New insights into the ACLY-mediated metabolic and epigenetic interplay in macrophages [0.03%]
探讨巨噬细胞中ACLY介导的代谢与表观遗传相互作用的新见解
Leyi Yuan,Tong Wang,Yajuan Song et al.
Leyi Yuan et al.
Macrophages are plastic innate immune cells that polarize into pro-inflammatory M1 or anti-inflammatory M2 phenotypes in response to microenvironmental signals, with their dynamic balance governing inflammation resolution and tissue homeost...
Design, synthesis, and antibacterial activity study of pyrroloquinazoline diamine derivatives [0.03%]
含二胺基吡咯并[2,3-d]嘧啶类衍生物的设计合成及抗菌活性研究
Muchun Cheng,YaJing Tian,JieYa Shang et al.
Muchun Cheng et al.
To combat antimicrobial resistance (AMR), a novel series of pyrrolo[3,2-f]quinazoline-diamine (PQD) derivatives (5a-5z) featuring a flexible benzyl-oxo-benzyl side chain were designed and synthesised via structural optimisation of lead comp...
Nanozymes: bridging nanoscale characteristics and catalytic mechanisms for advanced biomedical applications [0.03%]
纳米酶：用于先进生物医学应用的纳米特性和催化机制之间的桥梁
Yunqin Sun,Yunchang Yang,Xinyao Kang et al.
Yunqin Sun et al.
Nanozymes-nanomaterials with intrinsic enzyme-like activity-have emerged as a transformative paradigm in biomedicine. Their catalytic proficiency is fundamentally dictated by unique nanoscale characteristics, particularly tuneable surface d...
Design, synthesis, and biological evaluation of 6-aryl-3-(3,4,5-trimethoxyphenyl)imidazo[1,2-a]pyridine derivatives as novel tubulin inhibitors with potent anticancer efficacy [0.03%]
设计、合成及生物活性评价新的微管蛋白抑制剂6-芳基-3-(3,4,5-三甲氧基苯基)咪唑并[1,2-a]吡啶衍生物用于抗肿瘤作用研究
Wen Xu,Yujing Zhang,Qianqian Xu et al.
Wen Xu et al.
Tubulin, the fundamental component of microtubules, remains a critical target in anticancer therapy. The development of small-molecule tubulin polymerization inhibitors continues to drive the discovery of novel chemotherapeutic agents. Thro...
Shikonin suppresses diffuse large B-cell lymphoma progression by inducing ferritinophagy and ferroptosis via lncRNA ADPGK-AS1 downregulation [0.03%]
芍药苷通过下调长链非编码RNA ADPGK-AS1诱导铁死亡自噬从而抑制弥漫性大B细胞淋巴瘤进展
Can Chen,Xiaofei Chen,Xilian Huang et al.
Can Chen et al.
Shikonin, a natural compound, exhibits antitumor effects in DLBCL, but its mechanism remains unclear. Shikonin's cytotoxicity in DLBCL cells was assessed by MTT assays. Ferroptosis and lipid peroxidation markers were analysed via flow cytom...
Discovery of a novel and potent KRASG12V-targeting peptide with antiproliferative activity against colorectal cancer cells [0.03%]
一种针对KRASG12V的新型抗增殖多肽及其对结直肠癌细胞的作用研究
Hai Zhang,Shudan Yang,Yuting Wang et al.
Hai Zhang et al.
Despite the clinical relevance of KRASG12V in colorectal cancer, KRASG12V-specific inhibitors remain limited. Through structure-based virtual screening of a 59,319-member peptide library, we identified four KRASG12V-targeting peptides, amon...
Lidocaine enhances antitumor effects of sorafenib and GW5074 in colorectal cancer cells [0.03%]
利多卡因增强索拉非尼和GW5074在结直肠癌细胞中的抗肿瘤效应
Tzu-Chiao Lin,Zih-Syuan Wu,Shih-Ming Huang et al.
Tzu-Chiao Lin et al.
Targeted therapies have broadened the treatment landscape for colorectal cancer (CRC), highlighting the need for rational combination strategies. Although sorafenib and GW5074 show therapeutic promise and lidocaine may sensitise cancer cell...
Design, synthesis, and anti-inflammatory evaluation of novel analogues derived from the natural product reticuline [0.03%]
来源于天然产物网地辛的新型类似物的设计、合成及抗炎活性评价
Yanyan Feng,Tong Li,Cheng Chen et al.
Yanyan Feng et al.
The natural alkaloid reticuline exhibits promising anti-inflammatory activity in preclinical models; however, its development is hindered by moderate potency and limited accessibility. To overcome these hurdles, we developed an efficient sy...
Targeting the BMX in cancer: molecular mechanisms and emerging therapeutic strategies [0.03%]
癌症中的BMX靶向治疗：分子机制和新兴的治疗策略
Man Zhang,Jinchi Chen,Rong Liang et al.
Man Zhang et al.
Bone Marrow Tyrosine Kinase on Chromosome X (BMX), also known as epithelial/endothelial cell kinase (ETK), is a core member of the Tec family of non-receptor tyrosine kinases. Structurally, BMX kinase contains an N-terminal PH domain, a BH ...
Design, synthesis, anticancer activity, and mechanistic investigation of 4,5,6,7-tetrahydrobenzo[ b]thiophene carboxamides as CDK-2 inhibitors: in vitro and in silico DFT and molecular docking study [0.03%]
设计、合成及抗癌活性和机制研究：作为CDK-2抑制剂的4,5,6,7-四氢苯并噻吩类羧酸胺：体外实验以及基于密度泛函理论与分子对接的计算模拟研究
Kurls E Anwer,Ramadan M Ramadan,Eman S Nossier et al.
Kurls E Anwer et al.
Utilising drug design methodologies including bioisosteric modification and substituents variation, sets of 4,5,6,7-tetrahydrobenzo[b]thiophene carboxamides were synthesised, by conventional heating and eco-friendly microwave-assisted techn...