Effect of summer daylight exposure and genetic background on growth in growth hormone-deficient children [0.03%]
夏日光照和遗传背景对生长激素缺乏儿童生长的影响
C De Leonibus,P Chatelain,C Knight et al.
C De Leonibus et al.
The response to growth hormone in humans is dependent on phenotypic, genetic and environmental factors. The present study in children with growth hormone deficiency (GHD) collected worldwide characterised gene-environment interactions on gr...
Comparative Study
The pharmacogenomics journal. 2016 Nov;16(6):540-550. DOI:10.1038/tpj.2015.67 2016
R Bisso-Machado,V Ramallo,V R Paixão-Côrtes et al.
R Bisso-Machado et al.
N-acetyltransferase 2 (NAT2) is responsible for metabolizing xenobiotics; NAT2 polymorphisms lead to three phenotypes: rapid, intermediate and slow acetylators. We aimed to investigate NAT2 diversity in Native Americans. NAT2 exon 2 was seq...
Comparative Study
The pharmacogenomics journal. 2016 Nov;16(6):559-565. DOI:10.1038/tpj.2015.72 2016
Positive impact of ABCB1 polymorphisms in overall survival and complete remission in acute myeloid leukemia: a systematic review and meta-analysis [0.03%]
ABCB1多态性对急性髓系白血病总生存率和完全缓解的积极影响：系统评价和meta分析
J E Megías-Vericat,L Rojas,M J Herrero et al.
J E Megías-Vericat et al.
Clinical pharmacology of tenofovir clearance: a pharmacokinetic/pharmacogenetic study on plasma and urines [0.03%]
替诺福韦排泄的临床药理：对血浆和尿液的研究
A Calcagno,J Cusato,L Marinaro et al.
A Calcagno et al.
The HIV virus and hepatitis B virus nucleotide reverse transcriptase inhibitor tenofovir has been associated with proximal tubular toxicity; the latter was found to be predicted by plasma concentrations and with single-nucleotide polymorphi...
Analysis of the effects of depression associated polymorphisms on the activity of the BICC1 promoter in amygdala neurones [0.03%]
抑郁症关联多态位点在杏仁核神经元中对BICC1启动子活性影响的分析研究
S Davidson,L Shanley,P Cowie et al.
S Davidson et al.
The Bicaudal C Homolog 1 (BICC1) gene, which encodes an RNA binding protein, has been identified by genome wide association studies (GWAS) as a candidate gene associated with major depressive disorder (MDD). We explored the hypothesis that ...
Germline polymorphisms in genes involved in the Hippo pathway as recurrence biomarkers in stages II/III colon cancer [0.03%]
与Hippo信号通路相关基因的胚系多态性作为II/III期结肠癌复发生物标志物的研究
A Sebio,S Matsusaka,W Zhang et al.
A Sebio et al.
The Hippo pathway regulates tissue growth and cell fate. In colon cancer, Hippo pathway deregulation promotes cellular quiescence and resistance to 5-Fluorouracil (5-Fu). In this study, 14 polymorphisms in 8 genes involved in the Hippo path...
Multicenter Study
The pharmacogenomics journal. 2016 Aug;16(4):312-9. DOI:10.1038/tpj.2015.64 2016
Role of genetic variation in docetaxel-induced neutropenia and pharmacokinetics [0.03%]
多西他赛诱导的中性粒细胞减少和药代动力学中的遗传变异作用分析
A J M Nieuweboer,M Smid,A-J M de Graan et al.
A J M Nieuweboer et al.
Docetaxel is used for treatment of several solid malignancies. In this study, we aimed for predicting docetaxel clearance and docetaxel-induced neutropenia by developing several genetic models. Therefore, pharmacokinetic data and absolute n...
Polymorphisms of ABCC5 and NOS3 genes influence doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia [0.03%]
surviviors儿童急性淋巴细胞白血病 Survivors中ABCC5和NOS3基因多态性影响朵塞替辛的心脏毒性
M Krajinovic,J Elbared,S Drouin et al.
M Krajinovic et al.
Anthracyclines are efficient chemotherapy agents. However, their use is limited by anthracycline-induced cardiotoxicity (CT). We investigated the influence of polymorphisms in doxorubicin metabolic and functional pathways on late-onset CT a...
Randomized Controlled Trial
The pharmacogenomics journal. 2016 Nov;16(6):530-535. DOI:10.1038/tpj.2015.63 2016
Genome-wide association study on antipsychotic-induced weight gain in the CATIE sample [0.03%]
基于CATIE样本的抗精神病药物所致体重增加的全基因组关联研究
E J Brandl,A K Tiwari,C C Zai et al.
E J Brandl et al.
Antipsychotic-induced weight gain (AIWG) is a common side effect with a high genetic contribution. We reanalyzed genome-wide association study (GWAS) data from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) selectin...
Meta-Analysis
The pharmacogenomics journal. 2016 Aug;16(4):352-6. DOI:10.1038/tpj.2015.59 2016
Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content [0.03%]
由基因二倍体型和细胞色素P450还原酶含量差异导致的CYP2C19催化药物代谢的个体间差异性
Y Shirasaka,A S Chaudhry,M McDonald et al.
Y Shirasaka et al.
Large interindividual variability has been observed in the metabolism of CYP2C19 substrates in vivo. The study aimed to evaluate sources of this variability in CYP2C19 activity, focusing on CYP2C19 diplotypes and the cytochrome P450 oxidore...