Hypoxia-induced XBP1s-MYDGF axis suppresses ferroptosis through UBQLN1-mediated stabilization of LCN2 in gastric cancer [0.03%]
缺氧诱导的XBP1s-MYDGF轴通过UBQLN1介导LCN2稳定抑制胃癌铁死亡
Qi Zhou,Hongyan Qi,Yonghui Zou et al.
Qi Zhou et al.
Solid tumors such as gastric cancers exploit hypoxia-induced adaptive mechanisms to evade cell death. Here, we identify a hypoxia-triggered signaling axis in which the spliced form of XBP1s transcriptionally activates MYDGF. We demonstrate ...
Stress-responsive membrane proteins as execution nodes of tumor cell adaptation to microenvironmental stress [0.03%]
应激响应性膜蛋白是肿瘤细胞适应微环境应激的执行节点
Xin He,Taoying Huang,Zhen Wang et al.
Xin He et al.
Solid tumors arise within hostile microenvironments shaped by hypoxia, nutrient deprivation, acidosis, mechanical stress, immune pressure, and therapy-induced insults. Beyond malignant cells, stromal and immune components, including cancer-...
TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma [0.03%]
TAK1是横纹肌肉瘤中促癌信号传导和分化障碍的关键调节因子
Anh Tuan Vuong,Aniket S Joshi,Anirban Roy et al.
Anh Tuan Vuong et al.
Rhabdomyosarcoma (RMS) is a malignant soft tissue sarcoma with a skeletal muscle phenotype, accounting for approximately 50% of all pediatric soft tissue sarcomas and 8% of all childhood cancers. Although RMS cells express myogenic regulato...
SRSF10 promotes cisplatin resistance in bladder cancer via BIN1 Exon 12 retention and ANXA1 activation [0.03%]
SRSF10通过BIN1第12外显子滞留和ANXA1激活促进膀胱癌顺铂耐药性
Mengqing Xiao,Yanni Ma,Ganghua Zhang et al.
Mengqing Xiao et al.
RNA alternative splicing is a fundamental post-transcriptional mechanism that plays a key role in generating protein diversity. Previous studies from our group have shown that overexpression SRSF10 could promote liver cancer cell proliferat...
Deciphering functional intra-tumoral heterogeneity in BRAFV600E-driven mouse thyroid cancer reveals EMT trajectory and metabolic remodeling [0.03%]
解码BRAFV600E驱动的小鼠甲状腺癌的肿瘤内异质性，揭示上皮间充质转化轨迹和代谢重塑
Jing Yu,Siyi Shen,Rongkui Luo et al.
Jing Yu et al.
A better understanding of functional heterogeneity of tumor cells may lead to the improvement of the diagnosis and development of effective therapies for patients with papillary thyroid cancer (PTC). Here, the transcriptional heterogeneity ...
S100A6 promotes liver metastasis by activating FGFR3 signaling in BAP1-deficient uveal melanoma [0.03%]
BAP1缺陷型脉络膜黑色素瘤中S100A6通过激活FGFR3信号促进肝转移
Yonghao Li,Churun Zheng,Yanting Liang et al.
Yonghao Li et al.
Approximately 50% of uveal melanoma (UM) patients develop treatment-resistant liver metastases, surviving less than one year after diagnosis. While BRCA1-associated protein 1 (BAP1) deficiency strongly correlates with UM metastasis, its mec...
Pre-operative circulating tumor cells predict worse treatment outcome in patients with high-grade serous ovarian cancer [0.03%]
术前循环肿瘤细胞预测高级别浆液性卵巢癌患者预后较差
Annabelle Lobermeyer,Jenna Sophie Schöllhorn,Paul N Rademacher et al.
Annabelle Lobermeyer et al.
High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy. Pre- and post-operative, non-invasive biomarkers for reliable treatment outcome prediction, (minimal) residual disease detection, and prognosis are not ye...
Spliceosomal component SNRPE drives cell proliferation by regulating CTP synthase 1 mRNA splicing in ovarian cancer [0.03%]
剪接体成分SNRPE通过调节卵巢癌CTP合成酶1mRNA剪接促进细胞增殖
Yingying Pu,Zhongshao Chen,Qianqian Gao et al.
Yingying Pu et al.
Sustained proliferation is a hallmark of tumor cells. Cancer-associated alternative splicing (AS) events can provide proliferative advantages in tumors, suggesting that identifying aberrant RNA splicing events linked to proliferation in ova...
Trisomy 8 alters chromatin conformations and activates Y chromosome genes in stem cells to drive a pre-leukemic state [0.03%]
染色体8三体通过改变染色质构象并激活干细胞中的Y染色体基因来驱动白血病前期状态
Jie Bai,Kimi Araki,Daisuke Kurotaki et al.
Jie Bai et al.
The mechanistic role of trisomy 8 in the development of myelodysplastic syndrome (MDS) remains poorly defined. Here, we generated a trisomy 8 mouse model by transferring a human chromosome 8 into murine embryonic stem cells and prospectivel...
TWIST1 mediated transcriptional activation of SPON2 drives colorectal cancer peritoneal metastasis through stromal cell signaling network [0.03%]
TWIST1介导的SPON2转录激活通过间质细胞信号网络驱动结直肠癌腹膜转移
Zhuan Zhou,Alessandro La Ferlita,Manoj H Palavalli et al.
Zhuan Zhou et al.
Colorectal cancer (CRC) peritoneal metastasis (PM) accounts for 25-35% of stage IV cases. CRC PM carries a median overall survival of 16 months with systemic chemotherapy and an almost 0% 5-year survival rate. The molecular mechanisms drivi...