F Dionne,C Mitton,R Rassekh et al.
F Dionne et al.
Cisplatin is a widely used chemotherapy drug in the treatment of pediatric solid tumors, but it is associated with significant rates of ototoxicity (medication-induced hearing loss). A genetic test has recently been developed that can help ...
M A Reimers,B P Riley,G Kalsi et al.
M A Reimers et al.
We introduce a method for detecting variants in several genes of related function with small effect on a phenotype of interest. Our method uses logistic regression to test whether multiple alleles within a functional set have significantly ...
Growth hormone pharmacogenetics: the interactive effect of a microsatellite in the IGF1 promoter region with the GHR-exon 3 and -202 A/C IGFBP3 variants on treatment outcomes of children with severe GH deficiency [0.03%]
生长激素的药物基因学：IGF1启动区多态性与GHR第3外显子和IGFBP3-202A/C变异体在重度生长激素缺乏症患儿治疗效果中的交互作用
E F Costalonga,S R R Antonini,G Guerra Jr et al.
E F Costalonga et al.
Insulin-like growth factor type 1 (IGF1) is a mediator of growth hormone (GH) action, and therefore, IGF1 is a candidate gene for recombinant human GH (rhGH) pharmacogenetics. Lower serum IGF1 levels were found in adults homozygous for 19 c...
Informed consent in the context of pharmacogenomic research: ethical considerations [0.03%]
药物基因组学研究中的知情同意：伦理考量
H C Howard,Y Joly,D Avard et al.
H C Howard et al.
Although the scientific research surrounding pharmacogenomics (PGx) has been relatively plentiful, the ethical research concerning this discipline has developed rather conservatively. Following investigation of the ethical, legal and social...
Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling [0.03%]
锂和丙戊酸分子靶点的相互作用网络揭示了凋亡功能簇和神经营养素信号传导的显著富集现象
A Gupta,T G Schulze,V Nagarajan et al.
A Gupta et al.
The overall neurobiological mechanisms by which lithium and valproate stabilize mood in bipolar disorder patients have yet to be fully defined. The therapeutic efficacy and dissimilar chemical structures of these medications suggest that th...
Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping [0.03%]
通过表达量性状图谱定位人类ATP结合盒式转运蛋白的调节元件
P Matsson,S W Yee,S Markova et al.
P Matsson et al.
ATP-binding cassette (ABC) membrane transporters determine the disposition of many drugs, metabolites and endogenous compounds. Coding region variation in ABC transporters is the cause of many genetic disorders, but much less is known about...
Translational aspects of genetic factors in the prediction of drug response variability: a case study of warfarin pharmacogenomics in a multi-ethnic cohort from Asia [0.03%]
遗传因素在药物反应变异预测中的转化研究：来自亚洲多民族队列的华法林药物基因组学病例研究
S L Chan,C Suo,S C Lee et al.
S L Chan et al.
Genetic markers displaying highly significant statistical associations with complex phenotypes may not necessarily possess sufficient clinical validity to be useful. Understanding the contribution of these markers beyond readily available c...
Optimization of warfarin dose by population-specific pharmacogenomic algorithm [0.03%]
人群特异性药物基因组学算法优化华法林剂量
A Pavani,S M Naushad,Y Rupasree et al.
A Pavani et al.
To optimize the warfarin dose, a population-specific pharmacogenomic algorithm was developed using multiple linear regression model with vitamin K intake and cytochrome P450 IIC polypeptide9 (CYP2C9(*)2 and (*)3), vitamin K epoxide reductas...
Identification of CYP2C19*4B: pharmacogenetic implications for drug metabolism including clopidogrel responsiveness [0.03%]
CYP2C19*4B的鉴定及其对包括氯吡格雷反应性在内的药物代谢的药效基因组学意义
S A Scott,S Martis,I Peter et al.
S A Scott et al.
CYP2C19 is a principal enzyme involved in the bioactivation of the antiplatelet prodrug clopidogrel and common CYP2C19 loss-of-function alleles are associated with adverse cardiovascular events. To assess the impact of the CYP2C19*17 increa...
Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment [0.03%]
神经生长因子β多肽（NGFB）基因变异与阿片替代治疗剂量的关系研究
O Levran,E Peles,S Hamon et al.
O Levran et al.
Opioid addiction is a chronic disease with high genetic contribution and a large inter-individual variability in therapeutic response. The goal of this study was to identify pharmacodynamic factors that modulate methadone dose requirement. ...