Interaction between the Val158Met catechol-O-methyltransferase gene variant and second-generation antipsychotic treatment on blood pressure in children [0.03%]
第二代抗精神病药物治疗对携带Val158Met型儿茶酚-O-甲基转移酶基因变异的儿童血压的影响
A T Cote,C Panagiotopoulos,A M Devlin
A T Cote
Second-generation antipsychotic (SGA) medications are associated with cardiometabolic risk factors such as obesity and elevated blood pressure (BP) in some individuals. The goal of this study is to determine whether the Val158Met variant (r...
EGFR ligands and DNA repair genes: genomic predictors of complete response after capecitabine-based chemoradiotherapy in locally advanced rectal cancer [0.03%]
基于卡培他滨的化学放疗后局部晚期直肠癌完全缓解的基因组预测因素：EGFR配体和DNA修复基因
A Sebio,J Salazar,D Páez et al.
A Sebio et al.
Epidermal growth factor receptor (EGFR) activation by radiation leads to increased cell proliferation and acts as a radioresistance mechanism. Neoadjuvant chemoradiation is the standard of care for locally advanced rectal cancer, and to dat...
Impact of GATA4 variants on stable warfarin doses in patients with prosthetic heart valves [0.03%]
GATA4变异对机械心脏瓣膜患者稳定华法林剂量的影响
E Jeong,K E Lee,H Jeong et al.
E Jeong et al.
Interindividual variability in stable warfarin doses is largely attributed to VKORC1 and CYP2C9 variants. On the basis of a recent finding of the role of GATA4 in control of CYP2C9 expression, we tested a possible effect of GATA4 genotypes ...
Pharmacogenetics of warfarin in a paediatric population: time in therapeutic range, initial and stable dosing and adverse effects [0.03%]
华法林在儿科人群中的药物基因组学：治疗范围内的时间、初始和稳定剂量以及不良反应
D B Hawcutt,A A Ghani,L Sutton et al.
D B Hawcutt et al.
Warfarin is used in paediatric populations, but dosing algorithms incorporating pharmacogenetic data have not been developed for children. Previous studies have produced estimates of the effect of polymorphisms in Cytochrome P450 2C9 (CYP2C...
Functional characterization of 21 CYP2C19 allelic variants for clopidogrel 2-oxidation [0.03%]
克利匹特尔2-氧化的21个CYP2C19等位基因变异的功能表征
M Takahashi,T Saito,M Ito et al.
M Takahashi et al.
Genetic variations in cytochrome P450 2C19 (CYP2C19) contribute to interindividual variability in the metabolism of therapeutic agents such as clopidogrel. Polymorphisms in CYP2C19 are associated with large interindividual variations in the...
E Caiola,M Broggini,M Marabese
E Caiola
Drug resistance in epithelial ovarian cancer (EOC) limits the efficacy of therapies for this malignancy. This phenomenon might be partially explained by strong inter-individual genomic heterogeneity. Single nucleotide polymorphisms (SNPs) l...
Clinical outcomes associated with proton pump inhibitor use among clopidogrel-treated patients within CYP2C19 genotype groups following acute myocardial infarction [0.03%]
根据CYP2C19基因型在接受氯吡格雷治疗的急性心肌梗死后患者中使用质子泵抑制剂的相关临床结局
J P Depta,P A Lenzini,D E Lanfear et al.
J P Depta et al.
We examined clinical outcomes with proton pump inhibitors (PPI) use within CYP2C19 genotype groups during clopidogrel treatment following acute myocardial infarction (AMI). 2062 patients were genotyped for CYP2C19*2 and *17 variants in TRIU...
Observational Study
The pharmacogenomics journal. 2015 Feb;15(1):20-5. DOI:10.1038/tpj.2014.28 2015
Opinions, hopes and concerns regarding pharmacogenomics: a comparison of healthy individuals, heart failure patients and heart transplant recipients [0.03%]
健康个体、心力衰竭患者和心脏移植受者对药物基因组学的看法、希望与顾虑的对比研究
K Lachance,S Korol,E O&#x;Meara et al.
K Lachance et al.
It is not yet known whether healthy individuals and patients with a chronic disease have similar attitudes towards pharmacogenomics. Thus we conducted a survey of 175 healthy volunteers, 175 heart failure (HF) patients and 100 heart transpl...
Comparative Study
The pharmacogenomics journal. 2015 Feb;15(1):13-9. DOI:10.1038/tpj.2014.29 2015
Wnt signaling pathway pharmacogenetics in non-small cell lung cancer [0.03%]
非小细胞肺癌中Wnt信号通路的药物基因组学研究进展
D J Stewart,D W Chang,Y Ye et al.
D J Stewart et al.
Wingless-type protein (Wnt)/β-catenin pathway alterations in non-small cell lung cancer (NSCLC) are associated with poor prognosis and resistance. In 598 stage III-IV NSCLC patients receiving platinum-based chemotherapy at the MD Anderson ...
Establishment of CYP2D6 reference samples by multiple validated genotyping platforms [0.03%]
基于多平台验证基因分型建立CYP2D6参考样本库研究
H Fang,X Liu,J Ramírez et al.
H Fang et al.
Cytochrome P450 2D6 (cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6)), a highly polymorphic drug-metabolizing enzyme, is involved in the metabolism of one-quarter of the most commonly prescribed medications. Here we have appl...