Kevin M Bennett,Jennifer R Charlton,Edwin J Baldelomar
Kevin M Bennett
Purpose of the review: This review summarizes recent pivotal studies demonstrating the importance of nephron number as a potential clinical marker of kidney health, and highlights technological advances aimed at facilitat...
From K+ sensing to NCC on/off switching: KS-WNK1 as a spatial organizer of WNK signaling [0.03%]
从K+感应到NCC开关转换：KS-WNK1作为WNK信号的空间组织者
Laura Vergara,José A Cabrales-Alcaraz,Jessica Paola Bahena-López et al.
Laura Vergara et al.
Purpose of review: In the distal convoluted tubule (DCT), the NaCl cotransporter (NCC) regulates renal K+ homeostasis by controlling distal Na+ delivery. Although the kidney-specific WNK1 isoform kidney-specific with no l...
Seeing is believing: unraveling kidney function and remodeling in real time with in vivo imaging [0.03%]
见即相信：利用活体成像技术实时解开肾脏功能和重塑的奥秘
Anna Faivre,Anders M Kristensen,Ina Maria Schiessl
Anna Faivre
Purpose of review: Live imaging has become a transformative tool in kidney research, enabling real-time visualization of renal structure and function in vivo. With rapid technological progress, particularly in multiphoton...
Ayşe Balat
Ayşe Balat
Purpose of review: Children differ significantly from adults, and their biological characteristics make them the most vulnerable group in terms of disease. Childhood kidney disease exemplifies health inequality at nearly ...
Diagnosis and treatment of immune checkpoint inhibitor induced kidney disease [0.03%]
免疫检查点抑制剂所致肾病的诊断和治疗
Kavita Mistry,Roya Best,Christopher T Stueber et al.
Kavita Mistry et al.
Purpose of review: The use of immune checkpoint inhibitors (ICIs) is expanding in the treatment of a variety of cancer types; however, treatment with ICIs may result in off-target kidney inflammation in 3-5% of patients, ...
Dinesh Jothimani,Sarah Khan,Sravanthi Devireddy et al.
Dinesh Jothimani et al.
Purpose of review: Hepatorenal syndrome (HRS) is the extreme manifestation of acute renal dysfunction in patients with cirrhosis, resulting from systemic vasodilation and renal vasoconstriction, leading to a reduction in ...
Multimorbidity after renal transplantation: incidence and implications for patients [0.03%]
肾移植后的多发病：发病率及对患者的含义
Samuel Strain,Lisa Crowley
Samuel Strain
Purpose of review: Kidney transplant recipients are living longer with functioning grafts while remaining vulnerable to accumulating chronic conditions driven by preexisting CKD-related disease burden, ageing, and long-te...
WNK1 is a central osmolality sensor that regulates arginine vasopressin secretion [0.03%]
WNK1是一个中心渗透压感受器，调节血管加压素分泌
Xin Jin,Mohammad Amir,Jian Xie et al.
Xin Jin et al.
Purpose of review: Maintaining constant cellular osmolality is essential for physiological function in terrestrial animals. However, the molecular identity of the brain sensor(s) that detect extracellular hypertonicity an...
Isaac Chung,Mimi Chen,Lisa Anderson et al.
Isaac Chung et al.
Purpose of review: Cardiorenal syndrome is common, increasing in prevalence mainly due to increases in obesity, diabetes, hypertension and chronic kidney disease. The patients with cardiorenal syndrome are often frail and...
Rebecca Zoe Halter,Jennifer Nogueira Coelho,Jessica A Dominguez Rieg et al.
Rebecca Zoe Halter et al.
Purpose of review: Sex-dependent differences are evident in most organs and contribute to variability in physiological function and disease susceptibility, which can consequently affect therapeutic responses. The kidney i...