Identification of CYP2C19*4B: pharmacogenetic implications for drug metabolism including clopidogrel responsiveness
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CYP2C19 is a principal enzyme involved in the bioactivation of the antiplatelet prodrug clopidogrel and common CYP2C19 loss-of-function alleles are associated with adverse cardiovascular events. To assess the impact of the CYP2C19*17 increased activity allele ... ...
