Effects of diltiazem on pharmacokinetics of tacrolimus in relation to CYP3A5 genotype status in renal recipients: from retrospective to prospective [0.03%]
维拉帕米对肾移植受者他克莫司药代动力学的影响及与CYP3A5基因型状态的关系：从回顾性研究到前瞻性研究
J-L Li,X-D Wang,S-Y Chen et al.
J-L Li et al.
The impact of CYP3A5*3, a CYP3A5 nonexpresser genotype, on inhibitory effects of diltiazem on tacrolimus metabolism has not been assessed. In retrospective study, when coadministered with diltiazem, mean increments in dose-adjusted C(0D7), ...
Randomized Controlled Trial
The pharmacogenomics journal. 2011 Aug;11(4):300-6. DOI:10.1038/tpj.2010.42 2011
Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population [0.03%]
谷胱甘肽S转移酶T1和M1拷贝数变异可预测前列腺癌、膀胱癌的发病率及前列腺癌、膀胱癌5年生存率以及子宫体癌的发病率
M S Nørskov,R Frikke-Schmidt,S E Bojesen et al.
M S Nørskov et al.
Glutathione-S-transferase T1 (GSTT1) and GSTM1 detoxify carcinogens and thus potentially contribute to inter-individual susceptibility to cancer. We determined the ability of GST copy number variation (CNV) to predict the risk of cancer in ...
β-Arrestin2 influences the response to methadone in opioid-dependent patients [0.03%]
β-逮捕素2通过影响美沙酮依赖患者的治疗反应发挥作用
B Oneda,S Crettol,M Bochud et al.
B Oneda et al.
β-Arrestin2 (ARRB2) is a component of the G-protein-coupled receptor complex and is involved in μ-opioid and dopamine D(2) receptor signaling, two central processes in methadone signal transduction. We analyzed 238 patients in methadone m...
Multicenter Study
The pharmacogenomics journal. 2011 Aug;11(4):258-66. DOI:10.1038/tpj.2010.37 2011
Association of the histidine-triad nucleotide-binding protein-1 (HINT1) gene variants with nicotine dependence [0.03%]
组胺三联体核苷酸结合蛋白1(HINT1)基因多态性与尼古丁依赖的相关性分析
K J Jackson,Q Chen,J Chen et al.
K J Jackson et al.
The histidine triad nucleotide-binding protein-1 gene (HINT1) is implicated in schizophrenia and in the behavioral effects of morphine and amphetamine. Because nicotine dependence (ND) is highly comorbid with schizophrenia and other substan...
CYP2C9 allele frequency differences between populations of Mexican-Mestizo, Mexican-Tepehuano, and Spaniards [0.03%]
墨西哥混血人种、墨西哥特佩胡亚人和西班牙人的CYP2C9等位基因频率差异
P Dorado,M G Sosa-Macias,E M Peñas-Lledó et al.
P Dorado et al.
Earlier we had found that the CYP2C9*2 allelic frequency was lower in Mexican-Americans living in California than in Spaniards (SP). This was assumed to be related to the low CYP2C9*2 and *3 allele frequencies in Orientals. This study was t...
Dynamics of plasma proteome during leptin-replacement therapy in genetically based leptin deficiency [0.03%]
遗传性瘦素缺乏患者进行瘦素替代治疗过程中的血浆蛋白质组动态变化特征分析
V P Andreev,R C Dwivedi,G Paz-Filho et al.
V P Andreev et al.
The effects of leptin-replacement therapy on the plasma proteome of three unique adults with genetically based leptin deficiency were studied longitudinally during the course of recombinant human leptin-replacement treatment. Quantitative p...
Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs [0.03%]
CYP3A4内含子多态性影响肝表达及他汀类药物反应
D Wang,Y Guo,S A Wrighton et al.
D Wang et al.
Cytochrome P450 3A4 (CYP3A4) metabolizes ∼50% of all clinically used drugs. Although CYP3A4 expression varies widely between individuals, the contribution of genetic factors remains uncertain. In this study, we measured allelic CYP3A4 hete...
The effect of CYP3A5 polymorphism on dose-adjusted cyclosporine concentration in renal transplant recipients: a meta-analysis [0.03%]
CYP3A5多态性对肾移植受者调整剂量后环孢素浓度影响的荟萃分析
H J Zhu,S H Yuan,Y Fang et al.
H J Zhu et al.
Cyclosporine (CsA) is a substrate of cytochrome P450 (CYP) 3A5 and has a narrow therapeutic range with large inter-individual variability. CYP3A5*3 polymorphism is reported to be functional and may contribute to the inter-individual variabi...
Meta-Analysis
The pharmacogenomics journal. 2011 Jun;11(3):237-46. DOI:10.1038/tpj.2010.26 2011
Impact of CYP2C8*3 on paclitaxel clearance: a population pharmacokinetic and pharmacogenomic study in 93 patients with ovarian cancer [0.03%]
CYP2C8*3对紫杉醇清除率的影响：卵巢癌患者群体药代动力学和药物基因研究
T K Bergmann,C Brasch-Andersen,H Gréen et al.
T K Bergmann et al.
The primary purpose of this study was to evaluate the effect of CYP2C8*3 and three genetic ABCB1 variants on the elimination of paclitaxel. We studied 93 Caucasian women with ovarian cancer treated with paclitaxel and carboplatin. Using spa...
Pharmacogenetic profiling of Aurora kinase B is associated with overall survival in metastatic colorectal cancer [0.03%]
艾瑞希酶B的药物基因分型与转移性结直肠癌总生存期相关
A Pohl,M Azuma,W Zhang et al.
A Pohl et al.
Aurora kinases are conserved eukaryotic serine-threonine kinases, which serve as key regulators of mammalian mitosis. Several studies revealed a distinct correlation between inaccurate chromosome segregation, leading to chromosomal number i...