Natural multi-active nanoparticles integrated biological hydrogel microcarriers for wound healing [0.03%]
天然多效纳米粒子集成生物水凝胶微载体促进伤口愈合
Junyi Che,Danqing Huang,Yang Wang et al.
Junyi Che et al.
Bioactive substance-integrated hydrogels have demonstrated efficacy in diabetic wound treatment. However, challenges remain in identifying naturally derived, multifunctional active substances capable of addressing the complex pathophysiolog...
Metal-organic frameworks activate the cGAS-STING pathway for cancer immunotherapy [0.03%]
金属有机骨架通过激活cGAS-STING通路进行癌症免疫治疗
Shuxuan Zhu,Wenfei Xu,Hongxia Li et al.
Shuxuan Zhu et al.
Despite the major breakthroughs in immunotherapy, a substantial number of cancer patients continue to confront problems such as low response rates, which restrict the overall effectiveness of existing treatments. There is an urgent necessit...
Blood-brain barrier-penetrating Angiopep-2/Sirtuin 1 nanoparticles rescue sevoflurane neurotoxicity through multi-omics identified necroptosis pathways [0.03%]
穿透血脑屏障的Angiopep-2/沉默信息调节因子1纳米颗粒通过多组学识别的坏死性凋亡通路缓解异氟醚神经毒性
Yi Chang,Xue Zhang,Shuo Zhang et al.
Yi Chang et al.
Developmental neurotoxicity (DNT) induced by sevoflurane exposure poses significant risks to pediatric anesthesia, yet effective protective strategies remain limited. Here, we developed self-assembling Angiopep-2/SIRT1 nanoparticles (Ang/SI...
Self-assembled nanopeptide dendrites with high antifungal activity and protease hydrolytic stability for fungal keratitis treatment [0.03%]
一种高抗真菌活性和蛋白酶水解稳定性的纳米肽树枝状分子自组装体用于真菌性角膜炎治疗
Guoyu Li,Hongyu Chen,Wenwen Chen et al.
Guoyu Li et al.
The excessive use of antibiotics in recent years has contributed to an increase in microbial resistance, thereby compromising the health of both humans and animals and necessitating the development of innovative therapeutic strategies. In t...
Strategic advances in liposomes technology: translational paradigm in transdermal delivery for skin dermatosis [0.03%]
脂质体技术的进展在皮肤病透皮治疗中的应用研究
Anmol Choudhury,Apoorv Kirti,Sudakshya S Lenka et al.
Anmol Choudhury et al.
Liposomes, spherical vesicles made of phospholipids and cholesterol, have captivated researchers for their encapsulation abilities, biocompatibility, and versatility. This review delves into the core aspects and benefits of liposomal techno...
Bioengineered cardiovascular bypass grafts via in vivo self-assembly of scaffold-guided tubular tissue in rats [0.03%]
基于血管内支架引导组织管状结构自组装构建生物工程化心血管旁路移植血管（小鼠）
Shiqi Hu,Xiuhong Sun,Rui Zhou et al.
Shiqi Hu et al.
Cardiovascular bypass grafting remains a crucial therapeutic approach for complex atherosclerotic diseases. However, the clinical application of traditional grafts is hampered by limited autologous vessel availability, while the translation...
Bioengineered microneedles and nanomedicine as therapeutic platform for tissue regeneration [0.03%]
用于组织再生的生物工程微针和纳米医学治疗平台
Yi-An Mao,Shihui Xu,Xiaozhou Shi et al.
Yi-An Mao et al.
Tissue regeneration remains one of the most formidable challenges in modern medicine, particularly in the treatment of chronic wounds, organ damage, and degenerative diseases. These conditions are characterized by dysregulated healing, irre...
hUMSC-Exosomes suppress TREM1-p38 MAPK signaling via HMGB1-dependent mechanisms to reprogram microglial function and promote neuroprotection in ischemic stroke [0.03%]
人脐带源间质干细胞外泌体通过依赖于高迁移率族蛋白箱蛋白box protein 1机制抑制触发受体信号通路-1- p38丝裂原活化蛋白激酶信号转导重构缺血性卒中后的小胶质细胞功能并发挥神经保护作用
Zengyu Zhang,Rong Ji,Zhuohang Liu et al.
Zengyu Zhang et al.
Background: Ischemic stroke induces profound neuroinflammation, where microglial activation exacerbates secondary brain injury. Human umbilical mesenchymal stem cell-derived exosomes (hUMSC-Exos) exhibit therapeutic poten...
Engineered MEVs for photoreceptor-targeted delivery of USP25 to alleviate diabetic retinopathy [0.03%]
工程化MEV以视网膜靶向递送USP25缓解糖尿病视网膜病变
Yaoxiang Sun,Shenyuan Chen,Xiaoyuan Qi et al.
Yaoxiang Sun et al.
Diabetic retinopathy (DR) is the major cause of vision decline in adults worldwide. Photoreceptor loss is considered a main pathogenesis of retinal dysfunction in DR. Recently, mesenchymal stem cell-derived extracellular vesicles (MEVs) tre...
Imogolite nanotube modifications impact pulmonary toxicity in mice: implications for safe and sustainable by design (SSbD) [0.03%]
林素纳米管的改性影响小鼠肺毒性：面向可持续和安全设计（SSbD）的启示
Pernille Høgh Danielsen,Sarah Søs Poulsen,Alicja Mortensen et al.
Pernille Høgh Danielsen et al.
Background: Imogolite is a naturally occurring hollow aluminosilicate nanotube with potential for engineered applications due to its high aspect ratio, hydrophilicity, and polarization. However, these same features raise ...