Effects of CYP3A4, CYP3A5, and ABCB1 genetic variants on tacrolimus metabolism during the early period after kidney transplantation
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Tacrolimus (TAC) exhibits substantial interindividual pharmacokinetic variability, complicating early dose optimization after kidney transplantation. This study evaluated the effects of CYP3A5 rs776746 (6986A > G), CYP3A4 rs4646437 (G > A), and ABCB1 rs1045642... ...
