Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1 [0.03%]
大麻素受体(CNR1)和脂肪酸酰胺水解酶(FAAH)基因多态性与海洛因成瘾的关联：CNR1长重复序列的影响
D Proudnikov,T Kroslak,J C Sipe et al.
D Proudnikov et al.
Alterations in expression of a cannabinoid receptor (CNR1, CB1), and of fatty acid amide hydrolase (FAAH) that degrades endogenous ligands of CB1, may contribute to the development of addiction. The 385C>A in the FAAH gene and six polymorph...
ApoE genotyping as a progression-rate biomarker in phase II disease-modification trials for Alzheimer's disease [0.03%]
载脂蛋白E基因分型作为阿尔茨海默病二期疾病修饰试验中的进展速率生物标志物
D J Stone,C Molony,C Suver et al.
D J Stone et al.
Clinical Trial
The pharmacogenomics journal. 2010 Jun;10(3):161-4. DOI:10.1038/tpj.2009.58 2010
Ethical considerations in the collection of genetic data from critically ill patients: what do published studies reveal about potential directions for empirical ethics research? [0.03%]
遗传学数据的收集在重症监护中的伦理问题：已发表的研究如何揭示了实证研究的方向？
B D Freeman,C R Kennedy,H L Frankel et al.
B D Freeman et al.
Critical illness trials involving genetic data collection are increasingly commonplace and pose challenges not encountered in less acute settings, related in part to the precipitous, severe and incapacitating nature of the diseases involved...
Alternative-splicing forms of the major phase II conjugating UGT1A gene negatively regulate glucuronidation in human carcinoma cell lines [0.03%]
人癌细胞系中主要的二期结合UGT1A基因的可变剪接形式对其糖基化作用的负调控
J Bellemare,M Rouleau,M Harvey et al.
J Bellemare et al.
The UDP-glucuronosyltransferase UGT1A gene is a major biotransformation gene involved in the metabolism of a vast array of molecules. Recently, we uncovered a new series of alternative spliced isoforms referred to as isoforms 2 or UGT1As_i2...
Antipsychotic drugs upregulate lipogenic gene expression by disrupting intracellular trafficking of lipoprotein-derived cholesterol [0.03%]
抗精神病药物通过干扰细胞内胆固醇转运上调生脂基因表达
I Kristiana,L J Sharpe,V S Catts et al.
I Kristiana et al.
Antipsychotic drugs (APDs) have been reported to induce lipogenic genes. This has been proposed to contribute to their efficacy in treating schizophrenia and other psychiatric disorders, as well as the metabolic side effects often associate...
A multistep validation process of biomarkers for preclinical drug development [0.03%]
药物研发前期生物标志物多步验证过程
W M Freeman,G V Bixler,R M Brucklacher et al.
W M Freeman et al.
Biomarkers that can be measured in preclinical models in a high-throughput, reproducible manner offer the potential to increase the speed and efficacy of drug development. Development of therapeutic agents for many conditions is hampered by...
Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions [0.03%]
利培酮治疗自闭症的药物基因组学：八个候选基因与药物疗效和不良反应关联性分析
C T Correia,J P Almeida,P E Santos et al.
C T Correia et al.
Little has been reported on the factors, genetic or other, that underlie the variability in individual response, particularly for autism. In this study we simultaneously explored the effects of multiple candidate genes on clinical improveme...
Clinical Trial
The pharmacogenomics journal. 2010 Oct;10(5):418-30. DOI:10.1038/tpj.2009.63 2010
Role of Esrrg in the fibrate-mediated regulation of lipid metabolism genes in human ApoA-I transgenic mice [0.03%]
Esrrg在贝特类药物介导的人ApoA-I转基因小鼠脂质代谢基因调节中的作用
D Sanoudou,A Duka,K Drosatos et al.
D Sanoudou et al.
We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment. Multilevel bioinformatical analysis and str...
ADRA1A gene is associated with BMI in chronic schizophrenia patients exposed to antipsychotics [0.03%]
抗精神病药物治疗的慢性精神分裂症患者中ADRA1A基因与体质指数相关性研究
Y-R Liu,E-W Loh,T-H Lan et al.
Y-R Liu et al.
Noradrenaline and adrenaline are neurotransmitters of the sympathetic nervous system that interact with various adrenergic receptor (ADR) subtypes, and this regulates the basal metabolic rate, thermogenesis and efficiency of energy utilizat...
Gene network analysis of oxidative stress-mediated drug sensitivity in resistant ovarian carcinoma cells [0.03%]
耐药卵巢癌细胞中氧化应激介导的药物敏感性的基因网络分析
A K Maiti
A K Maiti
Drug resistance in cancer cells involves complex molecular mechanisms and ovarian carcinoma cells become resistant to chlorambucil (Cbl) after continuous treatment. This drug- and ionizing radiation-resistant cells have lower level of endog...