Advancing cancer gene therapy: the emerging role of nanoparticle delivery systems [0.03%]
癌症基因治疗的发展：纳米颗粒递送系统的作用日益重要
Maoze Wang,Huina Liu,Jinling Huang et al.
Maoze Wang et al.
Gene therapy holds immense potential due to its ability to precisely target oncogenes, making it a promising strategy for cancer treatment. Advances in genetic science and bioinformatics have expanded the applications of gene delivery techn...
Targeting phosphatidylserine in tumor cell membranes with a zinc-containing molecule to efficiently combat tumor metastasis [0.03%]
利用含锌分子靶向肿瘤细胞膜中的磷脂酰丝氨酸有效防治肿瘤转移
Xiao-Hong Zhou,Jia-Wei Wang,Wei You et al.
Xiao-Hong Zhou et al.
Metal drugs, such as platinum drugs, are widely used in tumor treatment. However, most traditional tumor treatments face the risk of failure due to the ineffective control over drug resistance and tumor metastasis. Targeting the cell membra...
A self-assembled multicomponent RNA nano-biopesticide for increasing the susceptibility of destructive bean flower thrips to insecticides via dsNrf2 [0.03%]
一种可自我组装的多组分RNA纳米生物农药可通过dsNrf2增加毁灭性刀豆花蓟马对杀虫剂的敏感性
Jiajia Zhao,Zeng Wang,Jiaming Yin et al.
Jiajia Zhao et al.
High resistance of bean flower thrips (BFT, Megalurothrips usitatus) has led to the unscientific application of insecticides to cause famous "toxic cowpea" incidents in China. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays an impo...
Structural optimization of Sr/Zn-phosphate conversion coatings triggered by ions preloading on micro/nanostructured titanium surfaces for bacterial infection control and enhanced osteogenesis [0.03%]
离子预加载触发的微/纳米结构钛表面Sr/Zn磷酸盐转化膜结构优化用于控制细菌感染和促进成骨作用
Kangqing Zuo,Aonan Li,Taoning Si et al.
Kangqing Zuo et al.
Phosphate conversion coatings on metallic implants can synergistically integrate functional components and structural regulation, offering excellent biocompatibility and osteogenic activity. However, the passive oxide layer on the titanium ...
Silicon-coated carbon quantum dots composite nanomaterials mediate pest resistance activation in tobacco (Nicotiana tabacum) [0.03%]
硅包覆碳量子点纳米复合材料介导烟草对病虫害抵抗性的激活作用
Kang-Li He,Jing-Han Yang,Fu-Xiao Yu et al.
Kang-Li He et al.
Background: Plant resistance inducers based on nanomaterials (NMs) are a cutting-edge and promising field of interdisciplinary research, focused on developing environmentally and ecologically friendly alternatives for pro...
Baicalein based nano-delivery system restores mitochondrial homeostasis through PPAR signaling pathway to promote wound healing in diabetes [0.03%]
基于 baicalein 的纳米输送系统通过 PPAR 信号通路恢复线粒体稳态以促进糖尿病伤口愈合
Danlei Qin,Weiting Hu,Yanqin Guo et al.
Danlei Qin et al.
Wound healing in diabetes is a substantial clinical challenge due to the hyperglycemic microenvironment, high pH, bacterial infection, persistent inflammation, and impaired cellular functions, attributed to mitochondrial dysfunction. Here, ...
Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy [0.03%]
基于纳米递送系统的中药活性成分整合在肿瘤免疫治疗中的应用
Hao Zheng,Yiquan Chen,Wei Luo et al.
Hao Zheng et al.
Tumor immune escape presents a significant challenge in cancer treatment, characterized by the upregulation of immune inhibitory molecules and dysfunction of immune cells. Tumor immunotherapy seeks to restore normal anti-tumor immune respon...
Outer membrane vesicles of Porphyromonas gingivalis impede bone regeneration by inducing ferroptosis via the Hippo-YAP signaling pathway [0.03%]
牙龈卟啉单胞菌外膜囊泡通过Hippo-YAP信号通路诱导铁死亡从而阻碍骨再生
Xinghong Luo,Yanzhen Wang,Tingting Ning et al.
Xinghong Luo et al.
Background: Although increasing evidence confirms that oral microbiota imbalance is a critical factor inhibiting bone regeneration, the specific mechanisms have remained unexplored. This study aims to use periodontitis as...
Enhanced therapeutic effects of all-trans retinoic acid nanostructured lipid carrier composite gel drug delivery system for alopecia areata [0.03%]
全反式维甲酸纳米结构脂质载体复合凝胶给药系统治疗斑秃的疗效观察
Lingling Zheng,Yang Du,Lulu Zhang et al.
Lingling Zheng et al.
Background: Alopecia areata (AA) affects approximately 2% of the global population and causes psychological distress. All-trans retinoic acid (ATRA) has the potential to promote hair regeneration; however, its clinical us...
The biological activity and potential of probiotics-derived extracellular vesicles as postbiotics in modulating microbiota-host communication [0.03%]
益生菌衍生的外泌体后生物活性及其在调节微生物组-宿主通讯中的潜力
Xiaoming Zhang,Ye Wang,Qiyu E et al.
Xiaoming Zhang et al.
Probiotics such as Lactobacillus and Bifidobacterium spp. have been shown to be critical for maintaining host homeostasis. In recent years, key compounds of postbiotics derived from probiotic metabolism and cellular secretion have been iden...