Unveiling the association between HMG-CoA reductase inhibitors and bladder cancer: a comprehensive analysis using Mendelian randomization, animal models, and transcriptomics [0.03%]
他汀类药物与膀胱癌关联的再思考：孟德尔随机化、动物模型和转录组学的综合分析
Houyi Wei,Zhilong Li,Kaiyu Qian et al.
Houyi Wei et al.
This study utilized Mendelian randomization (MR) analysis and genome-wide association study (GWAS) data to investigate the association between commonly prescribed drugs and bladder cancer (BLCA) risk. Our results revealed that HMG CoA reduc...
Opioid use disorder risk alleles in self-reported assigned African American/Afro-Caribbean and European biogeographical genetic ancestry groups and in males and females [0.03%]
基于自我报告的非洲血统和欧亚血统群体以及男性和女性中的阿片类药物使用障碍风险等位基因
Jon E Sprague,Caroline E Freiermuth,Joshua Lambert et al.
Jon E Sprague et al.
The influence of genetic variants related to opioid use disorder (OUD) was evaluated using multiple logistic regression analysis in self-reported assigned African American/Afro-Caribbean and European biogeographical ancestry groups (BGAGs) ...
Contribution of plasma levels of VEGF-A and angiopoietin-2 in addition to a genetic variant in KCNAB1 to predict the risk of bevacizumab-induced hypertension [0.03%]
血管内皮生长因子A和血管生成素2的血浆水平及KCNAB1遗传多态性与贝伐单抗致高血压风险的关系研究
Julia C F Quintanilha,William Kevin Kelly,Federico Innocenti
Julia C F Quintanilha
Bevacizumab-induced hypertension poses a therapeutic challenge and identifying biomarkers for hypertension can enhance therapy safety. Lower plasma levels of VEGF-A, angiopoietin-2, and rs6770663 in KCNAB1 were previously associated with in...
Risk of anthracycline-induced cardiac dysfunction in adolescent and young adult (AYA) cancer survivors: role of genetic susceptibility loci [0.03%]
蒽环类药物诱发的心脏功能障碍在青少年和年轻成人癌症幸存者中的发病风险：易感基因位点的作用
Lily K Stafford,Xiaohui Tang,Amanda Brandt et al.
Lily K Stafford et al.
There is a known genetic susceptibility to anthracycline-induced cardiac dysfunction in childhood cancer survivors, but this has not been adequately shown in adolescent and young adult (AYA) patients. Our aim was to determine if the previou...
Predictive role of ITPA genetic variants in thiopurine-related myelotoxicity in Crohn's disease patients [0.03%]
ITPA基因变异在克罗恩病患者硫嘌呤相关骨髓毒性的预测作用
Juliana Salazar,Pau Riera,Jordi Gordillo et al.
Juliana Salazar et al.
Thiopurines, an effective therapy for Crohn's disease (CD), often lead to adverse events (AEs). Gene polymorphisms affecting thiopurine metabolism may predict AEs. This retrospective study in CD patients (n = 114) with TPMT activity > 5 Uni...
Nimodipine-associated standard dose reductions and neurologic outcomes after aneurysmal subarachnoid hemorrhage: the era of pharmacogenomics [0.03%]
尼莫地平相关标准剂量减少与动脉瘤性蛛网膜下腔出血后的神经结果：药物基因组学的时代
Adriana Vázquez-Medina,Marion T Turnbull,Courtney L James et al.
Adriana Vázquez-Medina et al.
Nimodipine, an L-type cerebroselective calcium channel antagonist, is the only drug approved by the US Food and Drug Administration for the neuroprotection of patients with aneurysmal subarachnoid hemorrhage (aSAH). Four randomized, placebo...
Pharmacokinetic and neuroimmune pharmacogenetic impacts on slow-release morphine cancer pain control and adverse effects [0.03%]
缓释吗啡癌痛镇痛及其不良反应的药代动力学和神经免疫药理遗传学效应
Daniel T Barratt,Pål Klepstad,Ola Dale et al.
Daniel T Barratt et al.
The aim was to determine if opioid neuroimmunopharmacology pathway gene polymorphisms alter serum morphine, morphine-3-glucuronide and morphine-6-glucuronide concentration-response relationships in 506 cancer patients receiving controlled-r...
APF2: an improved ensemble method for pharmacogenomic variant effect prediction [0.03%]
改进的药理遗传学变异效应预测集成方法APF2
Yitian Zhou,Sebastian Pirmann,Volker M Lauschke
Yitian Zhou
Lack of efficacy or adverse drug response are common phenomena in pharmacological therapy causing considerable morbidity and mortality. It is estimated that 20-30% of this variability in drug response stems from variations in genes encoding...
Pharmacogenomics in Lebanon: current status, challenges and opportunities [0.03%]
黎巴嫩的药物基因组学：现状、挑战与机遇
Lorenzo Chidiac,Hady Yazbeck,Rami Mahfouz et al.
Lorenzo Chidiac et al.
Pharmacogenomics (PGx) research and applications are of utmost relevance in Lebanon considering its population genetic diversity. Moreover, as a country with regional leadership in medicine and higher education, Lebanon holds a strong poten...
Inosine monophosphate dehydrogenase type 2 polymorphism IMPDH2 3757T>C (rs11706052) and 12-month evolution of the graft function in renal transplant recipients on mycophenolate-based immunosuppression [0.03%]
鸟苷单磷酸脱氢酶第二型基因多型性(IMPDH2 3757T>C，rs11706052)与肾移植受者接受霉酚酸免疫抑制治疗一年后移入器官功能的演变关系
Luka Penezić,Sandra Nađ-Škegro,Ayla Hadžavdić et al.
Luka Penezić et al.
Variant allele at the inosine monophosphate dehydrogenase type 2 polymorphism IMPDH2 3757T>C has been associated with increased enzyme activity and reduced susceptibility to mycophenolic acid (MPA) in vitro. It has been suggested associated...