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Functional characterization of 21 CYP2C19 allelic variants for clopidogrel 2-oxidation

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Genetic variations in cytochrome P450 2C19 (CYP2C19) contribute to interindividual variability in the metabolism of therapeutic agents such as clopidogrel. Polymorphisms in CYP2C19 are associated with large interindividual variations in the therapeutic efficac... ...