Interleukin 28B polymorphisms as predictors of sustained virological response in chronic hepatitis C: systematic review and meta-analysis [0.03%]
白细胞介素28B多态性与慢性丙型肝炎持续病毒学应答之间的关系：系统评价和meta分析
E Cariani,L Roli,G Missale et al.
E Cariani et al.
Polymorphism of interleukin 28B gene represents a powerful outcome predictor for interferon-based regimens in hepatitis C virus infection. However, some studies report conflicting results. The predictive value of interleukin 28B genotype ov...
Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally damaging variant [0.03%]
外排转运体ABCC11常见蛋白变异的功能表征及功能损害变异T546M的鉴定
R Arlanov,T Lang,G Jedlitschky et al.
R Arlanov et al.
Multidrug resistance protein 8 (ABCC11) is an efflux transporter for anionic lipophilic compounds, conferring resistance to antiviral and anticancer agents like 5-fluorouracil (5-FU). ABCC11 missense variants may contribute to variability i...
Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis [0.03%]
复制PTPRC作为风湿性关节炎患者对TNF抑制剂反应的遗传生物标志物
A Ferreiro-Iglesias,A Montes,E Perez-Pampin et al.
A Ferreiro-Iglesias et al.
Genetic biomarkers could be useful for orienting treatment of patients with rheumatoid arthritis (RA), but none has been convincingly validated yet. Putative biomarkers include 14 single nucleotide polymorphisms that have shown association ...
A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis [0.03%]
类风湿关节炎基因组范围的关联研究鉴定出一个与抗TNF治疗反应相关的新的遗传位点
A Julià,A Fernandez-Nebro,F Blanco et al.
A Julià et al.
Anti-Tumor Necrosis Factor (anti-TNF) drugs are biologic agents commonly used to treat rheumatoid arthritis (RA). However, anti-TNFs are not effective in approximately one out of four treated patients. We conducted a Genome-Wide Association...
Clinical validity of new genetic biomarkers of irinotecan neutropenia: an independent replication study [0.03%]
新的基因生物标志物引起伊立替康引起的中性粒细胞减少的临床验证：一项独立重复研究
D J Crona,J Ramirez,W Qiao et al.
D J Crona et al.
The overall goal of this study was to provide evidence for the clinical validity of nine genetic variants in five genes previously associated with irinotecan neutropenia and pharmacokinetics. Variants associated with absolute neutrophil cou...
Unravelling the transcriptomic landscape of the major phase II UDP-glucuronosyltransferase drug metabolizing pathway using targeted RNA sequencing [0.03%]
利用靶向RNA测序解析II相UDP-葡萄糖醛酸转移酶药物代谢途径的转录组谱系
A Tourancheau,G Margaillan,M Rouleau et al.
A Tourancheau et al.
A comprehensive view of the human UDP-glucuronosyltransferase (UGT) transcriptome is a prerequisite to the establishment of an individual's UGT metabolic glucuronidation signature. Here, we uncover the transcriptome landscape of the 10 huma...
A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics [0.03%]
乳铁凝集素基因非同义多态性与β-内酰胺类抗生素过敏反应有关
J A Cornejo-García,A Romano,R M Guéant-Rodríguez et al.
J A Cornejo-García et al.
Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcɛRI pathway, such as galectin-3, a β-galactoside-bi...
The P2 promoter of the IGF1 gene is a major epigenetic locus for GH responsiveness [0.03%]
生长激素反应性主要表观遗传位点IGF1基因的P2启动子
M Ouni,M P Belot,A L Castell et al.
M Ouni et al.
Short children using growth hormone (GH) to accelerate their growth respond to this treatment with a variable efficacy. The causes of this individual variability are multifactorial and could involve epigenetics. Quantifying the impact of ep...
Limited clinical utility of genotype-guided warfarin initiation dosing algorithms versus standard therapy: a meta-analysis and trial sequential analysis of 11 randomized controlled trials [0.03%]
一种以基因型指导的华法令起始剂量算法与标准治疗方法相比具有有限临床实用性的系统评价和meta分析及试验序贯分析：一项针对11项随机对照试验的综合分析
H L Tang,W L Shi,X G Li et al.
H L Tang et al.
In terms of inconsistent conclusions across all relevant randomized controlled trials (RCTs) and available meta-analyses, we aimed to use a meta-analysis and trial sequential analysis (TSA) to evaluate whether clinical utility of a genotype...
Neuronal cell adhesion genes and antidepressant response in three independent samples [0.03%]
神经元细胞黏附基因和抗抑郁药的疗效：三个独立队列的验证研究
C Fabbri,C Crisafulli,D Gurwitz et al.
C Fabbri et al.
Drug-effect phenotypes in human lymphoblastoid cell lines recently allowed to identify CHL1 (cell adhesion molecule with homology to L1CAM), GAP43 (growth-associated protein 43) and ITGB3 (integrin beta 3) as new candidates for involvement ...
Clinical Trial
The pharmacogenomics journal. 2015 Dec;15(6):538-48. DOI:10.1038/tpj.2015.15 2015