High-efficiency genotype analysis from formalin-fixed, paraffin-embedded tumor tissues [0.03%]
高效分析甲醛固定石蜡包埋的肿瘤组织基因型
M J Sikora,J N Thibert,J Salter et al.
M J Sikora et al.
Single-nucleotide polymorphisms (SNPs) can be assayed using DNA isolated from archival formalin-fixed, paraffin-embedded (FFPE) samples, making retrospective pharmacogenetic studies possible. In this study, we describe methods that signific...
Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors [0.03%]
多态人前列腺素H合成酶-2蛋白及其与环氧化酶底物和抑制剂的相互作用
W Liu,E M Poole,C M Ulrich et al.
W Liu et al.
The cyclooxygenase (COX) activity of prostaglandin H synthase-2 (PGHS-2) is implicated in colorectal cancer and is targeted by nonsteroidal anti-inflammatory drugs (NSAIDs) and dietary n-3 fatty acids. We used purified, recombinant proteins...
Changes in the gene expression profile of gastric cancer cells in response to ibuprofen: a gene pathway analysis [0.03%]
基因路径分析指导的吲哚美辛诱导的胃癌细胞系中的基因表达谱变化研究
P Bonelli,F M Tuccillo,R Calemma et al.
P Bonelli et al.
Nonsteroidal anti-inflammatory drugs possess antiproliferative activities that can affect cancer cells. The aim of this study was to examine the antiproliferative effects of ibuprofen on the MKN-45 cell line. Cells were treated with ibuprof...
Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo [0.03%]
胸苷合成酶调节区域多态性与胸苷合成酶活性的关联分析
C E de Bock,M B Garg,N Scott et al.
C E de Bock et al.
Two known polymorphisms in the 5' enhancer region (ER) of the thymidylate synthase (TS) gene, a variable number of tandem repeats of a 28 bp sequence (2R/3R) and a further G>C single nucleotide substitution within the repeats, result in gen...
Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia [0.03%]
DISC1错义突变与超顽固性精神分裂症的关联研究
F Mouaffak,O Kebir,M Chayet et al.
F Mouaffak et al.
Three common missense variants of the Disrupted in Schizophrenia 1 (DISC1) gene, rs3738401 (Q264R), rs6675281 (L607F) and rs821616 (S704C), have been variably associated with the risk of schizophrenia. In a case-control study, we examine wh...
Multicenter Study
The pharmacogenomics journal. 2011 Aug;11(4):267-73. DOI:10.1038/tpj.2010.40 2011
Endothelial nitric oxide synthase gene haplotypes affect nitrite levels in black subjects [0.03%]
内皮型一氧化氮合酶基因的单倍体型影响黑人的硝酸盐水平
I F Metzger,M H Ishizawa,F Rios-Santos et al.
I F Metzger et al.
Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been associated with variations in nitric oxide (NO) formation and response to drugs in white subjects. We examined whether genetic polymorphisms (T-786C, b/a intron 4 ...
VEGF -460T → C polymorphism and its association with VEGF expression and outcome to FOLFOX-4 treatment in patients with colorectal carcinoma [0.03%]
血管内皮生长因子-460位点TC基因多态性与结直肠癌患者血管内皮生长因子表达及FOLFOX-4化疗预后的关系研究
M-H Chen,C-H Tzeng,P-M Chen et al.
M-H Chen et al.
The -460T → C polymorphism of vascular endothelial growth factor (VEGF) gene significantly increases its promoter activity. A pilot study was conducted to assess the influence of this polymorphism on clinicopathological features of patient...
Systematic generation of in vivo G protein-coupled receptor mutants in the rat [0.03%]
大鼠体内G蛋白偶联受体突变的系统生成
R van Boxtel,B Vroling,P Toonen et al.
R van Boxtel et al.
G-protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors that are involved in a wide range of physiological and pathological processes, and are targets for many therapeutic interventions. However, genetic mode...
Association between CYP2C19*17 and metabolism of amitriptyline, citalopram and clomipramine in Dutch hospitalized patients [0.03%]
CYP2C19*17与荷兰住院患者阿米替林、舍曲林和氯米帕明代谢之间的关系
A de Vos,J van der Weide,H M Loovers
A de Vos
Polymorphisms in genes coding for drug metabolizing enzymes, such as the cytochrome P450 enzymes CYP2C19 and CYP2D6, can lead to therapy failure and side effects. In earlier studies, the novel variant CYP2C19*17 increased metabolism of seve...
Polymorphisms C677T and A1298C in the MTHFR gene in Mexican patients with rheumatoid arthritis treated with methotrexate: implication with elevation of transaminases [0.03%]
墨西哥类风湿关节炎患者甲氨蝶呤治疗过程中MTHFR基因C677T和A1298C多态性与转氨酶升高之间的关系研究
J P Mena,M Salazar-Páramo,L González-López et al.
J P Mena et al.
Rheumatoid arthritis (RA) is the prototype of the rheumatic diseases worldwide. Methotrexate (MTX) is the drug of first choice in the treatment of this disease due to its immunosuppressant effect. However, side events are present in 30% of ...