S100A6 promotes liver metastasis by activating FGFR3 signaling in BAP1-deficient uveal melanoma
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Approximately 50% of uveal melanoma (UM) patients develop treatment-resistant liver metastases, surviving less than one year after diagnosis. While BRCA1-associated protein 1 (BAP1) deficiency strongly correlates with UM metastasis, its mechanistic role remain... ...