Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally damaging variant
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Multidrug resistance protein 8 (ABCC11) is an efflux transporter for anionic lipophilic compounds, conferring resistance to antiviral and anticancer agents like 5-fluorouracil (5-FU). ABCC11 missense variants may contribute to variability in drug response but ... ...
