A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants [0.03%]
一种GTP环化酶I反馈调节基因多态性改变转录活性并可能影响选择性5-羟色胺再摄取抑制剂抗抑郁药的疗效
P C McHugh,P R Joyce,X Deng et al.
P C McHugh et al.
Tetrahydrobiopterin (BH(4)) is an essential cofactor for synthesis of many neurotransmitters including serotonin. In serotonergic neurons, BH(4) is tightly regulated by GTP-cyclohydrolase I feedback regulator (GFRP). Given the pivotal role ...
Impact of ABCC2 haplotypes on transcriptional and posttranscriptional gene regulation and function [0.03%]
ABCC2基因型对转录和转录后基因调控及功能的影响
S Laechelt,E Turrini,A Ruehmkorf et al.
S Laechelt et al.
ABCC2 (MRP2) is an important export pump, expressed at tissue barriers. The genetic variants -24C>T, 1249G>A and 3972C>T are leading to inter-individual differences of bioavailability of various endogenous and exogenous compounds. Consideri...
Cytochrome P450 2C19*2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: a meta-analysis [0.03%]
氯吡格雷患者的细胞色素P450 2C19*2多态性与心血管事件复发风险的meta分析研究
F Sofi,B Giusti,R Marcucci et al.
F Sofi et al.
Several polymorphisms in genes that encode platelet components (receptors or enzymes), or cytochrome P450 enzyme isoforms, involved in clopidogrel metabolism, have been proposed as possible mechanisms for nonresponsiveness to clopidogrel. A...
Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial [0.03%]
基于细胞色素P450 2D6、CYP2C19和SULT1A1基因型的他莫昔芬在中国人预防性试验中的疗效研究
D Serrano,M Lazzeroni,C-F Zambon et al.
D Serrano et al.
The role of pharmacogenomics and tamoxifen was investigated by analyzing several polymorphisms of cytochrome P450 and SULT1A1 gene in a nested case control study from the Italian Tamoxifen Prevention Trial. This study included 182 Caucasian...
Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians [0.03%]
性别和CYP3A5基因型影响总CYP3A活性：埃塞俄比亚人高的CYP3A活性及独特的CYP3A5变异等位基因分布
E Gebeyehu,E Engidawork,A Bijnsdorp et al.
E Gebeyehu et al.
The objectives of the this study were to assess the influence of CYP3A5 genotype and sex on the variability in total CYP3A activity and to compare 4β-hydroxycholesterol and omeprazole sulfoxidation as phenotypic markers for CYP3A activity ...
Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions [0.03%]
为什么青年女性会吸烟？第六部分：注意力的控制研究：尼古丁与表型的相互作用
A Rigbi,A Yakir,K Sarner-Kanyas et al.
A Rigbi et al.
In prior studies we found that young, female smokers manifest poorer performance than non-smokers on attention-related tasks and that these findings can be moderated by variation in nicotinic acetylcholine receptor (nAChR) genes. We predict...
Randomized Controlled Trial
The pharmacogenomics journal. 2011 Feb;11(1):45-52. DOI:10.1038/tpj.2010.15 2011
Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity [0.03%]
细胞色素P450 2C8和3A5的多态性与紫杉醇神经毒性有关
S Leskelä,C Jara,L J Leandro-García et al.
S Leskelä et al.
Neurotoxicity is one of the most relevant dose-limiting toxicities of the anticancer drug paclitaxel. It exhibits substantial interindividual variability of unknown molecular basis, and represents one of the major challenges for the improve...
Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project [0.03%]
五羟色胺转运蛋白基因多态性与生活事件的交互作用预测GENDEP项目中抗抑郁药物的疗效
R Keers,R Uher,P Huezo-Diaz et al.
R Keers et al.
There is substantial inter-individual variation in response to antidepressants, and genetic variation may, in part, explain these differences. For example, there is evidence to suggest that variation in the serotonin transporter gene (SLC6A...
Association study of MDR1 and 5-HT2C genetic polymorphisms and antipsychotic-induced metabolic disturbances in female patients with schizophrenia [0.03%]
多药耐药相关蛋白1和5-羟色胺2C受体基因多态性与女性精神分裂症患者抗精神病药物代谢障碍关联研究
M R Kuzman,V Medved,N Bozina et al.
M R Kuzman et al.
The objective of this study was to determine the association of 5-HT2C (serotonin 2C receptor) and MDR1 (multidrug resistant protein) genetic polymorphisms and antipsychotic-induced metabolic abnormalities among female patients with DSM IV ...
BDNF Val66Met genotype and 6-month remission rates in late-life depression [0.03%]
晚年的抑郁症患者中BDNF Val66Met基因型与6个月的缓解率之间的关系
W D Taylor,D R McQuoid,A Ashley-Koch et al.
W D Taylor et al.
Although not observed in younger adult cohorts, in older individuals the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with major depressive disorder (MDD) risk. It is further associated with subjective social...