Design and Pictet-Spengler enabled synthesis of carboxamide-substituted imidazo[1,2- a]quinoxalines as dual EGFR and tubulin targeting anticancer agents
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In this study, we report the Pictet-Spengler enabled synthesis of a series of eighteen carboxamide-substituted imidazo[1,2-a]quinoxaline derivatives (JRC-1-JRC-18) targeting epidermal growth factor receptor (EGFR) and tubulin. Compounds JRC-2 and JRC-6 exhibit... ...
