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NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD

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The efficacy of thiopurines, including azathioprine (AZA) and 6-mercaptopurine (6MP), has been demonstrated for the treatment of inflammatory bowel disease (IBD). The most common and serious adverse event of treatment with thiopurines altered by doctors is leu... ...