Cytotoxic iridoid glycosides from the aerial parts of Paederia yunnanensis [0.03%]
云南过路黄地上部分的细胞毒性环烯醚萜苷类化合物
Jiang Hu,Gui-Hua Yu,Feng-Ming Xu et al.
Jiang Hu et al.
Three previously undescribed iridoid glycosides, 6α-O-trans-sinapoyl-paederosidic acid ethyl ester (1), 6'-O-trans-feruloyl-paederosidic acid methyl ester (2), and 10-O-trans-p-coumaroyl-(4S,6R)-3,4-dihydro-3β-ethoxypaederoside (3), were ...
Resveratrol affects proliferation, apoptosis and migration of fibroblast cells as well as inhibits COL1A1/2 and TGFB2/3 gene expression [0.03%]
白藜芦醇影响成纤维细胞的增殖、凋亡和迁移，并抑制COL1A1/2和TGFB2/3基因表达
Mei-Li Li,Kun Pang,Lei Qiao et al.
Mei-Li Li et al.
Primary fibroblasts isolated from pterygium and skin pathological scar were identified by immunofluorescence staining. It was found by CCK8 and TUNEL that high-dose resveratrol, a Chinese medicine monomer, could inhibit proliferation, promo...
Analytical method development and validation for monosaccharide profiling in Lignosus rhinocerotis using rP-HPLC [0.03%]
Lignosus rhinocerotis中单糖分析方法的建立及验证
Solehah Mohd Rosdan Bushra,Ruzilawati Abu Bakar,Asma Abdullah Nurul
Solehah Mohd Rosdan Bushra
Lignosus rhinocerotis is rich in polysaccharide with diverse -bioactivities. This study developed a pre-column derivatization reversed-phase high-performance liquid chromatography (RP-HPLC) method for analyzing monosaccharides in Lignosus r...
Synthesis and biological evaluation of oleanolic acid derivatives as potential c-kit inhibitors [0.03%]
作为潜在c-kit抑制剂的熊果酸衍生物的合成及生物活性评估
Zhen-Yu Kuai,Zheng-Fei Zhu,Xuan Zeng et al.
Zhen-Yu Kuai et al.
The 3-O-(4'-imidazole)-12-en-olean-28-amide derivatives 7-1 to 7-11 through modification the C-3 and C-28 of the natural product oleanolic acid were prepared, and their structures were confirmed by MS,1H NMR and 13C NMR. The antitumor activ...
Jie-Yi Zhou,Chen-Yang Cui,Li-Na Mao et al.
Jie-Yi Zhou et al.
A comprehensive study was carried out on Penicillium brocae G2131, which originated from Yunnan Menghai Pu'er tea. This study resulted in the identification of five compounds, one of which is a newly discovered compound: (5aR)-6-((2R,5R,E)-...
Exploration and computational assessment of ochrocephalamine G from Oxytropis ochrocephala as an anti-HBV candidate [0.03%]
基于计算方法探究唐松草头孢素G作为抗HBV候选药物的潜力
Ya-Kun Zhang,Zhan Xue,Jian-Bo Tong et al.
Ya-Kun Zhang et al.
Three compounds, including a novel quinolizidine alkaloid, ochrocephalamine G (1), were isolated from Oxytropis ochrocephala. Structural elucidation was achieved through spectroscopic analysis and electronic circular dichroism. Biological a...
Analysis of intestinal bacterial carboxylesterase-mediated metabolites and the potential antitumour molecular mechanism of angoroside C [0.03%]
安格罗昔洛地素C的肠道细菌羧酸酯酶介导代谢产物及潜在抗肿瘤分子机制分析
Jian-Ye Song,Xiang Hui,Ru Feng et al.
Jian-Ye Song et al.
Angoroside C (AgrC) is a compound with many pharmacological properties. However, its antitumour potential has not been well studied. The low bioavailability of AgrC suggests a strong link to gut bacteria. Therefore, we identified and quanti...
Cynatroside B2, a new anti-inflammatory C21 steroid from the roots and rhizomes of Vincetoxicum atratum [0.03%]
来源于大苦荬根及根茎的抗炎成分 cynatroside B2
Jing-Yu Zhang,Yi-Nuo Shi,Sheng Dong et al.
Jing-Yu Zhang et al.
A series of C21 steroidal glycosides were isolated from the roots and rhizomes of Vincetoxicum atratum (Bunge) C. Morren et Decne., including a new compound, cynatroside B2 (1), and seven known compounds (2-8). Their structures were identif...
Exploring the potential anticancer targets and mechanistic pathways of Elsholtzia densa essential oil based on network pharmacology [0.03%]
基于网络药理学探究阴行草精油潜在的抗肿瘤靶点及机制路径
Qian Wang,Xiao-Ying Wang,Jin Tao et al.
Qian Wang et al.
This study aimed to assess the composition of Elsholtzia densa essential oil (EBE) and identify potential targets for inhibiting human hepatocellular carcinoma cell proliferation. The plants were collected from four regions: Jiuzhi, Qinghai...
Pachyphyllanone, a new cycloartane triterpenoid isolated from Aglaia pachyphylla and its cytotoxic activity [0.03%]
来自Aglaia pachyphylla的新环阿托罗烷三萜衍生物及其细胞毒性作用
Wahyu Safriansyah,Endang Juliansyah,Rustaman et al.
Wahyu Safriansyah et al.
Aglaia pachyphylla is a species from the Aglaia genus (Meliaceae) and the chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (1), along with four known compounds (2-5) were isolated from ...