From K+ sensing to NCC on/off switching: KS-WNK1 as a spatial organizer of WNK signaling
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Purpose of review: In the distal convoluted tubule (DCT), the NaCl cotransporter (NCC) regulates renal K+ homeostasis by controlling distal Na+ delivery. Although the kidney-specific WNK1 isoform kidney-specific with no lysine (k... ...