Anthocyanin-functionalized selenocysteine nanotherapeutics alleviate cisplatin nephrotoxicity by inhibiting oxidative stress and ferroptosis [0.03%]
花青素功能硒半胱氨酸纳米药物通过抑制氧化应激和铁死亡来缓解顺铂肾毒性
Hongyan Zhu,Xingyuan Wu,Yulin Tan et al.
Hongyan Zhu et al.
Although cisplatin (CDDP) remains a widely used chemotherapeutic agent in clinical cancer treatment, severe oxidative stress and inflammatory responses induced by CDDP are still major causes of acute kidney injury (AKI) in patients. Our pre...
A mitochondria-targeted nanomedicine for myocardial ischemia/reperfusion injury with synergistic antioxidant and anti-inflammatory properties [0.03%]
一种针对线粒体的纳米药物用于心肌缺血/再灌注损伤，具有协同抗氧化和抗炎作用
Congcong Li,Zhengfeng Zhang,Chao Luo et al.
Congcong Li et al.
Acute myocardial infarction (AMI) remains the leading cause of mortality worldwide, posing a significant threat to global public health. Although revascularization strategies such as percutaneous coronary intervention represent the standard...
Multi-modal single-cell platform for nanoparticle-enhanced time-series metabolic profiles of CD8+ T cell exhaustion in tumor immunosurveillance [0.03%]
一种多模态单细胞平台技术，利用纳米颗粒增强监测肿瘤免疫监视中CD8+T细胞衰竭的代谢轮廓变化
Chenjie Yang,Mingxia Gao,Xiangmin Zhang et al.
Chenjie Yang et al.
Cytotoxic T cells (CD8+) play a pivotal role in immunosurveillance by identifying and eliminating tumor cells. However, the onset of CD8+ T cell exhaustion, characterized by overexpression of immune checkpoint receptors, impairs their funct...
A trimer ancestral spike-based mRNA vaccine confers cross-generational protection against SADS-CoV [0.03%]
一种三聚体祖先刺突基质mrna疫苗可使后代免受猪传染性腹泻病毒的侵害
Teng Zhang,Jiale Yao,Xinchun Guo et al.
Teng Zhang et al.
The emergence of coronavirus variants that evade vaccine protection poses a serious threat to both human health and animal husbandry, including the novel SADS-CoV, an emerging bat-derived coronavirus. Herein, we introduce a "phylogenetic an...
Itaconate-functionalized tetrahedral framework nucleic acids break the dry eye vicious cycle through dual antioxidant and anti-inflammatory actions [0.03%]
衣康酸修饰的四面体框架核酸通过双重抗氧化和抗炎作用打破干眼恶性循环
Kai Jiang,Zhenyi Lin,Mingrui Cheng et al.
Kai Jiang et al.
Dry eye disease (DED) is a prevalent ocular surface disorder characterized by chronic inflammation and oxidative stress, significantly impacting vision and quality of life. Although reactive oxygen species (ROS) serve as a key upstream regu...
Smart hybrid nanomaterials for chronic infections: microbiome-responsive and sustainable therapeutic platforms [0.03%]
用于慢性感染的智能纳米杂化材料：响应微生物组且可持续治疗平台
Hina Singh,Sri Renukadevi Balusamy,Johan Sukweenadhi et al.
Hina Singh et al.
Chronic wounds remain a persistent clinical challenge due to their complex pathology involving prolonged inflammation, microbial biofilms, and impaired tissue regeneration. Emerging research highlights the dynamic role of the human microbio...
Nanocorona-engineered gold nanostars orchestrate photothermal augmented immunotherapy and durable cancer vaccination [0.03%]
纳米 coronae 工程金纳米星调节光热增强免疫治疗和持久的癌症疫苗接种
Jun Young Park,Su Hyun Lim,Gayeon Kim et al.
Jun Young Park et al.
Protein coronas inevitably cloak nanoparticles in vivo, yet their therapeutic potential remains largely untapped. Here we engineer a single-protein nanocorona by adsorbing immunoglobulin G onto PEGylated gold nanostars and reveal a dual-mod...
Apigenin regulates CCR5/JAK1/STAT1/MMPs signaling to alleviate secondary brain injury after intracerebral hemorrhage and its enhanced delivery via targeted nanoparticles [0.03%]
染料木素通过靶向纳米粒经脑内给药调节CCR5/JAK1/STAT1/MMPs信号通路缓解出血性卒中后继发性脑损伤及其增强递送机制研究
Jia-Wei Wu,Yi-Ting Zhou,Bing-Xin Wang et al.
Jia-Wei Wu et al.
Intracerebral hemorrhage (ICH), a severe cerebrovascular disorder with high mortality, leads to secondary brain injury (SBI) primarily through neuroinflammation and blood-brain barrier (BBB) disruption. Among the pathological cascades, exce...
A TEMPO-loaded DNA hydrogel enabling integrated early diagnosis and treatment of osteoarthritis [0.03%]
一种用于软骨组织精准修复的智能DNA水凝胶材料研究
Hong Huang,Mingze Tang,Pengcheng Hu et al.
Hong Huang et al.
Osteoarthritis (OA) is a chronic inflammatory disease characterized primarily by cartilage degradation. Current imaging techniques often detect OA only after irreversible cartilage damage has occurred, and no drugs are available to halt dis...
Programmed nanozyme hydrogel enabling spatiotemporal modulation of wound healing achieves skin regeneration after biofilm infection [0.03%]
程序化纳米酶水凝胶实现时空调节伤口愈合以实现生物膜感染后的皮肤再生
Ze-Ming Zhuang,Yi Wang,Fa-Wei Xu et al.
Ze-Ming Zhuang et al.
Skin regeneration after wound healing is challenging, especially following infection. Wound repair is a staged yet continuous program, necessitating distinct therapeutic approaches at each stage. Regulation of infection-induced excessive re...