endotheliopathy), which contributes to a cascade of adverse events, including cerebral hemorrhage, edema and acute lung injury (ALI), and leads to poor clinical outcomes. Protecting en...
Tailored brain metastatic tumor cells-derived apoptotic bodies ameliorate Alzheimer's disease by promoting microglia efferocytosis and neuroinflammation mitigation [0.03%]
趋化的脑转移瘤细胞源性凋亡体通过促进小胶质细胞清除凋亡和减轻神经炎症来改善阿尔茨海默病
Zhenlong Mu,Yang Chen,Yunfeng Hu et al.
Zhenlong Mu et al.
Neuroinflammation, characterized by microglial overactivation and oxidative stress, plays a critical role in the initiation and progression of Alzheimer's disease (AD). In this study, we focus on simulating the natural efferocytosis process...
Single-cell in situ mapping of glioblastoma and astrocyte cell lines treated with a carbon dot-mediated riluzole nanotherapeutic agent: a live-cell µFTIR and soft X-ray tomography approach [0.03%]
单细胞原位绘制用碳点介导的利鲁唑纳米治疗剂处理的胶质母细胞瘤和星形胶质细胞系：活细胞微傅里叶变换红外光谱和软X射线层析成像方法
Tanja Dučić,Eva Pereiro,Milena Ninkovic et al.
Tanja Dučić et al.
Nanoparticle-based drug carriers offer a promising alternative to conventional cancer therapies by enabling targeted delivery and reducing off-target toxicity. Here, we used synthesised and characterised carbon-based nanoparticles derived f...
Astragalus polysaccharide-based nano-platforms loading PTX to boost chemo-immunotherapy for triple-negative breast cancer with intrinsic GLUT-targeting ability and immunoregulatory activity [0.03%]
具有固有GLUT靶向能力和免疫调节活性的黄芪多糖基纳米平台负载PTX以增强三阴性乳腺癌的化疗免疫疗法
Jinshuai Lan,Wenlong Nie,Zhijun Bi et al.
Jinshuai Lan et al.
Chemo-immunotherapy shows great promises for triple-negative breast cancer (TNBC) treatment, including PTX. However, the chemo-immunotherapy of PTX is limited, due to its upregulation of PD-L1 expression on tumor cells and bone marrow suppr...
Engineering bispecific HER2xVEGF designed ankyrin repeat proteins for targeted nanobiotechnology applications [0.03%]
工程化双特异性HER2xVEGF设计锚蛋白重复蛋白用于靶向纳米生物技术应用
Feng Chen,Michelle S Bradbury
Feng Chen
Background: Targeting both tumor cell surface receptors and soluble pro-angiogenic factors is a promising strategy to improve cancer treatment specificity and reduce therapy resistance. Human epidermal growth factor recep...
Sodium alginate piezoelectric hydrogel loaded with extracellular vesicles derived from bone marrow mesenchymal stem cells promotes repair of Achilles tendon rupture [0.03%]
载有骨髓间充质干细胞来源的细胞外囊泡的海藻酸钠压电水凝胶促进跟腱断裂修复
Ao Duan,Bingqing Lin,Zhencheng Xiong et al.
Ao Duan et al.
Accelerated repair of Achilles tendon rupture and prevention of re-rupture continue to pose significant technical challenges in orthopedic surgery and rehabilitation. Extracellular vesicles (EVs) derived from bone marrow mesenchymal stem ce...
Bioinspired catalytic nanogel as an inflammatory cascade-targeted therapeutic for rheumatoid arthritis [0.03%]
仿生炎性级联靶向催化纳米凝胶治疗类风湿性关节炎
Yi Jin,Nengjie Yang,Siyu Chen et al.
Yi Jin et al.
The inflammatory cascade is a key driver of chronic inflammation in rheumatoid arthritis (RA) and facilitates the migration of circulating immune cells into the inflamed joints. Recent studies have unveiled the complexity of this cascade, w...
Targeting tumor microenvironment with biomimetic nanovesicles for non-small cell lung cancer gene therapy [0.03%]
仿生纳米囊泡靶向肿瘤微环境用于非小细胞肺癌基因治疗
Qihang Yan,Li Gong,Zihui Tan et al.
Qihang Yan et al.
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with therapeutic outcomes often constrained by the complexity of the tumor microenvironment (TME). Comprising diverse cell types and signaling molecules...