British South Asian ancestry participants views of pharmacogenomics clinical implementation and research: a thematic analysis [0.03%]
英国南亚血统人群对药物基因组学临床应用和研究的观点：主题分析
Emma F Magavern,Faiza Durrani,Mehru Raza et al.
Emma F Magavern et al.
Background: South Asian ancestry populations are underrepresented in genomic studies and therapeutics trials. British South Asians suffer from multi-morbidity leading to polypharmacy. Our objective was to elucidate Britis...
George P Patrinos,Negar Sarhangi,Behnaz Sarrami et al.
George P Patrinos et al.
Personalized medicine is a novel frontier in health care that is based on each person's unique genetic makeup. It represents an exciting opportunity to improve the future of individualized health care for all individuals. Pharmacogenomics, ...
The INGENIOUS trial: Impact of pharmacogenetic testing on adverse events in a pragmatic clinical trial [0.03%]
INGENIOUS研究：药理基因组检测对务实型临床试验不良事件的影响
Michael T Eadon,Marc B Rosenman,Pengyue Zhang et al.
Michael T Eadon et al.
Adverse drug events (ADEs) account for a significant mortality, morbidity, and cost burden. Pharmacogenetic testing has the potential to reduce ADEs and inefficacy. The objective of this INGENIOUS trial (NCT02297126) analysis was to determi...
Randomized Controlled Trial
The pharmacogenomics journal. 2023 Nov;23(6):169-177. DOI:10.1038/s41397-023-00315-w 2023
Assessment of clinically actionable pharmacogenetic markers to stratify anti-seizure medications [0.03%]
临床可操作的药物基因标志物评估 用于划分抗癫痫类药物
Debleena Guin,Yasha Hasija,Ritushree Kukreti
Debleena Guin
Epilepsy treatment is challenging due to heterogeneous syndromes, different seizure types and higher inter-individual variability. Identification of genetic variants predicting drug efficacy, tolerability and risk of adverse-effects for ant...
Genome-wide association study on pharmacological outcomes of musculoskeletal pain in UK Biobank [0.03%]
英国生物样本库中肌肉骨骼疼痛药物疗效的全基因组关联研究
Song Li,Geert Poelmans,Regina L M van Boekel et al.
Song Li et al.
The pharmacological management of musculoskeletal pain starts with NSAIDs, followed by weak or strong opioids until the pain is under control. However, the treatment outcome is usually unsatisfying due to inter-individual differences. To in...
HLA-DQA1*05 and upstream variants of PPARGC1B are associated with infliximab persistence in Japanese Crohn's disease patients [0.03%]
与日本克罗恩病患者英夫利西单抗维持治疗相关的HLA-DQA1*05和PPARGC1B上游变异体
Fumiko Shimoda,Takeo Naito,Yoichi Kakuta et al.
Fumiko Shimoda et al.
Recently, the HLA-DQA1*05 (rs2097432) genetic variation has been reported to be linked to early infliximab (IFX) treatment failure in the Caucasian Crohn's disease (CD) population, but that evidence is scarce in the Asian population. This s...
Correction to: One year of experience with combined pharmacokinetic/pharmacogenetic monitoring of anti-TNF alpha agents: a retrospective study [0.03%]
抗TNF-α药物联合药代动力学/药物基因组学监测一年经验的更正：一项回顾性研究
Stefania Cheli,Diego Savino,Annalisa De Silvestri et al.
Stefania Cheli et al.
Published Erratum
The pharmacogenomics journal. 2023 Sep;23(5):140. DOI:10.1038/s41397-023-00311-0 2023
SLCO1B1*5 is protective against non-senile cataracts in cohort prescribed statins: analysis in a British-South Asian cohort [0.03%]
SLCO1B1*5通过降低非老年性白内障风险而对服用他汀类药物的英国-南亚人群产生保护作用：一项基于英国-南亚人群队列的研究分析
Emma F Magavern,David A van Heel;Genes & Health Research Team;Damian Smedley,Mark J Caulfield
Emma F Magavern
Background: Reported association between statin use and cataract risk is controversial. The SLCO1B1 gene encodes a transport protein responsible for statin clearance. The aim of this study was to investigate a possible as...
Association between functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to rituximab in patients with autoimmune diseases: a meta-analysis [0.03%]
Fcgr3a和Fcgr2a基因多态性与自身免疫性疾病利妥昔单抗疗效的meta分析
Young Ho Lee,Gwan Gyu Song
Young Ho Lee
Objectives: To investigate the association between the functional Fc gamma receptor 3 A (FCGR3A) V158F and FCGR2A R131H polymorphisms and rituximab therapy in patients with autoimmune diseases. ...
Knowledge and attitudes of medical and pharmacy students about pharmacogenomics: a systematic review and meta-analysis [0.03%]
医学生和药学学生的药物基因组学知识和态度系统评价和meta分析
Chen Li,Xiaona Su,Qidi Sun et al.
Chen Li et al.
Pharmacogenomics (PGx) is rapidly growing branch of molecular genetics with high potentials to influence therapeutics. This review evaluates knowledge and attitudes of medical and pharmacy students about PGx. A literature search was conduct...