Epithelial interferon-stimulated gene programs modulate chemotherapy sensitivity in colorectal cancer via EPSTI1 [0.03%]
Erdogan Pekcan Erkan,Emmi Hämäläinen,Julia Kolikova et al.
Erdogan Pekcan Erkan et al.
Although chemotherapy in colorectal cancer (CRC) primarily targets epithelial tumor cells, the epithelial cell-intrinsic mechanisms underlying heterogeneous treatment responses remain poorly understood. We integrated the genomic, transcript...
Cholangiocarcinoma:Unveiling the cold tumor microenvironment and strategies for immune rejuvenation [0.03%]
Wenqi Xu,Shuhan Liu,Longlong Sun et al.
Wenqi Xu et al.
Cholangiocarcinoma (CCA) remains a therapeutic challenge due to its "immune cold" phenotype, defined by a desmoplastic fortress and profound T cell exclusion. This review characterizes the multi layered immune escape mechanisms, ranging fro...
PTEN-AKT2 regulates mixed lineage liver cancer development and sensitizes cancer cells to TGFβ treatment [0.03%]
Qi Tang,Ielyzaveta Slarve,Jingyu Chen et al.
Qi Tang et al.
Primary liver cancers, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), arise from the neoplastic transformation of hepatocytes and cholangiocytes, respectively. Loss or downregulation of PTEN, a tumor suppressor negat...
Tumor-derived PTX3 drives an immunosuppressive myeloid landscape and inhibits CD8 T cell-mediated anti-tumor immunity via PI3K-dependent signaling [0.03%]
肿瘤衍生的PTX3通过PI3K依赖性信号驱动免疫抑制性髓样细胞景观并抑制CD8 T细胞介导的抗肿瘤免疫反应
Mohamed Y Zaky,Monika Vashisht,Mohammad A I Al-Hatamleh et al.
Mohamed Y Zaky et al.
Cancer immunotherapy, particularly immune checkpoint inhibitors (ICIs), has emerged as a pillar of modern oncology. However, clinical response rates in head and neck squamous cell carcinoma (HNSCC) remain modest, underscoring the need to id...
The Inv(16) Oncogene CBFB::MYH11 is Required for the Survival of Leukemia Cells in the Blood and Spleen, but not the Bone Marrow [0.03%]
.Inv(16)癌基因CBFB::MYH11是维持血液和脾脏中白血病细胞存活所必需的，但并非骨髓中白血病细胞生存的必需条件
Sipra Panda,Yiqian Wang,Venkatasai Rahul Dogiparthi et al.
Sipra Panda et al.
Inversion of chromosome 16 [inv(16)] generates the fusion gene CBFB::MYH11 (CM) and is one of the most common chromosomal rearrangements in Acute Myeloid Leukemia (AML). Expression of CM is required for leukemia initiation. Patients with in...
Imbalanced p53-RB signaling triggers cGAS-STING-mediated immune activation in early oral cancer development [0.03%]
TP53-RB信号失调通过cGAS-STING介导的免疫激活触发口腔早期癌症的发展
Zichao Lu,Yasuhiro Mouri,Wenhua Shao et al.
Zichao Lu et al.
Combined alterations of TP53 and CDKN2A are frequently observed in head and neck squamous cell carcinoma (HNSCC); however, their cooperative roles in oral carcinogenesis remain unclear. To investigate their interaction under carcinogenic st...
Inhibition of PINK1/Parkin-mediated mitophagy enhances the susceptibility of breast cancer to cuproptosis [0.03%]
PINK1/Parkin介导的线粒体自噬抑制可增强乳腺癌对铜死亡的敏感性
Chaoyi Tang,Ka Su,Zexu Zhan et al.
Chaoyi Tang et al.
Cuproptosis is a novel form of programmed cell death characterized by the accumulation of copper ions in the mitochondria, the formation of DLAT oligomers, and the depletion of Fe-S cluster proteins. However, the alterations in mitochondria...
Editorial Expression of Concern: Interleukin-6 activates phosphoinositol-3' kinase in multiple myeloma tumor cells by signaling through RAS-dependent and, separately, through p85-dependent pathways [0.03%]
对编辑部关注的表述：通过RAS依赖性以及分别通过p85依赖性的途径在多发性骨髓瘤肿瘤细胞中互 interleukin-6激活磷oinositol-3' kinase
Jung-Hsin Hsu,Yijiang Shi,Patrick Frost et al.
Jung-Hsin Hsu et al.
Correction to: MiR-106b expression determines the proliferation paradox of TGF-β in breast cancer cells [0.03%]
Correction to: MiR-106b表达决定了TGF-β在乳腺癌细胞中的增殖悖论
C Gong,S Qu,B Liu et al.
C Gong et al.
Published Erratum
Oncogene. 2026 Aug 10. DOI:10.1038/s41388-026-03954-y 2026
Complementary intra- and extracellular AGR2 activities support epithelial ovarian cancer cell aggressiveness [0.03%]
细胞内和细胞外 AGR2 的协同作用可增强上皮性卵巢癌的侵袭性
Marianne Guilbard,Saïd Taouji,Marc Aubry et al.
Marianne Guilbard et al.
Anterior Gradient 2 (AGR2) is an endoplasmic reticulum (ER)-resident protein that belongs to the protein disulphide isomerase (PDI) family, and whose expression and secretion are induced by stress. Extracellular (secreted) AGR2 has been pro...