Meta-analysis reveals significant association of 3'-UTR VNTR in SLC6A3 with smoking cessation in Caucasian populations [0.03%]
荟萃分析显示SLC6A3的3 '-UTR可变数量串联重复序列与高加索人种吸烟终止存在显著关联
Y Ma,W Yuan,W Cui et al.
Y Ma et al.
Many studies have examined the association between SLC6A3 3'-untranslated region (UTR) variable number tandem repeat (VNTR) polymorphism and smoking cessation; however, the results are inconclusive, primarily because of the small-to-moderat...
Meta-Analysis
The pharmacogenomics journal. 2016 Feb;16(1):10-7. DOI:10.1038/tpj.2015.44 2016
The -308 TNFα and the -174 IL-6 promoter polymorphisms associate with effective anti-TNFα treatment in seronegative spondyloarthritis [0.03%]
-308肿瘤坏死因子α和-174白细胞介素6启动子多态性与血清阴性脊柱关节病患者抗肿瘤坏死因子α治疗效果相关性研究
M Fabris,L Quartuccio,C Fabro et al.
M Fabris et al.
The genetic predisposition to a long-term efficacy of anti-tumor necrosis factor (TNF)α treatment in seronegative spondyloarthritis (SpA) was investigated by analysing the possible correlation between several single nucleotide gene polymor...
Multicenter Study
The pharmacogenomics journal. 2016 Jun;16(3):238-42. DOI:10.1038/tpj.2015.49 2016
Genetic screening reveals a link between Wnt signaling and antitubulin drugs [0.03%]
基因筛选揭示了Wnt信号和抗微管药物之间的联系
A H Khan,J S Bloom,E Faridmoayer et al.
A H Khan et al.
The antitubulin drugs, paclitaxel (PX) and colchicine (COL), inhibit cell growth and are therapeutically valuable. PX stabilizes microtubules, while COL promotes their depolymerization. But, the drug concentrations that alter tubulin polyme...
Germline and somatic genetic predictors of pathological response in neoadjuvant settings of rectal and esophageal cancers: systematic review and meta-analysis [0.03%]
直肠癌和食管癌新辅助治疗背景下遗传性和体细胞性遗传预测因子的系统性回顾及meta分析研究
L E Salnikova,D S Kolobkov
L E Salnikova
Oncologists have pointed out an urgent need for biomarkers that can be useful for clinical application to predict the susceptibility of patients to preoperative therapy. This review collects, evaluates and combines data on the influence of ...
Network analysis of gene expression in mice provides new evidence of involvement of the mTOR pathway in antipsychotic-induced extrapyramidal symptoms [0.03%]
小鼠基因表达的网络分析为mTOR通路参与抗精神病药物引起的锥体外系症状提供了新的证据
S Mas,P Gassó,D Boloc et al.
S Mas et al.
To identify potential candidate genes for future pharmacogenetic studies of antipsychotic (AP)-induced extrapyramidal symptoms (EPS), we used gene expression arrays to analyze changes induced by risperidone in mice strains with different su...
CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy [0.03%]
墨西哥混血癫痫患者的细胞色素P450 2C9、细胞色素P450 2C19和ATP结合盒转运蛋白B1基因多态性与苯妥英钠浓度相关性的研究
A Ortega-Vázquez,P Dorado,I Fricke-Galindo et al.
A Ortega-Vázquez et al.
We aimed to explore the possible influence of CYP2C9 (*2, *3 and IVS8-109 A>T), CYP2C19 (*2, *3 and *17) and ABCB1 (1236C>T, 2677G>A/T and 3435C>T) on phenytoin (PHT) plasma concentrations in 64 Mexican Mestizo (MM) patients with epilepsy c...
NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD [0.03%]
NUDT15 R139C 型患者因使用硫嘌呤导致早期严重的脱发和白细胞减少症
Y Kakuta,T Naito,M Onodera et al.
Y Kakuta et al.
The efficacy of thiopurines, including azathioprine (AZA) and 6-mercaptopurine (6MP), has been demonstrated for the treatment of inflammatory bowel disease (IBD). The most common and serious adverse event of treatment with thiopurines alter...
CES1 genetic variation affects the activation of angiotensin-converting enzyme inhibitors [0.03%]
ACE插入/删除多态性影响血管紧张素转换酶抑制剂的活性
X Wang,G Wang,J Shi et al.
X Wang et al.
The aim of the study was to determine the effect of carboxylesterase 1 (CES1) genetic variation on the activation of angiotensin-converting enzyme inhibitor (ACEI) prodrugs. In vitro incubation study of human liver, intestine and kidney s9 ...
Genetic risk of subsequent esophageal cancer in lymphoma and breast cancer long-term survival patients: a pilot study [0.03%]
淋巴瘤和乳腺癌长期生存患者随后发生食道癌的遗传风险：初步研究
E Boldrin,E Rumiato,M Fassan et al.
E Boldrin et al.
The occurrence of a second primary esophageal carcinoma (EC) in long-term cancer survivors may represent a late effect of previous radio-chemotherapeutic treatment. To identify the genetic factors that could increase this risk, we analyzed ...
Genome-wide association study of leukotriene modifier response in asthma [0.03%]
哮喘患者白三烯调节剂反应的全基因组关联研究
A Dahlin,A Litonjua,C G Irvin et al.
A Dahlin et al.
Heterogeneous therapeutic responses to leukotriene modifiers (LTMs) are likely due to variation in patient genetics. Although prior candidate gene studies implicated multiple pharmacogenetic loci, to date, no genome-wide association study (...
Clinical Trial
The pharmacogenomics journal. 2016 Apr;16(2):151-7. DOI:10.1038/tpj.2015.34 2016