Primary prevention of chronic kidney disease in type 2 diabetes mellitus with sodium-glucose cotransporter 2 inhibitors [0.03%]
钠-葡萄糖协同转运蛋白2抑制剂在2型糖尿病慢性肾脏病一级预防中的作用
Melanie Wanigatunga,Michael W Holliday,Sankar D Navaneethan
Melanie Wanigatunga
Purpose of review: Sodium-glucose cotransporter 2 inhibitors (SGLT2is) have emerged as a transformative class of agents that provide significant kidney and cardiovascular protection for those with diabetic kidney disease....
Financial and policy challenges of delivering kidney replacement therapies in resource-limited settings [0.03%]
资源匮乏条件下提供肾脏替代治疗的财政和政策挑战
Anukul Ghimire,Olalekan E Ojo,Aminu K Bello
Anukul Ghimire
Purpose of review: The adoption of a resolution to prevent and control kidney disease at the 2025 World Health Assembly has set the stage for the global community to address barriers in providing life-saving kidney replac...
The role of kir4.1/Kir5.1 in mediating the effect of angiotensin-II on Na-Cl-cotransporter [0.03%]
Kir4.1/Kir5.1在介导血管紧张素II对Na-Cl同向转运体的作用中的作用研究
Wen-Hui Wang,Dao-Hong Lin
Wen-Hui Wang
Purpose of review: Angiotensin-II plays an important role in regulating thiazide-sensitive Na-Cl-cotransporter (NCC) encoded by Slc12A3. Moreover, inwardly-rectifying-K+ (Kir) channels 4.1/Kir5.1 encoded by Kcnj10 and Kcn...
Role of the calcium-sensing receptor in regulating calcium transport in the thick ascending limb [0.03%]
钙感受器在调节髓拌粗段钙转运中的作用
Milos Bogdanovic,Henrik Dimke
Milos Bogdanovic
Purpose of review: The calcium-sensing receptor (CASR) is a principal regulator of calcium balance. In the kidney, it directly modulates calcium reabsorption in the thick ascending limb (TAL). This review focuses on the C...
Social determinants of chronic kidney disease: from association to clinical and population action [0.03%]
慢性肾脏病的社会决定因素：从中观到临床和人群行动
Ricardo Silvariño,Laura Sola
Ricardo Silvariño
Purpose of review: To synthesize recent evidence on how social determinants -socioeconomic conditions, health system, physical environment, psychosocial factors, life course, structural forces, migration, gender, and popu...
Rosa Moyses,Aline Martin
Rosa Moyses
Tally Naveh-Many,Efrat Brook,Alia Hassan
Tally Naveh-Many
Purpose of review: Parathyroid hormone (PTH) regulates mineral metabolism and bone strength. Beyond the well-characterized roles of calcium, phosphate, vitamin D, and fibroblast growth factor 23 (FGF23), emerging evidence...
Living after acute kidney injury: understanding the physical and psychosocial consequences [0.03%]
急性肾损伤后的生存状况——理解生理和心理的社会后果
Joana Gameiro,José Agapito Fonseca,José António Lopes
Joana Gameiro
Purpose of review: Acute kidney injury (AKI) is increasingly recognized as a condition with important long-term consequences, beyond kidney specific outcomes. This review addresses the growing population of AKI survivors ...
Novel developments in untangling the significance of Epac signaling in the kidney [0.03%]
解读Epac信号通路在肾脏中意义的新进展
Kyrylo Pyrshev,Oleg Zaika,Xiaodong Cheng et al.
Kyrylo Pyrshev et al.
Purpose of review: Exchange proteins directly activated by cAMP (Epac1 and Epac2) are abundantly expressed in the glomerulus and epithelial cells of the renal tubule. Epac activity is rather benign at baseline, but it can...
Abbal Koirala,Aditi Singh,Duvuru Geetha
Abbal Koirala
Purpose of review: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is now recognized as a complex immune-mediated inflammatory disorder rather than a purely pauci-immune small-vessel vasculitis. Ad...